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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for SRF

Z-value: 1.15

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_431390940.193.6e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_137801160 23.15 ENST00000239938.4
EGR1
early growth response 1
chr10_-_64576105 12.75 ENST00000242480.3
ENST00000411732.1
EGR2
early growth response 2
chr8_-_22550815 6.89 ENST00000317216.2
EGR3
early growth response 3
chr19_+_45971246 5.63 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr4_+_87928140 5.48 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr19_+_2476116 3.80 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr12_+_52445191 3.79 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr2_-_106054952 3.22 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr10_+_112257596 3.20 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr2_-_106015527 3.18 ENST00000344213.4
ENST00000358129.4
FHL2
four and a half LIM domains 2
chr2_-_106015491 3.16 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
FHL2
four and a half LIM domains 2
chr7_-_27183263 3.06 ENST00000222726.3
HOXA5
homeobox A5
chr14_+_75745477 2.57 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_73520667 2.44 ENST00000545030.1
ENST00000436467.2
EGR4
early growth response 4
chr6_-_16761678 2.36 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr19_-_17356697 1.99 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr17_+_42634844 1.80 ENST00000315323.3
FZD2
frizzled family receptor 2
chr14_-_74226961 1.79 ENST00000286523.5
ENST00000435371.1
ELMSAN1
ELM2 and Myb/SANT-like domain containing 1
chr1_-_208084729 1.55 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr2_-_209118974 1.54 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr3_+_49027308 1.50 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr19_+_1026566 1.49 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr19_+_1026298 1.48 ENST00000263097.4
CNN2
calponin 2
chr9_+_131644781 1.39 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr15_+_83776324 1.35 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr5_-_111093167 1.28 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr7_+_5919458 1.24 ENST00000416608.1
OCM
oncomodulin
chr9_-_98269481 1.18 ENST00000418258.1
ENST00000553011.1
ENST00000551845.1
PTCH1
patched 1
chr3_+_143690640 1.09 ENST00000315691.3
C3orf58
chromosome 3 open reading frame 58
chr17_+_3379284 1.08 ENST00000263080.2
ASPA
aspartoacylase
chr9_-_79520989 1.07 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr15_+_96873921 1.05 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr6_-_111804905 1.03 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr11_-_57282349 0.95 ENST00000528450.1
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr2_+_87769459 0.94 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr4_+_81118647 0.93 ENST00000415738.2
PRDM8
PR domain containing 8
chr2_-_112237835 0.92 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr8_+_1993152 0.86 ENST00000262113.4
MYOM2
myomesin 2
chr5_-_53606396 0.84 ENST00000504924.1
ENST00000507646.2
ENST00000502271.1
ARL15
ADP-ribosylation factor-like 15
chr2_+_191792376 0.82 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr9_+_124088860 0.80 ENST00000373806.1
GSN
gelsolin
chr1_+_16085244 0.79 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr12_-_6772303 0.77 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
ING4
inhibitor of growth family, member 4
chr1_-_91487770 0.77 ENST00000337393.5
ZNF644
zinc finger protein 644
chr7_-_44180673 0.74 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
MYL7
myosin, light chain 7, regulatory
chr8_+_1993173 0.72 ENST00000523438.1
MYOM2
myomesin 2
chr4_+_87928413 0.72 ENST00000544085.1
AFF1
AF4/FMR2 family, member 1
chr8_+_97597148 0.68 ENST00000521590.1
SDC2
syndecan 2
chr6_+_151561085 0.66 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_176923846 0.66 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr5_-_176923803 0.66 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr20_+_35169885 0.66 ENST00000279022.2
ENST00000346786.2
MYL9
myosin, light chain 9, regulatory
chr2_-_172087824 0.65 ENST00000521943.1
TLK1
tousled-like kinase 1
chr12_-_15104040 0.61 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr7_+_94285637 0.61 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr5_-_33892046 0.57 ENST00000352040.3
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_+_223889285 0.54 ENST00000433674.2
CAPN2
calpain 2, (m/II) large subunit
chr2_-_128432639 0.54 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIMS2
LIM and senescent cell antigen-like domains 2
chr15_+_74218787 0.52 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr19_+_13134772 0.49 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_59989791 0.49 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr19_-_47975417 0.48 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr6_-_159466042 0.48 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr3_+_9834758 0.47 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr7_-_107643674 0.47 ENST00000222399.6
LAMB1
laminin, beta 1
chr11_-_2162468 0.45 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_105585022 0.45 ENST00000314641.5
BVES
blood vessel epicardial substance
chr12_-_50616382 0.39 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr11_-_2162162 0.39 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_-_94285402 0.38 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr16_-_11375179 0.38 ENST00000312511.3
PRM1
protamine 1
chr12_-_50616122 0.37 ENST00000552823.1
ENST00000552909.1
LIMA1
LIM domain and actin binding 1
chr7_-_44180884 0.36 ENST00000458240.1
ENST00000223364.3
MYL7
myosin, light chain 7, regulatory
chr11_-_102323489 0.35 ENST00000361236.3
TMEM123
transmembrane protein 123
chr17_+_73452695 0.35 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
KIAA0195
chr3_-_9834375 0.33 ENST00000343450.2
ENST00000301964.2
TADA3
transcriptional adaptor 3
chr1_+_11994715 0.33 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr5_-_179050660 0.30 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr7_-_94285472 0.27 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr11_-_102323740 0.27 ENST00000398136.2
TMEM123
transmembrane protein 123
chr7_-_94285511 0.25 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr18_+_54318566 0.25 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr17_-_10560619 0.25 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr2_-_161056762 0.24 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr17_-_55911970 0.23 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr10_-_16859361 0.23 ENST00000377921.3
RSU1
Ras suppressor protein 1
chr10_-_16859442 0.23 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr16_+_86229728 0.21 ENST00000601250.1
LINC01082
long intergenic non-protein coding RNA 1082
chr17_-_4890919 0.20 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr19_-_15344243 0.20 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr1_-_86043921 0.19 ENST00000535924.2
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr6_+_151561506 0.19 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_40679584 0.18 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr19_-_15343773 0.17 ENST00000435261.1
ENST00000594042.1
EPHX3
epoxide hydrolase 3
chr17_+_33474860 0.17 ENST00000394570.2
UNC45B
unc-45 homolog B (C. elegans)
chr19_+_57901208 0.17 ENST00000366197.5
ENST00000596282.1
ENST00000597400.1
ENST00000598895.1
ENST00000336128.7
ENST00000596617.1
ZNF548
AC003002.6
zinc finger protein 548
Uncharacterized protein
chr10_+_88428370 0.15 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LDB3
LIM domain binding 3
chr19_-_35166604 0.15 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chrX_-_153602991 0.14 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr5_+_92919043 0.14 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_+_33474826 0.13 ENST00000268876.5
ENST00000433649.1
ENST00000378449.1
UNC45B
unc-45 homolog B (C. elegans)
chr1_-_168106536 0.13 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
GPR161
G protein-coupled receptor 161
chr2_+_74120094 0.12 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
ACTG2
actin, gamma 2, smooth muscle, enteric
chr3_+_187930719 0.12 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_-_4890649 0.12 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr2_-_96811170 0.11 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr8_+_53850991 0.11 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr15_+_33603147 0.10 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr17_-_72358001 0.09 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr17_-_79479789 0.08 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
ACTG1
actin, gamma 1
chr1_+_223889310 0.08 ENST00000434648.1
CAPN2
calpain 2, (m/II) large subunit
chr11_+_86667117 0.08 ENST00000531827.1
RP11-736K20.6
RP11-736K20.6
chr17_-_79481666 0.08 ENST00000575659.1
ACTG1
actin, gamma 1
chr13_+_27825706 0.07 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr11_+_17281900 0.07 ENST00000530527.1
NUCB2
nucleobindin 2
chr12_-_125398850 0.06 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.1
UBC
ubiquitin C
chr12_+_59989918 0.06 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr7_-_121944491 0.06 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr6_+_43139037 0.06 ENST00000265354.4
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr3_+_9834227 0.05 ENST00000287613.7
ENST00000397261.3
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr5_+_66254698 0.04 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_219347203 0.03 ENST00000366927.3
LYPLAL1
lysophospholipase-like 1
chrX_+_22056165 0.03 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_+_219347186 0.03 ENST00000366928.5
LYPLAL1
lysophospholipase-like 1
chr16_-_3350614 0.03 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr6_-_159466136 0.03 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr13_+_27825446 0.03 ENST00000311549.6
RPL21
ribosomal protein L21
chr17_-_46671323 0.02 ENST00000239151.5
HOXB5
homeobox B5
chr4_-_109087872 0.01 ENST00000510624.1
LEF1
lymphoid enhancer-binding factor 1
chr18_-_54318353 0.01 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr11_-_65667884 0.01 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr10_-_17659234 0.01 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.2 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
4.3 12.8 GO:0035284 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
1.9 9.6 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.0 3.1 GO:0060435 bronchiole development(GO:0060435)
0.9 6.9 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.5 1.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 3.8 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.4 1.6 GO:0071655 glial cell-derived neurotrophic factor secretion(GO:0044467) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.4 1.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.3 2.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 1.1 GO:0010157 response to chlorate(GO:0010157)
0.3 1.1 GO:0009956 radial pattern formation(GO:0009956)
0.2 5.6 GO:0051412 response to corticosterone(GO:0051412)
0.2 1.8 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.2 3.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 0.8 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 0.8 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.8 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.2 1.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.2 0.5 GO:0060931 sinoatrial node cell development(GO:0060931)
0.1 0.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 2.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.3 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.7 GO:0008218 bioluminescence(GO:0008218)
0.1 0.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.6 GO:0071461 cellular response to redox state(GO:0071461)
0.1 2.0 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.5 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.6 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.6 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.3 GO:0030167 proteoglycan catabolic process(GO:0030167) regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.6 GO:0016540 protein autoprocessing(GO:0016540)
0.0 1.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 2.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.0 1.0 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.7 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 1.1 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 1.3 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0071286 cellular response to magnesium ion(GO:0071286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0035976 AP1 complex(GO:0035976)
0.3 2.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.2 1.0 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 0.5 GO:0005607 laminin-2 complex(GO:0005607)
0.1 1.1 GO:0044294 dendritic growth cone(GO:0044294)
0.1 8.3 GO:0031430 M band(GO:0031430)
0.1 6.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.6 GO:0046930 pore complex(GO:0046930)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 4.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 1.8 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 23.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.5 12.8 GO:0071837 HMG box domain binding(GO:0071837)
0.5 1.5 GO:0051990 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.4 2.4 GO:0034046 poly(G) binding(GO:0034046)
0.2 3.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.1 GO:0005119 smoothened binding(GO:0005119)
0.2 0.8 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 2.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.6 GO:0043199 sulfate binding(GO:0043199)
0.1 1.1 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 7.8 GO:0050681 androgen receptor binding(GO:0050681)
0.1 0.5 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.1 1.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 5.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 2.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.8 GO:0031005 filamin binding(GO:0031005)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 8.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 2.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 11.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 44.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 9.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 2.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 3.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 1.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 5.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 21.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 13.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 6.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 2.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis