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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for SRF
Z-value: 1.15
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | 0.19 | 3.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 23.2 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
| 4.3 | 12.8 | GO:0035284 | rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 1.9 | 9.6 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.9 | 6.9 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.2 | 5.6 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.4 | 3.8 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.2 | 3.2 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 1.0 | 3.1 | GO:0060435 | bronchiole development(GO:0060435) |
| 0.1 | 2.9 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.0 | 2.8 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 6.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 4.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 2.6 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.3 | 2.0 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.0 | 1.8 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 1.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.6 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 1.1 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 1.1 | GO:0030126 | COPI vesicle coat(GO:0030126) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 23.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.5 | 12.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 11.8 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 8.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 7.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 5.0 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.2 | 3.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 2.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 2.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.4 | 2.4 | GO:0034046 | poly(G) binding(GO:0034046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 44.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 9.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 2.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 2.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 13.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 6.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 3.8 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 2.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.2 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 2.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |