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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TCF7L1

Z-value: 0.72

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Transcription factors associated with TCF7L1

Gene Symbol Gene ID Gene Info
TCF7L1
ENSG00000152284.4 transcription factor 7 like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v2_chr2_+_85360499_85360598-0.029.3e-01Click!

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_72440901 2.68 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr13_-_72441315 2.65 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr4_-_186877502 2.19 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr1_+_61330931 1.77 ENST00000371191.1
NFIA
nuclear factor I/A
chr9_+_75263565 1.11 ENST00000396237.3
TMC1
transmembrane channel-like 1
chr2_+_69240302 1.09 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr1_+_82266053 0.89 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_-_148804275 0.86 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr7_-_27213893 0.86 ENST00000283921.4
HOXA10
homeobox A10
chr3_+_20081515 0.84 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr10_+_54074033 0.71 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr5_+_175288631 0.71 ENST00000509837.1
CPLX2
complexin 2
chr14_+_21236586 0.68 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr14_+_75230011 0.65 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr2_+_69240511 0.65 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr17_+_30813576 0.63 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_+_16085244 0.61 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr10_+_112631547 0.60 ENST00000280154.7
ENST00000393104.2
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr10_-_25241499 0.60 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr20_+_30598231 0.59 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr19_-_11450249 0.59 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr16_+_30406721 0.57 ENST00000320159.2
ZNF48
zinc finger protein 48
chr5_+_170846640 0.55 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr2_+_11679963 0.54 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr7_-_27219849 0.51 ENST00000396344.4
HOXA10
homeobox A10
chr14_+_23846328 0.50 ENST00000382809.2
CMTM5
CKLF-like MARVEL transmembrane domain containing 5
chr2_+_16080659 0.49 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chrX_-_39956656 0.49 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr1_-_94079648 0.48 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr2_-_208031542 0.48 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr15_-_82338460 0.46 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr16_-_4850471 0.46 ENST00000592019.1
ENST00000586153.1
ROGDI
rogdi homolog (Drosophila)
chr11_-_76155618 0.45 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr13_+_39612485 0.44 ENST00000379599.2
NHLRC3
NHL repeat containing 3
chr11_-_76155700 0.44 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr12_+_56324933 0.43 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr3_+_123813509 0.42 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr2_+_69240415 0.42 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr11_-_62474803 0.42 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr10_+_71562180 0.41 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr13_+_39612442 0.41 ENST00000470258.1
ENST00000379600.3
NHLRC3
NHL repeat containing 3
chr4_-_157892498 0.41 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr14_+_75746781 0.39 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_116225999 0.38 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr12_+_56324756 0.38 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr4_-_157892167 0.37 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr13_+_76210448 0.36 ENST00000377499.5
LMO7
LIM domain 7
chr8_+_29952914 0.36 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr17_+_80416050 0.35 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr21_+_18811205 0.33 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr17_+_80416482 0.33 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr17_-_46690839 0.32 ENST00000498634.2
HOXB8
homeobox B8
chr11_-_87908600 0.32 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chrX_-_100183894 0.32 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr6_+_96025341 0.31 ENST00000369293.1
ENST00000358812.4
MANEA
mannosidase, endo-alpha
chr7_+_115850547 0.31 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr16_-_15736881 0.31 ENST00000540441.2
KIAA0430
KIAA0430
chr3_+_52813932 0.31 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr12_+_80603233 0.30 ENST00000547103.1
ENST00000458043.2
OTOGL
otogelin-like
chr10_+_71561704 0.30 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr10_+_115312766 0.30 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr12_+_9067123 0.29 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr10_+_76585303 0.29 ENST00000372725.1
KAT6B
K(lysine) acetyltransferase 6B
chr20_-_17511962 0.28 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr7_+_73868439 0.28 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr10_+_71561630 0.28 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr1_+_59762642 0.28 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr8_+_29953163 0.28 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr6_+_143929307 0.28 ENST00000427704.2
ENST00000305766.6
PHACTR2
phosphatase and actin regulator 2
chr8_-_16859690 0.27 ENST00000180166.5
FGF20
fibroblast growth factor 20
chrX_-_117119243 0.27 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr4_-_157892055 0.26 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr11_-_94965667 0.26 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr2_-_208031943 0.26 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_-_7297833 0.26 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chrX_-_32173579 0.25 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr17_+_35851570 0.25 ENST00000394386.1
DUSP14
dual specificity phosphatase 14
chr10_+_71561649 0.25 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr2_+_179184955 0.25 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr14_+_105941118 0.24 ENST00000550577.1
ENST00000538259.2
CRIP2
cysteine-rich protein 2
chr4_-_70626314 0.24 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chrX_+_135229600 0.23 ENST00000370690.3
FHL1
four and a half LIM domains 1
chr13_+_76334498 0.23 ENST00000534657.1
LMO7
LIM domain 7
chr7_+_90339169 0.23 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr7_-_19813192 0.22 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr15_-_64995399 0.22 ENST00000559753.1
ENST00000560258.2
ENST00000559912.2
ENST00000326005.6
OAZ2
ornithine decarboxylase antizyme 2
chr1_+_93913713 0.22 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr16_-_4852915 0.22 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr17_-_7297519 0.22 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr10_-_87551311 0.22 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr5_-_175964366 0.22 ENST00000274811.4
RNF44
ring finger protein 44
chr2_+_234621551 0.22 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_+_137483579 0.22 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr7_+_80275621 0.21 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr6_-_32145861 0.21 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr4_+_113152978 0.21 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr16_-_73082274 0.21 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chrX_+_135229559 0.21 ENST00000394155.2
FHL1
four and a half LIM domains 1
chr5_-_148930960 0.20 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chrX_-_135962876 0.20 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr14_-_35344093 0.20 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chrX_-_128788914 0.20 ENST00000429967.1
ENST00000307484.6
APLN
apelin
chr7_-_148581251 0.20 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr16_-_18812746 0.20 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ARL6IP1
RP11-1035H13.3
ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr7_-_148581360 0.19 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr14_-_23624511 0.19 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr18_+_29769978 0.19 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr9_-_27005686 0.19 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr1_+_87794150 0.19 ENST00000370544.5
LMO4
LIM domain only 4
chr4_+_113152881 0.19 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr1_-_54303934 0.19 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr18_-_31802282 0.18 ENST00000535475.1
NOL4
nucleolar protein 4
chr10_+_7745303 0.18 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr13_+_76334795 0.18 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr21_+_30671690 0.18 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr18_-_31802056 0.18 ENST00000538587.1
NOL4
nucleolar protein 4
chr7_+_128828713 0.18 ENST00000249373.3
SMO
smoothened, frizzled family receptor
chr13_+_76334567 0.17 ENST00000321797.8
LMO7
LIM domain 7
chr13_+_24144796 0.17 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr8_-_33424636 0.17 ENST00000256257.1
RNF122
ring finger protein 122
chrX_+_100646190 0.17 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr6_+_119215308 0.17 ENST00000229595.5
ASF1A
anti-silencing function 1A histone chaperone
chr20_+_18794370 0.17 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr10_+_22605374 0.17 ENST00000448361.1
COMMD3
COMM domain containing 3
chr19_-_48048518 0.17 ENST00000595558.1
ENST00000263351.5
ZNF541
zinc finger protein 541
chr3_+_183353356 0.16 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr16_+_2820912 0.16 ENST00000570539.1
SRRM2
serine/arginine repetitive matrix 2
chr17_+_75447326 0.16 ENST00000591088.1
SEPT9
septin 9
chr14_-_23451467 0.16 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr6_-_107436473 0.16 ENST00000369042.1
BEND3
BEN domain containing 3
chr10_+_22605304 0.16 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr17_-_56065484 0.16 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr10_+_7745232 0.15 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_99052382 0.15 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr1_+_200993071 0.15 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
RP11-168O16.1
chr5_+_43603229 0.15 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chrX_+_152760397 0.15 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr17_+_57297807 0.15 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr17_+_62223320 0.15 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr12_+_70760056 0.15 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr8_-_6914251 0.15 ENST00000330590.2
DEFA5
defensin, alpha 5, Paneth cell-specific
chr12_-_48963829 0.14 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr10_+_11206925 0.14 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr4_+_78078304 0.14 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr8_-_29940464 0.14 ENST00000521265.1
ENST00000536273.1
TMEM66
transmembrane protein 66
chr1_-_54303949 0.14 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr11_-_65381643 0.14 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr8_+_32579341 0.14 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr14_+_21214039 0.14 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr1_+_36348790 0.14 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr12_+_53491220 0.14 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr7_+_80231466 0.14 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr10_-_104192405 0.13 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr6_+_32146131 0.13 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr7_+_80275752 0.13 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr15_+_52043758 0.13 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr19_+_11071546 0.13 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr18_+_3449821 0.13 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr6_-_11779403 0.12 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr15_-_79103757 0.12 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chrX_+_100645812 0.12 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chrX_-_153599578 0.12 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chrX_+_54835493 0.12 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr21_-_34144157 0.12 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr4_+_170581213 0.11 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr14_+_39644387 0.11 ENST00000553331.1
ENST00000216832.4
PNN
pinin, desmosome associated protein
chr20_+_55966444 0.11 ENST00000356208.5
ENST00000440234.2
RBM38
RNA binding motif protein 38
chr13_+_24144509 0.11 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_79567314 0.11 ENST00000503539.1
ENST00000504675.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr4_-_85419603 0.11 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr1_+_154244987 0.10 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr14_-_73493784 0.10 ENST00000553891.1
ZFYVE1
zinc finger, FYVE domain containing 1
chr1_+_212797789 0.10 ENST00000294829.3
FAM71A
family with sequence similarity 71, member A
chr19_+_8274204 0.10 ENST00000561053.1
ENST00000251363.5
ENST00000559450.1
ENST00000559336.1
CERS4
ceramide synthase 4
chr19_+_8274185 0.10 ENST00000558268.1
ENST00000558331.1
CERS4
ceramide synthase 4
chr1_-_20126365 0.10 ENST00000294543.6
ENST00000375122.2
TMCO4
transmembrane and coiled-coil domains 4
chr2_+_48796120 0.10 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr2_+_33172221 0.10 ENST00000354476.3
LTBP1
latent transforming growth factor beta binding protein 1
chr19_+_11071652 0.10 ENST00000344626.4
ENST00000429416.3
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr1_+_78383813 0.10 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr8_-_145047688 0.10 ENST00000356346.3
PLEC
plectin
chr4_+_79567362 0.10 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr7_+_90338712 0.09 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr17_-_61819229 0.09 ENST00000447001.3
ENST00000392950.4
STRADA
STE20-related kinase adaptor alpha
chr14_-_23451845 0.09 ENST00000262713.2
AJUBA
ajuba LIM protein
chr17_-_61819121 0.09 ENST00000245865.5
ENST00000375840.4
ENST00000582137.1
ENST00000579549.1
ENST00000582030.1
ENST00000584110.1
ENST00000580288.1
ENST00000336174.6
ENST00000579340.1
ENST00000580338.1
STRADA
STE20-related kinase adaptor alpha
chr9_-_74979420 0.09 ENST00000343431.2
ENST00000376956.3
ZFAND5
zinc finger, AN1-type domain 5
chr10_-_91295304 0.08 ENST00000341233.4
ENST00000371790.4
SLC16A12
solute carrier family 16, member 12
chr7_+_80275953 0.08 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr1_+_185703513 0.08 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr14_+_20923350 0.08 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr10_-_104179682 0.08 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chr19_-_49864746 0.07 ENST00000598810.1
TEAD2
TEA domain family member 2
chr22_+_24105394 0.07 ENST00000305199.5
ENST00000382821.3
C22orf15
chromosome 22 open reading frame 15
chr1_-_54304212 0.07 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr3_-_149375783 0.07 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr9_-_35650900 0.07 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr5_-_114515734 0.07 ENST00000514154.1
ENST00000282369.3
TRIM36
tripartite motif containing 36
chr3_-_134093275 0.07 ENST00000513145.1
ENST00000422605.2
AMOTL2
angiomotin like 2
chr13_-_67802549 0.07 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.7 5.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 0.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.8 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 0.6 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.2 0.6 GO:0036446 myofibroblast differentiation(GO:0036446) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) regulation of myofibroblast differentiation(GO:1904760)
0.2 0.6 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.2 0.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 1.1 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.5 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.4 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.4 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.4 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.6 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.6 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.3 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.1 2.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.2 GO:1904020 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 0.4 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.2 GO:0007418 positive regulation of hh target transcription factor activity(GO:0007228) ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 1.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 1.4 GO:0060065 uterus development(GO:0060065)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 0.1 GO:0072560 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.2 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 1.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.0 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.9 GO:0006301 postreplication repair(GO:0006301)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.8 GO:0000125 PCAF complex(GO:0000125)
0.1 0.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 2.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.6 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.3 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 1.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.7 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 0.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation