ISMARA results: STAT4

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for STAT4

Z-value: 0.58

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Transcription factors associated with STAT4

Gene Symbol	Gene ID	Gene Info
STAT4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000138378.13	signal transducer and activator of transcription 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT4	hg19_v2_chr2_-_192016316_192016325	-0.52	7.6e-03	Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_76957214 Show fit	3.88	ENST00000306621.3	CXCL11 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) ligand 11
chr6_+_32821924 Show fit	3.18	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 Show fit	2.70	ENST00000354258.4	TAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_122399444 Show fit	2.63	ENST00000474629.2	PARP14 Ensembl NCBI GeneCards UniProt NextProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr5_+_131409476 Show fit	2.61	ENST00000296871.2	CSF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_8000872 Show fit	2.55	ENST00000377507.3	TNFRSF9 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor receptor superfamily, member 9
chr15_+_67458357 Show fit	2.50	ENST00000537194.2	SMAD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SMAD family member 3
chr17_-_34207295 Show fit	2.43	ENST00000463941.1 ENST00000293272.3	CCL5 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 5
chr5_-_121413974 Show fit	1.70	ENST00000231004.4	LOX Ensembl NCBI GeneCards UniProt NextProt Show fit	lysyl oxidase
chr19_+_10197463 Show fit	1.56	ENST00000590378.1 ENST00000397881.3	C19orf66 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 19 open reading frame 66

Showing 1 to 10 of 196 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.9	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.0	3.6	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.6	3.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.7	2.7	GO:0046967	cytosol to ER transport(GO:0046967)
0.5	2.5	GO:0061767	negative regulation of lung blood pressure(GO:0061767)
0.4	2.5	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.6	2.4	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1	1.7	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	1.5	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.2	1.3	GO:0021564	vagus nerve development(GO:0021564)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.9	GO:1990111	spermatoproteasome complex(GO:1990111)
0.4	2.7	GO:0042825	TAP complex(GO:0042825)
0.3	2.5	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	1.8	GO:0005581	collagen trimer(GO:0005581)
0.1	1.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	1.2	GO:0034707	chloride channel complex(GO:0034707)
0.4	1.1	GO:0070557	PCNA-p21 complex(GO:0070557)
0.1	1.0	GO:0032059	muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.2	0.6	GO:0005588	collagen type V trimer(GO:0005588)
0.2	0.6	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.9	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	3.7	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4	2.7	GO:0046979	TAP2 binding(GO:0046979)
0.0	2.6	GO:0070851	growth factor receptor binding(GO:0070851)
0.5	2.5	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.1	2.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3	2.4	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.1	2.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3	1.7	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	1.3	GO:0008307	structural constituent of muscle(GO:0008307)

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	3.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	2.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	2.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	2.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	2.4	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	2.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	1.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	1.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	3.6	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	2.7	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	2.6	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	1.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	1.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.6	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.6	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL

Showing 1 to 10 of 18 entries

Results for STAT4

Z-value: 0.58

Motif logo

Transcription factors associated with STAT4

Activity-expression correlation:

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: