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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TCF3_MYOG
Z-value: 2.04
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Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYOG | hg19_v2_chr1_-_203055129_203055164 | -0.63 | 7.4e-04 | Click! |
| TCF3 | hg19_v2_chr19_-_1652575_1652621 | -0.30 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 38.6 | GO:0031424 | keratinization(GO:0031424) |
| 5.8 | 34.8 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.5 | 16.7 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 5.4 | 16.1 | GO:0035284 | central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 1.9 | 15.5 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.9 | 13.8 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 1.0 | 13.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.9 | 11.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 10.7 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 1.1 | 10.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.2 | 32.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 28.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 28.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 14.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 1.9 | 13.3 | GO:1990393 | 3M complex(GO:1990393) |
| 1.1 | 11.5 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 10.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 10.7 | GO:0045178 | basal part of cell(GO:0045178) |
| 2.0 | 10.0 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 33.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.2 | 32.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 19.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.0 | 16.2 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 15.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 13.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 2.4 | 12.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 11.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 11.0 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 10.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 11.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 10.2 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 7.6 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.2 | 6.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 6.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 6.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 34.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 13.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 11.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 9.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.4 | 9.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 8.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 7.5 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 7.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 7.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 7.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |