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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TCF7L2

Z-value: 0.47

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710516_114710675-0.193.7e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_72441315 1.62 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr13_-_72440901 1.58 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr1_+_61330931 1.34 ENST00000371191.1
NFIA
nuclear factor I/A
chr7_-_27213893 1.12 ENST00000283921.4
HOXA10
homeobox A10
chr7_-_27219849 0.89 ENST00000396344.4
HOXA10
homeobox A10
chr11_+_7597639 0.78 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_63005405 0.75 ENST00000374878.1
ENST00000437457.2
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr2_+_69240302 0.65 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr13_+_24144796 0.64 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_+_162351503 0.58 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr17_-_67138015 0.58 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr10_+_54074033 0.53 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr8_+_29952914 0.52 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr5_-_111093167 0.49 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr2_+_89890533 0.44 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr4_+_30721968 0.41 ENST00000361762.2
PCDH7
protocadherin 7
chr8_+_29953163 0.40 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr13_+_24144509 0.39 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr5_+_175288631 0.37 ENST00000509837.1
CPLX2
complexin 2
chr22_-_32860427 0.37 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
BPIFC
BPI fold containing family C
chr13_-_67802549 0.37 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr8_-_16859690 0.35 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr13_+_76334498 0.35 ENST00000534657.1
LMO7
LIM domain 7
chr20_-_17511962 0.35 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr1_-_110933663 0.33 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr7_-_148581360 0.33 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chrX_-_10588595 0.33 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr18_+_46065483 0.31 ENST00000382998.4
CTIF
CBP80/20-dependent translation initiation factor
chrX_-_10588459 0.31 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_110933611 0.30 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr1_-_94079648 0.30 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr10_-_25241499 0.30 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr7_-_148581251 0.30 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chrX_-_32173579 0.28 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr21_+_18811205 0.28 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr16_+_29819372 0.28 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_29819446 0.27 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr11_+_45944190 0.26 ENST00000401752.1
ENST00000389968.3
ENST00000325468.5
ENST00000536139.1
GYLTL1B
glycosyltransferase-like 1B
chr2_+_177028805 0.26 ENST00000249440.3
HOXD3
homeobox D3
chr12_-_48963829 0.26 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr5_-_148930960 0.25 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr2_+_69240511 0.24 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr1_-_161993616 0.24 ENST00000294794.3
OLFML2B
olfactomedin-like 2B
chr12_-_12491608 0.24 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr5_-_135290705 0.24 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr18_+_46065393 0.24 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr7_+_27282319 0.24 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr7_+_99613195 0.23 ENST00000324306.6
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr6_-_32145861 0.23 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr12_+_9067123 0.22 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr15_+_57511609 0.22 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr2_-_55647057 0.22 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr2_-_55646957 0.22 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr11_-_94965667 0.22 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr13_+_76334567 0.22 ENST00000321797.8
LMO7
LIM domain 7
chr12_-_54694807 0.22 ENST00000435572.2
NFE2
nuclear factor, erythroid 2
chr10_+_101542462 0.22 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr11_-_76155618 0.21 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr13_+_76334795 0.21 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr1_+_147013182 0.21 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr7_+_73868439 0.21 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr1_+_78383813 0.21 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr14_+_75230011 0.20 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr11_-_62474803 0.20 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_40315640 0.20 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr15_-_90294523 0.20 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chr12_+_80603233 0.20 ENST00000547103.1
ENST00000458043.2
OTOGL
otogelin-like
chr18_+_29769978 0.20 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr11_-_76155700 0.19 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr17_-_63557759 0.19 ENST00000307078.5
AXIN2
axin 2
chr2_+_173686303 0.19 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_69240415 0.19 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr14_-_81425828 0.18 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr2_+_204801471 0.18 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr1_-_40367668 0.17 ENST00000397332.2
ENST00000429311.1
MYCL
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
chr19_+_50084561 0.17 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr22_+_19950060 0.17 ENST00000449653.1
COMT
catechol-O-methyltransferase
chr20_+_59654146 0.16 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr11_-_41481135 0.16 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chrX_+_54835493 0.16 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr6_-_112575838 0.16 ENST00000455073.1
LAMA4
laminin, alpha 4
chr7_-_80141328 0.15 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr17_-_38256973 0.15 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr3_-_134093275 0.14 ENST00000513145.1
ENST00000422605.2
AMOTL2
angiomotin like 2
chr17_+_68100989 0.14 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr1_-_54303934 0.14 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr12_+_70760056 0.14 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr9_+_125796806 0.14 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chrX_-_100183894 0.14 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr3_+_183353356 0.14 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr17_+_75447326 0.14 ENST00000591088.1
SEPT9
septin 9
chr1_+_207039154 0.14 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr6_-_28220002 0.14 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr16_-_73082274 0.14 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr2_+_33701286 0.14 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_48796120 0.13 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr17_+_79679299 0.13 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr7_+_80275621 0.13 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chrX_+_152760397 0.13 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr6_+_155537771 0.13 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_112575758 0.13 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr1_+_223101757 0.13 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr9_-_130712995 0.13 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr17_+_42081914 0.13 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr6_+_32146131 0.13 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr2_+_234621551 0.12 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr10_-_105677427 0.12 ENST00000369764.1
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr12_+_85673868 0.12 ENST00000316824.3
ALX1
ALX homeobox 1
chr2_+_201936458 0.12 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr3_-_134093395 0.12 ENST00000249883.5
AMOTL2
angiomotin like 2
chr9_-_15510287 0.12 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chrX_-_110655306 0.12 ENST00000371993.2
DCX
doublecortin
chr3_-_149375783 0.11 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr4_-_69215467 0.11 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr9_+_139221880 0.11 ENST00000392945.3
ENST00000440944.1
GPSM1
G-protein signaling modulator 1
chr4_+_170581213 0.11 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr1_-_109935819 0.11 ENST00000538502.1
SORT1
sortilin 1
chr8_-_133123406 0.11 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr12_+_6982725 0.11 ENST00000433346.1
LRRC23
leucine rich repeat containing 23
chrX_+_46937745 0.10 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chrX_+_41306575 0.10 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr6_-_112575687 0.10 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr10_-_104179682 0.10 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chr1_+_154244987 0.10 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr7_+_99613212 0.10 ENST00000426572.1
ENST00000535170.1
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr1_-_54304212 0.09 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr5_+_102201509 0.09 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr14_+_21236586 0.09 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr5_+_102201430 0.09 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr12_-_6982442 0.09 ENST00000523102.1
ENST00000524270.1
ENST00000519357.1
SPSB2
splA/ryanodine receptor domain and SOCS box containing 2
chrX_+_106163626 0.09 ENST00000336803.1
CLDN2
claudin 2
chr17_+_80416050 0.09 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr3_-_33686743 0.09 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr20_+_57875658 0.09 ENST00000371025.3
EDN3
endothelin 3
chr1_+_180199393 0.09 ENST00000263726.2
LHX4
LIM homeobox 4
chr18_-_52989217 0.09 ENST00000570287.2
TCF4
transcription factor 4
chr5_+_60628074 0.09 ENST00000252744.5
ZSWIM6
zinc finger, SWIM-type containing 6
chr4_+_78078304 0.09 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chrX_+_47004599 0.09 ENST00000329236.7
RBM10
RNA binding motif protein 10
chr14_+_23235886 0.09 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like
chr6_-_112575912 0.09 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr2_+_201936707 0.08 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr1_-_54303949 0.08 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr1_+_16330723 0.08 ENST00000329454.2
C1orf64
chromosome 1 open reading frame 64
chr17_+_80416482 0.08 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr6_+_152130240 0.08 ENST00000427531.2
ESR1
estrogen receptor 1
chr7_+_150076406 0.08 ENST00000329630.5
ZNF775
zinc finger protein 775
chr10_-_87551311 0.07 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr3_+_174577070 0.07 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr10_-_104192405 0.07 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr13_-_36429763 0.07 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chrX_-_39956656 0.07 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr16_+_53242350 0.07 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_166028709 0.07 ENST00000595430.1
AL626787.1
AL626787.1
chr17_-_39646116 0.07 ENST00000328119.6
KRT36
keratin 36
chr12_-_52779433 0.07 ENST00000257951.3
KRT84
keratin 84
chr3_-_42452050 0.06 ENST00000441172.1
ENST00000287748.3
LYZL4
lysozyme-like 4
chr15_-_82338460 0.06 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr4_-_157892498 0.06 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr10_+_71561704 0.06 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr17_+_34848049 0.06 ENST00000588902.1
ENST00000591067.1
ZNHIT3
zinc finger, HIT-type containing 3
chr2_+_71357744 0.06 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr14_+_32798547 0.06 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr6_+_132873832 0.06 ENST00000275200.1
TAAR8
trace amine associated receptor 8
chrX_+_47004639 0.06 ENST00000345781.6
RBM10
RNA binding motif protein 10
chr1_-_115053781 0.06 ENST00000358465.2
ENST00000369543.2
TRIM33
tripartite motif containing 33
chr17_-_47308128 0.06 ENST00000413580.1
ENST00000511066.1
PHOSPHO1
phosphatase, orphan 1
chrX_-_153599578 0.05 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr16_+_72088376 0.05 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr19_-_59030921 0.05 ENST00000354590.3
ENST00000596739.1
ZBTB45
zinc finger and BTB domain containing 45
chr19_-_59031118 0.05 ENST00000600990.1
ZBTB45
zinc finger and BTB domain containing 45
chr5_-_157002775 0.05 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr20_+_57875457 0.05 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr15_-_89764929 0.05 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chrX_+_100646190 0.05 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr17_-_7297833 0.04 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr8_-_95220775 0.04 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr17_-_7297519 0.04 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr14_-_75179774 0.04 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr5_+_54455946 0.04 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr7_+_80275752 0.04 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr22_+_41347363 0.04 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr4_-_157892055 0.04 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr11_-_6677018 0.04 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr20_+_57875758 0.04 ENST00000395654.3
EDN3
endothelin 3
chr10_+_71561630 0.03 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr4_-_109684120 0.03 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ETNPPL
ethanolamine-phosphate phospho-lyase
chr3_+_137483579 0.03 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr7_-_148725733 0.03 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr21_-_35284635 0.03 ENST00000429238.1
AP000304.12
AP000304.12
chr5_+_175815732 0.03 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr12_+_52056548 0.03 ENST00000545061.1
ENST00000355133.3
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr17_-_40169659 0.03 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chrX_-_122866874 0.02 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr10_+_115312766 0.02 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chrX_+_100645812 0.02 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr2_+_204732487 0.02 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr17_-_47308100 0.02 ENST00000503902.1
ENST00000512250.1
PHOSPHO1
phosphatase, orphan 1
chr19_-_39924349 0.02 ENST00000602153.1
RPS16
ribosomal protein S16
chr7_+_110731062 0.01 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 1.1 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.6 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.9 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.3 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.1 0.3 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.3 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0016999 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.1 2.1 GO:0060065 uterus development(GO:0060065)
0.1 0.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:1904253 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 1.1 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0015743 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:1904833 L-ascorbic acid biosynthetic process(GO:0019853) positive regulation of superoxide dismutase activity(GO:1901671) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of removal of superoxide radicals(GO:1904833)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.3 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.2 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.3 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:2000980 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.4 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.6 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.5 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.2 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.1 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.0 0.5 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo