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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for STAT1_STAT3_BCL6

Z-value: 0.54

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Transcription factors associated with STAT1_STAT3_BCL6

Gene Symbol Gene ID Gene Info
ENSG00000115415.14 signal transducer and activator of transcription 1
ENSG00000168610.10 signal transducer and activator of transcription 3
ENSG00000113916.13 BCL6 transcription repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BCL6hg19_v2_chr3_-_187454281_1874543570.637.4e-04Click!
STAT3hg19_v2_chr17_-_40540586_405406000.291.6e-01Click!
STAT1hg19_v2_chr2_-_191878162_191878313-0.058.0e-01Click!

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_10381769 1.80 ENST00000423829.2
ENST00000588645.1
intercellular adhesion molecule 1
chr12_+_122064673 1.53 ENST00000537188.1
ORAI calcium release-activated calcium modulator 1
chr16_-_67517716 1.27 ENST00000290953.2
agouti related protein homolog (mouse)
chr17_+_32582293 1.11 ENST00000580907.1
ENST00000225831.4
chemokine (C-C motif) ligand 2
chr3_-_187455680 0.92 ENST00000438077.1
B-cell CLL/lymphoma 6
chr1_-_41328018 0.89 ENST00000372638.2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr5_+_131409476 0.81 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr21_+_26934165 0.79 ENST00000456917.1
MIR155 host gene (non-protein coding)
chr12_+_93964746 0.76 ENST00000536696.2
suppressor of cytokine signaling 2
chr12_+_53443963 0.67 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_+_97203082 0.61 ENST00000454558.2
AT rich interactive domain 5A (MRF1-like)
chr19_-_4831701 0.61 ENST00000248244.5
toll-like receptor adaptor molecule 1
chr12_+_53443680 0.58 ENST00000314250.6
ENST00000451358.1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_-_173020056 0.49 ENST00000239468.2
ENST00000404377.3
tumor necrosis factor (ligand) superfamily, member 18
chr22_-_39636914 0.47 ENST00000381551.4
platelet-derived growth factor beta polypeptide
chr22_-_39637135 0.47 ENST00000440375.1
platelet-derived growth factor beta polypeptide
chr1_+_221051699 0.44 ENST00000366903.6
H2.0-like homeobox
chr12_-_120687948 0.42 ENST00000458477.2
paxillin
chr12_+_122064398 0.39 ENST00000330079.7
ORAI calcium release-activated calcium modulator 1
chr3_+_101568349 0.39 ENST00000326151.5
ENST00000326172.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr7_+_2598628 0.39 ENST00000402050.2
ENST00000404984.1
ENST00000415271.2
ENST00000438376.2
IQ motif containing E
chr1_-_153521597 0.38 ENST00000368712.1
S100 calcium binding protein A3
chr17_+_32683456 0.37 ENST00000225844.2
chemokine (C-C motif) ligand 13
chr22_-_31503490 0.36 ENST00000400299.2
Selenoprotein M
chrX_-_139866723 0.36 ENST00000370532.2
cerebellar degeneration-related protein 1, 34kDa
chr19_-_4540486 0.35 ENST00000306390.6
leucine-rich alpha-2-glycoprotein 1
chr17_-_26697304 0.35 ENST00000536498.1
vitronectin
chr4_-_76957214 0.34 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr8_-_95274536 0.33 ENST00000297596.2
ENST00000396194.2
GTP binding protein overexpressed in skeletal muscle
chr12_-_9913489 0.32 ENST00000228434.3
ENST00000536709.1
CD69 molecule
chr19_+_35773242 0.32 ENST00000222304.3
hepcidin antimicrobial peptide
chr15_+_84322827 0.31 ENST00000286744.5
ENST00000567476.1
ADAMTS-like 3
chr15_-_42448788 0.31 ENST00000382396.4
ENST00000397272.3
phospholipase A2, group IVF
chr19_-_40324767 0.31 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr14_-_81408031 0.29 ENST00000216517.6
centrosomal protein 128kDa
chr18_+_6729698 0.28 ENST00000383472.4
Rho GTPase activating protein 28
chr20_-_49308048 0.28 ENST00000327979.2
family with sequence similarity 65, member C
chr1_+_155099927 0.26 ENST00000368407.3
ephrin-A1
chr1_-_153521714 0.26 ENST00000368713.3
S100 calcium binding protein A3
chr19_-_40324255 0.26 ENST00000593685.1
ENST00000600611.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr22_+_38609538 0.25 ENST00000407965.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr7_-_140178775 0.25 ENST00000474576.1
ENST00000473444.1
ENST00000471104.1
makorin ring finger protein 1
chr3_+_187871060 0.24 ENST00000448637.1
LIM domain containing preferred translocation partner in lipoma
chr17_-_34207295 0.23 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr22_+_38597889 0.23 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr6_-_32784687 0.22 ENST00000447394.1
ENST00000438763.2
major histocompatibility complex, class II, DO beta
chr19_+_44081344 0.22 ENST00000599207.1
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr9_-_134151915 0.22 ENST00000372271.3
family with sequence similarity 78, member A
chr19_+_11200038 0.22 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
low density lipoprotein receptor
chr19_+_47835404 0.21 ENST00000595464.1
complement component 5a receptor 2
chr6_+_36646435 0.21 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_46740730 0.21 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
coagulation factor II (thrombin)
chr17_+_77021702 0.20 ENST00000392445.2
ENST00000354124.3
C1q and tumor necrosis factor related protein 1
chr22_+_24990746 0.19 ENST00000456869.1
ENST00000411974.1
gamma-glutamyltransferase 1
chr10_+_104005272 0.19 ENST00000369983.3
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr5_+_118691706 0.19 ENST00000415806.2
tumor necrosis factor, alpha-induced protein 8
chr3_-_64211112 0.19 ENST00000295902.6
prickle homolog 2 (Drosophila)
chr17_-_18950310 0.19 ENST00000573099.1
GRB2-related adaptor protein
chr2_+_1488435 0.18 ENST00000446278.1
ENST00000469607.1
thyroid peroxidase
chr12_-_42877726 0.18 ENST00000548696.1
prickle homolog 1 (Drosophila)
chr7_+_117120017 0.17 ENST00000003084.6
ENST00000454343.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr9_-_117880477 0.17 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
tenascin C
chrX_+_144908928 0.17 ENST00000408967.2
transmembrane protein 257
chr11_+_71710973 0.17 ENST00000393707.4
interleukin 18 binding protein
chrX_-_65253506 0.17 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr7_-_107443652 0.17 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
solute carrier family 26 (anion exchanger), member 3
chr19_+_50145328 0.17 ENST00000360565.3
SR-related CTD-associated factor 1
chr11_+_71710648 0.17 ENST00000260049.5
interleukin 18 binding protein
chr3_+_111393659 0.17 ENST00000477665.1
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_-_155511887 0.16 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chr21_-_31744557 0.16 ENST00000399889.2
keratin associated protein 13-2
chr6_+_30131318 0.16 ENST00000376688.1
tripartite motif containing 15
chr17_+_6347729 0.16 ENST00000572447.1
family with sequence similarity 64, member A
chr14_+_22458631 0.16 ENST00000390444.1
T cell receptor alpha variable 16
chr17_+_6347761 0.16 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr7_+_2599056 0.16 ENST00000325979.7
ENST00000423395.1
IQ motif containing E
chrX_-_10544942 0.16 ENST00000380779.1
midline 1 (Opitz/BBB syndrome)
chr2_+_101591314 0.16 ENST00000450763.1
neuronal PAS domain protein 2
chr17_+_36858694 0.15 ENST00000563897.1
CTB-58E17.1
chr14_-_30396948 0.15 ENST00000331968.5
protein kinase D1
chr22_+_31518938 0.15 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
inositol polyphosphate-5-phosphatase J
chr4_+_69313145 0.15 ENST00000305363.4
transmembrane protease, serine 11E
chr3_-_119379427 0.15 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
popeye domain containing 2
chr9_+_125796806 0.14 ENST00000373642.1
G protein-coupled receptor 21
chr12_+_56618102 0.14 ENST00000267023.4
ENST00000380198.2
ENST00000341463.5
nucleic acid binding protein 2
chr1_-_168464875 0.14 ENST00000422253.1
RP5-968D22.3
chr19_+_7598890 0.14 ENST00000221249.6
ENST00000601668.1
ENST00000601001.1
patatin-like phospholipase domain containing 6
chr4_-_76823681 0.14 ENST00000286719.7
protein phosphatase, EF-hand calcium binding domain 2
chr1_-_11107280 0.13 ENST00000400897.3
ENST00000400898.3
mannan-binding lectin serine peptidase 2
chr4_+_126237554 0.13 ENST00000394329.3
FAT atypical cadherin 4
chr3_+_111393501 0.13 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr19_+_55327923 0.13 ENST00000391728.4
ENST00000326542.7
ENST00000358178.4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
chr1_-_203198790 0.13 ENST00000367229.1
ENST00000255427.3
ENST00000535569.1
chitinase 1 (chitotriosidase)
chr20_-_18774614 0.13 ENST00000412553.1
long intergenic non-protein coding RNA 652
chr11_+_64059464 0.13 ENST00000394525.2
potassium channel, subfamily K, member 4
chr7_+_74508372 0.13 ENST00000356115.5
ENST00000430511.2
ENST00000312575.7
GTF2I repeat domain containing 2B
chr11_+_6226782 0.13 ENST00000316375.2
chromosome 11 open reading frame 42
chr8_+_145726472 0.13 ENST00000528430.1
protein phosphatase 1, regulatory subunit 16A
chr12_+_66696322 0.12 ENST00000247815.4
helicase (DNA) B
chr2_+_202122703 0.12 ENST00000447616.1
ENST00000358485.4
caspase 8, apoptosis-related cysteine peptidase
chr6_-_33548006 0.12 ENST00000374467.3
BCL2-antagonist/killer 1
chr16_-_67260691 0.12 ENST00000447579.1
ENST00000393992.1
ENST00000424285.1
leucine rich repeat containing 29
chr16_-_74734672 0.12 ENST00000306247.7
ENST00000575686.1
mixed lineage kinase domain-like
chr6_-_33547975 0.12 ENST00000442998.2
ENST00000360661.5
BCL2-antagonist/killer 1
chr2_-_105030466 0.12 ENST00000449772.1
AC068535.3
chr14_+_24779376 0.12 ENST00000530080.1
leukotriene B4 receptor 2
chr15_-_72523924 0.12 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
pyruvate kinase, muscle
chr12_-_88974236 0.12 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KIT ligand
chr15_+_74165945 0.12 ENST00000535547.2
ENST00000300504.2
ENST00000562056.1
TBC1 domain family, member 21
chr17_-_76274572 0.12 ENST00000374945.1
RP11-219G17.4
chr22_+_20748456 0.11 ENST00000420626.1
ENST00000356671.5
zinc finger protein 74
chr19_+_13229126 0.11 ENST00000292431.4
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr22_-_50523760 0.11 ENST00000395876.2
megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_-_126327398 0.11 ENST00000383572.2
thioredoxin reductase 3 neighbor
chr10_+_6625733 0.11 ENST00000607982.1
ENST00000608526.1
PRKCQ antisense RNA 1
chr19_+_18530146 0.11 ENST00000348495.6
ENST00000270061.7
single stranded DNA binding protein 4
chr19_+_49535169 0.11 ENST00000474913.1
ENST00000359342.6
chorionic gonadotropin, beta polypeptide 2
chr12_-_48213568 0.11 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
histone deacetylase 7
chr4_-_140477353 0.11 ENST00000406354.1
ENST00000506866.2
SET domain containing (lysine methyltransferase) 7
chr7_-_75443118 0.11 ENST00000222902.2
chemokine (C-C motif) ligand 24
chr8_+_22462145 0.11 ENST00000308511.4
ENST00000523801.1
ENST00000521301.1
cell cycle and apoptosis regulator 2
chr4_-_2758015 0.10 ENST00000510267.1
ENST00000503235.1
ENST00000315423.7
TNFAIP3 interacting protein 2
chr12_-_7261772 0.10 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
complement component 1, r subcomponent-like
chr9_-_123239632 0.10 ENST00000416449.1
CDK5 regulatory subunit associated protein 2
chr14_-_25479811 0.10 ENST00000550887.1
syntaxin binding protein 6 (amisyn)
chr1_-_154150651 0.10 ENST00000302206.5
tropomyosin 3
chr3_-_123512688 0.10 ENST00000475616.1
myosin light chain kinase
chr11_+_61197572 0.10 ENST00000542074.1
ENST00000534878.1
ENST00000537782.1
ENST00000543265.1
succinate dehydrogenase complex assembly factor 2
chr14_+_23842018 0.10 ENST00000397242.2
ENST00000329715.2
interleukin 25
chr14_-_81408093 0.10 ENST00000555265.1
centrosomal protein 128kDa
chr11_-_19223523 0.10 ENST00000265968.3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr11_-_111782484 0.10 ENST00000533971.1
crystallin, alpha B
chr8_-_82395461 0.09 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr19_+_7599128 0.09 ENST00000545201.2
patatin-like phospholipase domain containing 6
chr2_-_79386786 0.09 ENST00000393878.1
ENST00000305165.2
ENST00000409839.3
regenerating islet-derived 3 alpha
chr3_+_44840679 0.09 ENST00000425755.1
kinesin family member 15
chr14_+_94577074 0.09 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
interferon, alpha-inducible protein 27
chr6_+_116782527 0.09 ENST00000368606.3
ENST00000368605.1
family with sequence similarity 26, member F
chr19_+_7599597 0.09 ENST00000414982.3
ENST00000450331.3
patatin-like phospholipase domain containing 6
chr19_-_6737241 0.09 ENST00000430424.4
ENST00000597298.1
G protein-coupled receptor 108
chr18_-_5396271 0.09 ENST00000579951.1
erythrocyte membrane protein band 4.1-like 3
chr18_+_6729725 0.09 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
Rho GTPase activating protein 28
chr18_+_23806437 0.09 ENST00000578121.1
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr15_+_75182346 0.09 ENST00000569931.1
ENST00000352410.4
ENST00000566377.1
ENST00000569233.1
ENST00000567132.1
ENST00000564633.1
ENST00000568907.1
ENST00000563422.1
ENST00000564003.1
ENST00000562800.1
ENST00000563786.1
ENST00000535694.1
ENST00000323744.6
ENST00000568828.1
ENST00000562606.1
ENST00000565576.1
ENST00000567570.1
mannose phosphate isomerase
chr20_+_23331373 0.09 ENST00000254998.2
NTF2-like export factor 1
chr6_-_117150198 0.09 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
G protein-coupled receptor, family C, group 6, member A
chr22_+_33197683 0.09 ENST00000266085.6
TIMP metallopeptidase inhibitor 3
chr16_-_46782221 0.09 ENST00000394809.4
myosin light chain kinase 3
chr19_-_6737576 0.09 ENST00000601716.1
ENST00000264080.7
G protein-coupled receptor 108
chr12_+_13197218 0.09 ENST00000197268.8
KIAA1467
chr11_+_57365150 0.09 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_+_9294822 0.09 ENST00000377403.2
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr4_+_158141899 0.08 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr11_-_61197480 0.08 ENST00000439958.3
ENST00000394888.4
cleavage and polyadenylation specific factor 7, 59kDa
chrX_-_70473957 0.08 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
zinc finger, MYM-type 3
chr18_-_10748498 0.08 ENST00000579949.1
piezo-type mechanosensitive ion channel component 2
chr1_-_150780757 0.08 ENST00000271651.3
cathepsin K
chr13_+_111767650 0.08 ENST00000449979.1
ENST00000370623.3
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_153004800 0.08 ENST00000392661.3
small proline-rich protein 1B
chr12_-_56352368 0.08 ENST00000549404.1
premelanosome protein
chr17_+_32646055 0.08 ENST00000394620.1
chemokine (C-C motif) ligand 8
chr14_-_25519095 0.08 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
syntaxin binding protein 6 (amisyn)
chr10_-_25010795 0.08 ENST00000416305.1
ENST00000376410.2
Rho GTPase activating protein 21
chr17_-_73851285 0.08 ENST00000589642.1
ENST00000593002.1
ENST00000590221.1
ENST00000344296.4
ENST00000587374.1
ENST00000585462.1
ENST00000433525.2
ENST00000254806.3
WW domain binding protein 2
chr4_+_155484155 0.08 ENST00000509493.1
fibrinogen beta chain
chr7_+_142031986 0.08 ENST00000547918.2
T cell receptor beta variable 7-1 (non-functional)
chr1_-_154127518 0.08 ENST00000368559.3
ENST00000271854.3
nucleoporin 210kDa-like
chr6_-_43484621 0.08 ENST00000506469.1
ENST00000503972.1
Yip1 domain family, member 3
chr19_-_44304167 0.08 ENST00000594013.1
LY6/PLAUR domain containing 5
chr16_-_3030407 0.08 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
protein kinase, membrane associated tyrosine/threonine 1
chr5_+_140579162 0.08 ENST00000536699.1
ENST00000354757.3
protocadherin beta 11
chr6_+_32821924 0.08 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr12_-_42877764 0.08 ENST00000455697.1
prickle homolog 1 (Drosophila)
chr11_+_60163775 0.08 ENST00000300187.6
ENST00000395005.2
membrane-spanning 4-domains, subfamily A, member 14
chr2_+_37423618 0.07 ENST00000402297.1
ENST00000397064.2
ENST00000406711.1
ENST00000392061.2
ENST00000397226.2
CEBPZ antisense RNA 1
chr2_-_84686552 0.07 ENST00000393868.2
succinate-CoA ligase, alpha subunit
chr18_-_44181442 0.07 ENST00000398722.4
lipoxygenase homology domains 1
chr1_-_200379180 0.07 ENST00000294740.3
zinc finger protein 281
chr4_-_21546272 0.07 ENST00000509207.1
Kv channel interacting protein 4
chr3_-_42744312 0.07 ENST00000416756.1
ENST00000441594.1
hedgehog acyltransferase-like
chr1_+_17906970 0.07 ENST00000375415.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_155006224 0.07 ENST00000368424.3
DC-STAMP domain containing 2
chr19_+_2476116 0.07 ENST00000215631.4
ENST00000587345.1
growth arrest and DNA-damage-inducible, beta
chr7_-_100881041 0.07 ENST00000412417.1
ENST00000414035.1
claudin 15
chr3_+_121613265 0.07 ENST00000295605.2
solute carrier family 15 (oligopeptide transporter), member 2
chr11_+_5646213 0.07 ENST00000429814.2
tripartite motif containing 34
chr17_+_40912764 0.07 ENST00000589683.1
ENST00000588928.1
receptor (G protein-coupled) activity modifying protein 2
chr11_+_60163918 0.07 ENST00000526375.1
ENST00000531783.1
ENST00000395001.1
membrane-spanning 4-domains, subfamily A, member 14
chr19_+_42746927 0.07 ENST00000378108.1
AC006486.1
chr1_+_248185250 0.07 ENST00000355281.1
olfactory receptor, family 2, subfamily L, member 5
chr3_+_183894566 0.07 ENST00000439647.1
adaptor-related protein complex 2, mu 1 subunit
chr14_-_107083690 0.07 ENST00000455737.1
ENST00000390629.2
immunoglobulin heavy variable 4-59
chr2_-_99917639 0.07 ENST00000308528.4
lysozyme G-like 1
chr20_-_43280361 0.07 ENST00000372874.4
adenosine deaminase
chr6_+_159290917 0.07 ENST00000367072.1
chromosome 6 open reading frame 99
chr2_-_175499294 0.07 ENST00000392547.2
WAS/WASL interacting protein family, member 1
chr16_-_75498308 0.07 ENST00000569540.1
transmembrane protein 170A
chr20_-_25320367 0.07 ENST00000450393.1
ENST00000491682.1
abhydrolase domain containing 12
chr1_+_171810606 0.07 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
dynamin 3
chr19_+_49128209 0.07 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
sphingosine kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.4 1.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.3 0.9 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.2 0.9 GO:0090678 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.2 0.8 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 1.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.5 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.1 1.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 0.3 GO:1990641 cellular response to bile acid(GO:1903413) response to iron ion starvation(GO:1990641)
0.1 0.4 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.2 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1 0.6 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of antigen processing and presentation of peptide antigen(GO:0002584)
0.1 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.3 GO:2000690 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.1 0.2 GO:0038178 complement component C5a signaling pathway(GO:0038178) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.1 0.2 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.1 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.1 0.1 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 0.2 GO:2000110 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.3 GO:1903978 regulation of microglial cell activation(GO:1903978)
0.1 0.2 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.1 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.0 0.2 GO:0051801 cytolysis in other organism involved in symbiotic interaction(GO:0051801)
0.0 0.3 GO:0014028 notochord formation(GO:0014028)
0.0 0.2 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.1 GO:0042704 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.1 GO:0052148 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.1 GO:0060901 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.0 0.2 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.4 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.0 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.0 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.0 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.0 GO:0015817 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.0 GO:0019056 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.2 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.1 GO:0030222 response to nematode(GO:0009624) eosinophil differentiation(GO:0030222)
0.0 0.4 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.1 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.1 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.0 0.0 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.0 0.0 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.3 GO:1900116 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.0 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.0 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.0 GO:0051685 maintenance of ER location(GO:0051685)
0.0 0.0 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.6 GO:0097342 ripoptosome(GO:0097342)
0.0 1.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.1 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:1990015 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.3 GO:0042007 interleukin-18 binding(GO:0042007)
0.1 0.2 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.9 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.1 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0001855 complement component C4b binding(GO:0001855)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0017129 triglyceride binding(GO:0017129)
0.0 0.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.0 0.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.0 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport