Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for THRA_RXRB

Z-value: 0.63

Motif logo

logo of logo of

Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
THRA
ENSG00000126351.8 thyroid hormone receptor alpha
RXRB
ENSG00000204231.6 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RXRBhg19_v2_chr6_-_33168391_33168465-0.242.5e-01Click!
THRAhg19_v2_chr17_+_38219063_382191540.067.7e-01Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_58469591 0.82 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr19_+_1248547 0.72 ENST00000586757.1
ENST00000300952.2
MIDN
midnolin
chr2_-_55459437 0.67 ENST00000401408.1
CLHC1
clathrin heavy chain linker domain containing 1
chr2_-_55459294 0.67 ENST00000407122.1
ENST00000406437.2
CLHC1
clathrin heavy chain linker domain containing 1
chr4_+_126237554 0.67 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chr14_+_88852059 0.64 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr19_-_52227221 0.63 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr12_-_114843889 0.63 ENST00000405440.2
TBX5
T-box 5
chr9_+_27109392 0.56 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr17_-_39216344 0.47 ENST00000391418.2
KRTAP2-3
keratin associated protein 2-3
chr9_-_33402506 0.45 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr11_+_7618413 0.42 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_+_67999999 0.40 ENST00000329153.5
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr11_-_27722021 0.39 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
BDNF
brain-derived neurotrophic factor
chr14_-_106054659 0.39 ENST00000390539.2
IGHA2
immunoglobulin heavy constant alpha 2 (A2m marker)
chr22_-_21581926 0.38 ENST00000401924.1
GGT2
gamma-glutamyltransferase 2
chr15_-_80215984 0.37 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chrX_-_132887729 0.34 ENST00000406757.2
GPC3
glypican 3
chr13_-_33760216 0.33 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_41196077 0.33 ENST00000448827.2
TREML4
triggering receptor expressed on myeloid cells-like 4
chr17_-_58469687 0.33 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr6_+_41196052 0.33 ENST00000341495.2
TREML4
triggering receptor expressed on myeloid cells-like 4
chr2_+_230787213 0.33 ENST00000409992.1
FBXO36
F-box protein 36
chr21_+_45773515 0.32 ENST00000397932.2
ENST00000300481.9
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr1_+_163039143 0.32 ENST00000531057.1
ENST00000527809.1
ENST00000367908.4
RGS4
regulator of G-protein signaling 4
chr14_+_23352374 0.31 ENST00000267396.4
ENST00000536884.1
REM2
RAS (RAD and GEM)-like GTP binding 2
chr22_+_23165153 0.31 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr22_+_22712087 0.31 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr12_-_95510743 0.31 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr8_-_18666360 0.31 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_150693318 0.30 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr2_+_230787201 0.30 ENST00000283946.3
FBXO36
F-box protein 36
chr22_+_29138013 0.30 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr22_+_23134974 0.30 ENST00000390314.2
IGLV2-11
immunoglobulin lambda variable 2-11
chr1_+_185703513 0.29 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr2_-_183387283 0.28 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr14_+_58765103 0.28 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr2_-_183387430 0.28 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr11_+_7534999 0.27 ENST00000528947.1
ENST00000299492.4
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_176056974 0.26 ENST00000510387.1
ENST00000506696.1
SNCB
synuclein, beta
chr14_+_88851874 0.26 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chr7_-_151433342 0.26 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_151433393 0.26 ENST00000492843.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr9_+_109625378 0.26 ENST00000277225.5
ENST00000457913.1
ENST00000472574.1
ZNF462
zinc finger protein 462
chr17_+_4981535 0.26 ENST00000318833.3
ZFP3
ZFP3 zinc finger protein
chr6_+_125524785 0.26 ENST00000392482.2
TPD52L1
tumor protein D52-like 1
chr19_+_32836499 0.25 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr12_-_96184533 0.25 ENST00000343702.4
ENST00000344911.4
NTN4
netrin 4
chr1_+_160147176 0.25 ENST00000470705.1
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr11_-_17565854 0.25 ENST00000005226.7
USH1C
Usher syndrome 1C (autosomal recessive, severe)
chr16_-_67700594 0.24 ENST00000602644.1
ENST00000243878.4
ENKD1
enkurin domain containing 1
chr12_-_111926342 0.24 ENST00000389154.3
ATXN2
ataxin 2
chr12_+_102513950 0.24 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr6_+_139456226 0.24 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr21_+_45773139 0.24 ENST00000397928.1
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr7_+_120969045 0.24 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr5_+_170288856 0.24 ENST00000523189.1
RANBP17
RAN binding protein 17
chr1_+_229440129 0.23 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr12_-_52995291 0.23 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chr3_-_187009646 0.23 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr9_-_114246635 0.23 ENST00000338205.5
KIAA0368
KIAA0368
chr10_+_76586348 0.23 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B
K(lysine) acetyltransferase 6B
chr17_-_44270133 0.23 ENST00000262419.6
ENST00000393476.3
KANSL1
KAT8 regulatory NSL complex subunit 1
chr17_+_44928946 0.22 ENST00000290015.2
ENST00000393461.2
WNT9B
wingless-type MMTV integration site family, member 9B
chr17_+_43922241 0.22 ENST00000329196.5
SPPL2C
signal peptide peptidase like 2C
chr2_-_183387064 0.22 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr17_-_7082861 0.21 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr9_-_104249319 0.21 ENST00000374847.1
TMEM246
transmembrane protein 246
chr3_+_10068095 0.21 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr12_-_5352315 0.21 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr22_-_29138386 0.21 ENST00000544772.1
CHEK2
checkpoint kinase 2
chr12_+_52668394 0.20 ENST00000423955.2
KRT86
keratin 86
chr5_-_162887071 0.20 ENST00000302764.4
NUDCD2
NudC domain containing 2
chr9_+_75263565 0.20 ENST00000396237.3
TMC1
transmembrane channel-like 1
chr9_+_35490101 0.20 ENST00000361226.3
RUSC2
RUN and SH3 domain containing 2
chr1_+_70876891 0.19 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr14_-_106174960 0.19 ENST00000390547.2
IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_76751926 0.19 ENST00000285871.4
ENST00000431197.1
CCDC146
coiled-coil domain containing 146
chr8_+_110552831 0.19 ENST00000530629.1
EBAG9
estrogen receptor binding site associated, antigen, 9
chr3_-_49726486 0.19 ENST00000449682.2
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_32827759 0.19 ENST00000373534.3
TSSK3
testis-specific serine kinase 3
chr11_+_65190245 0.19 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr19_-_58485895 0.19 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr1_-_38218577 0.19 ENST00000540011.1
EPHA10
EPH receptor A10
chr7_-_56160666 0.19 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr12_+_123874589 0.18 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr17_+_37894570 0.18 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr12_-_122018859 0.18 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr12_+_56401268 0.18 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr2_-_49381646 0.18 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr3_-_183273477 0.18 ENST00000341319.3
KLHL6
kelch-like family member 6
chr1_+_22962948 0.18 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr7_-_56160625 0.18 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr2_+_220491973 0.17 ENST00000358055.3
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr10_-_33625154 0.17 ENST00000265371.4
NRP1
neuropilin 1
chr6_-_150039249 0.17 ENST00000543571.1
LATS1
large tumor suppressor kinase 1
chr19_-_45826125 0.17 ENST00000221476.3
CKM
creatine kinase, muscle
chr15_-_45422056 0.17 ENST00000267803.4
ENST00000559014.1
ENST00000558851.1
ENST00000559988.1
ENST00000558996.1
ENST00000558422.1
ENST00000559226.1
ENST00000558326.1
ENST00000558377.1
ENST00000559644.1
DUOXA1
dual oxidase maturation factor 1
chr2_-_49381572 0.17 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr19_+_19639670 0.17 ENST00000436027.5
YJEFN3
YjeF N-terminal domain containing 3
chr20_+_32254286 0.17 ENST00000330271.4
ACTL10
actin-like 10
chr11_-_58343319 0.17 ENST00000395074.2
LPXN
leupaxin
chr11_+_100862811 0.17 ENST00000303130.2
TMEM133
transmembrane protein 133
chr15_-_51914996 0.17 ENST00000251076.5
DMXL2
Dmx-like 2
chr3_-_50340996 0.17 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1
hyaluronoglucosaminidase 1
chr22_+_22764088 0.17 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr6_-_89673280 0.16 ENST00000369475.3
ENST00000369485.4
ENST00000538899.1
ENST00000265607.6
RNGTT
RNA guanylyltransferase and 5'-phosphatase
chr2_-_230786679 0.16 ENST00000543084.1
ENST00000343290.5
ENST00000389044.4
ENST00000283943.5
TRIP12
thyroid hormone receptor interactor 12
chr1_+_70876926 0.16 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr2_-_100106419 0.16 ENST00000393445.3
ENST00000258428.3
REV1
REV1, polymerase (DNA directed)
chr1_-_151431647 0.16 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr4_+_7194247 0.16 ENST00000507866.2
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr13_-_76111945 0.16 ENST00000355801.4
ENST00000406936.3
COMMD6
COMM domain containing 6
chr9_-_139305051 0.16 ENST00000371725.3
ENST00000298537.7
SDCCAG3
serologically defined colon cancer antigen 3
chr2_-_74779744 0.16 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr17_+_37894179 0.16 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr3_-_114343768 0.16 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_52946923 0.16 ENST00000267119.5
KRT71
keratin 71
chr12_-_80328949 0.16 ENST00000450142.2
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr1_-_204121298 0.15 ENST00000367199.2
ETNK2
ethanolamine kinase 2
chr1_+_241815577 0.15 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr17_+_6899366 0.15 ENST00000251535.6
ALOX12
arachidonate 12-lipoxygenase
chr1_-_204121102 0.15 ENST00000367202.4
ETNK2
ethanolamine kinase 2
chr17_+_58499844 0.15 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr11_+_55594695 0.15 ENST00000378397.1
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr1_-_205719295 0.15 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr9_+_131452239 0.15 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr3_+_40518599 0.15 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
ZNF619
zinc finger protein 619
chr17_+_48046538 0.15 ENST00000240306.3
DLX4
distal-less homeobox 4
chr22_+_23264766 0.15 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr5_+_147691979 0.14 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr3_+_179322481 0.14 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr12_-_102513843 0.14 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr1_+_28764653 0.14 ENST00000373836.3
PHACTR4
phosphatase and actin regulator 4
chr1_+_93544821 0.14 ENST00000370303.4
MTF2
metal response element binding transcription factor 2
chr20_+_18125727 0.14 ENST00000489634.2
CSRP2BP
CSRP2 binding protein
chr16_-_72206034 0.14 ENST00000537465.1
ENST00000237353.10
PMFBP1
polyamine modulated factor 1 binding protein 1
chrX_-_70326455 0.14 ENST00000374251.5
CXorf65
chromosome X open reading frame 65
chr1_+_17634689 0.13 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr8_+_63161491 0.13 ENST00000523211.1
ENST00000524201.1
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr19_+_19639704 0.13 ENST00000514277.4
YJEFN3
YjeF N-terminal domain containing 3
chr14_+_57857262 0.13 ENST00000555166.1
ENST00000556492.1
ENST00000554703.1
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr19_-_35719609 0.13 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr7_+_73868439 0.13 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr22_-_20255212 0.13 ENST00000416372.1
RTN4R
reticulon 4 receptor
chr17_+_27369918 0.13 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr14_+_81421861 0.13 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr1_+_178482262 0.13 ENST00000367641.3
ENST00000367639.1
TEX35
testis expressed 35
chr1_+_178482212 0.13 ENST00000319416.2
ENST00000258298.2
ENST00000367643.3
ENST00000367642.3
TEX35
testis expressed 35
chr16_+_67700673 0.13 ENST00000403458.4
ENST00000602365.1
C16orf86
chromosome 16 open reading frame 86
chr3_+_12330560 0.13 ENST00000397026.2
PPARG
peroxisome proliferator-activated receptor gamma
chr6_+_13272904 0.13 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr12_+_7023491 0.13 ENST00000541477.1
ENST00000229277.1
ENO2
enolase 2 (gamma, neuronal)
chr2_+_220492116 0.13 ENST00000373760.2
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr20_+_33146510 0.13 ENST00000397709.1
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr1_+_20396649 0.13 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr11_-_77122928 0.12 ENST00000528203.1
ENST00000528592.1
ENST00000528633.1
ENST00000529248.1
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr14_+_24616588 0.12 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr2_+_231860830 0.12 ENST00000424440.1
ENST00000452881.1
ENST00000433428.2
ENST00000455816.1
ENST00000440792.1
ENST00000423134.1
SPATA3
spermatogenesis associated 3
chr3_-_45957088 0.12 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr19_-_46974664 0.12 ENST00000438932.2
PNMAL1
paraneoplastic Ma antigen family-like 1
chr8_-_99954788 0.12 ENST00000523601.1
STK3
serine/threonine kinase 3
chr12_+_102514019 0.12 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr9_+_27109133 0.12 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr19_-_46974741 0.12 ENST00000313683.10
ENST00000602246.1
PNMAL1
paraneoplastic Ma antigen family-like 1
chr3_-_126236605 0.12 ENST00000290868.2
UROC1
urocanate hydratase 1
chr8_+_103563792 0.12 ENST00000285402.3
ODF1
outer dense fiber of sperm tails 1
chr3_+_14989186 0.12 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr16_-_2379688 0.12 ENST00000567910.1
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr7_+_100187196 0.11 ENST00000468962.1
ENST00000427939.2
FBXO24
F-box protein 24
chr5_+_162887556 0.11 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chrX_-_10851762 0.11 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_93544791 0.11 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
MTF2
metal response element binding transcription factor 2
chr18_+_268148 0.11 ENST00000581677.1
RP11-705O1.8
RP11-705O1.8
chr4_-_54457783 0.11 ENST00000263925.7
ENST00000512247.1
LNX1
ligand of numb-protein X 1, E3 ubiquitin protein ligase
chrX_-_30327495 0.11 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr3_-_38992052 0.11 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr9_-_72374848 0.11 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr7_+_142982023 0.11 ENST00000359333.3
ENST00000409244.1
ENST00000409541.1
ENST00000410004.1
TMEM139
transmembrane protein 139
chrX_+_76709648 0.11 ENST00000439435.1
FGF16
fibroblast growth factor 16
chr14_-_21492251 0.11 ENST00000554398.1
NDRG2
NDRG family member 2
chr8_+_37553261 0.10 ENST00000331569.4
ZNF703
zinc finger protein 703
chr5_-_162887054 0.10 ENST00000517501.1
NUDCD2
NudC domain containing 2
chr14_+_77228532 0.10 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr14_-_21492113 0.10 ENST00000554094.1
NDRG2
NDRG family member 2
chr3_+_9404526 0.10 ENST00000452837.2
ENST00000417036.1
ENST00000419437.1
ENST00000345094.3
ENST00000515662.2
THUMPD3
THUMP domain containing 3
chr7_-_140179276 0.10 ENST00000443720.2
ENST00000255977.2
MKRN1
makorin ring finger protein 1
chr11_+_63993738 0.10 ENST00000441250.2
ENST00000279206.3
NUDT22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
chr19_-_41196534 0.10 ENST00000252891.4
NUMBL
numb homolog (Drosophila)-like
chr7_+_5085452 0.10 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr3_-_51813009 0.10 ENST00000398780.3
IQCF6
IQ motif containing F6
chr22_+_31277661 0.10 ENST00000454145.1
ENST00000453621.1
ENST00000431368.1
ENST00000535268.1
OSBP2
oxysterol binding protein 2
chr1_+_154300217 0.10 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr2_+_179316163 0.10 ENST00000409117.3
DFNB59
deafness, autosomal recessive 59
chr5_+_145583156 0.10 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr4_+_48343339 0.10 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr1_-_173886491 0.10 ENST00000367698.3
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_+_61129456 0.10 ENST00000278826.6
TMEM138
transmembrane protein 138
chr11_-_77123065 0.09 ENST00000530617.1
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr17_+_42264395 0.09 ENST00000587989.1
ENST00000590235.1
TMUB2
transmembrane and ubiquitin-like domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 0.6 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.2 0.7 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.4 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.7 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.3 GO:0051598 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.1 0.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.6 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.4 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.3 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.2 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.9 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.1 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.3 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.2 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.2 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 0.2 GO:2001301 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.6 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.2 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.2 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.1 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.2 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.1 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 0.2 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.4 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.0 0.1 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309) positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.0 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.0 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 0.2 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0072719 cellular response to cisplatin(GO:0072719)
0.0 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.1 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071745 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.0 GO:0043159 acrosomal matrix(GO:0043159)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.4 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.8 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.3 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.3 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 0.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.2 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.1 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0019961 interferon binding(GO:0019961)
0.0 0.6 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.0 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.0 GO:0004040 amidase activity(GO:0004040)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo