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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SREBF2

Z-value: 0.49

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.528.3e-03Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_11200038 1.21 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr20_+_33464238 1.14 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr20_+_33464407 1.06 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr5_+_159656437 0.75 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr15_+_47476275 0.74 ENST00000558014.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr10_-_116444371 0.64 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr5_-_43313574 0.61 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr5_-_39425068 0.61 ENST00000515700.1
ENST00000339788.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr8_-_17579726 0.53 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr9_+_126131131 0.42 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr15_-_73075964 0.39 ENST00000563907.1
ADPGK
ADP-dependent glucokinase
chr19_-_11308190 0.34 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr11_-_73309228 0.33 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr2_-_56150184 0.33 ENST00000394554.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr22_+_42229100 0.33 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr17_-_40075219 0.32 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr12_-_48398104 0.31 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr2_-_26205340 0.29 ENST00000264712.3
KIF3C
kinesin family member 3C
chr11_+_2923423 0.28 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr5_-_107703556 0.28 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr11_+_2923499 0.28 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr17_-_40075197 0.27 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr9_+_131452239 0.26 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr15_-_73076030 0.26 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr19_-_18392422 0.26 ENST00000252818.3
JUND
jun D proto-oncogene
chr11_+_2923619 0.25 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr6_-_32152020 0.24 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr6_-_39902160 0.24 ENST00000340692.5
MOCS1
molybdenum cofactor synthesis 1
chr5_-_149535421 0.23 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_55505184 0.22 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr6_-_32152064 0.22 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr6_+_79577189 0.21 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr3_-_160117301 0.21 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr6_-_32151999 0.21 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr8_+_26435359 0.21 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr3_-_171527560 0.19 ENST00000331659.2
PP13439
PP13439
chr6_-_52860171 0.18 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr6_+_151561085 0.16 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr10_-_3827371 0.15 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr16_+_66914264 0.15 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr6_+_41604747 0.14 ENST00000419164.1
ENST00000373051.2
MDFI
MyoD family inhibitor
chrX_-_112084043 0.14 ENST00000304758.1
AMOT
angiomotin
chr10_-_3827417 0.14 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chrX_-_153236620 0.13 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr6_-_32083106 0.11 ENST00000442721.1
TNXB
tenascin XB
chr17_-_39274606 0.10 ENST00000391413.2
KRTAP4-11
keratin associated protein 4-11
chr9_+_131451480 0.10 ENST00000322030.8
SET
SET nuclear oncogene
chr11_+_65383227 0.09 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr6_+_43968306 0.09 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr18_-_21166841 0.08 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr11_+_22688150 0.08 ENST00000454584.2
GAS2
growth arrest-specific 2
chr14_-_74959978 0.07 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr14_+_56046914 0.07 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr14_-_74959994 0.07 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chrX_+_27826107 0.07 ENST00000356790.2
MAGEB10
melanoma antigen family B, 10
chr14_+_56046990 0.06 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
KTN1
kinectin 1 (kinesin receptor)
chr20_+_58533471 0.06 ENST00000244047.5
ENST00000348616.4
CDH26
cadherin 26
chr6_-_53213780 0.06 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr13_+_24844819 0.06 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr14_-_74960030 0.06 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chrX_-_153236819 0.06 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr1_+_231297798 0.06 ENST00000444294.3
TRIM67
tripartite motif containing 67
chr16_+_2083265 0.06 ENST00000565855.1
ENST00000566198.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr12_+_50344516 0.05 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chr3_+_5020801 0.05 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr16_+_31225337 0.05 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr3_+_160117418 0.04 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr14_-_35183886 0.04 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chrX_-_153237258 0.04 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr1_+_247582097 0.04 ENST00000391827.2
NLRP3
NLR family, pyrin domain containing 3
chr6_-_52859968 0.03 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr3_+_46742823 0.02 ENST00000326431.3
TMIE
transmembrane inner ear
chr15_+_33010175 0.02 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr19_-_46285646 0.02 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr7_-_44580861 0.02 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr6_+_42141029 0.02 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr1_+_197237352 0.01 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr2_+_232572361 0.00 ENST00000409321.1
PTMA
prothymosin, alpha
chr11_+_65479462 0.00 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5
K(lysine) acetyltransferase 5
chr1_+_39796810 0.00 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chrX_+_47229982 0.00 ENST00000377073.3
ZNF157
zinc finger protein 157

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.3 1.2 GO:1905167 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 0.7 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.2 0.6 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.8 GO:0046618 drug export(GO:0046618)
0.1 0.2 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.4 GO:0014028 notochord formation(GO:0014028)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.2 GO:0072275 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.3 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.3 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.8 GO:0019433 bile acid and bile salt transport(GO:0015721) triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.7 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.2 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 0.7 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.2 0.2 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.2 1.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.8 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 0.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0032052 bile acid binding(GO:0032052)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis