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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TCF21

Z-value: 0.58

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Transcription factors associated with TCF21

Gene Symbol Gene ID Gene Info
TCF21
ENSG00000118526.6 transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF21hg19_v2_chr6_+_134210243_134210276-0.242.5e-01Click!

Activity profile of TCF21 motif

Sorted Z-values of TCF21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_79115503 0.83 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr2_-_7005785 0.64 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_92414952 0.52 ENST00000449584.1
ENST00000427104.1
ENST00000355011.3
ENST00000448194.1
ENST00000426141.1
ENST00000450792.1
ENST00000548992.1
ENST00000552654.1
ENST00000457265.1
BRDT
bromodomain, testis-specific
chr3_+_145782358 0.51 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr4_+_154622652 0.49 ENST00000260010.6
TLR2
toll-like receptor 2
chr17_-_39183452 0.46 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr7_-_41742697 0.45 ENST00000242208.4
INHBA
inhibin, beta A
chr11_+_117103441 0.45 ENST00000531287.1
ENST00000531452.1
RNF214
ring finger protein 214
chr9_+_27109392 0.45 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr11_+_7597639 0.42 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_-_225811747 0.41 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr22_-_22863466 0.40 ENST00000406426.1
ENST00000360412.2
ZNF280B
zinc finger protein 280B
chr3_-_182833863 0.40 ENST00000492597.1
MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr1_-_9129598 0.40 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr12_+_69201923 0.39 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr8_+_144295067 0.36 ENST00000330824.2
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr19_-_52408257 0.36 ENST00000354957.3
ENST00000600738.1
ENST00000595418.1
ENST00000599530.1
ZNF649
zinc finger protein 649
chr21_-_10990830 0.36 ENST00000361285.4
ENST00000342420.5
ENST00000328758.5
TPTE
transmembrane phosphatase with tensin homology
chr21_-_10990888 0.35 ENST00000298232.7
TPTE
transmembrane phosphatase with tensin homology
chr22_-_50964558 0.34 ENST00000535425.1
ENST00000439934.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr6_-_128841503 0.34 ENST00000368215.3
ENST00000532331.1
ENST00000368213.5
ENST00000368207.3
ENST00000525459.1
ENST00000368210.3
ENST00000368226.4
ENST00000368227.3
PTPRK
protein tyrosine phosphatase, receptor type, K
chr2_+_231280954 0.34 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100
SP100 nuclear antigen
chr1_-_8000872 0.34 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr2_+_231280908 0.33 ENST00000427101.2
ENST00000432979.1
SP100
SP100 nuclear antigen
chr8_-_92053212 0.31 ENST00000285419.3
TMEM55A
transmembrane protein 55A
chr5_+_170288856 0.30 ENST00000523189.1
RANBP17
RAN binding protein 17
chr2_+_7017796 0.30 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_+_2036149 0.30 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
PRKCZ
protein kinase C, zeta
chr5_+_140430979 0.30 ENST00000306549.3
PCDHB1
protocadherin beta 1
chr5_+_135364584 0.29 ENST00000442011.2
ENST00000305126.8
TGFBI
transforming growth factor, beta-induced, 68kDa
chrX_-_106960285 0.29 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr5_-_42811986 0.29 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr1_+_78354175 0.29 ENST00000401035.3
ENST00000457030.1
ENST00000330010.8
NEXN
nexilin (F actin binding protein)
chr11_+_74862032 0.29 ENST00000289575.5
ENST00000341411.4
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_+_78354297 0.29 ENST00000334785.7
NEXN
nexilin (F actin binding protein)
chr1_+_22962948 0.28 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr11_+_47270475 0.28 ENST00000481889.2
ENST00000436778.1
ENST00000531660.1
ENST00000407404.1
NR1H3
nuclear receptor subfamily 1, group H, member 3
chrX_-_11445856 0.28 ENST00000380736.1
ARHGAP6
Rho GTPase activating protein 6
chr17_-_53809473 0.28 ENST00000575734.1
TMEM100
transmembrane protein 100
chr5_+_49962772 0.27 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr17_+_39261584 0.27 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr12_+_104458235 0.26 ENST00000229330.4
HCFC2
host cell factor C2
chr1_+_223101757 0.25 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr1_-_205391178 0.25 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr19_+_57999079 0.25 ENST00000426954.2
ENST00000354197.4
ENST00000523882.1
ENST00000520540.1
ENST00000519310.1
ENST00000442920.2
ENST00000523312.1
ENST00000424930.2
ZNF419
zinc finger protein 419
chr4_+_164415594 0.25 ENST00000509657.1
ENST00000358572.5
TMA16
translation machinery associated 16 homolog (S. cerevisiae)
chr9_-_130541017 0.24 ENST00000314830.8
SH2D3C
SH2 domain containing 3C
chr16_+_83932684 0.24 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr19_+_57999101 0.24 ENST00000347466.6
ENST00000523138.1
ENST00000415379.2
ENST00000521754.1
ENST00000221735.7
ENST00000518999.1
ENST00000521137.1
ZNF419
zinc finger protein 419
chr1_+_22963158 0.23 ENST00000438241.1
C1QA
complement component 1, q subcomponent, A chain
chr11_+_47270436 0.23 ENST00000395397.3
ENST00000405576.1
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr6_+_31554962 0.23 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr1_-_161014731 0.22 ENST00000368020.1
USF1
upstream transcription factor 1
chr17_+_71228740 0.22 ENST00000268942.8
ENST00000359042.2
C17orf80
chromosome 17 open reading frame 80
chr12_-_58329819 0.22 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr16_-_5147743 0.22 ENST00000587133.1
ENST00000458008.4
ENST00000427587.4
FAM86A
family with sequence similarity 86, member A
chr17_+_72772621 0.22 ENST00000335464.5
ENST00000417024.2
ENST00000578764.1
ENST00000582773.1
ENST00000582330.1
TMEM104
transmembrane protein 104
chr11_-_1643368 0.22 ENST00000399682.1
KRTAP5-4
keratin associated protein 5-4
chr3_-_81792780 0.21 ENST00000489715.1
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr5_-_102455801 0.21 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr6_+_13182751 0.21 ENST00000415087.1
PHACTR1
phosphatase and actin regulator 1
chr14_+_24099318 0.21 ENST00000432832.2
DHRS2
dehydrogenase/reductase (SDR family) member 2
chr11_-_30038490 0.21 ENST00000328224.6
KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr4_-_186347099 0.21 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr18_-_47376197 0.21 ENST00000592688.1
MYO5B
myosin VB
chr3_-_194119083 0.21 ENST00000401815.1
GP5
glycoprotein V (platelet)
chr11_-_5323226 0.21 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr9_+_34646651 0.21 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr6_+_31554779 0.21 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr2_+_44001172 0.20 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1
chr4_-_123844084 0.20 ENST00000339154.2
NUDT6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr2_+_38177575 0.20 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr14_-_53258180 0.20 ENST00000554230.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr14_+_67999999 0.20 ENST00000329153.5
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_-_25830785 0.20 ENST00000468082.1
SLC17A1
solute carrier family 17 (organic anion transporter), member 1
chr11_+_74862140 0.20 ENST00000525650.1
ENST00000454962.2
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr4_-_153303658 0.19 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_+_116832789 0.19 ENST00000368599.3
FAM26E
family with sequence similarity 26, member E
chr4_-_123843597 0.19 ENST00000510735.1
ENST00000304430.5
NUDT6
nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr8_-_20040638 0.18 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr6_+_31555045 0.18 ENST00000396101.3
ENST00000490742.1
LST1
leukocyte specific transcript 1
chr19_-_43702231 0.18 ENST00000597374.1
ENST00000599371.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr2_+_219537015 0.18 ENST00000440309.1
ENST00000424080.1
STK36
serine/threonine kinase 36
chr11_-_615570 0.18 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr4_+_114214125 0.18 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr17_+_4487294 0.18 ENST00000338859.4
SMTNL2
smoothelin-like 2
chr18_+_56807096 0.18 ENST00000588875.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr11_-_82997420 0.18 ENST00000455220.2
ENST00000529689.1
CCDC90B
coiled-coil domain containing 90B
chr9_+_34646624 0.18 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr11_+_32112431 0.18 ENST00000054950.3
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr17_+_7462103 0.18 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr5_-_58571935 0.17 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_71498552 0.17 ENST00000346333.6
ENST00000359244.4
ENST00000426628.2
FAM86C1
family with sequence similarity 86, member C1
chr1_-_24741525 0.17 ENST00000374409.1
STPG1
sperm-tail PG-rich repeat containing 1
chr3_+_148583043 0.17 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr19_-_4867665 0.17 ENST00000592528.1
ENST00000589494.1
ENST00000585479.1
ENST00000221957.4
PLIN3
perilipin 3
chr1_+_153600869 0.17 ENST00000292169.1
ENST00000368696.3
ENST00000436839.1
S100A1
S100 calcium binding protein A1
chr17_+_77030267 0.17 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr13_+_41635617 0.17 ENST00000542082.1
WBP4
WW domain binding protein 4
chrX_+_140982452 0.17 ENST00000544766.1
MAGEC3
melanoma antigen family C, 3
chr4_-_4543700 0.17 ENST00000505286.1
ENST00000306200.2
STX18
syntaxin 18
chr12_-_52585765 0.17 ENST00000313234.5
ENST00000394815.2
KRT80
keratin 80
chr1_+_12524965 0.17 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_161993422 0.16 ENST00000367940.2
OLFML2B
olfactomedin-like 2B
chr6_+_30585486 0.16 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr1_-_39339777 0.16 ENST00000397572.2
MYCBP
MYC binding protein
chr1_-_167522982 0.16 ENST00000370509.4
CREG1
cellular repressor of E1A-stimulated genes 1
chr3_+_113666748 0.16 ENST00000330212.3
ENST00000498275.1
ZDHHC23
zinc finger, DHHC-type containing 23
chr9_-_100954910 0.16 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr12_+_112563335 0.16 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAFD1
TRAF-type zinc finger domain containing 1
chr7_-_148787768 0.16 ENST00000491431.1
ENST00000451334.3
ENST00000316286.9
ZNF786
zinc finger protein 786
chr3_-_105588231 0.16 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_+_6947720 0.16 ENST00000414517.2
ZNF215
zinc finger protein 215
chr4_+_106816644 0.15 ENST00000506666.1
ENST00000503451.1
NPNT
nephronectin
chr11_-_14913765 0.15 ENST00000334636.5
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr13_-_50510622 0.15 ENST00000378195.2
SPRYD7
SPRY domain containing 7
chr14_-_45431091 0.15 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
KLHL28
kelch-like family member 28
chr2_+_219536749 0.15 ENST00000295709.3
ENST00000392106.2
ENST00000392105.3
ENST00000455724.1
STK36
serine/threonine kinase 36
chr19_+_11651942 0.15 ENST00000587087.1
CNN1
calponin 1, basic, smooth muscle
chr20_-_3662866 0.15 ENST00000356518.2
ENST00000379861.4
ADAM33
ADAM metallopeptidase domain 33
chr11_+_31531291 0.15 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr4_-_24914576 0.15 ENST00000502801.1
ENST00000428116.2
CCDC149
coiled-coil domain containing 149
chr9_+_125137565 0.15 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr20_-_23402028 0.14 ENST00000398425.3
ENST00000432543.2
ENST00000377026.4
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr6_-_143771799 0.14 ENST00000237283.8
ADAT2
adenosine deaminase, tRNA-specific 2
chr22_+_38071615 0.14 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr6_-_26250835 0.14 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr2_+_234602305 0.14 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_-_15413035 0.14 ENST00000378116.4
ENST00000455654.1
FAM171A1
family with sequence similarity 171, member A1
chr7_+_99102267 0.14 ENST00000326775.5
ENST00000451158.1
ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr16_-_31076332 0.14 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr1_-_114429997 0.13 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr2_-_17981462 0.13 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chr17_-_33864772 0.13 ENST00000361112.4
SLFN12L
schlafen family member 12-like
chr1_-_226076843 0.13 ENST00000272134.5
LEFTY1
left-right determination factor 1
chr17_+_45286387 0.13 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr6_-_28891709 0.13 ENST00000377194.3
ENST00000377199.3
TRIM27
tripartite motif containing 27
chr15_-_42749711 0.13 ENST00000565611.1
ENST00000263805.4
ENST00000565948.1
ZNF106
zinc finger protein 106
chr18_-_19997878 0.13 ENST00000391403.2
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr3_-_52868931 0.13 ENST00000486659.1
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr15_+_90895471 0.13 ENST00000354377.3
ENST00000379090.5
ZNF774
zinc finger protein 774
chr2_-_190627481 0.13 ENST00000264151.5
ENST00000520350.1
ENST00000521630.1
ENST00000517895.1
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr2_-_158345462 0.13 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr17_+_71229346 0.13 ENST00000535032.2
ENST00000582793.1
C17orf80
chromosome 17 open reading frame 80
chr8_-_20040601 0.13 ENST00000265808.7
ENST00000522513.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr20_+_42839722 0.13 ENST00000442383.1
ENST00000435163.1
OSER1-AS1
OSER1 antisense RNA 1 (head to head)
chr3_-_52869205 0.13 ENST00000446157.2
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr6_-_27835357 0.13 ENST00000331442.3
HIST1H1B
histone cluster 1, H1b
chr13_-_50510434 0.12 ENST00000361840.3
SPRYD7
SPRY domain containing 7
chr11_+_125496124 0.12 ENST00000533778.2
ENST00000534070.1
CHEK1
checkpoint kinase 1
chr1_-_31230650 0.12 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chrX_+_107334895 0.12 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr9_+_27109133 0.12 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr11_-_104827425 0.12 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr19_+_11406821 0.12 ENST00000316737.1
ENST00000592955.1
ENST00000590327.1
TSPAN16
tetraspanin 16
chr3_-_105587879 0.12 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr17_+_7461849 0.12 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chrX_+_15756382 0.11 ENST00000318636.3
CA5B
carbonic anhydrase VB, mitochondrial
chr20_-_52210368 0.11 ENST00000371471.2
ZNF217
zinc finger protein 217
chr12_+_122326662 0.11 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chrX_+_128872998 0.11 ENST00000371106.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr7_+_66205712 0.11 ENST00000451741.2
ENST00000442563.1
ENST00000450873.2
ENST00000284957.5
KCTD7
RABGEF1
potassium channel tetramerization domain containing 7
RAB guanine nucleotide exchange factor (GEF) 1
chr22_+_36044411 0.11 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr6_+_53948328 0.11 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr11_-_1507965 0.11 ENST00000329957.6
MOB2
MOB kinase activator 2
chr21_+_37692481 0.11 ENST00000400485.1
MORC3
MORC family CW-type zinc finger 3
chrX_-_108868390 0.11 ENST00000372101.2
KCNE1L
KCNE1-like
chr11_-_14913190 0.11 ENST00000532378.1
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr11_+_58910295 0.11 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr2_-_70418032 0.11 ENST00000425268.1
ENST00000428751.1
ENST00000417203.1
ENST00000417865.1
ENST00000428010.1
ENST00000447804.1
ENST00000264434.2
C2orf42
chromosome 2 open reading frame 42
chr3_-_49058479 0.11 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr14_+_45431379 0.11 ENST00000361577.3
ENST00000361462.2
ENST00000382233.2
FAM179B
family with sequence similarity 179, member B
chr19_+_46801639 0.11 ENST00000244303.6
ENST00000339613.2
ENST00000533145.1
ENST00000472815.1
HIF3A
hypoxia inducible factor 3, alpha subunit
chr2_+_233562015 0.11 ENST00000427233.1
ENST00000373566.3
ENST00000373563.4
ENST00000428883.1
ENST00000456491.1
ENST00000409480.1
ENST00000421433.1
ENST00000425040.1
ENST00000430720.1
ENST00000409547.1
ENST00000423659.1
ENST00000409196.3
ENST00000409451.3
ENST00000429187.1
ENST00000440945.1
GIGYF2
GRB10 interacting GYF protein 2
chr19_+_36486078 0.11 ENST00000378887.2
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr10_-_12084770 0.11 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr15_+_93447675 0.11 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr7_+_99102573 0.11 ENST00000394170.2
ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr2_+_56411131 0.11 ENST00000407595.2
CCDC85A
coiled-coil domain containing 85A
chr3_-_54962100 0.11 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr7_-_76255444 0.11 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr20_-_1165117 0.10 ENST00000381894.3
TMEM74B
transmembrane protein 74B
chr11_-_117103208 0.10 ENST00000320934.3
ENST00000530269.1
PCSK7
proprotein convertase subtilisin/kexin type 7
chr17_-_7297833 0.10 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr15_+_65337708 0.10 ENST00000334287.2
SLC51B
solute carrier family 51, beta subunit
chr16_-_46655538 0.10 ENST00000303383.3
SHCBP1
SHC SH2-domain binding protein 1
chr11_+_74660278 0.10 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr1_-_150669604 0.10 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr19_-_41903161 0.10 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5
exosome component 5
chr17_-_79650689 0.10 ENST00000574938.1
ENST00000570561.1
ENST00000573392.1
ENST00000576135.1
ARL16
ADP-ribosylation factor-like 16
chr11_+_34127142 0.10 ENST00000257829.3
ENST00000531159.2
NAT10
N-acetyltransferase 10 (GCN5-related)
chr11_+_74862100 0.10 ENST00000532236.1
ENST00000531756.1
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr2_-_27603582 0.10 ENST00000323703.6
ENST00000436006.1
ZNF513
zinc finger protein 513
chr1_-_248903150 0.10 ENST00000590317.1
LYPD8
LY6/PLAUR domain containing 8
chr1_-_6550625 0.10 ENST00000377725.1
ENST00000340850.5
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_165414414 0.10 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr8_+_99439214 0.10 ENST00000287042.4
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr4_+_47487285 0.10 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr19_-_17186229 0.09 ENST00000253669.5
ENST00000448593.2
HAUS8
HAUS augmin-like complex, subunit 8
chr10_+_98592009 0.09 ENST00000540664.1
ENST00000371103.3
LCOR
ligand dependent nuclear receptor corepressor

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.2 0.5 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.2 0.5 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.2 0.7 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.2 0.5 GO:0070340 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.2 0.5 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.4 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.1 0.4 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.4 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.3 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.2 GO:0097195 pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.2 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.0 0.2 GO:2001293 fatty-acyl-CoA catabolic process(GO:0036115) malonyl-CoA metabolic process(GO:2001293)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.4 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.1 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.2 GO:1990539 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.1 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.0 0.1 GO:0043585 nose morphogenesis(GO:0043585)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0035803 egg coat formation(GO:0035803)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.0 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.1 GO:0090521 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.1 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.0 GO:1904647 response to rotenone(GO:1904647)
0.0 0.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)
0.0 0.1 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.0 GO:0034963 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.0 GO:0070781 response to biotin(GO:0070781)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.2 0.5 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.5 GO:0005602 complement component C1 complex(GO:0005602)
0.1 0.4 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 0.5 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.5 GO:0032810 sterol response element binding(GO:0032810)
0.1 0.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 0.3 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 0.5 GO:0035473 lipase binding(GO:0035473)
0.1 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.3 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.3 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.0 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.0 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)