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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX4

Z-value: 0.47

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Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 T-box transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX4hg19_v2_chr17_+_59529743_59529798-0.213.1e-01Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186732048 1.85 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
SORBS2
sorbin and SH3 domain containing 2
chr9_+_40028620 1.55 ENST00000426179.1
AL353791.1
AL353791.1
chr11_-_33913708 1.35 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_102268484 1.18 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_-_13487784 1.16 ENST00000379287.3
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr4_-_102268628 1.09 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr9_-_75567962 1.03 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_-_157189180 0.99 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr9_+_71986182 0.84 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr5_+_68788594 0.82 ENST00000396442.2
ENST00000380766.2
OCLN
occludin
chr11_-_33891362 0.82 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_+_134514093 0.74 ENST00000398015.3
EPHB1
EPH receptor B1
chr2_+_61108650 0.73 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr12_-_7848364 0.66 ENST00000329913.3
GDF3
growth differentiation factor 3
chr2_+_61108771 0.61 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr10_+_94833642 0.50 ENST00000224356.4
ENST00000394139.1
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr19_-_46526304 0.47 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr4_+_102268904 0.46 ENST00000527564.1
ENST00000529296.1
AP001816.1
Uncharacterized protein
chr4_-_114682597 0.44 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr7_+_107220660 0.44 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr7_+_107220899 0.44 ENST00000379117.2
ENST00000473124.1
BCAP29
B-cell receptor-associated protein 29
chr17_+_35849937 0.42 ENST00000394389.4
DUSP14
dual specificity phosphatase 14
chr4_-_114682936 0.41 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr17_-_37557846 0.40 ENST00000394294.3
ENST00000583610.1
ENST00000264658.6
FBXL20
F-box and leucine-rich repeat protein 20
chr8_+_95907993 0.40 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr2_-_160473114 0.35 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr1_+_27114418 0.32 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr18_-_53068911 0.32 ENST00000537856.3
TCF4
transcription factor 4
chr3_-_49459865 0.31 ENST00000427987.1
AMT
aminomethyltransferase
chr3_-_49459878 0.31 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
AMT
aminomethyltransferase
chr14_+_75746781 0.30 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chrX_-_133930285 0.29 ENST00000486347.1
ENST00000343004.5
FAM122B
family with sequence similarity 122B
chr13_+_115047097 0.29 ENST00000351487.5
UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr11_-_18343669 0.29 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr2_+_62933001 0.28 ENST00000263991.5
ENST00000354487.3
EHBP1
EH domain binding protein 1
chr16_-_2205352 0.28 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr1_+_154377669 0.27 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr2_+_103089756 0.27 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr10_+_45406627 0.26 ENST00000389583.4
TMEM72
transmembrane protein 72
chr20_+_11898507 0.26 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chrX_-_19689106 0.24 ENST00000379716.1
SH3KBP1
SH3-domain kinase binding protein 1
chr14_+_75745477 0.24 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr8_-_99954788 0.22 ENST00000523601.1
STK3
serine/threonine kinase 3
chr19_+_10131437 0.22 ENST00000587782.1
RDH8
retinol dehydrogenase 8 (all-trans)
chr2_-_160472952 0.22 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_+_62932779 0.21 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1
EH domain binding protein 1
chrX_+_123095546 0.21 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr14_+_21467414 0.20 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr6_-_13487825 0.20 ENST00000603223.1
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr12_+_57853918 0.20 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr2_-_111291587 0.20 ENST00000437167.1
RGPD6
RANBP2-like and GRIP domain containing 6
chr1_+_27114589 0.19 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr13_-_46543805 0.19 ENST00000378921.2
ZC3H13
zinc finger CCCH-type containing 13
chr17_-_39203519 0.19 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr11_-_114271139 0.18 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr2_-_61697862 0.17 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr8_-_95907423 0.17 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chrX_+_123480375 0.16 ENST00000360027.4
SH2D1A
SH2 domain containing 1A
chr22_+_40441456 0.16 ENST00000402203.1
TNRC6B
trinucleotide repeat containing 6B
chr16_+_67596310 0.16 ENST00000264010.4
ENST00000401394.1
CTCF
CCCTC-binding factor (zinc finger protein)
chr12_+_104324112 0.15 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr12_-_90024360 0.15 ENST00000393164.2
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr15_+_89402148 0.14 ENST00000560601.1
ACAN
aggrecan
chr14_+_23344345 0.14 ENST00000551466.1
LRP10
low density lipoprotein receptor-related protein 10
chr9_-_74979420 0.14 ENST00000343431.2
ENST00000376956.3
ZFAND5
zinc finger, AN1-type domain 5
chr8_+_103563792 0.14 ENST00000285402.3
ODF1
outer dense fiber of sperm tails 1
chr1_+_145507587 0.14 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chrX_+_123480421 0.14 ENST00000477673.2
SH2D1A
SH2 domain containing 1A
chr11_+_4116054 0.14 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr11_+_111749650 0.14 ENST00000528125.1
C11orf1
chromosome 11 open reading frame 1
chr17_-_26220366 0.14 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr16_+_85645007 0.14 ENST00000405402.2
GSE1
Gse1 coiled-coil protein
chr7_-_127032741 0.13 ENST00000393313.1
ENST00000265827.3
ENST00000434602.1
ZNF800
zinc finger protein 800
chr13_-_52027134 0.13 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr11_+_18343800 0.13 ENST00000453096.2
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr6_+_32132360 0.13 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr12_-_91348949 0.13 ENST00000358859.2
CCER1
coiled-coil glutamate-rich protein 1
chr15_-_90294523 0.13 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chr5_-_74807418 0.12 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr1_+_228395755 0.12 ENST00000284548.11
ENST00000570156.2
ENST00000422127.1
ENST00000366707.4
ENST00000366709.4
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr4_-_140222358 0.12 ENST00000505036.1
ENST00000544855.1
ENST00000539002.1
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr19_+_39279838 0.11 ENST00000314980.4
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr14_-_45603657 0.11 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr12_+_50451331 0.11 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chr2_-_85895295 0.11 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr1_-_44482979 0.11 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_+_27282319 0.11 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr1_-_1009683 0.10 ENST00000453464.2
RNF223
ring finger protein 223
chrX_+_46771848 0.10 ENST00000218343.4
PHF16
jade family PHD finger 3
chr6_+_79577189 0.10 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chrX_+_46771711 0.10 ENST00000424392.1
ENST00000397189.1
PHF16
jade family PHD finger 3
chr10_+_7860460 0.10 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr11_-_7818520 0.10 ENST00000329434.2
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr20_+_58630972 0.10 ENST00000313426.1
C20orf197
chromosome 20 open reading frame 197
chr11_+_1940786 0.10 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr5_+_56469939 0.10 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr2_+_172864490 0.09 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr1_-_85930246 0.09 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr11_+_111750206 0.09 ENST00000530214.1
ENST00000530799.1
C11orf1
chromosome 11 open reading frame 1
chr2_+_37458776 0.08 ENST00000002125.4
ENST00000336237.6
ENST00000431821.1
NDUFAF7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr20_+_2517253 0.08 ENST00000358864.1
TMC2
transmembrane channel-like 2
chr22_-_20231207 0.08 ENST00000425986.1
RTN4R
reticulon 4 receptor
chr5_+_56469843 0.08 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr14_+_53196872 0.08 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr5_+_74807886 0.08 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr3_+_52811596 0.07 ENST00000542827.1
ENST00000273283.2
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr11_+_122709200 0.07 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr12_-_53097247 0.07 ENST00000341809.3
ENST00000537195.1
KRT77
keratin 77
chr7_+_133261209 0.07 ENST00000545148.1
EXOC4
exocyst complex component 4
chr11_+_18344106 0.07 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr21_+_30502806 0.07 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr11_+_120081475 0.07 ENST00000328965.4
OAF
OAF homolog (Drosophila)
chr3_+_63805017 0.07 ENST00000295896.8
C3orf49
chromosome 3 open reading frame 49
chr1_-_226076843 0.06 ENST00000272134.5
LEFTY1
left-right determination factor 1
chr17_-_61973929 0.06 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
CSH1
chorionic somatomammotropin hormone 1 (placental lactogen)
chr5_+_74807581 0.06 ENST00000241436.4
ENST00000352007.5
POLK
polymerase (DNA directed) kappa
chr14_+_90864504 0.05 ENST00000544280.2
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr1_+_16062820 0.05 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr6_+_39760129 0.05 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chrX_+_123480194 0.05 ENST00000371139.4
SH2D1A
SH2 domain containing 1A
chr15_+_41913690 0.05 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr3_+_142315225 0.05 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
PLS1
plastin 1
chr7_-_71801980 0.05 ENST00000329008.5
CALN1
calneuron 1
chr12_+_21525818 0.05 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
IAPP
islet amyloid polypeptide
chr11_-_129062093 0.05 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr5_+_56469775 0.04 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr8_+_73449625 0.04 ENST00000523207.1
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr9_-_74980113 0.04 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chrM_+_10053 0.04 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr15_-_83474806 0.04 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr11_+_111749942 0.03 ENST00000260276.3
C11orf1
chromosome 11 open reading frame 1
chr17_+_30771279 0.03 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr5_-_54281491 0.03 ENST00000381405.4
ESM1
endothelial cell-specific molecule 1
chr2_-_40680578 0.03 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr4_-_186456766 0.03 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr11_-_118972575 0.02 ENST00000432443.2
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr12_+_65672702 0.02 ENST00000538045.1
ENST00000535239.1
MSRB3
methionine sulfoxide reductase B3
chr1_+_114471972 0.02 ENST00000369559.4
ENST00000369554.2
HIPK1
homeodomain interacting protein kinase 1
chr2_-_37458749 0.02 ENST00000234170.5
CEBPZ
CCAAT/enhancer binding protein (C/EBP), zeta
chr16_-_67965756 0.02 ENST00000571044.1
ENST00000571605.1
CTRL
chymotrypsin-like
chr11_-_5248294 0.02 ENST00000335295.4
HBB
hemoglobin, beta
chr11_-_34535332 0.01 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr3_+_137728842 0.01 ENST00000183605.5
CLDN18
claudin 18
chr13_-_36429763 0.01 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr4_-_186456652 0.01 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr11_+_114271251 0.01 ENST00000375490.5
RBM7
RNA binding motif protein 7
chr8_+_87111059 0.01 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr5_-_60240858 0.01 ENST00000426742.2
ENST00000265038.5
ENST00000543101.1
ENST00000439176.1
ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8
chr18_-_56296182 0.01 ENST00000361673.3
ALPK2
alpha-kinase 2
chr12_+_58148842 0.01 ENST00000266643.5
MARCH9
membrane-associated ring finger (C3HC4) 9
chr7_-_27142290 0.01 ENST00000222718.5
HOXA2
homeobox A2
chr5_-_54281407 0.01 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr1_+_114471809 0.01 ENST00000426820.2
HIPK1
homeodomain interacting protein kinase 1
chr11_+_64073699 0.01 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr17_+_57970469 0.00 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 1.0 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 1.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 0.7 GO:1902725 trans-synaptic signaling by trans-synaptic complex(GO:0099545) negative regulation of satellite cell differentiation(GO:1902725)
0.2 0.5 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.1 0.5 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.1 0.6 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.7 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 2.2 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 1.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.2 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.1 GO:0060913 cardiac cell fate determination(GO:0060913)
0.1 0.8 GO:1901725 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of histone deacetylase activity(GO:1901725)
0.1 0.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.0 1.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.8 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309)
0.0 0.2 GO:0070602 maintenance of DNA methylation(GO:0010216) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 0.4 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.5 GO:0035976 AP1 complex(GO:0035976)
0.1 0.5 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.0 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 0.6 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 0.5 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 1.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.0 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 2.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.4 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway