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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TCF7L1

Z-value: 0.72

Motif logo

Transcription factors associated with TCF7L1

Gene Symbol Gene ID Gene Info
ENSG00000152284.4 transcription factor 7 like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v2_chr2_+_85360499_85360598-0.029.3e-01Click!

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_72440901 2.68 ENST00000359684.2
dachshund homolog 1 (Drosophila)
chr13_-_72441315 2.65 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
dachshund homolog 1 (Drosophila)
chr4_-_186877502 2.19 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
sorbin and SH3 domain containing 2
chr1_+_61330931 1.77 ENST00000371191.1
nuclear factor I/A
chr9_+_75263565 1.11 ENST00000396237.3
transmembrane channel-like 1
chr2_+_69240302 1.09 ENST00000303714.4
anthrax toxin receptor 1
chr1_+_82266053 0.89 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr3_-_148804275 0.86 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
helicase-like transcription factor
chr7_-_27213893 0.86 ENST00000283921.4
homeobox A10
chr3_+_20081515 0.84 ENST00000263754.4
K(lysine) acetyltransferase 2B
chr10_+_54074033 0.71 ENST00000373970.3
dickkopf WNT signaling pathway inhibitor 1
chr5_+_175288631 0.71 ENST00000509837.1
complexin 2
chr14_+_21236586 0.68 ENST00000326783.3
epididymal protein 3B
chr14_+_75230011 0.65 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLP motif containing 1
chr2_+_69240511 0.65 ENST00000409349.3
anthrax toxin receptor 1
chr17_+_30813576 0.63 ENST00000313401.3
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_+_16085244 0.61 ENST00000400773.1
filamin binding LIM protein 1
chr10_+_112631547 0.60 ENST00000280154.7
ENST00000393104.2
programmed cell death 4 (neoplastic transformation inhibitor)
chr10_-_25241499 0.60 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
phosphoribosyl transferase domain containing 1
chr20_+_30598231 0.59 ENST00000300415.8
ENST00000262659.8
cerebral cavernous malformation 2-like
chr19_-_11450249 0.59 ENST00000222120.3
RAB3D, member RAS oncogene family
chr16_+_30406721 0.57 ENST00000320159.2
zinc finger protein 48
chr5_+_170846640 0.55 ENST00000274625.5
fibroblast growth factor 18
chr2_+_11679963 0.54 ENST00000263834.5
growth regulation by estrogen in breast cancer 1
chr7_-_27219849 0.51 ENST00000396344.4
homeobox A10
chr14_+_23846328 0.50 ENST00000382809.2
CKLF-like MARVEL transmembrane domain containing 5
chr2_+_16080659 0.49 ENST00000281043.3
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chrX_-_39956656 0.49 ENST00000397354.3
ENST00000378444.4
BCL6 corepressor
chr1_-_94079648 0.48 ENST00000370247.3
breast cancer anti-estrogen resistance 3
chr2_-_208031542 0.48 ENST00000423015.1
Kruppel-like factor 7 (ubiquitous)
chr15_-_82338460 0.46 ENST00000558133.1
ENST00000329713.4
mex-3 RNA binding family member B
chr16_-_4850471 0.46 ENST00000592019.1
ENST00000586153.1
rogdi homolog (Drosophila)
chr11_-_76155618 0.45 ENST00000530759.1
RP11-111M22.3
chr13_+_39612485 0.44 ENST00000379599.2
NHL repeat containing 3
chr11_-_76155700 0.44 ENST00000572035.1
RP11-111M22.3
chr12_+_56324933 0.43 ENST00000549629.1
ENST00000555218.1
diacylglycerol kinase, alpha 80kDa
chr3_+_123813509 0.42 ENST00000460856.1
ENST00000240874.3
kalirin, RhoGEF kinase
chr2_+_69240415 0.42 ENST00000409829.3
anthrax toxin receptor 1
chr11_-_62474803 0.42 ENST00000533982.1
ENST00000360796.5
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr10_+_71562180 0.41 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
collagen, type XIII, alpha 1
chr13_+_39612442 0.41 ENST00000470258.1
ENST00000379600.3
NHL repeat containing 3
chr4_-_157892498 0.41 ENST00000502773.1
platelet derived growth factor C
chr14_+_75746781 0.39 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_116225999 0.38 ENST00000317613.6
regulator of G-protein signaling 3
chr12_+_56324756 0.38 ENST00000331886.5
ENST00000555090.1
diacylglycerol kinase, alpha 80kDa
chr4_-_157892167 0.37 ENST00000541126.1
platelet derived growth factor C
chr13_+_76210448 0.36 ENST00000377499.5
LIM domain 7
chr8_+_29952914 0.36 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
leptin receptor overlapping transcript-like 1
chr17_+_80416050 0.35 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
nuclear prelamin A recognition factor
chr21_+_18811205 0.33 ENST00000440664.1
chromosome 21 open reading frame 37
chr17_+_80416482 0.33 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
nuclear prelamin A recognition factor
chr17_-_46690839 0.32 ENST00000498634.2
homeobox B8
chr11_-_87908600 0.32 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38, member RAS oncogene family
chrX_-_100183894 0.32 ENST00000328526.5
ENST00000372956.2
XK, Kell blood group complex subunit-related, X-linked
chr6_+_96025341 0.31 ENST00000369293.1
ENST00000358812.4
mannosidase, endo-alpha
chr7_+_115850547 0.31 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
testis derived transcript (3 LIM domains)
chr16_-_15736881 0.31 ENST00000540441.2
KIAA0430
chr3_+_52813932 0.31 ENST00000537050.1
inter-alpha-trypsin inhibitor heavy chain 1
chr12_+_80603233 0.30 ENST00000547103.1
ENST00000458043.2
otogelin-like
chr10_+_71561704 0.30 ENST00000520267.1
collagen, type XIII, alpha 1
chr10_+_115312766 0.30 ENST00000351270.3
hyaluronan binding protein 2
chr12_+_9067123 0.29 ENST00000543824.1
polyhomeotic homolog 1 (Drosophila)
chr10_+_76585303 0.29 ENST00000372725.1
K(lysine) acetyltransferase 6B
chr20_-_17511962 0.28 ENST00000377873.3
beaded filament structural protein 1, filensin
chr7_+_73868439 0.28 ENST00000424337.2
GTF2I repeat domain containing 1
chr10_+_71561630 0.28 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr1_+_59762642 0.28 ENST00000371218.4
ENST00000303721.7
FGGY carbohydrate kinase domain containing
chr8_+_29953163 0.28 ENST00000518192.1
leptin receptor overlapping transcript-like 1
chr6_+_143929307 0.28 ENST00000427704.2
ENST00000305766.6
phosphatase and actin regulator 2
chr8_-_16859690 0.27 ENST00000180166.5
fibroblast growth factor 20
chrX_-_117119243 0.27 ENST00000539496.1
ENST00000469946.1
kelch-like family member 13
chr4_-_157892055 0.26 ENST00000422544.2
platelet derived growth factor C
chr11_-_94965667 0.26 ENST00000542176.1
ENST00000278499.2
sestrin 3
chr2_-_208031943 0.26 ENST00000421199.1
ENST00000457962.1
Kruppel-like factor 7 (ubiquitous)
chr17_-_7297833 0.26 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3 readthrough (NMD candidate)
chrX_-_32173579 0.25 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
dystrophin
chr17_+_35851570 0.25 ENST00000394386.1
dual specificity phosphatase 14
chr10_+_71561649 0.25 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr2_+_179184955 0.25 ENST00000315022.2
oxysterol binding protein-like 6
chr14_+_105941118 0.24 ENST00000550577.1
ENST00000538259.2
cysteine-rich protein 2
chr4_-_70626314 0.24 ENST00000510821.1
sulfotransferase family, cytosolic, 1B, member 1
chrX_+_135229600 0.23 ENST00000370690.3
four and a half LIM domains 1
chr13_+_76334498 0.23 ENST00000534657.1
LIM domain 7
chr7_+_90339169 0.23 ENST00000436577.2
cyclin-dependent kinase 14
chr7_-_19813192 0.22 ENST00000422233.1
ENST00000433641.1
transmembrane protein 196
chr15_-_64995399 0.22 ENST00000559753.1
ENST00000560258.2
ENST00000559912.2
ENST00000326005.6
ornithine decarboxylase antizyme 2
chr1_+_93913713 0.22 ENST00000604705.1
ENST00000370253.2
formin binding protein 1-like
chr16_-_4852915 0.22 ENST00000322048.7
rogdi homolog (Drosophila)
chr17_-_7297519 0.22 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3 readthrough (NMD candidate)
chr10_-_87551311 0.22 ENST00000536331.1
glutamate receptor, ionotropic, delta 1
chr5_-_175964366 0.22 ENST00000274811.4
ring finger protein 44
chr2_+_234621551 0.22 ENST00000608381.1
ENST00000373414.3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_+_137483579 0.22 ENST00000306087.1
SRY (sex determining region Y)-box 14
chr7_+_80275621 0.21 ENST00000426978.1
ENST00000432207.1
CD36 molecule (thrombospondin receptor)
chr6_-_32145861 0.21 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr4_+_113152978 0.21 ENST00000309703.6
adaptor-related protein complex 1 associated regulatory protein
chr16_-_73082274 0.21 ENST00000268489.5
zinc finger homeobox 3
chrX_+_135229559 0.21 ENST00000394155.2
four and a half LIM domains 1
chr5_-_148930960 0.20 ENST00000261798.5
ENST00000377843.2
casein kinase 1, alpha 1
chrX_-_135962876 0.20 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chr14_-_35344093 0.20 ENST00000382422.2
bromodomain adjacent to zinc finger domain, 1A
chrX_-_128788914 0.20 ENST00000429967.1
ENST00000307484.6
apelin
chr7_-_148581251 0.20 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
enhancer of zeste homolog 2 (Drosophila)
chr16_-_18812746 0.20 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr7_-_148581360 0.19 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
enhancer of zeste homolog 2 (Drosophila)
chr14_-_23624511 0.19 ENST00000529705.2
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr18_+_29769978 0.19 ENST00000269202.6
ENST00000581447.1
meprin A, beta
chr9_-_27005686 0.19 ENST00000380055.5
leucine rich repeat containing 19
chr1_+_87794150 0.19 ENST00000370544.5
LIM domain only 4
chr4_+_113152881 0.19 ENST00000274000.5
adaptor-related protein complex 1 associated regulatory protein
chr1_-_54303934 0.19 ENST00000537333.1
NDC1 transmembrane nucleoporin
chr18_-_31802282 0.18 ENST00000535475.1
nucleolar protein 4
chr10_+_7745303 0.18 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr13_+_76334795 0.18 ENST00000526202.1
ENST00000465261.2
LIM domain 7
chr21_+_30671690 0.18 ENST00000399921.1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr18_-_31802056 0.18 ENST00000538587.1
nucleolar protein 4
chr7_+_128828713 0.18 ENST00000249373.3
smoothened, frizzled family receptor
chr13_+_76334567 0.17 ENST00000321797.8
LIM domain 7
chr13_+_24144796 0.17 ENST00000403372.2
tumor necrosis factor receptor superfamily, member 19
chr8_-_33424636 0.17 ENST00000256257.1
ring finger protein 122
chrX_+_100646190 0.17 ENST00000471855.1
ribosomal protein L36a
chr6_+_119215308 0.17 ENST00000229595.5
anti-silencing function 1A histone chaperone
chr20_+_18794370 0.17 ENST00000377428.2
SCP2 sterol-binding domain containing 1
chr10_+_22605374 0.17 ENST00000448361.1
COMM domain containing 3
chr19_-_48048518 0.17 ENST00000595558.1
ENST00000263351.5
zinc finger protein 541
chr3_+_183353356 0.16 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
kelch-like family member 24
chr16_+_2820912 0.16 ENST00000570539.1
serine/arginine repetitive matrix 2
chr17_+_75447326 0.16 ENST00000591088.1
septin 9
chr14_-_23451467 0.16 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
ajuba LIM protein
chr6_-_107436473 0.16 ENST00000369042.1
BEN domain containing 3
chr10_+_22605304 0.16 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1 readthrough
COMM domain containing 3
chr17_-_56065484 0.16 ENST00000581208.1
vascular endothelial zinc finger 1
chr10_+_7745232 0.15 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_99052382 0.15 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr1_+_200993071 0.15 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
chr5_+_43603229 0.15 ENST00000344920.4
ENST00000512996.2
nicotinamide nucleotide transhydrogenase
chrX_+_152760397 0.15 ENST00000331595.4
ENST00000431891.1
biglycan
chr17_+_57297807 0.15 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
glycerophosphodiester phosphodiesterase domain containing 1
chr17_+_62223320 0.15 ENST00000580828.1
ENST00000582965.1
small nucleolar RNA, H/ACA box 76
chr12_+_70760056 0.15 ENST00000258111.4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr8_-_6914251 0.15 ENST00000330590.2
defensin, alpha 5, Paneth cell-specific
chr12_-_48963829 0.14 ENST00000301046.2
ENST00000549817.1
lactalbumin, alpha-
chr10_+_11206925 0.14 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr4_+_78078304 0.14 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
cyclin G2
chr8_-_29940464 0.14 ENST00000521265.1
ENST00000536273.1
transmembrane protein 66
chr1_-_54303949 0.14 ENST00000234725.8
NDC1 transmembrane nucleoporin
chr11_-_65381643 0.14 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
mitogen-activated protein kinase kinase kinase 11
chr8_+_32579341 0.14 ENST00000519240.1
ENST00000539990.1
neuregulin 1
chr14_+_21214039 0.14 ENST00000326842.2
epididymal protein 3A
chr1_+_36348790 0.14 ENST00000373204.4
argonaute RISC catalytic component 1
chr12_+_53491220 0.14 ENST00000548547.1
ENST00000301464.3
insulin-like growth factor binding protein 6
chr7_+_80231466 0.14 ENST00000309881.7
ENST00000534394.1
CD36 molecule (thrombospondin receptor)
chr10_-_104192405 0.13 ENST00000369937.4
CUE domain containing 2
chr6_+_32146131 0.13 ENST00000375094.3
ring finger protein 5, E3 ubiquitin protein ligase
chr7_+_80275752 0.13 ENST00000419819.2
CD36 molecule (thrombospondin receptor)
chr15_+_52043758 0.13 ENST00000249700.4
ENST00000539962.2
tropomodulin 2 (neuronal)
chr19_+_11071546 0.13 ENST00000358026.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr18_+_3449821 0.13 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGFB-induced factor homeobox 1
chr6_-_11779403 0.12 ENST00000414691.3
androgen-dependent TFPI-regulating protein
chr15_-_79103757 0.12 ENST00000388820.4
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chrX_+_100645812 0.12 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chrX_-_153599578 0.12 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chrX_+_54835493 0.12 ENST00000396224.1
melanoma antigen family D, 2
chr21_-_34144157 0.12 ENST00000331923.4
PAX3 and PAX7 binding protein 1
chr4_+_170581213 0.11 ENST00000507875.1
chloride channel, voltage-sensitive 3
chr14_+_39644387 0.11 ENST00000553331.1
ENST00000216832.4
pinin, desmosome associated protein
chr20_+_55966444 0.11 ENST00000356208.5
ENST00000440234.2
RNA binding motif protein 38
chr13_+_24144509 0.11 ENST00000248484.4
tumor necrosis factor receptor superfamily, member 19
chr4_+_79567314 0.11 ENST00000503539.1
ENST00000504675.1
long intergenic non-protein coding RNA 1094
chr4_-_85419603 0.11 ENST00000295886.4
NK6 homeobox 1
chr1_+_154244987 0.10 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HCLS1 associated protein X-1
chr14_-_73493784 0.10 ENST00000553891.1
zinc finger, FYVE domain containing 1
chr1_+_212797789 0.10 ENST00000294829.3
family with sequence similarity 71, member A
chr19_+_8274204 0.10 ENST00000561053.1
ENST00000251363.5
ENST00000559450.1
ENST00000559336.1
ceramide synthase 4
chr19_+_8274185 0.10 ENST00000558268.1
ENST00000558331.1
ceramide synthase 4
chr1_-_20126365 0.10 ENST00000294543.6
ENST00000375122.2
transmembrane and coiled-coil domains 4
chr2_+_48796120 0.10 ENST00000394754.1
STON1-GTF2A1L readthrough
chr2_+_33172221 0.10 ENST00000354476.3
latent transforming growth factor beta binding protein 1
chr19_+_11071652 0.10 ENST00000344626.4
ENST00000429416.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr1_+_78383813 0.10 ENST00000342754.5
nexilin (F actin binding protein)
chr8_-_145047688 0.10 ENST00000356346.3
plectin
chr4_+_79567362 0.10 ENST00000512322.1
long intergenic non-protein coding RNA 1094
chr7_+_90338712 0.09 ENST00000265741.3
ENST00000406263.1
cyclin-dependent kinase 14
chr17_-_61819229 0.09 ENST00000447001.3
ENST00000392950.4
STE20-related kinase adaptor alpha
chr14_-_23451845 0.09 ENST00000262713.2
ajuba LIM protein
chr17_-_61819121 0.09 ENST00000245865.5
ENST00000375840.4
ENST00000582137.1
ENST00000579549.1
ENST00000582030.1
ENST00000584110.1
ENST00000580288.1
ENST00000336174.6
ENST00000579340.1
ENST00000580338.1
STE20-related kinase adaptor alpha
chr9_-_74979420 0.09 ENST00000343431.2
ENST00000376956.3
zinc finger, AN1-type domain 5
chr10_-_91295304 0.08 ENST00000341233.4
ENST00000371790.4
solute carrier family 16, member 12
chr7_+_80275953 0.08 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36 molecule (thrombospondin receptor)
chr1_+_185703513 0.08 ENST00000271588.4
ENST00000367492.2
hemicentin 1
chr14_+_20923350 0.08 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr10_-_104179682 0.08 ENST00000406432.1
pleckstrin and Sec7 domain containing
chr19_-_49864746 0.07 ENST00000598810.1
TEA domain family member 2
chr22_+_24105394 0.07 ENST00000305199.5
ENST00000382821.3
chromosome 22 open reading frame 15
chr1_-_54304212 0.07 ENST00000540001.1
NDC1 transmembrane nucleoporin
chr3_-_149375783 0.07 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr9_-_35650900 0.07 ENST00000259608.3
signaling threshold regulating transmembrane adaptor 1
chr5_-_114515734 0.07 ENST00000514154.1
ENST00000282369.3
tripartite motif containing 36
chr3_-_134093275 0.07 ENST00000513145.1
ENST00000422605.2
angiomotin like 2
chr13_-_67802549 0.07 ENST00000328454.5
ENST00000377865.2
protocadherin 9

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.7 5.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 0.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.8 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 0.6 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.2 0.6 GO:0036446 myofibroblast differentiation(GO:0036446) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) regulation of myofibroblast differentiation(GO:1904760)
0.2 0.6 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.2 0.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 1.1 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.4 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.4 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.4 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.6 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.6 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.3 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.1 2.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:1904020 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 0.4 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.2 GO:0007418 positive regulation of hh target transcription factor activity(GO:0007228) ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 1.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 1.4 GO:0060065 uterus development(GO:0060065)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 0.1 GO:0072560 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.2 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 1.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.0 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.9 GO:0006301 postreplication repair(GO:0006301)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.8 GO:0000125 PCAF complex(GO:0000125)
0.1 0.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 2.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.6 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.3 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 1.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.7 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 0.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation