ISMARA results: TBX1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX1

Z-value: 0.67

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Transcription factors associated with TBX1

Gene Symbol	Gene ID	Gene Info
TBX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000184058.8	T-box transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX1	hg19_v2_chr22_+_19744226_19744226	0.24	2.5e-01	Click!

Activity profile of TBX1 motif

Sorted Z-values of TBX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_35454953 Show fit	0.91	ENST00000404801.1	ZNF792 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 792
chr10_-_131762105 Show fit	0.91	ENST00000368648.3 ENST00000355311.5	EBF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	early B-cell factor 3
chr19_-_58864848 Show fit	0.82	ENST00000263100.3	A1BG Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-1-B glycoprotein
chr7_-_138363824 Show fit	0.81	ENST00000419765.3	SVOPL Ensembl NCBI GeneCards UniProt NextProt Show fit	SVOP-like
chr1_-_111174054 Show fit	0.76	ENST00000369770.3	KCNA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium voltage-gated channel, shaker-related subfamily, member 2
chr19_-_51875894 Show fit	0.76	ENST00000600427.1 ENST00000595217.1 ENST00000221978.5	NKG7 Ensembl NCBI GeneCards UniProt NextProt Show fit	natural killer cell group 7 sequence
chr1_-_154127518 Show fit	0.74	ENST00000368559.3 ENST00000271854.3	NUP210L Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleoporin 210kDa-like
chr11_-_33913708 Show fit	0.72	ENST00000257818.2	LMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 2 (rhombotin-like 1)
chr6_-_13487784 Show fit	0.71	ENST00000379287.3	GFOD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	glucose-fructose oxidoreductase domain containing 1
chr18_+_8717369 Show fit	0.66	ENST00000359865.3 ENST00000400050.3 ENST00000306285.7	SOGA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SOGA family member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)
0.0	1.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	0.9	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.9	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.9	GO:0043968	histone H2A acetylation(GO:0043968)
0.2	0.8	GO:0021633	optic nerve structural organization(GO:0021633)
0.0	0.8	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.8	GO:2000249	regulation of actin cytoskeleton reorganization(GO:2000249)
0.1	0.7	GO:0010726	positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0	0.7	GO:0016180	snRNA processing(GO:0016180)

Showing 1 to 10 of 305 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.1	1.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	1.0	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.9	GO:0032982	myosin filament(GO:0032982)
0.1	0.8	GO:0032039	integrator complex(GO:0032039)
0.1	0.8	GO:0045179	apical cortex(GO:0045179)
0.0	0.8	GO:0033010	paranodal junction(GO:0033010)
0.0	0.8	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.8	GO:0048786	presynaptic active zone(GO:0048786)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	1.1	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	0.8	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.8	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.7	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.7	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.7	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.7	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.2	0.6	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	0.6	GO:0060961	phospholipase D inhibitor activity(GO:0060961)

Showing 1 to 10 of 201 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.7	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.7	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.6	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.4	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.3	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.3	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	0.2	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.2	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	0.8	REACTOME OPSINS	Genes involved in Opsins
0.0	0.8	REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	Genes involved in Acetylcholine Binding And Downstream Events
0.0	0.8	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.7	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.6	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.6	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Showing 1 to 10 of 33 entries

Results for TBX1

Z-value: 0.67

Motif logo

Transcription factors associated with TBX1

Activity-expression correlation:

Activity profile of TBX1 motif

Sorted Z-values of TBX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: