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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TFAP2E

Z-value: 0.49

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.048.3e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56623433 1.33 ENST00000570176.1
MT3
metallothionein 3
chr20_+_58508817 0.73 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr6_+_7108210 0.58 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1
ras responsive element binding protein 1
chr17_+_37824700 0.56 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr2_+_75061108 0.56 ENST00000290573.2
HK2
hexokinase 2
chr6_+_7107830 0.54 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr1_+_104068562 0.53 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr9_-_86432547 0.49 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr2_-_177502254 0.46 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chr2_+_38893208 0.45 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr6_+_7107999 0.45 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1
ras responsive element binding protein 1
chr17_+_37824411 0.39 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr17_+_37824217 0.39 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr11_-_61062762 0.36 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_+_104068312 0.35 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr11_+_63974135 0.35 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
FERMT3
fermitin family member 3
chr6_+_292051 0.33 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr12_-_15942503 0.33 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr12_-_15942309 0.32 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr2_-_174828892 0.31 ENST00000418194.2
SP3
Sp3 transcription factor
chr3_+_110790590 0.31 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr1_+_17634689 0.30 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr2_+_241375069 0.27 ENST00000264039.2
GPC1
glypican 1
chr5_-_115152651 0.27 ENST00000250535.4
CDO1
cysteine dioxygenase type 1
chr5_+_176237478 0.27 ENST00000329542.4
UNC5A
unc-5 homolog A (C. elegans)
chr10_-_112678976 0.26 ENST00000448814.1
BBIP1
BBSome interacting protein 1
chr12_+_53773944 0.26 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr10_-_112678692 0.25 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr15_-_65503801 0.25 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr2_+_38893047 0.23 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr1_-_11866034 0.22 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_66045634 0.22 ENST00000528852.1
ENST00000311445.6
CNIH2
cornichon family AMPA receptor auxiliary protein 2
chr10_-_112678904 0.22 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr3_+_155860751 0.21 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr19_+_38794797 0.21 ENST00000301246.5
ENST00000588605.1
C19orf33
chromosome 19 open reading frame 33
chrX_+_49028265 0.21 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr19_-_11039188 0.21 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr17_+_74070853 0.20 ENST00000329003.3
GALR2
galanin receptor 2
chr3_+_32280159 0.20 ENST00000458535.2
ENST00000307526.3
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr12_+_53443963 0.18 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr6_+_150070831 0.17 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr19_-_39264072 0.17 ENST00000599035.1
ENST00000378626.4
LGALS7
lectin, galactoside-binding, soluble, 7
chrX_+_131157290 0.16 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr8_+_125463048 0.16 ENST00000328599.3
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr20_-_13619550 0.16 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
TASP1
taspase, threonine aspartase, 1
chr2_-_45236540 0.16 ENST00000303077.6
SIX2
SIX homeobox 2
chr3_+_4535025 0.16 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr19_+_4969116 0.16 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chrX_+_131157322 0.16 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr11_+_116700614 0.15 ENST00000375345.1
APOC3
apolipoprotein C-III
chr11_+_116700600 0.15 ENST00000227667.3
APOC3
apolipoprotein C-III
chr19_+_36195429 0.15 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chr17_-_47755436 0.15 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP
speckle-type POZ protein
chr6_+_13272904 0.15 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr2_+_74741569 0.15 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr1_-_114355083 0.15 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr22_+_35653445 0.14 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr7_-_140624499 0.14 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr2_+_232573222 0.14 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr3_+_4535155 0.14 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_-_154531095 0.14 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr12_+_57984965 0.14 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chrX_+_152783131 0.14 ENST00000349466.2
ENST00000370186.1
ATP2B3
ATPase, Ca++ transporting, plasma membrane 3
chr11_-_118305921 0.14 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr1_+_211433275 0.13 ENST00000367005.4
RCOR3
REST corepressor 3
chr19_-_54676884 0.13 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr17_+_48423453 0.13 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr4_+_75480629 0.12 ENST00000380846.3
AREGB
amphiregulin B
chr2_+_232573208 0.12 ENST00000409115.3
PTMA
prothymosin, alpha
chr5_-_151304337 0.11 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr10_-_98273668 0.11 ENST00000357947.3
TLL2
tolloid-like 2
chr19_-_54676846 0.11 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr10_+_99894380 0.11 ENST00000370584.3
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr7_-_100065686 0.11 ENST00000423266.1
ENST00000456330.1
TSC22D4
TSC22 domain family, member 4
chr12_-_48213568 0.11 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr3_+_52813932 0.10 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr11_-_113345995 0.10 ENST00000355319.2
ENST00000542616.1
DRD2
dopamine receptor D2
chr2_+_232572361 0.10 ENST00000409321.1
PTMA
prothymosin, alpha
chr10_+_99894399 0.10 ENST00000298999.3
ENST00000314594.5
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr9_-_21077939 0.10 ENST00000380232.2
IFNB1
interferon, beta 1, fibroblast
chr9_+_19230433 0.10 ENST00000434457.2
ENST00000602925.1
DENND4C
DENN/MADD domain containing 4C
chr16_+_69599861 0.09 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr11_+_82612740 0.09 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr1_+_182584314 0.09 ENST00000566297.1
RP11-317P15.4
RP11-317P15.4
chr1_+_43148625 0.09 ENST00000436427.1
YBX1
Y box binding protein 1
chr11_-_66056478 0.09 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr16_+_69599899 0.08 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr3_-_48130314 0.08 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr15_+_23810853 0.08 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr16_+_69600058 0.08 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr14_-_25519095 0.08 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr14_+_21214039 0.07 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr9_+_35605274 0.07 ENST00000336395.5
TESK1
testis-specific kinase 1
chr1_-_201346761 0.07 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
TNNT2
troponin T type 2 (cardiac)
chr6_+_150070857 0.07 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr14_+_24837226 0.07 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr9_+_128024067 0.07 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
GAPVD1
GTPase activating protein and VPS9 domains 1
chr9_+_136501478 0.07 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr15_+_27112296 0.07 ENST00000554038.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr6_+_42531798 0.06 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_+_901847 0.06 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr11_+_64009072 0.06 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr8_+_17780346 0.06 ENST00000325083.8
PCM1
pericentriolar material 1
chrX_+_115567767 0.05 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr14_-_25519317 0.05 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chr17_-_47755338 0.05 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr7_+_100464760 0.05 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr17_-_42992856 0.05 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr4_+_154387480 0.05 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
KIAA0922
chr11_-_6633799 0.04 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr3_-_136471204 0.04 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr4_+_41992489 0.04 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr4_-_82393009 0.04 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr5_-_179719048 0.04 ENST00000523583.1
ENST00000393360.3
ENST00000455781.1
ENST00000347470.4
ENST00000452135.2
ENST00000343111.6
MAPK9
mitogen-activated protein kinase 9
chr3_-_55521323 0.04 ENST00000264634.4
WNT5A
wingless-type MMTV integration site family, member 5A
chr15_+_27112380 0.03 ENST00000554596.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr11_-_35440796 0.03 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_35441524 0.03 ENST00000395750.1
ENST00000449068.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_+_11039391 0.03 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr15_+_27112251 0.02 ENST00000400081.3
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr15_+_27112058 0.02 ENST00000355395.5
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr14_-_64010046 0.02 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr12_+_72666407 0.02 ENST00000261180.4
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr17_-_31620006 0.02 ENST00000225823.2
ASIC2
acid-sensing (proton-gated) ion channel 2
chr11_+_118478313 0.02 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr3_-_48632593 0.01 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr19_-_46389359 0.01 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr1_-_11865351 0.01 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2000374 cadmium ion homeostasis(GO:0055073) lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
0.4 1.6 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.3 1.3 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.2 0.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.3 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.6 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.7 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.3 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.3 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 0.3 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.3 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.3 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:1900166 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.4 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.0 GO:0061346 cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.7 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.3 0.9 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 1.3 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.3 GO:0034618 arginine binding(GO:0034618)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.6 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.7 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac