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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for STAT4

Z-value: 0.58

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Transcription factors associated with STAT4

Gene Symbol Gene ID Gene Info
STAT4
ENSG00000138378.13 signal transducer and activator of transcription 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT4hg19_v2_chr2_-_192016316_192016325-0.527.6e-03Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_76957214 3.88 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_+_32821924 3.18 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 2.70 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_122399444 2.63 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr5_+_131409476 2.61 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_8000872 2.55 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr15_+_67458357 2.50 ENST00000537194.2
SMAD3
SMAD family member 3
chr17_-_34207295 2.43 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr5_-_121413974 1.70 ENST00000231004.4
LOX
lysyl oxidase
chr19_+_10197463 1.56 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr2_-_202563414 1.44 ENST00000409474.3
ENST00000315506.7
ENST00000359962.5
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr9_+_72658490 1.31 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr11_+_20044096 1.29 ENST00000533917.1
NAV2
neuron navigator 2
chr2_-_202562774 1.21 ENST00000396886.3
ENST00000409143.1
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chrX_-_154563889 1.13 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr6_+_36646435 1.11 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr14_+_24630465 1.11 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr7_-_115670792 1.00 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr7_-_115670804 0.94 ENST00000320239.7
TFEC
transcription factor EC
chr16_+_4674787 0.75 ENST00000262370.7
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr16_+_4674814 0.74 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr14_+_22538811 0.73 ENST00000390450.3
TRAV22
T cell receptor alpha variable 22
chr3_-_164913777 0.73 ENST00000475390.1
SLITRK3
SLIT and NTRK-like family, member 3
chr19_+_57106647 0.72 ENST00000328070.6
ZNF71
zinc finger protein 71
chr10_+_6625605 0.71 ENST00000414894.1
ENST00000449648.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr6_-_32811771 0.70 ENST00000395339.3
ENST00000374882.3
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chrX_+_144908928 0.64 ENST00000408967.2
TMEM257
transmembrane protein 257
chrX_+_149861836 0.63 ENST00000542156.1
ENST00000370390.3
ENST00000490316.2
ENST00000445323.2
ENST00000544228.1
ENST00000451863.2
MTMR1
myotubularin related protein 1
chr9_-_134585221 0.62 ENST00000372190.3
ENST00000427994.1
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr2_-_190044480 0.60 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr1_+_68150744 0.60 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr14_+_55034599 0.57 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr1_-_144994840 0.56 ENST00000369351.3
ENST00000369349.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_41740181 0.56 ENST00000442711.1
INHBA
inhibin, beta A
chr4_-_140477353 0.52 ENST00000406354.1
ENST00000506866.2
SETD7
SET domain containing (lysine methyltransferase) 7
chr3_+_111260856 0.51 ENST00000352690.4
CD96
CD96 molecule
chr17_+_7358889 0.49 ENST00000575379.1
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr3_+_38179969 0.45 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr2_+_68961905 0.45 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961934 0.44 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr11_+_64216546 0.42 ENST00000316124.2
AP003774.4
HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185
chr3_+_171561127 0.41 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr11_+_117070904 0.39 ENST00000529792.1
TAGLN
transgelin
chr1_+_17906970 0.39 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_+_50145328 0.39 ENST00000360565.3
SCAF1
SR-related CTD-associated factor 1
chr6_+_32811861 0.39 ENST00000453426.1
TAPSAR1
TAP1 and PSMB8 antisense RNA 1
chr15_-_75660919 0.39 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
MAN2C1
mannosidase, alpha, class 2C, member 1
chr1_-_231005310 0.38 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr1_+_202431859 0.36 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr13_+_97928395 0.36 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr9_-_85882145 0.35 ENST00000328788.1
FRMD3
FERM domain containing 3
chr1_-_144994909 0.35 ENST00000369347.4
ENST00000369354.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_5020801 0.35 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chrX_-_137793826 0.33 ENST00000315930.6
FGF13
fibroblast growth factor 13
chr17_-_77924627 0.33 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr12_+_20848282 0.31 ENST00000545604.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr15_+_64680003 0.31 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr2_+_68962014 0.30 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr12_+_20848377 0.30 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr15_+_63340858 0.29 ENST00000560615.1
TPM1
tropomyosin 1 (alpha)
chr15_+_63340775 0.29 ENST00000559281.1
ENST00000317516.7
TPM1
tropomyosin 1 (alpha)
chr5_+_137203465 0.28 ENST00000239926.4
MYOT
myotilin
chr10_+_6625733 0.28 ENST00000607982.1
ENST00000608526.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr19_+_50528971 0.28 ENST00000598809.1
ENST00000595661.1
ENST00000391821.2
ZNF473
zinc finger protein 473
chr17_+_41132564 0.28 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr22_-_31536480 0.28 ENST00000215885.3
PLA2G3
phospholipase A2, group III
chr19_+_50529212 0.27 ENST00000270617.3
ENST00000445728.3
ENST00000601364.1
ZNF473
zinc finger protein 473
chr4_-_187476721 0.27 ENST00000307161.5
MTNR1A
melatonin receptor 1A
chr2_+_171785824 0.26 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr7_+_117120106 0.26 ENST00000426809.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr15_-_100882191 0.25 ENST00000268070.4
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr15_+_63340734 0.25 ENST00000560959.1
TPM1
tropomyosin 1 (alpha)
chr20_+_8112824 0.25 ENST00000378641.3
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
chr1_-_161279749 0.25 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
MPZ
myelin protein zero
chr7_+_117120017 0.24 ENST00000003084.6
ENST00000454343.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr10_-_6622201 0.23 ENST00000539722.1
ENST00000397176.2
PRKCQ
protein kinase C, theta
chr1_+_50571949 0.23 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chrX_-_46187069 0.23 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr19_+_35168547 0.22 ENST00000502743.1
ENST00000509528.1
ENST00000506901.1
ZNF302
zinc finger protein 302
chr16_+_67261008 0.22 ENST00000304800.9
ENST00000563953.1
ENST00000565201.1
TMEM208
transmembrane protein 208
chr11_-_133715394 0.22 ENST00000299140.3
ENST00000532889.1
SPATA19
spermatogenesis associated 19
chr19_+_56905024 0.22 ENST00000591172.1
ENST00000589888.1
ENST00000587979.1
ENST00000585659.1
ENST00000593109.1
ZNF582-AS1
ZNF582 antisense RNA 1 (head to head)
chr4_-_155511887 0.22 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr11_-_85338311 0.21 ENST00000376104.2
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_77088989 0.21 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_-_161519682 0.21 ENST00000367969.3
ENST00000443193.1
FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr13_-_26795840 0.20 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr16_+_78056412 0.20 ENST00000299642.4
ENST00000575655.1
CLEC3A
C-type lectin domain family 3, member A
chr1_-_28384598 0.20 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr12_+_58138664 0.20 ENST00000257910.3
TSPAN31
tetraspanin 31
chr20_-_21494654 0.19 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr3_+_155838337 0.19 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_128563652 0.18 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_46761118 0.18 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr12_+_58138800 0.18 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr1_+_244515930 0.17 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr1_-_185597619 0.17 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1
GS1-204I12.1
chr15_+_63340647 0.17 ENST00000404484.4
TPM1
tropomyosin 1 (alpha)
chr11_-_62752455 0.17 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr3_+_45429998 0.16 ENST00000265537.3
ENST00000415258.1
ENST00000431023.1
ENST00000414984.1
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr9_-_116837249 0.16 ENST00000466610.2
AMBP
alpha-1-microglobulin/bikunin precursor
chr3_+_111260980 0.16 ENST00000438817.2
CD96
CD96 molecule
chr6_-_25874440 0.16 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr4_-_140477928 0.16 ENST00000274031.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr11_-_62752429 0.15 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr17_-_41132410 0.15 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr5_-_64777733 0.15 ENST00000381055.3
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chrX_-_65253506 0.15 ENST00000427538.1
VSIG4
V-set and immunoglobulin domain containing 4
chr3_+_187871060 0.14 ENST00000448637.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_40909354 0.14 ENST00000313164.9
C7
complement component 7
chr3_-_196242233 0.14 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr4_+_41258786 0.14 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_+_5541267 0.13 ENST00000423158.3
NTF3
neurotrophin 3
chr1_-_33502528 0.13 ENST00000354858.6
AK2
adenylate kinase 2
chr1_-_120935894 0.13 ENST00000369383.4
ENST00000369384.4
FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr17_-_38210644 0.13 ENST00000394128.2
ENST00000394127.2
ENST00000356271.3
ENST00000535071.2
ENST00000580885.1
ENST00000543759.2
ENST00000537674.2
ENST00000580517.1
ENST00000578161.1
MED24
mediator complex subunit 24
chr3_-_156534754 0.13 ENST00000472943.1
ENST00000473352.1
LINC00886
long intergenic non-protein coding RNA 886
chr2_-_29297127 0.13 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chr10_+_106028923 0.13 ENST00000338595.2
GSTO2
glutathione S-transferase omega 2
chr4_+_158141843 0.12 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr10_+_115312766 0.12 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr19_+_37709076 0.12 ENST00000590503.1
ENST00000589413.1
ZNF383
zinc finger protein 383
chr4_+_158141806 0.12 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_-_194119995 0.12 ENST00000323007.3
GP5
glycoprotein V (platelet)
chr18_+_61144160 0.12 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_113885138 0.11 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr11_-_119999611 0.11 ENST00000529044.1
TRIM29
tripartite motif containing 29
chr4_-_46126093 0.11 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr3_+_130064359 0.11 ENST00000432398.2
ENST00000265379.6
COL6A5
collagen, type VI, alpha 5
chr1_+_9299895 0.11 ENST00000602477.1
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_-_57678772 0.11 ENST00000311128.5
DENND6A
DENN/MADD domain containing 6A
chr3_-_108672742 0.11 ENST00000261047.3
GUCA1C
guanylate cyclase activator 1C
chr12_-_49245936 0.11 ENST00000308025.3
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr6_+_134210243 0.11 ENST00000367882.4
TCF21
transcription factor 21
chr12_+_26164645 0.11 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr2_-_37193606 0.10 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr12_-_11175219 0.10 ENST00000390673.2
TAS2R19
taste receptor, type 2, member 19
chr6_+_84222220 0.10 ENST00000369700.3
PRSS35
protease, serine, 35
chr11_+_73003824 0.10 ENST00000538328.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_205391178 0.10 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr11_-_119999539 0.10 ENST00000541857.1
TRIM29
tripartite motif containing 29
chr11_-_10590238 0.09 ENST00000256178.3
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr3_-_108672609 0.09 ENST00000393963.3
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr1_-_33502441 0.09 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
AK2
adenylate kinase 2
chr1_-_161337662 0.09 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr18_+_61143994 0.09 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_+_108977520 0.09 ENST00000540898.1
FOXO3
forkhead box O3
chr12_-_91398796 0.09 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr19_-_54663473 0.09 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr6_+_31540056 0.09 ENST00000418386.2
LTA
lymphotoxin alpha
chr6_+_52051171 0.09 ENST00000340057.1
IL17A
interleukin 17A
chr6_+_139349817 0.08 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr1_+_10534944 0.08 ENST00000356607.4
ENST00000538836.1
ENST00000491661.2
PEX14
peroxisomal biogenesis factor 14
chr3_-_148939835 0.08 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chr15_-_60690932 0.08 ENST00000559818.1
ANXA2
annexin A2
chr5_+_140753444 0.08 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr19_+_42746927 0.08 ENST00000378108.1
AC006486.1
AC006486.1
chr4_-_140005443 0.08 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
ELF2
E74-like factor 2 (ets domain transcription factor)
chr19_+_44617511 0.08 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr1_+_214163033 0.07 ENST00000607425.1
PROX1
prospero homeobox 1
chr12_+_100750846 0.07 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr2_-_84686552 0.07 ENST00000393868.2
SUCLG1
succinate-CoA ligase, alpha subunit
chr15_+_57998821 0.07 ENST00000299638.3
POLR2M
polymerase (RNA) II (DNA directed) polypeptide M
chr19_-_56904799 0.07 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
ZNF582
zinc finger protein 582
chr6_+_25754927 0.07 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr3_-_15469045 0.07 ENST00000450816.2
METTL6
methyltransferase like 6
chr8_+_38586068 0.06 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr19_-_50529193 0.06 ENST00000596445.1
ENST00000599538.1
VRK3
vaccinia related kinase 3
chr15_+_57998923 0.06 ENST00000380557.4
POLR2M
polymerase (RNA) II (DNA directed) polypeptide M
chr12_-_11139511 0.06 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chr6_+_32407619 0.06 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr10_+_17794251 0.05 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr16_-_20338748 0.05 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr19_-_44952635 0.05 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
ZNF229
zinc finger protein 229
chr3_+_15468862 0.04 ENST00000396842.2
EAF1
ELL associated factor 1
chr1_+_40997233 0.03 ENST00000372699.3
ENST00000372697.3
ENST00000372696.3
ZNF684
zinc finger protein 684
chr3_-_15469006 0.03 ENST00000443029.1
ENST00000383790.3
ENST00000383789.5
METTL6
methyltransferase like 6
chr12_-_39299406 0.03 ENST00000331366.5
CPNE8
copine VIII
chrX_+_106045891 0.03 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1D8B
TBC1 domain family, member 8B (with GRAM domain)
chr2_-_175547571 0.03 ENST00000409415.3
ENST00000359761.3
ENST00000272746.5
WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_123957942 0.02 ENST00000398178.3
TRDN
triadin
chr14_-_21490590 0.02 ENST00000557633.1
NDRG2
NDRG family member 2
chr10_+_104404644 0.02 ENST00000462202.2
TRIM8
tripartite motif containing 8
chr4_-_155533787 0.02 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
FGG
fibrinogen gamma chain
chr5_-_127674883 0.02 ENST00000507835.1
FBN2
fibrillin 2
chr3_+_50649302 0.02 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr8_-_114449112 0.02 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr5_-_16509101 0.02 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr16_+_19467772 0.02 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr4_+_158141899 0.02 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_-_41750922 0.01 ENST00000226382.2
PHOX2B
paired-like homeobox 2b
chr6_-_123958141 0.01 ENST00000334268.4
TRDN
triadin
chr7_-_92855762 0.01 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr14_+_20811766 0.01 ENST00000250416.5
ENST00000527915.1
PARP2
poly (ADP-ribose) polymerase 2
chr9_-_27297126 0.01 ENST00000380031.1
ENST00000537675.1
ENST00000380032.3
EQTN
equatorin, sperm acrosome associated
chr2_+_231921574 0.00 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.6 3.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.6 2.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 2.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.4 2.5 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.4 3.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 1.1 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.2 0.7 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.6 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.5 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.2 1.3 GO:0021564 vagus nerve development(GO:0021564)
0.1 1.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 1.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.3 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.3 GO:0097254 renal tubular secretion(GO:0097254)
0.1 0.2 GO:0080154 regulation of fertilization(GO:0080154) activation of meiosis(GO:0090427)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.2 GO:2000570 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 0.6 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 0.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.1 GO:0060435 bronchiole development(GO:0060435)
0.1 0.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.7 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0051685 maintenance of ER location(GO:0051685)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 3.6 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:2000645 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0015747 hexose phosphate transport(GO:0015712) urate transport(GO:0015747) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.7 GO:0042825 TAP complex(GO:0042825)
0.4 1.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 2.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0032059 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 2.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.4 2.7 GO:0046979 TAP2 binding(GO:0046979)
0.4 1.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 2.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.3 1.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.5 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 3.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 2.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0019862 IgA binding(GO:0019862)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 1.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.1 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 2.6 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 3.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 3.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport