ISMARA results: TBX5

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TBX5

Z-value: 0.77

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Transcription factors associated with TBX5

Gene Symbol	Gene ID	Gene Info
TBX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000089225.15	T-box transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX5	hg19_v2_chr12_-_114841703_114841726	0.38	6.0e-02	Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_55581954 Show fit	2.72	ENST00000336787.1	RAB27A Ensembl NCBI GeneCards UniProt NextProt Show fit	RAB27A, member RAS oncogene family
chr15_+_89182156 Show fit	2.45	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 Show fit	2.44	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 Show fit	2.06	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr11_-_72385437 Show fit	1.86	ENST00000418754.2 ENST00000542969.2 ENST00000334456.5	PDE2A Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 2A, cGMP-stimulated
chr2_-_175870085 Show fit	1.46	ENST00000409156.3	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr5_+_113697983 Show fit	1.37	ENST00000264773.3	KCNN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_77020325 Show fit	1.30	ENST00000311661.4	C1QTNF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	C1q and tumor necrosis factor related protein 1
chr17_+_77020224 Show fit	1.29	ENST00000339142.2	C1QTNF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	C1q and tumor necrosis factor related protein 1
chr2_-_175869936 Show fit	1.20	ENST00000409900.3	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	7.0	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.6	4.4	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.5	2.7	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.1	2.7	GO:0008045	motor neuron axon guidance(GO:0008045)
0.1	2.0	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.5	1.9	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.2	1.6	GO:1903943	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	1.4	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0	1.3	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.0	1.2	GO:0045824	negative regulation of innate immune response(GO:0045824)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.8	GO:0015030	Cajal body(GO:0015030)
0.0	4.2	GO:0005581	collagen trimer(GO:0005581)
0.2	2.7	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	1.9	GO:0042734	presynaptic membrane(GO:0042734)
0.1	1.6	GO:0097342	CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1	0.9	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	0.6	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.1	0.6	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.6	GO:0099634	postsynaptic specialization membrane(GO:0099634)
0.0	0.6	GO:0032433	filopodium tip(GO:0032433)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	7.0	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	4.6	GO:0005518	collagen binding(GO:0005518)
0.0	3.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	2.8	GO:0031489	myosin V binding(GO:0031489)
0.1	2.0	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.3	1.9	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0	1.6	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3	1.4	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.2	1.2	GO:0034711	inhibin binding(GO:0034711)
0.1	0.9	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)

Showing 1 to 10 of 85 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	2.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	1.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.8	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.8	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	4.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	1.5	REACTOME PI3K EVENTS IN ERBB4 SIGNALING	Genes involved in PI3K events in ERBB4 signaling
0.0	1.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression

Showing 1 to 10 of 25 entries

Results for TBX5

Z-value: 0.77

Motif logo

Transcription factors associated with TBX5

Activity-expression correlation:

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: