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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.90
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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000105967.11 | transcription factor EC | |
| ENSG00000187098.10 | melanocyte inducing transcription factor | |
| ENSG00000133794.13 | aryl hydrocarbon receptor nuclear translocator like | |
| ENSG00000123095.5 | basic helix-loop-helix family member e41 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MITF | hg19_v2_chr3_+_69812877_69812962, hg19_v2_chr3_+_69928256_69928385 | -0.37 | 6.8e-02 | Click! |
| BHLHE41 | hg19_v2_chr12_-_26278030_26278060 | -0.10 | 6.5e-01 | Click! |
| TFEC | hg19_v2_chr7_-_115670804_115670867, hg19_v2_chr7_-_115608304_115608352 | 0.07 | 7.3e-01 | Click! |
| ARNTL | hg19_v2_chr11_+_13299186_13299432 | 0.06 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_11866034 Show fit | 3.78 |
ENST00000376590.3
|
methylenetetrahydrofolate reductase (NAD(P)H) |
|
| chr10_-_105452917 Show fit | 2.59 |
ENST00000427662.2
|
SH3 and PX domains 2A |
|
| chr11_+_67159416 Show fit | 2.12 |
ENST00000307980.2
ENST00000544620.1 |
RAD9 homolog A (S. pombe) |
|
| chr1_+_11866207 Show fit | 2.11 |
ENST00000312413.6
ENST00000346436.6 |
chloride channel, voltage-sensitive 6 |
|
| chr1_+_11866270 Show fit | 2.11 |
ENST00000376497.3
ENST00000376487.3 ENST00000376496.3 |
chloride channel, voltage-sensitive 6 |
|
| chr17_-_47841485 Show fit | 2.10 |
ENST00000506156.1
ENST00000240364.2 |
family with sequence similarity 117, member A |
|
| chr7_-_27205136 Show fit | 1.83 |
ENST00000396345.1
ENST00000343483.6 |
homeobox A9 |
|
| chr5_+_41904431 Show fit | 1.82 |
ENST00000381647.2
|
chromosome 5 open reading frame 51 |
|
| chr12_-_122751002 Show fit | 1.78 |
ENST00000267199.4
|
vacuolar protein sorting 33 homolog A (S. cerevisiae) |
|
| chr15_+_41913690 Show fit | 1.77 |
ENST00000563576.1
|
MGA, MAX dimerization protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.7 | 3.4 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.8 | 3.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 2.9 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.7 | 2.7 | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells(GO:1903691) |
| 0.4 | 2.6 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.1 | 2.6 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 2.5 | GO:0043297 | apical junction assembly(GO:0043297) |
| 0.1 | 2.3 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 2.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 2.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.6 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 2.5 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.2 | 2.1 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 1.9 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.5 | 1.4 | GO:0019034 | viral replication complex(GO:0019034) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.7 | 3.4 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 3.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 2.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 2.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.4 | 2.1 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.0 | 1.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.5 | 1.5 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 1.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 1.4 | GO:0034046 | poly(G) binding(GO:0034046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 2.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.6 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.2 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 1.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.1 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 1.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 1.0 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 1.0 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |