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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX3

Z-value: 0.71

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Transcription factors associated with TBX3

Gene Symbol Gene ID Gene Info
TBX3
ENSG00000135111.10 T-box transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX3hg19_v2_chr12_-_115121962_115121987-0.038.7e-01Click!

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 1.90 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr11_+_20044600 1.22 ENST00000311043.8
NAV2
neuron navigator 2
chr6_-_32821599 1.10 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr21_+_27011899 0.90 ENST00000425221.2
JAM2
junctional adhesion molecule 2
chr2_-_217559517 0.88 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr11_+_1718425 0.83 ENST00000382160.1
KRTAP5-6
keratin associated protein 5-6
chr17_+_41132564 0.78 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr21_-_15918618 0.74 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_138386097 0.68 ENST00000421622.1
SVOPL
SVOP-like
chr14_-_107283278 0.68 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr1_+_167599330 0.67 ENST00000367854.3
ENST00000361496.3
RCSD1
RCSD domain containing 1
chr11_-_1629693 0.66 ENST00000399685.1
KRTAP5-3
keratin associated protein 5-3
chr15_+_40861487 0.63 ENST00000315616.7
ENST00000559271.1
RPUSD2
RNA pseudouridylate synthase domain containing 2
chr3_+_42897512 0.63 ENST00000493193.1
ACKR2
atypical chemokine receptor 2
chr1_+_212606219 0.63 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr5_+_148521046 0.57 ENST00000326685.7
ENST00000356541.3
ENST00000309868.7
ABLIM3
actin binding LIM protein family, member 3
chr3_-_46068969 0.52 ENST00000542109.1
ENST00000395946.2
XCR1
chemokine (C motif) receptor 1
chr2_-_89513402 0.52 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr19_+_56717283 0.52 ENST00000376267.1
ZSCAN5C
zinc finger and SCAN domain containing 5C
chr4_-_80247162 0.51 ENST00000286794.4
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr12_+_4430371 0.50 ENST00000179259.4
C12orf5
chromosome 12 open reading frame 5
chr4_-_5021164 0.49 ENST00000506508.1
ENST00000509419.1
ENST00000307746.4
CYTL1
cytokine-like 1
chr2_+_202937972 0.48 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr9_+_35490101 0.47 ENST00000361226.3
RUSC2
RUN and SH3 domain containing 2
chr8_-_22014255 0.46 ENST00000424267.2
LGI3
leucine-rich repeat LGI family, member 3
chr19_-_10491234 0.44 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr8_-_22014339 0.43 ENST00000306317.2
LGI3
leucine-rich repeat LGI family, member 3
chrX_+_52926322 0.42 ENST00000430150.2
ENST00000452021.2
ENST00000412319.1
FAM156B
family with sequence similarity 156, member B
chr10_+_90750378 0.42 ENST00000355740.2
ENST00000352159.4
FAS
Fas cell surface death receptor
chr11_+_35198243 0.41 ENST00000528455.1
CD44
CD44 molecule (Indian blood group)
chr5_+_32788945 0.40 ENST00000326958.1
AC026703.1
AC026703.1
chr10_+_71561704 0.39 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr6_-_29324054 0.38 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr16_+_83932684 0.38 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr5_+_54320078 0.37 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr8_+_23386305 0.37 ENST00000519973.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr19_+_19322758 0.37 ENST00000252575.6
NCAN
neurocan
chr11_+_18433840 0.37 ENST00000541669.1
ENST00000280704.4
LDHC
lactate dehydrogenase C
chr7_-_112726393 0.35 ENST00000449591.1
ENST00000449735.1
ENST00000438062.1
ENST00000424100.1
GPR85
G protein-coupled receptor 85
chr10_+_71561630 0.34 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr4_-_46911223 0.33 ENST00000396533.1
COX7B2
cytochrome c oxidase subunit VIIb2
chr8_-_133123406 0.32 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr20_-_44539538 0.32 ENST00000372420.1
PLTP
phospholipid transfer protein
chrX_+_140984021 0.32 ENST00000409007.1
MAGEC3
melanoma antigen family C, 3
chr19_-_42931567 0.32 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr11_+_71259466 0.32 ENST00000528743.2
KRTAP5-9
keratin associated protein 5-9
chr19_-_51531272 0.31 ENST00000319720.7
KLK11
kallikrein-related peptidase 11
chr11_+_71238313 0.31 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr19_+_42724423 0.31 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr19_+_1077393 0.31 ENST00000590577.1
HMHA1
histocompatibility (minor) HA-1
chr10_+_60028818 0.30 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr2_-_24270217 0.30 ENST00000295148.4
ENST00000406895.3
C2orf44
chromosome 2 open reading frame 44
chr16_+_27078219 0.29 ENST00000418886.1
C16orf82
chromosome 16 open reading frame 82
chr19_-_51530916 0.29 ENST00000594768.1
KLK11
kallikrein-related peptidase 11
chr1_-_152552980 0.29 ENST00000368787.3
LCE3D
late cornified envelope 3D
chr2_-_4021609 0.29 ENST00000425949.1
ENST00000453880.1
ENST00000588796.1
AC107070.1
AC107070.1
chr14_+_96722152 0.28 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr19_-_14945933 0.28 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr12_+_50478977 0.28 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr1_+_171750776 0.28 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr8_-_7243080 0.28 ENST00000400156.4
ZNF705G
zinc finger protein 705G
chr13_-_46679144 0.28 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr18_-_19994830 0.27 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr2_-_4021643 0.27 ENST00000454455.1
AC107070.1
AC107070.1
chr9_+_125281420 0.27 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr11_-_104893863 0.27 ENST00000260315.3
ENST00000526056.1
ENST00000531367.1
ENST00000456094.1
ENST00000444749.2
ENST00000393141.2
ENST00000418434.1
ENST00000393139.2
CASP5
caspase 5, apoptosis-related cysteine peptidase
chr2_-_89266286 0.27 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr14_-_74417096 0.26 ENST00000286544.3
FAM161B
family with sequence similarity 161, member B
chr11_-_27722021 0.26 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
BDNF
brain-derived neurotrophic factor
chr10_-_90611566 0.26 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr20_+_30865429 0.26 ENST00000375712.3
KIF3B
kinesin family member 3B
chr14_+_77924204 0.26 ENST00000555133.1
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr17_+_74372662 0.26 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr18_-_5544241 0.25 ENST00000341928.2
ENST00000540638.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr3_+_122103014 0.25 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
FAM162A
family with sequence similarity 162, member A
chr18_-_25616519 0.24 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_157014865 0.24 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr19_+_496454 0.24 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
chr19_-_16682987 0.24 ENST00000431408.1
ENST00000436553.2
ENST00000595753.1
SLC35E1
solute carrier family 35, member E1
chr19_-_47291843 0.24 ENST00000542575.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_-_51810778 0.24 ENST00000413473.2
ENST00000401051.3
ENST00000527205.1
TTC39A
tetratricopeptide repeat domain 39A
chr1_+_172628154 0.24 ENST00000340030.3
ENST00000367721.2
FASLG
Fas ligand (TNF superfamily, member 6)
chr11_+_65082289 0.24 ENST00000279249.2
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr22_+_17956618 0.24 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr10_+_71561649 0.23 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr4_-_6202291 0.23 ENST00000282924.5
JAKMIP1
janus kinase and microtubule interacting protein 1
chr10_-_1071796 0.23 ENST00000277517.1
IDI2
isopentenyl-diphosphate delta isomerase 2
chr5_+_175740083 0.22 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr20_-_5931109 0.22 ENST00000203001.2
TRMT6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr7_-_99381884 0.22 ENST00000336411.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr3_+_148447887 0.22 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr6_-_55443958 0.21 ENST00000370850.2
HMGCLL1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chrX_+_140968348 0.21 ENST00000536088.1
ENST00000443323.2
MAGEC3
melanoma antigen family C, 3
chr3_+_118866222 0.21 ENST00000490594.1
RP11-484M3.5
Uncharacterized protein
chr14_+_74111578 0.21 ENST00000554113.1
ENST00000555631.2
ENST00000553645.2
ENST00000311089.3
ENST00000555919.3
ENST00000554339.1
ENST00000554871.1
DNAL1
dynein, axonemal, light chain 1
chr6_+_126661253 0.20 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
CENPW
centromere protein W
chr3_-_178976996 0.20 ENST00000485523.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr4_-_48908805 0.20 ENST00000273860.4
OCIAD2
OCIA domain containing 2
chr1_-_153085984 0.20 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr7_-_2883928 0.20 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr4_-_69215699 0.20 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr4_-_48908822 0.19 ENST00000508632.1
OCIAD2
OCIA domain containing 2
chr6_-_31514333 0.19 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr6_+_52285131 0.18 ENST00000433625.2
EFHC1
EF-hand domain (C-terminal) containing 1
chrX_-_54824673 0.18 ENST00000218436.6
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr12_-_88535842 0.18 ENST00000550962.1
ENST00000552810.1
CEP290
centrosomal protein 290kDa
chr4_-_48908737 0.18 ENST00000381464.2
OCIAD2
OCIA domain containing 2
chr16_+_66914264 0.18 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr1_-_110613276 0.18 ENST00000369792.4
ALX3
ALX homeobox 3
chr21_-_21630994 0.17 ENST00000436373.1
AP001171.1
AP001171.1
chr6_-_41254403 0.17 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr5_+_150040403 0.17 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chr4_-_84030996 0.17 ENST00000411416.2
PLAC8
placenta-specific 8
chr19_+_9361606 0.17 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr11_-_104972158 0.17 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr4_-_46911248 0.17 ENST00000355591.3
ENST00000505102.1
COX7B2
cytochrome c oxidase subunit VIIb2
chr2_+_90192768 0.17 ENST00000390275.2
IGKV1D-13
immunoglobulin kappa variable 1D-13
chr15_-_75017711 0.17 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr17_-_41132410 0.17 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr6_-_31514516 0.17 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr22_-_42915788 0.17 ENST00000323013.6
RRP7A
ribosomal RNA processing 7 homolog A (S. cerevisiae)
chr22_-_36031181 0.17 ENST00000594060.1
AL049747.1
AL049747.1
chr22_+_24999114 0.17 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr7_-_150675372 0.16 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr5_-_174871136 0.16 ENST00000393752.2
DRD1
dopamine receptor D1
chr2_+_17721920 0.16 ENST00000295156.4
VSNL1
visinin-like 1
chr6_-_52668605 0.16 ENST00000334575.5
GSTA1
glutathione S-transferase alpha 1
chr19_-_9092018 0.16 ENST00000397910.4
MUC16
mucin 16, cell surface associated
chr11_+_196738 0.16 ENST00000325113.4
ENST00000342593.5
ODF3
outer dense fiber of sperm tails 3
chr11_-_18258342 0.15 ENST00000278222.4
SAA4
serum amyloid A4, constitutive
chr11_+_130542851 0.15 ENST00000317019.2
C11orf44
chromosome 11 open reading frame 44
chr13_+_73356197 0.15 ENST00000326291.6
PIBF1
progesterone immunomodulatory binding factor 1
chr16_-_30381580 0.15 ENST00000409939.3
TBC1D10B
TBC1 domain family, member 10B
chr1_-_153283194 0.15 ENST00000290722.1
PGLYRP3
peptidoglycan recognition protein 3
chr7_-_99381798 0.15 ENST00000415003.1
ENST00000354593.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chrX_-_65259914 0.15 ENST00000374737.4
ENST00000455586.2
VSIG4
V-set and immunoglobulin domain containing 4
chr16_-_67360662 0.15 ENST00000304372.5
KCTD19
potassium channel tetramerization domain containing 19
chr10_+_94608218 0.15 ENST00000371543.1
EXOC6
exocyst complex component 6
chr14_-_24911971 0.15 ENST00000555365.1
ENST00000399395.3
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr12_-_70093190 0.15 ENST00000330891.5
BEST3
bestrophin 3
chr7_+_73106926 0.15 ENST00000453316.1
WBSCR22
Williams Beuren syndrome chromosome region 22
chrX_-_65259900 0.14 ENST00000412866.2
VSIG4
V-set and immunoglobulin domain containing 4
chr3_+_189349162 0.14 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr12_-_70093111 0.14 ENST00000548658.1
ENST00000476098.1
ENST00000331471.4
ENST00000393365.1
BEST3
bestrophin 3
chr9_-_95087604 0.14 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
NOL8
nucleolar protein 8
chr3_-_81792780 0.14 ENST00000489715.1
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_11865351 0.14 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr4_+_155484155 0.14 ENST00000509493.1
FGB
fibrinogen beta chain
chr22_-_39928823 0.14 ENST00000334678.3
RPS19BP1
ribosomal protein S19 binding protein 1
chr19_-_10491130 0.13 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr15_+_31196053 0.13 ENST00000561594.1
ENST00000362065.4
FAN1
FANCD2/FANCI-associated nuclease 1
chr4_+_103790462 0.13 ENST00000503643.1
CISD2
CDGSH iron sulfur domain 2
chr4_-_83765613 0.13 ENST00000503937.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr11_-_8285405 0.13 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr1_-_89488510 0.13 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr6_+_160542821 0.12 ENST00000366963.4
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr3_-_178984759 0.12 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr19_+_39936267 0.12 ENST00000359191.6
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr19_+_55385682 0.12 ENST00000391726.3
FCAR
Fc fragment of IgA, receptor for
chrX_+_22291065 0.12 ENST00000323684.1
ZNF645
zinc finger protein 645
chr5_+_35618058 0.12 ENST00000440995.2
SPEF2
sperm flagellar 2
chr5_+_145826867 0.12 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr5_+_35617940 0.12 ENST00000282469.6
ENST00000509059.1
ENST00000356031.3
ENST00000510777.1
SPEF2
sperm flagellar 2
chr1_+_220267429 0.12 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr9_+_71394945 0.12 ENST00000394264.3
FAM122A
family with sequence similarity 122A
chr12_-_8765446 0.12 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr4_-_83812402 0.11 ENST00000395310.2
SEC31A
SEC31 homolog A (S. cerevisiae)
chr6_-_52628271 0.11 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr7_+_76751926 0.11 ENST00000285871.4
ENST00000431197.1
CCDC146
coiled-coil domain containing 146
chr5_-_80689945 0.11 ENST00000307624.3
ACOT12
acyl-CoA thioesterase 12
chr5_-_40755987 0.11 ENST00000337702.4
TTC33
tetratricopeptide repeat domain 33
chr1_+_36396677 0.11 ENST00000373191.4
ENST00000397828.2
AGO3
argonaute RISC catalytic component 3
chr12_+_11081828 0.11 ENST00000381847.3
ENST00000396400.3
PRH2
proline-rich protein HaeIII subfamily 2
chr14_-_24912047 0.11 ENST00000553930.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr6_+_52285046 0.11 ENST00000371068.5
EFHC1
EF-hand domain (C-terminal) containing 1
chr9_+_273038 0.11 ENST00000487230.1
ENST00000469391.1
DOCK8
dedicator of cytokinesis 8
chr14_+_21785693 0.11 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr19_+_39936186 0.11 ENST00000432763.2
ENST00000402194.2
ENST00000601515.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr1_+_36396791 0.11 ENST00000246314.6
AGO3
argonaute RISC catalytic component 3
chr12_+_133757995 0.11 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr22_+_23063100 0.11 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr1_+_36396313 0.11 ENST00000324350.5
AGO3
argonaute RISC catalytic component 3
chr19_+_21265028 0.10 ENST00000291770.7
ZNF714
zinc finger protein 714
chr6_-_55443831 0.10 ENST00000428842.1
ENST00000358072.5
ENST00000508459.1
HMGCLL1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr5_-_137610254 0.10 ENST00000378362.3
GFRA3
GDNF family receptor alpha 3
chr3_+_148709128 0.10 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
GYG1
glycogenin 1
chr6_+_31021973 0.10 ENST00000570223.1
ENST00000566475.1
ENST00000426185.1
HCG22
HLA complex group 22
chr4_+_15704573 0.10 ENST00000265016.4
BST1
bone marrow stromal cell antigen 1
chr6_-_35888905 0.10 ENST00000510290.1
ENST00000423325.2
ENST00000373822.1
SRPK1
SRSF protein kinase 1
chr8_-_20161466 0.09 ENST00000381569.1
LZTS1
leucine zipper, putative tumor suppressor 1
chr17_+_38465441 0.09 ENST00000577646.1
ENST00000254066.5
RARA
retinoic acid receptor, alpha
chr17_-_55822653 0.09 ENST00000299415.2
AC007431.1
coiled-coil domain containing 182
chr2_+_162101247 0.09 ENST00000439050.1
ENST00000436506.1
AC009299.3
AC009299.3
chr2_+_241807870 0.09 ENST00000307503.3
AGXT
alanine-glyoxylate aminotransferase
chr5_-_137610300 0.09 ENST00000274721.3
GFRA3
GDNF family receptor alpha 3
chr10_+_50507181 0.09 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr1_-_182921119 0.09 ENST00000423786.1
SHCBP1L
SHC SH2-domain binding protein 1-like
chr15_+_31196080 0.09 ENST00000561607.1
ENST00000565466.1
FAN1
FANCD2/FANCI-associated nuclease 1
chr7_-_76255444 0.09 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr1_+_154229547 0.09 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 1.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.2 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.5 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.4 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.1 0.7 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.4 GO:0009822 alkaloid catabolic process(GO:0009822) calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.3 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.4 GO:0036115 fatty-acyl-CoA catabolic process(GO:0036115) malonyl-CoA metabolic process(GO:2001293)
0.1 0.3 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0019249 lactate biosynthetic process(GO:0019249)
0.1 0.2 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.1 0.2 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.1 0.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.6 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 0.4 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.1 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.3 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.4 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.2 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.1 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.1 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241)
0.0 1.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.2 GO:0048793 otic vesicle formation(GO:0030916) pronephros development(GO:0048793)
0.0 1.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.2 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.7 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.1 GO:0035803 egg coat formation(GO:0035803)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.2 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.1 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 2.5 GO:0031424 keratinization(GO:0031424)
0.0 0.0 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 1.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.1 GO:0042825 TAP complex(GO:0042825)
0.1 0.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.3 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.4 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.2 GO:0032044 DSIF complex(GO:0032044)
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.5 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.5 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 0.3 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.4 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.3 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.1 1.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.6 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.3 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.0 0.1 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0004132 dCMP deaminase activity(GO:0004132)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis