Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for STAT5A
Z-value: 1.04
Motif logo
Transcription factors associated with STAT5A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5A | hg19_v2_chr17_+_40440481_40440561 | 0.71 | 7.0e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_152214098 Show fit | 3.78 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr11_-_102668879 Show fit | 3.57 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr10_-_49812997 Show fit | 3.19 |
ENST00000417912.2
|
Rho GTPase activating protein 22 |
|
| chr19_+_10381769 Show fit | 3.04 |
ENST00000423829.2
ENST00000588645.1 |
intercellular adhesion molecule 1 |
|
| chr10_-_6019552 Show fit | 2.85 |
ENST00000379977.3
ENST00000397251.3 ENST00000397248.2 |
interleukin 15 receptor, alpha |
|
| chr15_+_67458357 Show fit | 2.84 |
ENST00000537194.2
|
SMAD family member 3 |
|
| chr6_-_32820529 Show fit | 2.69 |
ENST00000425148.2
|
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
|
| chr1_-_153521714 Show fit | 2.66 |
ENST00000368713.3
|
S100 calcium binding protein A3 |
|
| chr4_+_142558078 Show fit | 2.65 |
ENST00000529613.1
|
interleukin 15 |
|
| chr4_+_142557771 Show fit | 2.61 |
ENST00000514653.1
|
interleukin 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 1.0 | 5.2 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.5 | 4.1 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.1 | 3.8 | GO:0030728 | ovulation(GO:0030728) |
| 0.1 | 3.4 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.8 | 3.0 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.7 | 2.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.3 | 2.7 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 2.6 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.2 | 2.5 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 4.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 3.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 3.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 2.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 2.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 2.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.5 | 1.6 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.0 | 1.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.5 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.0 | 5.2 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 4.5 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 4.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 4.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 3.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.4 | 2.7 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.1 | 2.7 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 7.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 4.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 4.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 3.7 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 3.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 2.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.2 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 5.6 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 4.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 2.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 2.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |