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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SPI1

Z-value: 0.75

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Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
SPI1
ENSG00000066336.7 Spi-1 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47399942_47399961,
hg19_v2_chr11_-_47400078_47400127		0.183.8e-01Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_228678550 2.63 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr2_+_161993465 1.99 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr5_-_131826457 1.69 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr11_-_72432950 1.65 ENST00000426523.1
ENST00000429686.1
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_11382478 1.62 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_102188224 1.58 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr2_+_161993412 1.54 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr17_-_20370847 1.48 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr11_-_3862059 1.35 ENST00000396978.1
RHOG
ras homolog family member G
chr11_+_102188272 1.34 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr5_+_159895275 1.33 ENST00000517927.1
MIR146A
microRNA 146a
chr17_+_32582293 1.28 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr1_-_150738261 1.23 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr16_+_67063262 1.22 ENST00000565389.1
CBFB
core-binding factor, beta subunit
chr5_+_35856951 1.20 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr2_+_152214098 1.05 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_115670792 1.03 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr15_-_80263506 1.02 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr1_-_101360331 1.02 ENST00000416479.1
ENST00000370113.3
EXTL2
exostosin-like glycosyltransferase 2
chr6_-_154677900 1.01 ENST00000265198.4
ENST00000520261.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_-_184943610 1.01 ENST00000367511.3
FAM129A
family with sequence similarity 129, member A
chr7_-_115670804 1.00 ENST00000320239.7
TFEC
transcription factor EC
chr2_-_225811747 0.94 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr16_+_86544113 0.93 ENST00000262426.4
FOXF1
forkhead box F1
chr9_-_117568365 0.92 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr1_-_173174681 0.90 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_+_31553978 0.88 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr15_-_62457480 0.87 ENST00000380392.3
C2CD4B
C2 calcium-dependent domain containing 4B
chr8_-_119964434 0.86 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr12_+_45609862 0.81 ENST00000423947.3
ENST00000435642.1
ANO6
anoctamin 6
chr22_-_43042955 0.81 ENST00000402438.1
CYB5R3
cytochrome b5 reductase 3
chr3_+_119013185 0.80 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr20_+_44746939 0.78 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr6_-_43595039 0.77 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr17_+_7461613 0.76 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr6_-_154751629 0.74 ENST00000424998.1
CNKSR3
CNKSR family member 3
chr6_+_31553901 0.73 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr5_-_150460914 0.72 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr1_-_167487758 0.71 ENST00000362089.5
CD247
CD247 molecule
chr5_+_68530697 0.68 ENST00000256443.3
ENST00000514676.1
CDK7
cyclin-dependent kinase 7
chr17_+_21191341 0.68 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr1_-_167487808 0.66 ENST00000392122.3
CD247
CD247 molecule
chr4_+_103423055 0.64 ENST00000505458.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr11_-_85780853 0.64 ENST00000531930.1
ENST00000528398.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_+_127898312 0.63 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr16_+_67063855 0.62 ENST00000563939.2
CBFB
core-binding factor, beta subunit
chr2_-_153573965 0.61 ENST00000448428.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr6_+_31543334 0.60 ENST00000449264.2
TNF
tumor necrosis factor
chr16_-_21663919 0.58 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr13_-_33760216 0.58 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_+_45251804 0.58 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr11_-_31832785 0.57 ENST00000241001.8
PAX6
paired box 6
chr5_+_68530668 0.57 ENST00000506563.1
CDK7
cyclin-dependent kinase 7
chr2_-_175462456 0.57 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr11_-_31832862 0.57 ENST00000379115.4
PAX6
paired box 6
chr17_+_47287749 0.56 ENST00000419580.2
ABI3
ABI family, member 3
chr11_-_6502534 0.56 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
ARFIP2
ADP-ribosylation factor interacting protein 2
chr4_+_103422471 0.55 ENST00000226574.4
ENST00000394820.4
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr2_+_28615669 0.54 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr5_-_179047881 0.54 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_-_4338783 0.54 ENST00000601482.1
ENST00000600324.1
STAP2
signal transducing adaptor family member 2
chr2_+_103035102 0.53 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr11_-_6502580 0.53 ENST00000423813.2
ENST00000396777.3
ARFIP2
ADP-ribosylation factor interacting protein 2
chr19_-_4338838 0.52 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr17_+_7461580 0.52 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr4_+_86396321 0.51 ENST00000503995.1
ARHGAP24
Rho GTPase activating protein 24
chr15_-_50411412 0.51 ENST00000284509.6
ATP8B4
ATPase, class I, type 8B, member 4
chr11_-_31832581 0.51 ENST00000379111.2
PAX6
paired box 6
chr2_-_235405168 0.51 ENST00000339728.3
ARL4C
ADP-ribosylation factor-like 4C
chr18_+_11851383 0.50 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr3_-_172428959 0.50 ENST00000475381.1
ENST00000538775.1
ENST00000273512.3
ENST00000543711.1
NCEH1
neutral cholesterol ester hydrolase 1
chr11_-_72433346 0.49 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_34524049 0.48 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr17_+_32646055 0.48 ENST00000394620.1
CCL8
chemokine (C-C motif) ligand 8
chr16_+_31085714 0.48 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
ZNF646
zinc finger protein 646
chr17_+_4618734 0.48 ENST00000571206.1
ARRB2
arrestin, beta 2
chr6_-_32160622 0.48 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr6_+_31554826 0.48 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr20_+_44746885 0.48 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr16_+_57673430 0.47 ENST00000540164.2
ENST00000568531.1
GPR56
G protein-coupled receptor 56
chr10_+_114135952 0.47 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_31554456 0.47 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr2_+_143886877 0.47 ENST00000295095.6
ARHGAP15
Rho GTPase activating protein 15
chr2_+_97202480 0.47 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr8_+_81397876 0.46 ENST00000430430.1
ZBTB10
zinc finger and BTB domain containing 10
chr17_+_18218587 0.46 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr3_-_123512688 0.45 ENST00000475616.1
MYLK
myosin light chain kinase
chr12_+_54891495 0.45 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr11_+_128563652 0.44 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr17_+_42925270 0.44 ENST00000253410.2
ENST00000587021.1
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr2_+_97203082 0.44 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr7_+_112063192 0.44 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr16_+_67062996 0.44 ENST00000561924.2
CBFB
core-binding factor, beta subunit
chr3_+_142838091 0.43 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr1_-_31661000 0.42 ENST00000263693.1
ENST00000398657.2
ENST00000526106.1
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr5_-_58652788 0.42 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_-_43042968 0.42 ENST00000407623.3
ENST00000396303.3
ENST00000438270.1
CYB5R3
cytochrome b5 reductase 3
chr22_-_38699003 0.42 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chr15_+_75074410 0.42 ENST00000439220.2
CSK
c-src tyrosine kinase
chr22_-_17489112 0.41 ENST00000400588.1
GAB4
GRB2-associated binding protein family, member 4
chr7_+_134551583 0.41 ENST00000435928.1
CALD1
caldesmon 1
chr3_-_178789993 0.40 ENST00000432729.1
ZMAT3
zinc finger, matrin-type 3
chr14_+_74004051 0.40 ENST00000557556.1
ACOT1
acyl-CoA thioesterase 1
chr5_-_124080203 0.40 ENST00000504926.1
ZNF608
zinc finger protein 608
chrX_+_128913906 0.39 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr3_-_112693865 0.39 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1
CD200 receptor 1
chr17_-_1549011 0.39 ENST00000571272.1
ENST00000263071.4
ENST00000348987.3
SCARF1
scavenger receptor class F, member 1
chr7_-_151574191 0.39 ENST00000287878.4
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_+_36119929 0.38 ENST00000588161.1
ENST00000262633.4
ENST00000592202.1
ENST00000586618.1
RBM42
RNA binding motif protein 42
chr18_-_10748498 0.38 ENST00000579949.1
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr1_+_144989309 0.38 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr17_+_80332153 0.38 ENST00000313135.2
UTS2R
urotensin 2 receptor
chr14_-_35344093 0.38 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr4_+_4861385 0.38 ENST00000382723.4
MSX1
msh homeobox 1
chr5_+_67584174 0.37 ENST00000320694.8
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_5569588 0.37 ENST00000417101.1
ACTB
actin, beta
chr11_+_5474638 0.37 ENST00000341449.2
OR51I2
olfactory receptor, family 51, subfamily I, member 2
chr3_-_121379739 0.37 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_-_59064458 0.37 ENST00000502575.1
ENST00000507116.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_63052929 0.37 ENST00000439174.2
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr3_+_113465866 0.37 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr5_+_179125368 0.37 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
CANX
calnexin
chr2_+_69001913 0.37 ENST00000409030.3
ENST00000409220.1
ARHGAP25
Rho GTPase activating protein 25
chr17_-_3301704 0.37 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr6_-_11779174 0.36 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr19_+_36119975 0.36 ENST00000589559.1
ENST00000360475.4
RBM42
RNA binding motif protein 42
chr12_+_94071341 0.36 ENST00000542893.2
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr17_-_39211463 0.36 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr6_+_31554612 0.36 ENST00000211921.7
LST1
leukocyte specific transcript 1
chr10_-_100995603 0.36 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chr6_-_11779014 0.36 ENST00000229583.5
ADTRP
androgen-dependent TFPI-regulating protein
chr11_-_62599505 0.35 ENST00000377897.4
ENST00000394690.1
ENST00000541317.1
ENST00000294179.3
STX5
syntaxin 5
chr21_+_34775181 0.35 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr16_-_31085514 0.35 ENST00000300849.4
ZNF668
zinc finger protein 668
chr6_+_32811885 0.35 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1
PSMB9
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr12_+_96588279 0.35 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr10_+_111767720 0.35 ENST00000356080.4
ENST00000277900.8
ADD3
adducin 3 (gamma)
chr8_+_104311059 0.34 ENST00000358755.4
ENST00000523739.1
ENST00000540287.1
FZD6
frizzled family receptor 6
chr14_-_65569057 0.34 ENST00000555419.1
ENST00000341653.2
MAX
MYC associated factor X
chr1_+_168250194 0.34 ENST00000367821.3
TBX19
T-box 19
chr19_+_49838653 0.34 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr12_+_94071129 0.34 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr6_+_45390222 0.34 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr3_-_178790057 0.34 ENST00000311417.2
ZMAT3
zinc finger, matrin-type 3
chr1_-_205912577 0.34 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr6_-_32811771 0.34 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_128841503 0.34 ENST00000368215.3
ENST00000532331.1
ENST00000368213.5
ENST00000368207.3
ENST00000525459.1
ENST00000368210.3
ENST00000368226.4
ENST00000368227.3
PTPRK
protein tyrosine phosphatase, receptor type, K
chr12_+_45609893 0.34 ENST00000320560.8
ANO6
anoctamin 6
chr8_+_86089460 0.34 ENST00000418930.2
E2F5
E2F transcription factor 5, p130-binding
chr11_+_131781290 0.33 ENST00000425719.2
ENST00000374784.1
NTM
neurotrimin
chr14_-_65569244 0.33 ENST00000557277.1
ENST00000556892.1
MAX
MYC associated factor X
chr2_+_187454749 0.33 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr16_+_29674277 0.33 ENST00000395389.2
SPN
sialophorin
chr14_-_24616426 0.33 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr15_+_42787815 0.33 ENST00000564153.1
ENST00000349777.1
ENST00000567094.1
ENST00000566327.1
ENST00000568859.1
SNAP23
synaptosomal-associated protein, 23kDa
chr9_-_98269699 0.33 ENST00000429896.2
PTCH1
patched 1
chr17_+_7461849 0.33 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr16_+_28996364 0.33 ENST00000564277.1
LAT
linker for activation of T cells
chr15_-_55611306 0.32 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr6_-_167040731 0.32 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chrX_+_82763265 0.32 ENST00000373200.2
POU3F4
POU class 3 homeobox 4
chr11_-_64764435 0.32 ENST00000534177.1
ENST00000301887.4
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr21_-_40685536 0.32 ENST00000341322.4
BRWD1
bromodomain and WD repeat domain containing 1
chr16_-_67693846 0.32 ENST00000602850.1
ACD
adrenocortical dysplasia homolog (mouse)
chr12_-_58135903 0.32 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr16_+_2732476 0.32 ENST00000301738.4
ENST00000564195.1
KCTD5
potassium channel tetramerization domain containing 5
chr1_-_235098935 0.32 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr10_-_100995540 0.32 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chr6_+_26156551 0.32 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr4_-_10117949 0.32 ENST00000508079.1
WDR1
WD repeat domain 1
chr19_-_6737576 0.32 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chr3_-_46249878 0.31 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr19_+_13051206 0.31 ENST00000586760.1
CALR
calreticulin
chr19_-_47220335 0.31 ENST00000601806.1
ENST00000593363.1
ENST00000598633.1
ENST00000595515.1
ENST00000433867.1
PRKD2
protein kinase D2
chr16_+_23652773 0.31 ENST00000563998.1
ENST00000568589.1
ENST00000568272.1
DCTN5
dynactin 5 (p25)
chr3_+_109128837 0.31 ENST00000497996.1
RP11-702L6.4
RP11-702L6.4
chr3_-_27498235 0.31 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr10_+_26727333 0.31 ENST00000356785.4
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr15_+_42787452 0.31 ENST00000249647.3
SNAP23
synaptosomal-associated protein, 23kDa
chr4_+_8201091 0.31 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_-_175462934 0.30 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr9_-_137809718 0.30 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr3_-_196911002 0.30 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chr7_-_32338917 0.30 ENST00000396193.1
PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr2_-_153573887 0.30 ENST00000493468.2
ENST00000545856.1
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr6_-_11779403 0.30 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr1_+_9711781 0.30 ENST00000536656.1
ENST00000377346.4
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr10_-_111683308 0.29 ENST00000502935.1
ENST00000322238.8
ENST00000369680.4
XPNPEP1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr2_+_37571717 0.29 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr6_-_33290580 0.29 ENST00000446511.1
ENST00000446403.1
ENST00000414083.2
ENST00000266000.6
ENST00000374542.5
DAXX
death-domain associated protein
chr17_+_7461781 0.29 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_-_196910721 0.29 ENST00000443183.1
DLG1
discs, large homolog 1 (Drosophila)
chr8_+_86089619 0.29 ENST00000256117.5
ENST00000416274.2
E2F5
E2F transcription factor 5, p130-binding
chr6_+_31554636 0.29 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr19_-_6481776 0.28 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr19_-_18391708 0.28 ENST00000600972.1
JUND
jun D proto-oncogene
chr19_-_10450287 0.28 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr12_+_52306113 0.28 ENST00000547400.1
ENST00000550683.1
ENST00000419526.2
ACVRL1
activin A receptor type II-like 1
chr7_-_121944491 0.28 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr2_+_37571845 0.28 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.6 3.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.5 2.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.5 2.6 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.4 1.3 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.4 1.9 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 0.9 GO:0060458 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) right lung development(GO:0060458)
0.3 1.1 GO:0097045 phosphatidylserine exposure on blood platelet(GO:0097045)
0.3 0.9 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.3 1.4 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.2 1.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.2 0.6 GO:0046136 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) negative regulation of alkaline phosphatase activity(GO:0010693) positive regulation of translational initiation by iron(GO:0045994) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 0.2 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.2 0.6 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.2 0.6 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.2 2.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.2 0.7 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.2 1.3 GO:0033590 response to cobalamin(GO:0033590)
0.2 0.7 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2 3.3 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.1 0.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.4 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.4 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.1 0.3 GO:0042704 uterine wall breakdown(GO:0042704)
0.1 0.4 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.5 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.1 GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.5 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.3 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.6 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.5 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 1.2 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.6 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.3 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 3.3 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.7 GO:0030578 PML body organization(GO:0030578)
0.1 0.7 GO:0035897 proteolysis in other organism(GO:0035897)
0.1 0.8 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1 0.3 GO:0008355 olfactory learning(GO:0008355)
0.1 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.3 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.3 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 0.2 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.4 GO:0046203 spermidine catabolic process(GO:0046203)
0.1 0.6 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.4 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.1 0.3 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.1 0.2 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.1 0.1 GO:1904640 response to methionine(GO:1904640)
0.1 0.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.1 0.3 GO:0097325 negative regulation of extracellular matrix disassembly(GO:0010716) melanocyte proliferation(GO:0097325)
0.1 0.3 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.3 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.2 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.1 0.1 GO:2000412 positive regulation of thymocyte migration(GO:2000412)
0.1 0.2 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.1 0.4 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.3 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 0.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.1 0.2 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 1.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 0.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.5 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 1.1 GO:0015671 oxygen transport(GO:0015671)
0.1 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.2 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214)
0.1 0.2 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1 0.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.5 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.3 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 0.4 GO:0006226 dUMP biosynthetic process(GO:0006226)
0.1 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0035754 B cell chemotaxis(GO:0035754) mast cell differentiation(GO:0060374)
0.0 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:0030047 actin modification(GO:0030047)
0.0 0.1 GO:0048597 B cell selection(GO:0002339) B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.3 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.1 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.2 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 1.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.3 GO:0089700 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) protein kinase D signaling(GO:0089700)
0.0 0.4 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:1900155 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.0 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.4 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.2 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 0.4 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.0 1.1 GO:0030728 ovulation(GO:0030728)
0.0 0.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.5 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.9 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.0 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.4 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.4 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.6 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.2 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.4 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.3 GO:2001053 regulation of mesenchymal cell apoptotic process(GO:2001053)
0.0 0.1 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.2 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.1 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957)
0.0 0.1 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) peptidyl-glutamine modification(GO:0018199) isopeptide cross-linking(GO:0018262)
0.0 0.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.4 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0 0.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.7 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787) regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0 1.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.8 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.4 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 0.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.0 0.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.1 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.6 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.4 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 0.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.3 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0001562 response to protozoan(GO:0001562)
0.0 0.4 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.1 GO:1902262 hypermethylation of CpG island(GO:0044027) apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.1 GO:0070091 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.1 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 1.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.0 GO:0072679 thymocyte migration(GO:0072679)
0.0 0.0 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.4 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.0 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.0 GO:0048369 lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370)
0.0 0.1 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) negative regulation of metanephric glomerulus development(GO:0072299) regulation of metanephric glomerular mesangial cell proliferation(GO:0072301) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0051683 establishment of Golgi localization(GO:0051683)
0.0 3.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.0 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.0 0.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.0 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0001771 immunological synapse formation(GO:0001771)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 0.9 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.3 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.2 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.0 GO:0010157 response to chlorate(GO:0010157)
0.0 0.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.0 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 1.2 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.0 0.1 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.0 0.5 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.0 0.1 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.0 0.3 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.0 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.2 GO:0036021 endolysosome lumen(GO:0036021)
0.2 1.3 GO:0043196 varicosity(GO:0043196)
0.1 1.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.4 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 0.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.2 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.2 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 1.2 GO:0031209 SCAR complex(GO:0031209)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.3 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.1 0.8 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.3 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.4 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 4.2 GO:0030027 lamellipodium(GO:0030027)
0.0 2.6 GO:0001726 ruffle(GO:0001726)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.0 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.0 GO:0097422 tubular endosome(GO:0097422)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0060091 stereocilium tip(GO:0032426) kinocilium(GO:0060091)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.6 3.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.4 1.3 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.3 1.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.0 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.2 0.6 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.2 0.7 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.2 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.7 GO:0030305 heparanase activity(GO:0030305)
0.2 0.5 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.2 2.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.4 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.7 GO:0070513 death domain binding(GO:0070513)
0.1 0.4 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.4 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.1 5.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.3 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 1.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.4 GO:0004132 dCMP deaminase activity(GO:0004132)
0.1 0.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.5 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.2 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.3 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 0.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.4 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.1 0.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.3 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.3 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.3 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 1.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.4 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 1.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.8 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.9 GO:0051400 BH domain binding(GO:0051400)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0019863 IgE binding(GO:0019863)
0.0 0.4 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.3 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 1.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.0 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 1.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.4 GO:0001848 complement binding(GO:0001848)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.0 0.2 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.0 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.9 GO:0030276 clathrin binding(GO:0030276)
0.0 0.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 1.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 3.8 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.7 PID IFNG PATHWAY IFN-gamma pathway
0.0 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.6 PID MYC PATHWAY C-MYC pathway
0.0 2.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.6 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 6.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.7 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 2.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME SIGNAL AMPLIFICATION Genes involved in Signal amplification
0.0 0.9 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.0 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 3.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism