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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TFDP1
Z-value: 1.64
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Transcription factors associated with TFDP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFDP1 | hg19_v2_chr13_+_114239588_114239752 | -0.72 | 5.8e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_72353451 Show fit | 6.83 |
ENST00000376450.3
|
phosphodiesterase 2A, cGMP-stimulated |
|
| chr1_-_184943610 Show fit | 5.17 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
|
| chr11_-_72492878 Show fit | 3.40 |
ENST00000535054.1
ENST00000545082.1 |
StAR-related lipid transfer (START) domain containing 10 |
|
| chr11_-_72492903 Show fit | 3.08 |
ENST00000537947.1
|
StAR-related lipid transfer (START) domain containing 10 |
|
| chr5_+_113697983 Show fit | 2.99 |
ENST00000264773.3
|
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
|
| chr10_-_101380121 Show fit | 2.94 |
ENST00000370495.4
|
solute carrier family 25 (mitochondrial iron transporter), member 28 |
|
| chr6_+_37137939 Show fit | 2.69 |
ENST00000373509.5
|
pim-1 oncogene |
|
| chr1_+_169075554 Show fit | 2.55 |
ENST00000367815.4
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr12_+_52626898 Show fit | 2.53 |
ENST00000331817.5
|
keratin 7 |
|
| chr19_-_41196458 Show fit | 2.50 |
ENST00000598779.1
|
numb homolog (Drosophila)-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFDP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 6.8 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.5 | 6.5 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.0 | 5.9 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 1.7 | 5.2 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.4 | 4.1 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 1.3 | 4.0 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
| 0.0 | 3.5 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.4 | 3.4 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 3.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 3.4 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.6 | 6.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.5 | 6.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 6.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 5.7 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 4.3 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.1 | GO:0031256 | leading edge membrane(GO:0031256) |
| 0.0 | 3.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 3.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.8 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.0 | 6.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 5.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 5.0 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.4 | 4.8 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 3.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 3.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 3.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 3.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.6 | 3.0 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 8.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 5.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.6 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 3.4 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 3.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 3.0 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 7.4 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.2 | 7.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 5.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 3.5 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 3.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 3.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |