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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TCF12_ASCL2
Z-value: 1.61
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Transcription factors associated with TCF12_ASCL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF12 | hg19_v2_chr15_+_57210961_57211030 | -0.69 | 1.2e-04 | Click! |
| ASCL2 | hg19_v2_chr11_-_2292182_2292212 | 0.01 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_39280419 Show fit | 15.16 |
ENST00000394014.1
|
keratin associated protein 4-12 |
|
| chr2_-_7005785 Show fit | 11.24 |
ENST00000256722.5
ENST00000404168.1 ENST00000458098.1 |
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial |
|
| chr17_-_39306054 Show fit | 9.59 |
ENST00000343246.4
|
keratin associated protein 4-5 |
|
| chr15_+_89182178 Show fit | 9.27 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182156 Show fit | 9.09 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr17_-_39334460 Show fit | 8.83 |
ENST00000377726.2
|
keratin associated protein 4-2 |
|
| chr17_-_39254391 Show fit | 8.06 |
ENST00000333822.4
|
keratin associated protein 4-8 |
|
| chr15_+_89181974 Show fit | 8.00 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr17_-_39324424 Show fit | 7.34 |
ENST00000391356.2
|
keratin associated protein 4-3 |
|
| chr17_+_39261584 Show fit | 7.10 |
ENST00000391415.1
|
keratin associated protein 4-9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF12_ASCL2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.7 | GO:0042633 | molting cycle(GO:0042303) hair cycle(GO:0042633) |
| 5.3 | 26.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 3.7 | 11.2 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 2.1 | 10.7 | GO:0001315 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 8.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.3 | 6.6 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 1.2 | 6.1 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 2.0 | 5.9 | GO:2000374 | regulation of oxygen metabolic process(GO:2000374) |
| 0.1 | 5.6 | GO:0042088 | T-helper 1 type immune response(GO:0042088) |
| 0.5 | 5.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 15.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 11.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 11.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 10.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 1.9 | 5.7 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.0 | 4.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 4.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 4.5 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 4.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 26.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 11.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 1.3 | 11.6 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 2.8 | 11.2 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.5 | 10.3 | GO:0008556 | potassium-transporting ATPase activity(GO:0008556) |
| 0.0 | 9.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 6.5 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.6 | 6.0 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.5 | 5.2 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.3 | 5.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 9.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 8.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 7.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 5.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 3.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 3.7 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 5.7 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.2 | 5.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 5.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 4.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 4.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.5 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 4.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |