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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TAL1
Z-value: 1.37
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Transcription factors associated with TAL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAL1 | hg19_v2_chr1_-_47697387_47697457 | -0.42 | 3.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_113344755 Show fit | 2.36 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_-_56236734 Show fit | 2.15 |
ENST00000548629.1
|
matrix metallopeptidase 19 |
|
| chr2_-_7005785 Show fit | 1.91 |
ENST00000256722.5
ENST00000404168.1 ENST00000458098.1 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
|
| chr17_-_39306054 Show fit | 1.90 |
ENST00000343246.4
|
keratin associated protein 4-5 |
|
| chr1_-_8000872 Show fit | 1.76 |
ENST00000377507.3
|
tumor necrosis factor receptor superfamily, member 9 |
|
| chr17_-_39280419 Show fit | 1.73 |
ENST00000394014.1
|
keratin associated protein 4-12 |
|
| chr21_+_42798094 Show fit | 1.72 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr2_-_202562774 Show fit | 1.72 |
ENST00000396886.3
ENST00000409143.1 |
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) |
|
| chr3_-_127455200 Show fit | 1.68 |
ENST00000398101.3
|
monoglyceride lipase |
|
| chr15_+_84908573 Show fit | 1.66 |
ENST00000424966.1
ENST00000422563.2 |
golgin A6 family-like 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.8 | 4.2 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.5 | 4.1 | GO:0001554 | luteolysis(GO:0001554) |
| 0.1 | 3.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 3.6 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.4 | 3.2 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.3 | 3.1 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 3.0 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.0 | 2.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 2.8 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 4.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 4.2 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 4.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 3.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 2.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 2.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.2 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 2.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.1 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 9.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 6.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 4.5 | GO:0008556 | potassium-transporting ATPase activity(GO:0008556) |
| 1.4 | 4.3 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 3.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.3 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.2 | 3.1 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 2.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 2.8 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.1 | 2.8 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 3.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 2.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 1.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 5.9 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.1 | 5.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 4.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 2.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 2.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 2.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |