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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for STAT4

Z-value: 0.58

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Transcription factors associated with STAT4

Gene Symbol Gene ID Gene Info
ENSG00000138378.13 signal transducer and activator of transcription 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT4hg19_v2_chr2_-_192016316_192016325-0.527.6e-03Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76957214 3.88 ENST00000306621.3
chemokine (C-X-C motif) ligand 11
chr6_+_32821924 3.18 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 2.70 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_122399444 2.63 ENST00000474629.2
poly (ADP-ribose) polymerase family, member 14
chr5_+_131409476 2.61 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_8000872 2.55 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr15_+_67458357 2.50 ENST00000537194.2
SMAD family member 3
chr17_-_34207295 2.43 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr5_-_121413974 1.70 ENST00000231004.4
lysyl oxidase
chr19_+_10197463 1.56 ENST00000590378.1
ENST00000397881.3
chromosome 19 open reading frame 66
chr2_-_202563414 1.44 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr9_+_72658490 1.31 ENST00000377182.4
MAM domain containing 2
chr11_+_20044096 1.29 ENST00000533917.1
neuron navigator 2
chr2_-_202562774 1.21 ENST00000396886.3
ENST00000409143.1
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chrX_-_154563889 1.13 ENST00000369449.2
ENST00000321926.4
chloride intracellular channel 2
chr6_+_36646435 1.11 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr14_+_24630465 1.11 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr7_-_115670792 1.00 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr7_-_115670804 0.94 ENST00000320239.7
transcription factor EC
chr16_+_4674787 0.75 ENST00000262370.7
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr16_+_4674814 0.74 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr14_+_22538811 0.73 ENST00000390450.3
T cell receptor alpha variable 22
chr3_-_164913777 0.73 ENST00000475390.1
SLIT and NTRK-like family, member 3
chr19_+_57106647 0.72 ENST00000328070.6
zinc finger protein 71
chr10_+_6625605 0.71 ENST00000414894.1
ENST00000449648.1
PRKCQ antisense RNA 1
chr6_-_32811771 0.70 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chrX_+_144908928 0.64 ENST00000408967.2
transmembrane protein 257
chrX_+_149861836 0.63 ENST00000542156.1
ENST00000370390.3
ENST00000490316.2
ENST00000445323.2
ENST00000544228.1
ENST00000451863.2
myotubularin related protein 1
chr9_-_134585221 0.62 ENST00000372190.3
ENST00000427994.1
Rap guanine nucleotide exchange factor (GEF) 1
chr2_-_190044480 0.60 ENST00000374866.3
collagen, type V, alpha 2
chr1_+_68150744 0.60 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr14_+_55034599 0.57 ENST00000392067.3
ENST00000357634.3
sterile alpha motif domain containing 4A
chr1_-_144994840 0.56 ENST00000369351.3
ENST00000369349.3
phosphodiesterase 4D interacting protein
chr7_-_41740181 0.56 ENST00000442711.1
inhibin, beta A
chr4_-_140477353 0.52 ENST00000406354.1
ENST00000506866.2
SET domain containing (lysine methyltransferase) 7
chr3_+_111260856 0.51 ENST00000352690.4
CD96 molecule
chr17_+_7358889 0.49 ENST00000575379.1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr3_+_38179969 0.45 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
myeloid differentiation primary response 88
chr2_+_68961905 0.45 ENST00000295381.3
Rho GTPase activating protein 25
chr2_+_68961934 0.44 ENST00000409202.3
Rho GTPase activating protein 25
chr11_+_64216546 0.42 ENST00000316124.2
HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185
chr3_+_171561127 0.41 ENST00000334567.5
ENST00000450693.1
transmembrane protein 212
chr11_+_117070904 0.39 ENST00000529792.1
transgelin
chr1_+_17906970 0.39 ENST00000375415.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_+_50145328 0.39 ENST00000360565.3
SR-related CTD-associated factor 1
chr6_+_32811861 0.39 ENST00000453426.1
TAP1 and PSMB8 antisense RNA 1
chr15_-_75660919 0.39 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
mannosidase, alpha, class 2C, member 1
chr1_-_231005310 0.38 ENST00000470540.1
chromosome 1 open reading frame 198
chr1_+_202431859 0.36 ENST00000391959.3
ENST00000367270.4
protein phosphatase 1, regulatory subunit 12B
chr13_+_97928395 0.36 ENST00000445661.2
muscleblind-like splicing regulator 2
chr9_-_85882145 0.35 ENST00000328788.1
FERM domain containing 3
chr1_-_144994909 0.35 ENST00000369347.4
ENST00000369354.3
phosphodiesterase 4D interacting protein
chr3_+_5020801 0.35 ENST00000256495.3
basic helix-loop-helix family, member e40
chrX_-_137793826 0.33 ENST00000315930.6
fibroblast growth factor 13
chr17_-_77924627 0.33 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1 domain family, member 16
chr12_+_20848282 0.31 ENST00000545604.1
solute carrier organic anion transporter family, member 1C1
chr15_+_64680003 0.31 ENST00000261884.3
thyroid hormone receptor interactor 4
chr2_+_68962014 0.30 ENST00000467265.1
Rho GTPase activating protein 25
chr12_+_20848377 0.30 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
solute carrier organic anion transporter family, member 1C1
chr15_+_63340858 0.29 ENST00000560615.1
tropomyosin 1 (alpha)
chr15_+_63340775 0.29 ENST00000559281.1
ENST00000317516.7
tropomyosin 1 (alpha)
chr5_+_137203465 0.28 ENST00000239926.4
myotilin
chr10_+_6625733 0.28 ENST00000607982.1
ENST00000608526.1
PRKCQ antisense RNA 1
chr19_+_50528971 0.28 ENST00000598809.1
ENST00000595661.1
ENST00000391821.2
zinc finger protein 473
chr17_+_41132564 0.28 ENST00000361677.1
ENST00000589705.1
RUN domain containing 1
chr22_-_31536480 0.28 ENST00000215885.3
phospholipase A2, group III
chr19_+_50529212 0.27 ENST00000270617.3
ENST00000445728.3
ENST00000601364.1
zinc finger protein 473
chr4_-_187476721 0.27 ENST00000307161.5
melatonin receptor 1A
chr2_+_171785824 0.26 ENST00000452526.2
golgi reassembly stacking protein 2, 55kDa
chr7_+_117120106 0.26 ENST00000426809.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr15_-_100882191 0.25 ENST00000268070.4
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr15_+_63340734 0.25 ENST00000560959.1
tropomyosin 1 (alpha)
chr20_+_8112824 0.25 ENST00000378641.3
phospholipase C, beta 1 (phosphoinositide-specific)
chr1_-_161279749 0.25 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
myelin protein zero
chr7_+_117120017 0.24 ENST00000003084.6
ENST00000454343.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr10_-_6622201 0.23 ENST00000539722.1
ENST00000397176.2
protein kinase C, theta
chr1_+_50571949 0.23 ENST00000357083.4
ELAV like neuron-specific RNA binding protein 4
chrX_-_46187069 0.23 ENST00000446884.1
RP1-30G7.2
chr19_+_35168547 0.22 ENST00000502743.1
ENST00000509528.1
ENST00000506901.1
zinc finger protein 302
chr16_+_67261008 0.22 ENST00000304800.9
ENST00000563953.1
ENST00000565201.1
transmembrane protein 208
chr11_-_133715394 0.22 ENST00000299140.3
ENST00000532889.1
spermatogenesis associated 19
chr19_+_56905024 0.22 ENST00000591172.1
ENST00000589888.1
ENST00000587979.1
ENST00000585659.1
ENST00000593109.1
ZNF582 antisense RNA 1 (head to head)
chr4_-_155511887 0.22 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chr11_-_85338311 0.21 ENST00000376104.2
discs, large homolog 2 (Drosophila)
chr3_+_77088989 0.21 ENST00000461745.1
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_-_161519682 0.21 ENST00000367969.3
ENST00000443193.1
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr13_-_26795840 0.20 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
ring finger protein (C3H2C3 type) 6
chr16_+_78056412 0.20 ENST00000299642.4
ENST00000575655.1
C-type lectin domain family 3, member A
chr1_-_28384598 0.20 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr12_+_58138664 0.20 ENST00000257910.3
tetraspanin 31
chr20_-_21494654 0.19 ENST00000377142.4
NK2 homeobox 2
chr3_+_155838337 0.19 ENST00000490337.1
ENST00000389636.5
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_128563652 0.18 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_46761118 0.18 ENST00000230588.4
meprin A, alpha (PABA peptide hydrolase)
chr12_+_58138800 0.18 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
tetraspanin 31
chr1_+_244515930 0.17 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr1_-_185597619 0.17 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1
chr15_+_63340647 0.17 ENST00000404484.4
tropomyosin 1 (alpha)
chr11_-_62752455 0.17 ENST00000360421.4
solute carrier family 22 (organic anion transporter), member 6
chr3_+_45429998 0.16 ENST00000265537.3
ENST00000415258.1
ENST00000431023.1
ENST00000414984.1
leucyl-tRNA synthetase 2, mitochondrial
chr9_-_116837249 0.16 ENST00000466610.2
alpha-1-microglobulin/bikunin precursor
chr3_+_111260980 0.16 ENST00000438817.2
CD96 molecule
chr6_-_25874440 0.16 ENST00000361703.6
ENST00000397060.4
solute carrier family 17 (organic anion transporter), member 3
chr4_-_140477928 0.16 ENST00000274031.3
SET domain containing (lysine methyltransferase) 7
chr11_-_62752429 0.15 ENST00000377871.3
solute carrier family 22 (organic anion transporter), member 6
chr17_-_41132410 0.15 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr5_-_64777733 0.15 ENST00000381055.3
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chrX_-_65253506 0.15 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr3_+_187871060 0.14 ENST00000448637.1
LIM domain containing preferred translocation partner in lipoma
chr5_+_40909354 0.14 ENST00000313164.9
complement component 7
chr3_-_196242233 0.14 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chr4_+_41258786 0.14 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_+_5541267 0.13 ENST00000423158.3
neurotrophin 3
chr1_-_33502528 0.13 ENST00000354858.6
adenylate kinase 2
chr1_-_120935894 0.13 ENST00000369383.4
ENST00000369384.4
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr17_-_38210644 0.13 ENST00000394128.2
ENST00000394127.2
ENST00000356271.3
ENST00000535071.2
ENST00000580885.1
ENST00000543759.2
ENST00000537674.2
ENST00000580517.1
ENST00000578161.1
mediator complex subunit 24
chr3_-_156534754 0.13 ENST00000472943.1
ENST00000473352.1
long intergenic non-protein coding RNA 886
chr2_-_29297127 0.13 ENST00000331664.5
chromosome 2 open reading frame 71
chr10_+_106028923 0.13 ENST00000338595.2
glutathione S-transferase omega 2
chr4_+_158141843 0.12 ENST00000509417.1
ENST00000296526.7
glutamate receptor, ionotropic, AMPA 2
chr10_+_115312766 0.12 ENST00000351270.3
hyaluronan binding protein 2
chr19_+_37709076 0.12 ENST00000590503.1
ENST00000589413.1
zinc finger protein 383
chr4_+_158141806 0.12 ENST00000393815.2
glutamate receptor, ionotropic, AMPA 2
chr3_-_194119995 0.12 ENST00000323007.3
glycoprotein V (platelet)
chr18_+_61144160 0.12 ENST00000489441.1
ENST00000424602.1
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_113885138 0.11 ENST00000409930.3
interleukin 1 receptor antagonist
chr11_-_119999611 0.11 ENST00000529044.1
tripartite motif containing 29
chr4_-_46126093 0.11 ENST00000295452.4
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr3_+_130064359 0.11 ENST00000432398.2
ENST00000265379.6
collagen, type VI, alpha 5
chr1_+_9299895 0.11 ENST00000602477.1
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_-_57678772 0.11 ENST00000311128.5
DENN/MADD domain containing 6A
chr3_-_108672742 0.11 ENST00000261047.3
guanylate cyclase activator 1C
chr12_-_49245936 0.11 ENST00000308025.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr6_+_134210243 0.11 ENST00000367882.4
transcription factor 21
chr12_+_26164645 0.11 ENST00000542004.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr2_-_37193606 0.10 ENST00000379213.2
ENST00000263918.4
striatin, calmodulin binding protein
chr12_-_11175219 0.10 ENST00000390673.2
taste receptor, type 2, member 19
chr6_+_84222220 0.10 ENST00000369700.3
protease, serine, 35
chr11_+_73003824 0.10 ENST00000538328.1
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_205391178 0.10 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEM domain containing 1
chr11_-_119999539 0.10 ENST00000541857.1
tripartite motif containing 29
chr11_-_10590238 0.09 ENST00000256178.3
lymphatic vessel endothelial hyaluronan receptor 1
chr3_-_108672609 0.09 ENST00000393963.3
ENST00000471108.1
guanylate cyclase activator 1C
chr1_-_33502441 0.09 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
adenylate kinase 2
chr1_-_161337662 0.09 ENST00000367974.1
chromosome 1 open reading frame 192
chr18_+_61143994 0.09 ENST00000382771.4
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_+_108977520 0.09 ENST00000540898.1
forkhead box O3
chr12_-_91398796 0.09 ENST00000261172.3
ENST00000551767.1
epiphycan
chr19_-_54663473 0.09 ENST00000222224.3
leukocyte receptor cluster (LRC) member 1
chr6_+_31540056 0.09 ENST00000418386.2
lymphotoxin alpha
chr6_+_52051171 0.09 ENST00000340057.1
interleukin 17A
chr6_+_139349817 0.08 ENST00000367660.3
ABRA C-terminal like
chr1_+_10534944 0.08 ENST00000356607.4
ENST00000538836.1
ENST00000491661.2
peroxisomal biogenesis factor 14
chr3_-_148939835 0.08 ENST00000264613.6
ceruloplasmin (ferroxidase)
chr15_-_60690932 0.08 ENST00000559818.1
annexin A2
chr5_+_140753444 0.08 ENST00000517434.1
protocadherin gamma subfamily A, 6
chr19_+_42746927 0.08 ENST00000378108.1
AC006486.1
chr4_-_140005443 0.08 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
E74-like factor 2 (ets domain transcription factor)
chr19_+_44617511 0.08 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
zinc finger protein 225
chr1_+_214163033 0.07 ENST00000607425.1
prospero homeobox 1
chr12_+_100750846 0.07 ENST00000323346.5
solute carrier family 17 (vesicular glutamate transporter), member 8
chr2_-_84686552 0.07 ENST00000393868.2
succinate-CoA ligase, alpha subunit
chr15_+_57998821 0.07 ENST00000299638.3
polymerase (RNA) II (DNA directed) polypeptide M
chr19_-_56904799 0.07 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
zinc finger protein 582
chr6_+_25754927 0.07 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr3_-_15469045 0.07 ENST00000450816.2
methyltransferase like 6
chr8_+_38586068 0.06 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
transforming, acidic coiled-coil containing protein 1
chr19_-_50529193 0.06 ENST00000596445.1
ENST00000599538.1
vaccinia related kinase 3
chr15_+_57998923 0.06 ENST00000380557.4
polymerase (RNA) II (DNA directed) polypeptide M
chr12_-_11139511 0.06 ENST00000506868.1
taste receptor, type 2, member 50
chr6_+_32407619 0.06 ENST00000395388.2
ENST00000374982.5
major histocompatibility complex, class II, DR alpha
chr10_+_17794251 0.05 ENST00000377495.1
ENST00000338221.5
transmembrane protein 236
chr16_-_20338748 0.05 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
glycoprotein 2 (zymogen granule membrane)
chr19_-_44952635 0.05 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
zinc finger protein 229
chr3_+_15468862 0.04 ENST00000396842.2
ELL associated factor 1
chr1_+_40997233 0.03 ENST00000372699.3
ENST00000372697.3
ENST00000372696.3
zinc finger protein 684
chr3_-_15469006 0.03 ENST00000443029.1
ENST00000383790.3
ENST00000383789.5
methyltransferase like 6
chr12_-_39299406 0.03 ENST00000331366.5
copine VIII
chrX_+_106045891 0.03 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1 domain family, member 8B (with GRAM domain)
chr2_-_175547571 0.03 ENST00000409415.3
ENST00000359761.3
ENST00000272746.5
WAS/WASL interacting protein family, member 1
chr6_-_123957942 0.02 ENST00000398178.3
triadin
chr14_-_21490590 0.02 ENST00000557633.1
NDRG family member 2
chr10_+_104404644 0.02 ENST00000462202.2
tripartite motif containing 8
chr4_-_155533787 0.02 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
fibrinogen gamma chain
chr5_-_127674883 0.02 ENST00000507835.1
fibrillin 2
chr3_+_50649302 0.02 ENST00000446044.1
mitogen-activated protein kinase-activated protein kinase 3
chr8_-_114449112 0.02 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CUB and Sushi multiple domains 3
chr5_-_16509101 0.02 ENST00000399793.2
family with sequence similarity 134, member B
chr16_+_19467772 0.02 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
transmembrane channel-like 5
chr4_+_158141899 0.02 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr4_-_41750922 0.01 ENST00000226382.2
paired-like homeobox 2b
chr6_-_123958141 0.01 ENST00000334268.4
triadin
chr7_-_92855762 0.01 ENST00000453812.2
ENST00000394468.2
HEPACAM family member 2
chr14_+_20811766 0.01 ENST00000250416.5
ENST00000527915.1
poly (ADP-ribose) polymerase 2
chr9_-_27297126 0.01 ENST00000380031.1
ENST00000537675.1
ENST00000380032.3
equatorin, sperm acrosome associated
chr2_+_231921574 0.00 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.6 3.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.6 2.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 2.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.4 2.5 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.4 3.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 1.1 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.2 0.7 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.5 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.2 1.3 GO:0021564 vagus nerve development(GO:0021564)
0.1 1.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 1.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.3 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.3 GO:0097254 renal tubular secretion(GO:0097254)
0.1 0.2 GO:0080154 regulation of fertilization(GO:0080154) activation of meiosis(GO:0090427)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:2000570 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 0.6 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 0.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.1 GO:0060435 bronchiole development(GO:0060435)
0.1 0.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0051685 maintenance of ER location(GO:0051685)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 3.6 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:2000645 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0015747 hexose phosphate transport(GO:0015712) urate transport(GO:0015747) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.7 GO:0042825 TAP complex(GO:0042825)
0.4 1.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 2.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0032059 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 2.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.4 2.7 GO:0046979 TAP2 binding(GO:0046979)
0.4 1.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 2.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.3 1.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.5 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 3.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 2.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0019862 IgA binding(GO:0019862)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 1.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.1 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 2.6 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 3.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport