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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX15_MGA

Z-value: 0.79

Motif logo

Transcription factors associated with TBX15_MGA

Gene Symbol Gene ID Gene Info
ENSG00000092607.9 T-box transcription factor 15
ENSG00000174197.12 MAX dimerization protein MGA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MGAhg19_v2_chr15_+_41913690_41913753-0.213.1e-01Click!
TBX15hg19_v2_chr1_-_119530428_119530572,
hg19_v2_chr1_-_119532127_119532179
0.029.2e-01Click!

Activity profile of TBX15_MGA motif

Sorted Z-values of TBX15_MGA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_205290865 4.21 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr6_-_160166218 4.20 ENST00000537657.1
superoxide dismutase 2, mitochondrial
chr2_+_228678550 4.19 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr5_+_113697983 3.40 ENST00000264773.3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr2_+_102972363 2.39 ENST00000409599.1
interleukin 18 receptor 1
chr17_+_77021702 2.18 ENST00000392445.2
ENST00000354124.3
C1q and tumor necrosis factor related protein 1
chr7_-_105319536 1.98 ENST00000477775.1
ataxin 7-like 1
chr1_-_182641367 1.95 ENST00000508450.1
regulator of G-protein signaling 8
chr6_+_36646435 1.89 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr9_-_123676827 1.88 ENST00000546084.1
TNF receptor-associated factor 1
chr2_+_201994042 1.82 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr5_+_54320078 1.77 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr2_+_201994208 1.58 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr11_+_18477369 1.45 ENST00000396213.3
ENST00000280706.2
lactate dehydrogenase A-like 6A
chr4_-_146859623 1.31 ENST00000379448.4
ENST00000513320.1
zinc finger protein 827
chr15_+_60296421 1.27 ENST00000396057.4
forkhead box B1
chr2_-_175869936 1.21 ENST00000409900.3
chimerin 1
chr2_-_175870085 1.09 ENST00000409156.3
chimerin 1
chr2_+_202937972 1.09 ENST00000541917.1
ENST00000295844.3
uncharacterized protein KIAA2012
chr1_-_12677714 1.08 ENST00000376223.2
dehydrogenase/reductase (SDR family) member 3
chrX_+_56259316 1.07 ENST00000468660.1
Kruppel-like factor 8
chr8_+_123793633 1.06 ENST00000314393.4
zinc fingers and homeoboxes 2
chr14_+_55033815 1.03 ENST00000554335.1
sterile alpha motif domain containing 4A
chr17_-_20370847 0.99 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr21_+_37507210 0.96 ENST00000290354.5
carbonyl reductase 3
chr19_-_7990991 0.95 ENST00000318978.4
cortexin 1
chr4_-_170924888 0.93 ENST00000502832.1
ENST00000393704.3
microfibrillar-associated protein 3-like
chr5_-_124080203 0.87 ENST00000504926.1
zinc finger protein 608
chr20_-_22559211 0.86 ENST00000564492.1
long intergenic non-protein coding RNA 261
chr11_-_85779971 0.82 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr17_-_39306054 0.79 ENST00000343246.4
keratin associated protein 4-5
chr16_-_81110683 0.77 ENST00000565253.1
ENST00000378611.4
ENST00000299578.5
chromosome 16 open reading frame 46
chr14_+_55034599 0.74 ENST00000392067.3
ENST00000357634.3
sterile alpha motif domain containing 4A
chr14_+_95078714 0.73 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr14_+_55034330 0.72 ENST00000251091.5
sterile alpha motif domain containing 4A
chr9_-_140082983 0.72 ENST00000323927.2
anaphase promoting complex subunit 2
chr6_+_30294612 0.72 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
tripartite motif containing 39
chr11_+_61447845 0.69 ENST00000257215.5
diacylglycerol lipase, alpha
chr6_+_30295036 0.68 ENST00000376659.5
ENST00000428555.1
tripartite motif containing 39
chr4_+_8582287 0.68 ENST00000382487.4
G protein-coupled receptor 78
chr3_-_39196049 0.67 ENST00000514182.1
cysteine-serine-rich nuclear protein 1
chr14_+_22538811 0.66 ENST00000390450.3
T cell receptor alpha variable 22
chr14_+_67291158 0.66 ENST00000555456.1
gephyrin
chr9_+_34990219 0.65 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DnaJ (Hsp40) homolog, subfamily B, member 5
chr11_-_64703354 0.65 ENST00000532246.1
ENST00000279168.2
glycoprotein hormone alpha 2
chr11_-_6502580 0.65 ENST00000423813.2
ENST00000396777.3
ADP-ribosylation factor interacting protein 2
chr10_-_99531709 0.64 ENST00000266066.3
secreted frizzled-related protein 5
chr1_-_85930246 0.64 ENST00000426972.3
dimethylarginine dimethylaminohydrolase 1
chr11_-_6502534 0.63 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
ADP-ribosylation factor interacting protein 2
chr12_-_49351228 0.62 ENST00000541959.1
ENST00000447318.2
ADP-ribosylation factor 3
chr1_-_111148241 0.62 ENST00000440270.1
potassium voltage-gated channel, shaker-related subfamily, member 2
chr11_-_67275542 0.61 ENST00000531506.1
cyclin-dependent kinase 2 associated protein 2
chr6_+_83073952 0.60 ENST00000543496.1
trophoblast glycoprotein
chr14_-_65569244 0.60 ENST00000557277.1
ENST00000556892.1
MYC associated factor X
chr7_-_20826504 0.59 ENST00000418710.2
ENST00000361443.4
Sp8 transcription factor
chrX_+_102862834 0.59 ENST00000372627.5
ENST00000243286.3
transcription elongation factor A (SII)-like 3
chr12_-_50101003 0.58 ENST00000550488.1
formin-like 3
chr17_-_1619491 0.58 ENST00000570416.1
ENST00000575626.1
ENST00000610106.1
ENST00000608198.1
ENST00000609442.1
ENST00000334146.3
ENST00000576489.1
ENST00000608245.1
ENST00000609398.1
ENST00000608913.1
ENST00000574016.1
ENST00000571091.1
ENST00000573127.1
ENST00000609990.1
ENST00000576749.1
MIR22 host gene (non-protein coding)
chr17_-_10452929 0.58 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
myosin, heavy chain 2, skeletal muscle, adult
chr12_-_49351303 0.58 ENST00000256682.4
ADP-ribosylation factor 3
chr2_-_208030647 0.57 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr17_+_25958174 0.57 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr17_-_39216344 0.57 ENST00000391418.2
keratin associated protein 2-3
chr7_-_76255444 0.55 ENST00000454397.1
POM121 and ZP3 fusion
chr1_+_169077172 0.54 ENST00000499679.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr17_-_1619535 0.52 ENST00000573075.1
ENST00000574306.1
MIR22 host gene (non-protein coding)
chr2_+_154728426 0.51 ENST00000392825.3
ENST00000434213.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr1_-_26633067 0.51 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBX domain protein 11
chr12_+_22778291 0.51 ENST00000545979.1
ethanolamine kinase 1
chr6_+_108616054 0.51 ENST00000368977.4
lactation elevated 1
chr6_-_86099898 0.51 ENST00000455071.1
RP11-30P6.6
chr22_-_39639021 0.51 ENST00000455790.1
platelet-derived growth factor beta polypeptide
chrX_-_153775426 0.50 ENST00000393562.2
glucose-6-phosphate dehydrogenase
chr11_-_67276100 0.50 ENST00000301488.3
cyclin-dependent kinase 2 associated protein 2
chr9_+_102584128 0.50 ENST00000338488.4
ENST00000395097.2
nuclear receptor subfamily 4, group A, member 3
chr9_-_73029540 0.49 ENST00000377126.2
Kruppel-like factor 9
chr16_+_57220193 0.49 ENST00000564435.1
ENST00000562959.1
ENST00000394420.4
ENST00000568505.2
ENST00000537866.1
ring finger and SPRY domain containing 1
chr7_-_72972319 0.48 ENST00000223368.2
B-cell CLL/lymphoma 7B
chr17_-_7232585 0.48 ENST00000571887.1
ENST00000315614.7
ENST00000399464.2
ENST00000570460.1
neuralized E3 ubiquitin protein ligase 4
chr3_-_52443799 0.48 ENST00000470173.1
ENST00000296288.5
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr19_+_39390320 0.47 ENST00000576510.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_-_39324424 0.47 ENST00000391356.2
keratin associated protein 4-3
chr19_-_10450328 0.47 ENST00000160262.5
intercellular adhesion molecule 3
chr6_-_31620149 0.46 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BCL2-associated athanogene 6
chr4_+_66536248 0.45 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr12_-_26278030 0.45 ENST00000242728.4
basic helix-loop-helix family, member e41
chr1_+_8378140 0.45 ENST00000377479.2
solute carrier family 45, member 1
chr5_-_146258291 0.45 ENST00000394411.4
ENST00000453001.1
protein phosphatase 2, regulatory subunit B, beta
chr1_-_113247543 0.45 ENST00000414971.1
ENST00000534717.1
ras homolog family member C
chr18_+_32073253 0.44 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
dystrobrevin, alpha
chr22_-_41215291 0.44 ENST00000542412.1
ENST00000544408.1
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr4_+_156680518 0.44 ENST00000513437.1
guanylate cyclase 1, soluble, beta 3
chr19_-_10213335 0.44 ENST00000592641.1
ENST00000253109.4
angiopoietin-like 6
chr1_+_26737253 0.44 ENST00000326279.6
lin-28 homolog A (C. elegans)
chr6_+_108616243 0.43 ENST00000421954.1
lactation elevated 1
chr1_+_27561104 0.42 ENST00000361771.3
WD and tetratricopeptide repeats 1
chr2_+_171571827 0.42 ENST00000375281.3
Sp5 transcription factor
chr1_-_226129083 0.42 ENST00000420304.2
left-right determination factor 2
chr10_+_60028818 0.41 ENST00000333926.5
CDGSH iron sulfur domain 1
chr7_-_142176790 0.41 ENST00000390369.2
T cell receptor beta variable 7-4 (gene/pseudogene)
chr16_+_30662360 0.41 ENST00000542965.2
proline rich 14
chr12_-_322821 0.40 ENST00000359674.4
solute carrier family 6 (neurotransmitter transporter), member 12
chr1_-_150780757 0.40 ENST00000271651.3
cathepsin K
chr1_+_165796753 0.40 ENST00000367879.4
uridine-cytidine kinase 2
chr16_+_30662050 0.40 ENST00000568754.1
proline rich 14
chr3_-_50378343 0.40 ENST00000359365.4
Ras association (RalGDS/AF-6) domain family member 1
chr3_-_50378235 0.39 ENST00000357043.2
Ras association (RalGDS/AF-6) domain family member 1
chr1_+_15736359 0.39 ENST00000375980.4
EF-hand domain family, member D2
chr15_+_90319557 0.39 ENST00000341735.3
mesoderm posterior 2 homolog (mouse)
chr4_+_156680143 0.39 ENST00000505154.1
guanylate cyclase 1, soluble, beta 3
chr17_-_77924627 0.39 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1 domain family, member 16
chr6_-_10419871 0.39 ENST00000319516.4
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_146859787 0.38 ENST00000508784.1
zinc finger protein 827
chr15_+_89922345 0.38 ENST00000558982.1
long intergenic non-protein coding RNA 925
chr1_-_226374373 0.38 ENST00000366812.5
acyl-CoA binding domain containing 3
chr12_-_322504 0.38 ENST00000424061.2
solute carrier family 6 (neurotransmitter transporter), member 12
chr17_+_46184911 0.38 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
sorting nexin 11
chr1_-_44482979 0.38 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_-_54281407 0.37 ENST00000381403.4
endothelial cell-specific molecule 1
chrX_+_71354000 0.37 ENST00000510661.1
ENST00000535692.1
NHS-like 2
chr19_-_10450287 0.37 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr3_-_66551351 0.37 ENST00000273261.3
leucine-rich repeats and immunoglobulin-like domains 1
chr6_+_45390222 0.37 ENST00000359524.5
runt-related transcription factor 2
chr11_-_123185475 0.37 ENST00000527774.1
ENST00000527533.1
RP11-109E10.1
chr1_-_226129189 0.37 ENST00000366820.5
left-right determination factor 2
chr2_+_43864387 0.37 ENST00000282406.4
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr4_-_177116772 0.36 ENST00000280191.2
spermatogenesis associated 4
chr17_+_3118915 0.36 ENST00000304094.1
olfactory receptor, family 1, subfamily A, member 1
chr19_-_51527467 0.36 ENST00000593681.1
kallikrein-related peptidase 11
chr7_-_72971934 0.36 ENST00000411832.1
B-cell CLL/lymphoma 7B
chr4_+_156680153 0.36 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
guanylate cyclase 1, soluble, beta 3
chr11_+_73358594 0.35 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_74533734 0.35 ENST00000589342.1
cytoglobin
chr18_-_56296182 0.35 ENST00000361673.3
alpha-kinase 2
chr11_-_7847519 0.35 ENST00000328375.1
olfactory receptor, family 5, subfamily P, member 3
chr5_-_115872142 0.34 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr14_+_51026743 0.34 ENST00000358385.6
ENST00000357032.3
ENST00000354525.4
atlastin GTPase 1
chr20_+_44509857 0.34 ENST00000372523.1
ENST00000372520.1
zinc finger, SWIM-type containing 1
chr1_-_182641037 0.33 ENST00000483095.2
regulator of G-protein signaling 8
chrX_+_16804544 0.33 ENST00000380122.5
ENST00000398155.4
taxilin gamma
chr8_+_22428457 0.33 ENST00000517962.1
sorbin and SH3 domain containing 3
chr7_+_107110488 0.33 ENST00000304402.4
G protein-coupled receptor 22
chr3_-_197024394 0.33 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
discs, large homolog 1 (Drosophila)
chr1_+_41445413 0.33 ENST00000541520.1
CTP synthase 1
chr1_+_26737292 0.33 ENST00000254231.4
lin-28 homolog A (C. elegans)
chr19_-_3500635 0.32 ENST00000250937.3
deoxyhypusine hydroxylase/monooxygenase
chr3_-_66551397 0.32 ENST00000383703.3
leucine-rich repeats and immunoglobulin-like domains 1
chr13_+_113548643 0.32 ENST00000375608.3
MCF.2 cell line derived transforming sequence-like
chr3_+_127770455 0.32 ENST00000464451.1
Sec61 alpha 1 subunit (S. cerevisiae)
chr14_+_22520762 0.31 ENST00000390449.3
T cell receptor alpha variable 21
chr17_+_42925270 0.31 ENST00000253410.2
ENST00000587021.1
HIG1 hypoxia inducible domain family, member 1B
chr15_-_51058005 0.31 ENST00000261854.5
signal peptide peptidase like 2A
chr16_+_31044812 0.31 ENST00000313843.3
syntaxin 4
chr17_+_7465216 0.31 ENST00000321337.7
SUMO1/sentrin/SMT3 specific peptidase 3
chr20_+_825275 0.31 ENST00000541082.1
family with sequence similarity 110, member A
chr10_+_111765562 0.30 ENST00000360162.3
adducin 3 (gamma)
chr1_-_182640988 0.30 ENST00000367556.1
regulator of G-protein signaling 8
chr1_+_155099927 0.30 ENST00000368407.3
ephrin-A1
chr17_-_40428359 0.30 ENST00000293328.3
signal transducer and activator of transcription 5B
chr17_+_9066252 0.30 ENST00000436734.1
netrin 1
chr17_+_7210898 0.30 ENST00000572815.1
eukaryotic translation initiation factor 5A
chr20_+_2517253 0.29 ENST00000358864.1
transmembrane channel-like 2
chr19_-_14016877 0.29 ENST00000454313.1
ENST00000591586.1
ENST00000346736.2
chromosome 19 open reading frame 57
chr20_+_44098346 0.29 ENST00000372676.3
WAP four-disulfide core domain 2
chr19_-_10426663 0.29 ENST00000541276.1
ENST00000393708.3
ENST00000494368.1
ferredoxin 1-like
chr15_-_58357932 0.29 ENST00000347587.3
aldehyde dehydrogenase 1 family, member A2
chr15_-_88799384 0.29 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
neurotrophic tyrosine kinase, receptor, type 3
chr20_+_816695 0.29 ENST00000246100.3
family with sequence similarity 110, member A
chr6_+_84563295 0.29 ENST00000369687.1
ripply transcriptional repressor 2
chr3_+_9691117 0.28 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
myotubularin related protein 14
chr19_+_13135790 0.28 ENST00000358552.3
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_160279207 0.28 ENST00000327245.5
ATPase, class V, type 10B
chr6_-_62996066 0.28 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chr1_+_155100342 0.28 ENST00000368406.2
ephrin-A1
chr9_-_117692697 0.28 ENST00000223795.2
tumor necrosis factor (ligand) superfamily, member 8
chr8_-_82395461 0.28 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr19_+_45973120 0.28 ENST00000592811.1
ENST00000586615.1
FBJ murine osteosarcoma viral oncogene homolog B
chr2_-_26101314 0.28 ENST00000336112.4
ENST00000272341.4
additional sex combs like 2 (Drosophila)
chr19_-_12833164 0.27 ENST00000356861.5
transportin 2
chr6_+_43739697 0.27 ENST00000230480.6
vascular endothelial growth factor A
chr17_+_47296865 0.27 ENST00000573347.1
ABI family, member 3
chr1_+_92417716 0.27 ENST00000402388.1
bromodomain, testis-specific
chr8_-_145060593 0.27 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
poly (ADP-ribose) polymerase family, member 10
chr10_+_135204338 0.27 ENST00000468317.2
Mitochondrial GTPase 1
chr11_-_615570 0.27 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_-_38397285 0.27 ENST00000303868.5
WD repeat domain 87
chr11_-_83393457 0.27 ENST00000404783.3
discs, large homolog 2 (Drosophila)
chr8_+_102504651 0.26 ENST00000251808.3
ENST00000521085.1
grainyhead-like 2 (Drosophila)
chr10_+_135050908 0.26 ENST00000325980.9
VENT homeobox
chr5_-_54281491 0.26 ENST00000381405.4
endothelial cell-specific molecule 1
chr15_+_85523671 0.26 ENST00000310298.4
ENST00000557957.1
phosphodiesterase 8A
chr5_-_131347501 0.26 ENST00000543479.1
acyl-CoA synthetase long-chain family member 6
chr9_-_136024721 0.26 ENST00000393160.3
ral guanine nucleotide dissociation stimulator
chr20_+_4152356 0.26 ENST00000379460.2
spermine oxidase
chr10_-_97050777 0.26 ENST00000329399.6
PDZ and LIM domain 1
chr2_-_27718052 0.26 ENST00000264703.3
fibronectin type III domain containing 4
chr19_+_3762645 0.25 ENST00000330133.4
mitochondrial ribosomal protein L54
chr17_-_8066843 0.25 ENST00000404970.3
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_+_172628154 0.25 ENST00000340030.3
ENST00000367721.2
Fas ligand (TNF superfamily, member 6)
chr20_+_44657845 0.25 ENST00000243964.3
solute carrier family 12 (potassium/chloride transporter), member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX15_MGA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.8 4.2 GO:0003068 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.4 1.3 GO:0007412 axon target recognition(GO:0007412)
0.4 1.9 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.3 3.4 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.3 3.4 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.3 2.2 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 2.9 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.2 0.7 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 1.0 GO:1901662 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.2 0.6 GO:0002519 natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 0.7 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.2 0.5 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.5 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.2 1.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.2 0.6 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 1.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.4 GO:0071106 coenzyme A transport(GO:0015880) FAD transport(GO:0015883) coenzyme A transmembrane transport(GO:0035349) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.7 GO:0021633 optic nerve structural organization(GO:0021633)
0.1 1.4 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 0.4 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.5 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.5 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 2.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.5 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.3 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288)
0.1 0.3 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.3 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.3 GO:0097254 renal tubular secretion(GO:0097254)
0.1 0.4 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.4 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.3 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.6 GO:0035803 egg coat formation(GO:0035803)
0.1 0.6 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 0.3 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.3 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.1 4.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.5 GO:0051414 response to cortisol(GO:0051414)
0.1 0.1 GO:0060913 negative regulation of mesodermal cell fate specification(GO:0042662) cardiac cell fate determination(GO:0060913)
0.1 0.2 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.2 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.1 0.2 GO:0003285 atrioventricular node development(GO:0003162) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) septum secundum development(GO:0003285)
0.1 0.3 GO:0033159 regulation of chromatin assembly(GO:0010847) negative regulation of protein import into nucleus, translocation(GO:0033159) protein auto-ADP-ribosylation(GO:0070213)
0.1 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.4 GO:1903286 regulation of potassium ion import(GO:1903286)
0.1 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.1 1.4 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.1 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.3 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.3 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.3 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.3 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.4 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.5 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0086073 ventricular compact myocardium morphogenesis(GO:0003223) protein localization to adherens junction(GO:0071896) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.0 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.5 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.0 GO:0060300 regulation of cytokine activity(GO:0060300)
0.0 0.3 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.6 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0070904 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.1 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.3 GO:0002278 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.6 GO:0001778 plasma membrane repair(GO:0001778)
0.0 1.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.4 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.5 GO:0035437 maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.0 0.3 GO:0035799 ureter maturation(GO:0035799)
0.0 0.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.6 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.5 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.1 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 1.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.1 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.1 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.0 2.2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.5 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.2 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.2 GO:0051125 regulation of actin nucleation(GO:0051125)
0.0 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446)
0.0 0.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.0 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.3 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.0 0.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 1.0 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.3 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.4 GO:0001919 regulation of receptor recycling(GO:0001919)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 3.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.7 GO:0043196 varicosity(GO:0043196)
0.1 3.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 0.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 1.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.4 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.6 GO:0043219 lateral loop(GO:0043219)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0071141 SMAD protein complex(GO:0071141)
0.0 2.9 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.7 3.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.6 1.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.5 4.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 1.0 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 0.7 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 0.6 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.2 0.6 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 1.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.5 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 0.5 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 2.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.8 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.4 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) FAD transmembrane transporter activity(GO:0015230) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 1.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.5 GO:0005046 KDEL sequence binding(GO:0005046)
0.1 0.6 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.3 GO:0003883 CTP synthase activity(GO:0003883)
0.1 1.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.7 GO:0005123 death receptor binding(GO:0005123)
0.1 0.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.3 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.3 GO:0052894 norspermine:oxygen oxidoreductase activity(GO:0052894) N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity(GO:0052895)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.6 GO:0032190 acrosin binding(GO:0032190)
0.1 2.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.0 0.5 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 1.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.9 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.2 GO:0031730 CCR1 chemokine receptor binding(GO:0031726) CCR5 chemokine receptor binding(GO:0031730)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 2.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.0 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.0 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936) coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 3.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.0 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.6 PID ARF 3PATHWAY Arf1 pathway
0.0 4.2 PID FOXO PATHWAY FoxO family signaling
0.0 1.9 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.2 ST GAQ PATHWAY G alpha q Pathway
0.0 1.4 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.8 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 5.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.2 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 4.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.4 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 3.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors