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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TEAD3_TEAD1
Z-value: 1.47
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD1 | hg19_v2_chr11_+_12695944_12695989 | 0.75 | 1.4e-05 | Click! |
| TEAD3 | hg19_v2_chr6_-_35464817_35464894, hg19_v2_chr6_-_35464727_35464738 | 0.13 | 5.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.4 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 3.2 | 12.8 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.0 | 8.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 1.0 | 7.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.6 | 5.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.6 | 4.8 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 4.8 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.3 | 4.4 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.1 | 4.3 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.8 | 4.0 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | GO:0030018 | Z disc(GO:0030018) |
| 1.4 | 12.8 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 10.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.4 | 7.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 5.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 4.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 3.5 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 3.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 3.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 3.0 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 13.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 12.7 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 6.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 5.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.0 | 5.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 4.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.4 | 3.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 3.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.2 | 3.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 12.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 4.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 2.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 7.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 6.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 5.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 5.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 3.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.5 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.1 | 3.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |