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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX5

Z-value: 0.77

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Transcription factors associated with TBX5

Gene Symbol Gene ID Gene Info
TBX5
ENSG00000089225.15 T-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX5hg19_v2_chr12_-_114841703_1148417260.386.0e-02Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_55581954 2.72 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr15_+_89182156 2.45 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 2.44 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 2.06 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_72385437 1.86 ENST00000418754.2
ENST00000542969.2
ENST00000334456.5
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr2_-_175870085 1.46 ENST00000409156.3
CHN1
chimerin 1
chr5_+_113697983 1.37 ENST00000264773.3
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_77020325 1.30 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_77020224 1.29 ENST00000339142.2
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr2_-_175869936 1.20 ENST00000409900.3
CHN1
chimerin 1
chr1_-_153521714 1.18 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr8_+_123793633 1.03 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr2_+_201994042 1.01 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr1_-_205290865 0.96 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr17_+_77021702 0.93 ENST00000392445.2
ENST00000354124.3
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_+_60028818 0.91 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr1_-_12677714 0.91 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr17_+_77020146 0.91 ENST00000579760.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_+_83073952 0.90 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr5_+_54320078 0.87 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr11_-_72070206 0.86 ENST00000544382.1
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr17_+_74372662 0.85 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr3_+_133292759 0.79 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr14_+_22748980 0.78 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr19_-_39108568 0.76 ENST00000586296.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr5_+_125758865 0.74 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_125758813 0.74 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr3_-_182880541 0.73 ENST00000470251.1
ENST00000265598.3
LAMP3
lysosomal-associated membrane protein 3
chr6_-_11382478 0.66 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_-_50715196 0.65 ENST00000423026.2
SNX20
sorting nexin 20
chr5_-_16738451 0.63 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr19_-_39108643 0.63 ENST00000396857.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr2_+_201994208 0.62 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chrX_+_56259316 0.62 ENST00000468660.1
KLF8
Kruppel-like factor 8
chrX_-_83757399 0.60 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr19_-_39108552 0.60 ENST00000591517.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr11_-_85779971 0.60 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr20_+_816695 0.59 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr12_+_112563335 0.58 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAFD1
TRAF-type zinc finger domain containing 1
chr12_+_112563303 0.58 ENST00000412615.2
TRAFD1
TRAF-type zinc finger domain containing 1
chr15_-_58357932 0.57 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr11_-_34535332 0.55 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chrX_-_130423200 0.54 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr18_+_32073253 0.53 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA
dystrobrevin, alpha
chr16_+_57023406 0.53 ENST00000262510.6
ENST00000308149.7
ENST00000436936.1
NLRC5
NLR family, CARD domain containing 5
chr4_+_8582287 0.53 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chrX_-_130423386 0.52 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr10_-_99531709 0.50 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr19_-_47734448 0.50 ENST00000439096.2
BBC3
BCL2 binding component 3
chr11_+_35198118 0.49 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44
CD44 molecule (Indian blood group)
chr7_+_112063192 0.48 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr1_+_26737253 0.47 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr1_-_11042094 0.47 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr5_+_140864649 0.46 ENST00000306593.1
PCDHGC4
protocadherin gamma subfamily C, 4
chr17_-_74533734 0.44 ENST00000589342.1
CYGB
cytoglobin
chr12_-_111021110 0.42 ENST00000354300.3
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr6_+_30295036 0.41 ENST00000376659.5
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr17_+_30814707 0.41 ENST00000584792.1
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr6_+_30294612 0.41 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
TRIM39
tripartite motif containing 39
chr20_+_45523227 0.41 ENST00000327619.5
ENST00000357410.3
EYA2
eyes absent homolog 2 (Drosophila)
chr17_+_37784749 0.41 ENST00000394265.1
ENST00000394267.2
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr7_-_105319536 0.41 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr2_-_161350305 0.40 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr3_-_133748913 0.40 ENST00000310926.4
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr6_+_43445261 0.39 ENST00000372444.2
ENST00000372445.5
ENST00000436109.2
ENST00000372454.2
ENST00000442878.2
ENST00000259751.1
ENST00000372452.1
ENST00000372449.1
TJAP1
tight junction associated protein 1 (peripheral)
chrX_+_129473859 0.39 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_-_111174054 0.39 ENST00000369770.3
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr1_-_45288932 0.39 ENST00000438067.1
PTCH2
patched 2
chr6_+_37225540 0.39 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr5_+_140868717 0.39 ENST00000252087.1
PCDHGC5
protocadherin gamma subfamily C, 5
chr12_+_12764773 0.39 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr1_+_47901689 0.38 ENST00000334793.5
FOXD2
forkhead box D2
chr12_-_49351303 0.38 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr1_+_26737292 0.38 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr11_+_117947724 0.38 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chrX_+_102862834 0.37 ENST00000372627.5
ENST00000243286.3
TCEAL3
transcription elongation factor A (SII)-like 3
chrX_+_69642881 0.37 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
chr19_+_1000418 0.36 ENST00000234389.3
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr8_+_81398444 0.36 ENST00000455036.3
ENST00000426744.2
ZBTB10
zinc finger and BTB domain containing 10
chr17_+_56270084 0.36 ENST00000225371.5
EPX
eosinophil peroxidase
chr8_+_81397876 0.36 ENST00000430430.1
ZBTB10
zinc finger and BTB domain containing 10
chr6_+_45389893 0.35 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr6_+_25652432 0.35 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr6_-_45983549 0.34 ENST00000544153.1
CLIC5
chloride intracellular channel 5
chr12_+_54519842 0.34 ENST00000508564.1
RP11-834C11.4
RP11-834C11.4
chr1_-_183622442 0.34 ENST00000308641.4
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr3_-_182703688 0.33 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr17_-_3819751 0.33 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr17_+_34431212 0.33 ENST00000394495.1
CCL4
chemokine (C-C motif) ligand 4
chr16_-_69385681 0.33 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr2_+_68961905 0.33 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr4_-_186456652 0.33 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chrX_-_11445856 0.32 ENST00000380736.1
ARHGAP6
Rho GTPase activating protein 6
chr5_+_140810132 0.32 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr1_+_13910194 0.32 ENST00000376057.4
ENST00000510906.1
PDPN
podoplanin
chr9_+_140125385 0.32 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr12_-_49351228 0.32 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr6_-_19804973 0.32 ENST00000457670.1
ENST00000607810.1
ENST00000606628.1
RP4-625H18.2
RP4-625H18.2
chr4_-_186456766 0.32 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr11_+_86511549 0.31 ENST00000533902.2
PRSS23
protease, serine, 23
chr2_+_68961934 0.31 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr22_-_30722912 0.31 ENST00000215790.7
TBC1D10A
TBC1 domain family, member 10A
chr2_+_68962014 0.31 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr17_-_57184064 0.31 ENST00000262294.7
TRIM37
tripartite motif containing 37
chr16_+_2587965 0.31 ENST00000342085.4
ENST00000566659.1
PDPK1
3-phosphoinositide dependent protein kinase-1
chr22_-_30722866 0.31 ENST00000403477.3
TBC1D10A
TBC1 domain family, member 10A
chr11_-_59383617 0.30 ENST00000263847.1
OSBP
oxysterol binding protein
chr5_-_66492562 0.30 ENST00000256447.4
CD180
CD180 molecule
chr12_+_56511943 0.30 ENST00000257940.2
ENST00000552345.1
ENST00000551880.1
ENST00000546903.1
ENST00000551790.1
ZC3H10
ESYT1
zinc finger CCCH-type containing 10
extended synaptotagmin-like protein 1
chr16_+_57220193 0.30 ENST00000564435.1
ENST00000562959.1
ENST00000394420.4
ENST00000568505.2
ENST00000537866.1
RSPRY1
ring finger and SPRY domain containing 1
chr11_-_72145641 0.30 ENST00000538039.1
ENST00000445069.2
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr6_+_45390222 0.30 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr14_-_51297197 0.30 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr8_+_32405785 0.30 ENST00000287842.3
NRG1
neuregulin 1
chr7_-_76255444 0.29 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr17_+_34430980 0.29 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr20_-_45035198 0.28 ENST00000372176.1
ELMO2
engulfment and cell motility 2
chr2_-_89399845 0.28 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr10_+_133918175 0.28 ENST00000298622.4
JAKMIP3
Janus kinase and microtubule interacting protein 3
chr14_+_22520762 0.28 ENST00000390449.3
TRAV21
T cell receptor alpha variable 21
chrX_-_148713365 0.28 ENST00000511776.1
ENST00000507237.1
TMEM185A
transmembrane protein 185A
chr19_+_41949054 0.28 ENST00000378187.2
C19orf69
chromosome 19 open reading frame 69
chr5_-_176936844 0.28 ENST00000510380.1
ENST00000510898.1
ENST00000357198.4
DOK3
docking protein 3
chr4_+_140222609 0.28 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr19_-_42931567 0.28 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr8_-_9760839 0.27 ENST00000519461.1
ENST00000517675.1
LINC00599
long intergenic non-protein coding RNA 599
chr9_-_98784042 0.27 ENST00000412122.2
LINC00092
long intergenic non-protein coding RNA 92
chr2_+_101591314 0.27 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr11_+_65479702 0.26 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
KAT5
K(lysine) acetyltransferase 5
chr6_+_108977520 0.26 ENST00000540898.1
FOXO3
forkhead box O3
chrX_+_149887090 0.26 ENST00000538506.1
MTMR1
myotubularin related protein 1
chr2_+_5832799 0.26 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chr1_+_154975110 0.26 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr2_+_154728426 0.26 ENST00000392825.3
ENST00000434213.1
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr19_-_42721819 0.26 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2
death effector domain containing 2
chr5_-_54281407 0.25 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr11_-_72145669 0.25 ENST00000543042.1
ENST00000294053.3
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr15_+_81589254 0.25 ENST00000394652.2
IL16
interleukin 16
chr12_-_53228079 0.25 ENST00000330553.5
KRT79
keratin 79
chr7_-_93204033 0.25 ENST00000359558.2
ENST00000360249.4
ENST00000426151.1
CALCR
calcitonin receptor
chr22_-_31885514 0.25 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr7_+_29237354 0.25 ENST00000546235.1
CHN2
chimerin 2
chr7_-_142120321 0.25 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr19_+_10397648 0.25 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr8_+_13424352 0.25 ENST00000297324.4
C8orf48
chromosome 8 open reading frame 48
chr11_-_47470591 0.25 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr1_+_110993795 0.25 ENST00000271331.3
PROK1
prokineticin 1
chr12_+_104458235 0.24 ENST00000229330.4
HCFC2
host cell factor C2
chr17_-_39324424 0.24 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr10_+_82297658 0.24 ENST00000339284.2
SH2D4B
SH2 domain containing 4B
chr16_-_70285797 0.24 ENST00000435634.1
EXOSC6
exosome component 6
chr14_+_96858433 0.24 ENST00000267584.4
AK7
adenylate kinase 7
chr1_+_13910757 0.24 ENST00000376061.4
ENST00000513143.1
PDPN
podoplanin
chr19_-_4302375 0.24 ENST00000600114.1
ENST00000600349.1
ENST00000595645.1
ENST00000301272.2
TMIGD2
transmembrane and immunoglobulin domain containing 2
chr12_+_18891045 0.24 ENST00000317658.3
CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
chr4_-_175443943 0.23 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr1_-_85930246 0.23 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_+_127770455 0.23 ENST00000464451.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr5_+_66124590 0.23 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_-_107590383 0.23 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr8_+_32405728 0.23 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr10_+_82298088 0.23 ENST00000470604.2
SH2D4B
SH2 domain containing 4B
chr11_-_47470703 0.23 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr11_-_2182388 0.23 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
INS
INS-IGF2
insulin
INS-IGF2 readthrough
chr12_+_1738363 0.23 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr5_+_82767487 0.23 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr1_-_153518270 0.23 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr8_+_56014949 0.23 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr1_+_15736359 0.22 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr19_-_3500635 0.22 ENST00000250937.3
DOHH
deoxyhypusine hydroxylase/monooxygenase
chr12_-_121342170 0.22 ENST00000353487.2
SPPL3
signal peptide peptidase like 3
chr5_-_140070897 0.22 ENST00000448240.1
ENST00000438307.2
ENST00000415192.2
ENST00000457527.2
ENST00000307633.3
ENST00000507746.1
ENST00000431330.2
HARS
histidyl-tRNA synthetase
chr2_+_171571827 0.22 ENST00000375281.3
SP5
Sp5 transcription factor
chrX_+_95939638 0.22 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr11_-_57479673 0.22 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chr1_-_144995002 0.22 ENST00000369356.4
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_-_135248604 0.22 ENST00000515491.1
ENST00000504728.1
ENST00000506638.1
RP11-400D2.2
RP11-400D2.2
chr12_+_51818555 0.22 ENST00000453097.2
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr12_+_51818586 0.22 ENST00000394856.1
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr19_+_16308711 0.21 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr12_-_62586543 0.21 ENST00000416284.3
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr2_+_153191706 0.21 ENST00000288670.9
FMNL2
formin-like 2
chr11_-_123525289 0.21 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
SCN3B
sodium channel, voltage-gated, type III, beta subunit
chr17_-_37934466 0.21 ENST00000583368.1
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr19_-_10420459 0.21 ENST00000403352.1
ENST00000403903.3
ZGLP1
zinc finger, GATA-like protein 1
chr12_+_51818749 0.21 ENST00000514353.3
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr19_+_55795493 0.21 ENST00000309383.1
BRSK1
BR serine/threonine kinase 1
chr11_-_45939565 0.20 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr19_+_50380917 0.20 ENST00000535102.2
TBC1D17
TBC1 domain family, member 17
chr19_-_10450328 0.20 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr6_+_25652501 0.20 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chrX_+_21392553 0.20 ENST00000279451.4
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr11_-_72145426 0.20 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr2_-_118771701 0.20 ENST00000376300.2
ENST00000319432.5
CCDC93
coiled-coil domain containing 93
chr6_-_33239712 0.20 ENST00000436044.2
VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr1_-_25256368 0.20 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr12_+_53645870 0.20 ENST00000329548.4
MFSD5
major facilitator superfamily domain containing 5
chr8_-_53322303 0.20 ENST00000276480.7
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr14_-_24664540 0.20 ENST00000530563.1
ENST00000528895.1
ENST00000528669.1
ENST00000532632.1
TM9SF1
transmembrane 9 superfamily member 1
chr5_-_131347583 0.20 ENST00000379255.1
ENST00000430403.1
ENST00000544770.1
ENST00000379246.1
ENST00000414078.1
ENST00000441995.1
ACSL6
acyl-CoA synthetase long-chain family member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.6 4.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.5 1.9 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.5 2.7 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 0.8 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 0.6 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.2 0.5 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.2 1.6 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 0.5 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.4 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 1.4 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 0.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 0.7 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.4 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.7 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.4 GO:0002215 defense response to nematode(GO:0002215)
0.1 0.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.3 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.3 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.6 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.5 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.2 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.4 GO:0021633 optic nerve structural organization(GO:0021633)
0.1 0.2 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.5 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.5 GO:0035803 egg coat formation(GO:0035803)
0.1 0.5 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.1 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.1 0.2 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.1 0.6 GO:0035799 ureter maturation(GO:0035799)
0.1 2.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.3 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.1 0.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 2.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.5 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.2 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.1 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.3 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.4 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.3 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.2 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.2 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0001897 cytolysis by symbiont of host cells(GO:0001897) negative regulation of cytolysis(GO:0045918)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.0 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.0 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.8 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.9 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.7 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.3 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.1 GO:0035995 skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.4 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.4 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 1.2 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.1 GO:0072054 renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) inner medullary collecting duct development(GO:0072061)
0.0 0.4 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.0 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.0 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.3 GO:0048757 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.0 GO:0072717 transcription factor catabolic process(GO:0036369) cellular response to vitamin B1(GO:0071301) cellular response to actinomycin D(GO:0072717) response to formaldehyde(GO:1904404)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.5 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.2 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 6.8 GO:0015030 Cajal body(GO:0015030)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.6 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.6 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 4.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 1.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 1.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.6 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.2 1.2 GO:0034711 inhibin binding(GO:0034711)
0.1 0.8 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.4 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.4 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.5 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.3 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.3 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 2.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 2.8 GO:0031489 myosin V binding(GO:0031489)
0.1 0.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.2 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0005119 smoothened binding(GO:0005119)
0.1 0.3 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 4.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.5 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 3.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.6 GO:0043495 acetylcholine receptor binding(GO:0033130) protein anchor(GO:0043495)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.4 GO:0016594 glycine binding(GO:0016594)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.0 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.0 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.0 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.2 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 5.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.5 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex