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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TCF7
Z-value: 0.72
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Transcription factors associated with TCF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7 | hg19_v2_chr5_+_133451254_133451316 | 0.44 | 2.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 5.30 |
ENST00000377050.4
|
ubiquitin D |
|
| chr21_+_26934165 Show fit | 3.73 |
ENST00000456917.1
|
MIR155 host gene (non-protein coding) |
|
| chr10_-_49860525 Show fit | 1.98 |
ENST00000435790.2
|
Rho GTPase activating protein 22 |
|
| chr15_+_62359175 Show fit | 1.97 |
ENST00000355522.5
|
C2 calcium-dependent domain containing 4A |
|
| chr8_-_119964434 Show fit | 1.79 |
ENST00000297350.4
|
tumor necrosis factor receptor superfamily, member 11b |
|
| chr5_-_16936340 Show fit | 1.77 |
ENST00000507288.1
ENST00000513610.1 |
myosin X |
|
| chr2_+_108994466 Show fit | 1.48 |
ENST00000272452.2
|
sulfotransferase family, cytosolic, 1C, member 4 |
|
| chr1_+_169079823 Show fit | 1.48 |
ENST00000367813.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr4_-_139163491 Show fit | 1.42 |
ENST00000280612.5
|
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
|
| chr6_+_26383404 Show fit | 1.35 |
ENST00000416795.2
ENST00000494184.1 |
butyrophilin, subfamily 2, member A2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 2.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 2.3 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 2.3 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.6 | 1.8 | GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth(GO:0042489) |
| 0.6 | 1.7 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 0.3 | 1.5 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.1 | 1.4 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 1.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 1.2 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 1.8 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 1.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.6 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 1.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 0.8 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.8 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 0.7 | GO:0005726 | perichromatin fibrils(GO:0005726) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 2.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 2.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 1.8 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 1.7 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 1.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.3 | 1.4 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.1 | 1.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 1.2 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 1.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.5 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.0 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 1.0 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |