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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SPDEF

Z-value: 0.67

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Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524049_34524091-0.096.7e-01Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_77225071 2.55 ENST00000439557.2
ENST00000545553.1
MON1 secretory trafficking family member B
chr8_-_77912431 1.15 ENST00000357039.4
ENST00000522527.1
peroxisomal biogenesis factor 2
chr1_+_84630053 0.93 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_66662690 0.90 ENST00000488550.1
Meis homeobox 1
chr2_+_66662510 0.90 ENST00000272369.9
ENST00000407092.2
Meis homeobox 1
chr1_+_84630645 0.90 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_93551011 0.84 ENST00000248564.5
guanine nucleotide binding protein (G protein), gamma 11
chr2_-_54014127 0.80 ENST00000394717.2
GPR75-ASB3 readthrough
chr12_+_27396901 0.76 ENST00000541191.1
ENST00000389032.3
serine/threonine kinase 38 like
chr2_+_45878790 0.67 ENST00000306156.3
protein kinase C, epsilon
chr5_+_31532373 0.64 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
chromosome 5 open reading frame 22
chr17_+_47865917 0.62 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
K(lysine) acetyltransferase 7
chr12_+_29302119 0.62 ENST00000536681.3
fatty acyl CoA reductase 2
chr5_+_76326187 0.62 ENST00000312916.7
ENST00000506806.1
angiogenic factor with G patch and FHA domains 1
chr4_-_39640513 0.61 ENST00000511809.1
ENST00000505729.1
small integral membrane protein 14
chr2_-_63815628 0.57 ENST00000409562.3
WD repeat containing planar cell polarity effector
chr2_-_54014055 0.54 ENST00000263634.3
ENST00000406687.1
GPR75-ASB3 readthrough
chr16_+_77224732 0.53 ENST00000569610.1
ENST00000248248.3
ENST00000567291.1
ENST00000320859.6
ENST00000563612.1
ENST00000563279.1
MON1 secretory trafficking family member B
chr5_-_31532160 0.53 ENST00000511367.2
ENST00000513349.1
drosha, ribonuclease type III
chr1_-_28969517 0.51 ENST00000263974.4
ENST00000373824.4
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr2_-_128784846 0.51 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
Sin3A-associated protein, 130kDa
chr1_+_22351977 0.49 ENST00000420503.1
ENST00000416769.1
ENST00000404210.2
long intergenic non-protein coding RNA 339
chr10_-_119806085 0.47 ENST00000355624.3
RAB11 family interacting protein 2 (class I)
chr11_-_118122996 0.47 ENST00000525386.1
ENST00000527472.1
ENST00000278949.4
myelin protein zero-like 3
chr17_-_47755436 0.46 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr14_-_31926623 0.45 ENST00000356180.4
D-tyrosyl-tRNA deacylase 2 (putative)
chr7_+_77428149 0.45 ENST00000415251.2
ENST00000275575.7
putative homeodomain transcription factor 2
chr3_+_113616317 0.43 ENST00000440446.2
ENST00000488680.1
GRAM domain containing 1C
chr12_+_118814185 0.42 ENST00000543473.1
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr8_-_100025238 0.42 ENST00000521696.1
RP11-410L14.2
chr12_+_118814344 0.42 ENST00000397564.2
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr12_+_109490370 0.41 ENST00000257548.5
ENST00000536723.1
ENST00000536393.1
ubiquitin specific peptidase 30
chr5_+_161274940 0.41 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr3_-_32022733 0.40 ENST00000438237.2
ENST00000396556.2
oxysterol binding protein-like 10
chr7_+_77428066 0.39 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr16_-_25122785 0.39 ENST00000563962.1
ENST00000569920.1
RP11-449H11.1
chr14_+_24701628 0.38 ENST00000355299.4
ENST00000559836.1
guanosine monophosphate reductase 2
chr10_-_14996017 0.38 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DNA cross-link repair 1C
chr14_+_74417192 0.37 ENST00000554320.1
coenzyme Q6 monooxygenase
chr1_+_901847 0.36 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
pleckstrin homology domain containing, family N member 1
chr4_+_166128735 0.36 ENST00000226725.6
kelch-like family member 2
chr7_-_91875109 0.36 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1, ankyrin repeat containing
chr14_+_24701819 0.36 ENST00000560139.1
ENST00000559910.1
guanosine monophosphate reductase 2
chr14_+_24702073 0.36 ENST00000399440.2
guanosine monophosphate reductase 2
chr1_-_193028632 0.35 ENST00000421683.1
ubiquitin carboxyl-terminal hydrolase L5
chr4_+_153701081 0.34 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ADP-ribosylation factor interacting protein 1
chr12_-_64616019 0.34 ENST00000311915.8
ENST00000398055.3
ENST00000544871.1
chromosome 12 open reading frame 66
chr15_+_55700741 0.34 ENST00000569691.1
chromosome 15 open reading frame 65
chr12_-_123201337 0.33 ENST00000528880.2
hydroxycarboxylic acid receptor 3
chr6_-_150039249 0.33 ENST00000543571.1
large tumor suppressor kinase 1
chr6_-_139308777 0.33 ENST00000529597.1
ENST00000415951.2
ENST00000367663.4
ENST00000409812.2
RALBP1 associated Eps domain containing 1
chr6_-_139309378 0.33 ENST00000450536.2
ENST00000258062.5
RALBP1 associated Eps domain containing 1
chr10_-_14996070 0.33 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DNA cross-link repair 1C
chr7_+_114562172 0.32 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr4_-_39640700 0.32 ENST00000295958.5
small integral membrane protein 14
chr1_+_65886244 0.31 ENST00000344610.8
leptin receptor
chr14_-_78083112 0.30 ENST00000216484.2
serine palmitoyltransferase, long chain base subunit 2
chr6_-_150039170 0.30 ENST00000458696.2
ENST00000392273.3
large tumor suppressor kinase 1
chr12_-_132905789 0.29 ENST00000328957.8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr2_+_148602058 0.29 ENST00000241416.7
ENST00000535787.1
ENST00000404590.1
activin A receptor, type IIA
chr15_+_43663257 0.29 ENST00000260383.7
ENST00000564079.1
tubulin, gamma complex associated protein 4
chr11_+_36616355 0.29 ENST00000532470.2
chromosome 11 open reading frame 74
chr15_-_55700216 0.28 ENST00000569205.1
cell cycle progression 1
chr1_-_184723942 0.28 ENST00000318130.8
ER degradation enhancer, mannosidase alpha-like 3
chrX_-_152486108 0.28 ENST00000356661.5
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr3_+_29322437 0.27 ENST00000434693.2
RNA binding motif, single stranded interacting protein 3
chr7_-_91875358 0.27 ENST00000458177.1
ENST00000394507.1
ENST00000340022.2
ENST00000444960.1
KRIT1, ankyrin repeat containing
chr17_-_33905521 0.27 ENST00000225873.4
peroxisomal biogenesis factor 12
chr1_+_84630367 0.27 ENST00000370680.1
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_220462560 0.27 ENST00000456909.1
ENST00000295641.10
serine/threonine kinase 11 interacting protein
chr11_-_130786333 0.27 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
sorting nexin 19
chr8_+_100025476 0.27 ENST00000355155.1
ENST00000357162.2
ENST00000358544.2
ENST00000395996.1
ENST00000441350.2
vacuolar protein sorting 13 homolog B (yeast)
chr9_+_139377947 0.26 ENST00000354376.1
chromosome 9 open reading frame 163
chr1_+_67395922 0.26 ENST00000401042.3
ENST00000355356.3
mesoderm induction early response 1, transcriptional regulator
chr7_-_38948774 0.26 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr11_-_58345569 0.26 ENST00000528954.1
ENST00000528489.1
leupaxin
chr20_+_60697480 0.25 ENST00000370915.1
ENST00000253001.4
ENST00000400318.2
ENST00000279068.6
ENST00000279069.7
LSM14B, SCD6 homolog B (S. cerevisiae)
chr11_-_66115032 0.24 ENST00000311181.4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr15_-_80215984 0.23 ENST00000485386.1
ENST00000479961.1
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr7_+_128379449 0.23 ENST00000479257.1
calumenin
chr2_+_48667898 0.23 ENST00000281394.4
ENST00000294952.8
protein phosphatase 1, regulatory subunit 21
chr2_+_138721850 0.22 ENST00000329366.4
ENST00000280097.3
histamine N-methyltransferase
chr14_-_74416829 0.22 ENST00000534936.1
family with sequence similarity 161, member B
chr17_-_35969409 0.22 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
synergin, gamma
chr6_+_134274322 0.22 ENST00000367871.1
ENST00000237264.4
TBP-like 1
chr14_-_75593708 0.22 ENST00000557673.1
ENST00000238616.5
NIMA-related kinase 9
chr14_-_31926701 0.22 ENST00000310850.4
D-tyrosyl-tRNA deacylase 2 (putative)
chr1_+_235491714 0.22 ENST00000471812.1
ENST00000358966.2
ENST00000282841.5
ENST00000391855.2
geranylgeranyl diphosphate synthase 1
chr9_-_72374848 0.22 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
protein prenyltransferase alpha subunit repeat containing 1
chr11_+_111957497 0.21 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
succinate dehydrogenase complex, subunit D, integral membrane protein
chr2_-_63815860 0.21 ENST00000272321.7
ENST00000431065.1
WD repeat containing planar cell polarity effector
chr12_+_50794730 0.21 ENST00000523389.1
ENST00000518561.1
ENST00000347328.5
ENST00000550260.1
La ribonucleoprotein domain family, member 4
chr7_-_77427676 0.21 ENST00000257663.3
transmembrane protein 60
chr1_-_193028426 0.21 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
ubiquitin carboxyl-terminal hydrolase L5
chr3_+_57541975 0.20 ENST00000487257.1
ENST00000311180.8
phosphodiesterase 12
chr2_+_101618691 0.20 ENST00000409000.1
ENST00000409028.4
ENST00000409320.3
ENST00000409733.1
ENST00000409650.1
ENST00000409038.1
ribosomal protein L31
chr5_+_158690089 0.20 ENST00000296786.6
ubiquitin-like domain containing CTD phosphatase 1
chr7_+_99613195 0.19 ENST00000324306.6
zinc finger with KRAB and SCAN domains 1
chr18_+_19321281 0.19 ENST00000261537.6
mindbomb E3 ubiquitin protein ligase 1
chr4_+_144106080 0.19 ENST00000307017.4
ubiquitin specific peptidase 38
chr1_+_235492300 0.19 ENST00000476121.1
ENST00000497327.1
geranylgeranyl diphosphate synthase 1
chr15_-_55700522 0.19 ENST00000564092.1
ENST00000310958.6
cell cycle progression 1
chr19_-_36545649 0.19 ENST00000292894.1
THAP domain containing 8
chr19_-_53696587 0.19 ENST00000396424.3
ENST00000600412.1
zinc finger protein 665
chr15_-_55700457 0.18 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
cell cycle progression 1
chr2_+_219536749 0.18 ENST00000295709.3
ENST00000392106.2
ENST00000392105.3
ENST00000455724.1
serine/threonine kinase 36
chr12_+_123868320 0.18 ENST00000402868.3
ENST00000330479.4
SET domain containing (lysine methyltransferase) 8
chr9_-_86571628 0.18 ENST00000376344.3
chromosome 9 open reading frame 64
chr5_+_99871004 0.18 ENST00000312637.4
family with sequence similarity 174, member A
chr1_-_67896069 0.18 ENST00000370995.2
ENST00000361219.6
SERPINE1 mRNA binding protein 1
chr5_+_161275320 0.18 ENST00000437025.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_111506562 0.18 ENST00000485275.2
ENST00000369763.4
ligand dependent nuclear receptor interacting factor 1
chr7_+_128379346 0.18 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
calumenin
chr7_+_99613212 0.18 ENST00000426572.1
ENST00000535170.1
zinc finger with KRAB and SCAN domains 1
chr4_+_48833183 0.17 ENST00000503016.1
OCIA domain containing 1
chr3_-_133380731 0.17 ENST00000260810.5
topoisomerase (DNA) II binding protein 1
chr22_+_38201114 0.17 ENST00000340857.2
H1 histone family, member 0
chr14_+_69865401 0.16 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
solute carrier family 39, member 9
chr19_-_4723761 0.16 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
dipeptidyl-peptidase 9
chr14_+_60715928 0.16 ENST00000395076.4
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr20_+_49126881 0.16 ENST00000371621.3
ENST00000541713.1
protein tyrosine phosphatase, non-receptor type 1
chr19_-_36545128 0.16 ENST00000538849.1
THAP domain containing 8
chr4_+_48833160 0.15 ENST00000506801.1
OCIA domain containing 1
chr11_+_65383227 0.15 ENST00000355703.3
pecanex-like 3 (Drosophila)
chr5_+_86564739 0.15 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RAS p21 protein activator (GTPase activating protein) 1
chr4_+_48833015 0.15 ENST00000509122.1
ENST00000509664.1
ENST00000505922.2
ENST00000514981.1
OCIA domain containing 1
chr17_-_42092313 0.15 ENST00000587529.1
ENST00000206380.3
ENST00000542039.1
transmembrane protein 101
chr14_+_89029253 0.15 ENST00000251038.5
ENST00000359301.3
ENST00000302216.8
zinc finger CCCH-type containing 14
chr10_-_14996321 0.15 ENST00000378289.4
DNA cross-link repair 1C
chr14_-_69864993 0.15 ENST00000555373.1
enhancer of rudimentary homolog (Drosophila)
chr1_+_151043070 0.14 ENST00000368918.3
ENST00000368917.1
GA binding protein transcription factor, beta subunit 2
chr17_-_45908875 0.14 ENST00000351111.2
ENST00000414011.1
mitochondrial ribosomal protein L10
chr12_+_50794592 0.14 ENST00000293618.8
ENST00000429001.3
ENST00000548174.1
ENST00000548697.1
ENST00000548993.1
ENST00000398473.2
ENST00000522085.1
ENST00000518444.1
ENST00000551886.1
La ribonucleoprotein domain family, member 4
chr2_+_198380289 0.14 ENST00000233892.4
ENST00000409916.1
MOB family member 4, phocein
chrX_-_129402857 0.14 ENST00000447817.1
ENST00000370978.4
zinc finger protein 280C
chr12_+_106751436 0.14 ENST00000228347.4
polymerase (RNA) III (DNA directed) polypeptide B
chr20_-_34287259 0.14 ENST00000397425.1
ENST00000540053.1
ENST00000541387.1
ENST00000374092.4
NFS1 cysteine desulfurase
chr1_+_156698234 0.14 ENST00000368218.4
ENST00000368216.4
ribosomal RNA adenine dimethylase domain containing 1
chr12_-_6798616 0.14 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
zinc finger protein 384
chr1_-_193028621 0.14 ENST00000367455.4
ENST00000367454.1
ubiquitin carboxyl-terminal hydrolase L5
chrX_+_123480375 0.14 ENST00000360027.4
SH2 domain containing 1A
chr5_+_161274685 0.14 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_+_219537015 0.14 ENST00000440309.1
ENST00000424080.1
serine/threonine kinase 36
chr4_+_141445311 0.14 ENST00000323570.3
ENST00000511887.2
ELMO/CED-12 domain containing 2
chr17_-_62658186 0.13 ENST00000262435.9
SMAD specific E3 ubiquitin protein ligase 2
chr20_-_34287103 0.13 ENST00000374085.1
ENST00000419569.1
NFS1 cysteine desulfurase
chr1_-_67896095 0.13 ENST00000370994.4
SERPINE1 mRNA binding protein 1
chr4_+_159593418 0.13 ENST00000507475.1
ENST00000307738.5
electron-transferring-flavoprotein dehydrogenase
chr12_-_6798410 0.13 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
zinc finger protein 384
chr8_-_130951940 0.13 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
family with sequence similarity 49, member B
chr6_+_36853607 0.13 ENST00000480824.2
ENST00000355190.3
ENST00000373685.1
chromosome 6 open reading frame 89
chr2_+_198380763 0.13 ENST00000448447.2
ENST00000409360.1
MOB family member 4, phocein
chr20_-_34287220 0.13 ENST00000306750.3
NFS1 cysteine desulfurase
chr12_-_6798523 0.13 ENST00000319770.3
zinc finger protein 384
chr20_-_33999766 0.13 ENST00000349714.5
ENST00000438533.1
ENST00000359226.2
ENST00000374384.2
ENST00000374377.5
ENST00000407996.2
ENST00000424405.1
ENST00000542501.1
ENST00000397554.1
ENST00000540457.1
ENST00000374380.2
ENST00000374385.5
ubiquinol-cytochrome c reductase complex assembly factor 1
chr17_-_56082455 0.13 ENST00000578794.1
Uncharacterized protein
chr4_+_48833070 0.12 ENST00000511662.1
ENST00000508996.1
ENST00000507210.1
ENST00000264312.7
ENST00000396448.2
ENST00000512236.1
ENST00000509164.1
ENST00000511102.1
ENST00000381473.3
OCIA domain containing 1
chr18_+_21032781 0.12 ENST00000339486.3
RIO kinase 3
chr4_+_159593271 0.12 ENST00000512251.1
ENST00000511912.1
electron-transferring-flavoprotein dehydrogenase
chr12_-_121019165 0.12 ENST00000341039.2
ENST00000357500.4
processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
chr12_+_132434439 0.12 ENST00000333577.4
ENST00000389561.2
ENST00000389562.2
ENST00000332482.4
ENST00000330386.6
E1A binding protein p400
chr14_+_74416989 0.12 ENST00000334571.2
ENST00000554920.1
coenzyme Q6 monooxygenase
chr2_+_63816087 0.12 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
malate dehydrogenase 1, NAD (soluble)
chr21_-_46221684 0.12 ENST00000330942.5
ubiquitin-conjugating enzyme E2G 2
chr1_-_67896009 0.11 ENST00000370990.5
SERPINE1 mRNA binding protein 1
chr2_-_39103014 0.11 ENST00000295373.6
ENST00000417233.1
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
chr8_-_101964265 0.11 ENST00000395958.2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr10_-_15902449 0.11 ENST00000277632.3
family with sequence similarity 188, member A
chr13_+_25670268 0.11 ENST00000281589.3
poly(A) binding protein, cytoplasmic 3
chr2_+_37311645 0.11 ENST00000281932.5
G patch domain containing 11
chr2_-_37311445 0.11 ENST00000233099.5
ENST00000354531.2
HEAT repeat containing 5B
chr3_-_137893721 0.11 ENST00000505015.2
ENST00000260803.4
debranching RNA lariats 1
chr4_+_48833119 0.11 ENST00000444354.2
ENST00000509963.1
ENST00000509246.1
OCIA domain containing 1
chr11_+_61129456 0.10 ENST00000278826.6
transmembrane protein 138
chr2_+_48667983 0.10 ENST00000449090.2
protein phosphatase 1, regulatory subunit 21
chr6_-_31560729 0.10 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
natural cytotoxicity triggering receptor 3
chr8_-_56987061 0.10 ENST00000009589.3
ENST00000524349.1
ENST00000519606.1
ENST00000519807.1
ENST00000521262.1
ENST00000520627.1
ribosomal protein S20
chr7_-_6098770 0.10 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
eukaryotic translation initiation factor 2-alpha kinase 1
chr3_+_33840050 0.10 ENST00000457054.2
ENST00000413073.1
programmed cell death 6 interacting protein
chr1_+_171750776 0.10 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
methyltransferase like 13
chr12_+_102513950 0.10 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARP1 binding protein
chr11_-_130786400 0.10 ENST00000265909.4
sorting nexin 19
chr12_+_2162704 0.10 ENST00000480911.1
ENST00000399595.1
ENST00000399644.1
ENST00000399638.1
ENST00000399597.1
ENST00000399621.1
ENST00000399637.1
ENST00000399591.1
ENST00000399641.1
ENST00000347598.4
ENST00000399606.1
ENST00000399601.1
ENST00000344100.3
ENST00000399629.1
ENST00000327702.7
ENST00000399649.1
ENST00000402845.3
ENST00000399603.1
ENST00000399634.1
ENST00000399617.1
ENST00000406454.3
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr12_-_102513843 0.09 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr2_+_54014168 0.09 ENST00000405123.3
ENST00000185150.4
ENST00000378239.5
endoplasmic reticulum lectin 1
chr4_+_48833312 0.09 ENST00000508293.1
ENST00000513391.2
OCIA domain containing 1
chr1_-_235324772 0.09 ENST00000408888.3
RNA binding motif protein 34
chr2_+_3383439 0.09 ENST00000382110.2
ENST00000324266.5
trafficking protein particle complex 12
chr2_+_27805880 0.09 ENST00000379717.1
ENST00000355467.4
ENST00000556601.1
ENST00000416005.2
zinc finger protein 512
chr1_-_169337176 0.09 ENST00000472647.1
ENST00000367811.3
NME/NM23 family member 7
chr1_-_235324530 0.09 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RNA binding motif protein 34
chr13_+_27998681 0.09 ENST00000381140.4
general transcription factor IIIA
chr8_-_56987057 0.09 ENST00000518875.1
ribosomal protein S20
chr4_+_48833234 0.09 ENST00000510824.1
ENST00000425583.2
OCIA domain containing 1
chr16_-_70557430 0.09 ENST00000393612.4
ENST00000564653.1
ENST00000323786.5
component of oligomeric golgi complex 4
chrX_+_123480421 0.09 ENST00000477673.2
SH2 domain containing 1A
chr22_-_22337204 0.08 ENST00000430142.1
ENST00000357179.5
topoisomerase (DNA) III beta
chr15_-_59949693 0.08 ENST00000396063.1
ENST00000396064.3
ENST00000484743.1
ENST00000559706.1
ENST00000396060.2
general transcription factor IIA, 2, 12kDa
chr11_+_94706973 0.08 ENST00000536741.1
lysine (K)-specific demethylase 4D
chr22_-_41215328 0.08 ENST00000434185.1
ENST00000435456.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0019085 early viral transcription(GO:0019085)
0.3 2.1 GO:0097338 response to clozapine(GO:0097338)
0.2 0.6 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.2 0.6 GO:0072720 response to dithiothreitol(GO:0072720)
0.1 0.4 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.4 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.8 GO:0090521 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.1 0.6 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.6 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.4 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.1 0.3 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.4 GO:1990502 dense core granule maturation(GO:1990502)
0.1 1.8 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 1.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.3 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 0.2 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.3 GO:0042713 sperm ejaculation(GO:0042713)
0.0 0.2 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 1.1 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.3 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.0 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.7 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.3 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.1 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.3 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.1 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.1 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.3 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.1 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.5 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.2 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.8 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0070131 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) positive regulation of mitochondrial translation(GO:0070131) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.4 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:1902164 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:1902560 GMP reductase complex(GO:1902560)
0.1 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.2 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.8 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.7 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.8 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0044447 axoneme part(GO:0044447)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.5 GO:1902555 endoribonuclease complex(GO:1902555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.2 1.1 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.4 GO:0031071 cysteine desulfurase activity(GO:0031071)
0.1 0.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 2.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.3 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.4 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.3 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.7 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.1 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 1.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins