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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SREBF1_TFE3
Z-value: 1.07
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Transcription factors associated with SREBF1_TFE3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFE3 | hg19_v2_chrX_-_48901012_48901050 | -0.30 | 1.4e-01 | Click! |
| SREBF1 | hg19_v2_chr17_-_17740287_17740316 | 0.30 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_39382900 Show fit | 5.83 |
ENST00000377721.3
ENST00000455970.2 |
keratin associated protein 9-2 |
|
| chr1_+_221051699 Show fit | 4.96 |
ENST00000366903.6
|
H2.0-like homeobox |
|
| chr8_-_81083890 Show fit | 3.07 |
ENST00000518937.1
|
tumor protein D52 |
|
| chr17_+_78075498 Show fit | 2.92 |
ENST00000302262.3
|
glucosidase, alpha; acid |
|
| chr19_-_15236173 Show fit | 2.75 |
ENST00000527093.1
|
ilvB (bacterial acetolactate synthase)-like |
|
| chr4_-_101439242 Show fit | 2.62 |
ENST00000296420.4
|
endomucin |
|
| chr17_+_78075361 Show fit | 2.55 |
ENST00000577106.1
ENST00000390015.3 |
glucosidase, alpha; acid |
|
| chr12_+_93964746 Show fit | 2.49 |
ENST00000536696.2
|
suppressor of cytokine signaling 2 |
|
| chr14_-_54420133 Show fit | 2.48 |
ENST00000559501.1
ENST00000558984.1 |
bone morphogenetic protein 4 |
|
| chr4_-_16900410 Show fit | 2.42 |
ENST00000304523.5
|
LIM domain binding 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF1_TFE3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.0 | 7.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.4 | 5.5 | GO:0002086 | diaphragm contraction(GO:0002086) |
| 1.3 | 5.3 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.6 | 5.2 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 4.9 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.3 | 4.8 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.2 | 4.8 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.2 | 4.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 4.3 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 10.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 7.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 6.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 4.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.5 | 4.0 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 3.9 | GO:0005901 | caveola(GO:0005901) |
| 0.6 | 3.7 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.9 | 3.5 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 3.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 8.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 6.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.8 | 5.5 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.3 | 5.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.7 | 4.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 4.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.3 | 3.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.3 | 3.5 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.3 | 3.4 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 4.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 3.0 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 2.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.9 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 5.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 5.0 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 4.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 4.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 4.3 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 3.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 2.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 2.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |