Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for TBP
Z-value: 1.53
Motif logo
Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863421_170863484 | -0.29 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.5 | 16.2 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.5 | 14.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 3.0 | 12.2 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 3.6 | 10.8 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 0.1 | 8.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 7.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 6.8 | GO:0030728 | ovulation(GO:0030728) |
| 0.2 | 5.0 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 4.9 | GO:0007411 | axon guidance(GO:0007411) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 15.6 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 12.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 10.2 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 7.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 6.2 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 6.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 5.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 3.8 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 3.8 | GO:0044306 | neuron projection terminus(GO:0044306) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 1.0 | 15.5 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.9 | 14.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 13.1 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 11.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 9.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 8.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 5.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 5.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 4.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 30.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 11.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 4.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 4.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 4.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 2.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 38.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 14.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 7.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 5.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 4.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 4.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 3.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 3.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 3.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.6 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |