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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for THRB

Z-value: 0.31

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24207039_24207086-0.087.2e-01Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_77997785 1.36 ENST00000478255.1
AK5
adenylate kinase 5
chr20_+_37434329 1.05 ENST00000299824.1
ENST00000373331.2
PPP1R16B
protein phosphatase 1, regulatory subunit 16B
chr10_+_35456444 0.47 ENST00000361599.4
CREM
cAMP responsive element modulator
chr6_-_99842041 0.42 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr11_+_5617976 0.30 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr7_-_38394118 0.29 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr11_+_5617858 0.28 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr14_+_75761099 0.22 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr22_+_19938419 0.20 ENST00000412786.1
COMT
catechol-O-methyltransferase
chr11_-_18747727 0.20 ENST00000513874.1
IGSF22
immunoglobulin superfamily, member 22
chr8_-_100905925 0.19 ENST00000518171.1
COX6C
cytochrome c oxidase subunit VIc
chr8_+_19674651 0.19 ENST00000397977.3
INTS10
integrator complex subunit 10
chr1_-_113498616 0.17 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr11_+_57310114 0.17 ENST00000527972.1
ENST00000399154.2
SMTNL1
smoothelin-like 1
chr6_+_42883727 0.17 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr11_+_5617952 0.17 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr12_-_21810726 0.16 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr8_-_100905850 0.16 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C
cytochrome c oxidase subunit VIc
chr12_-_21810765 0.15 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr16_+_72088376 0.14 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr1_-_113498943 0.14 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chrX_+_101854096 0.13 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr8_-_100905363 0.13 ENST00000524245.1
COX6C
cytochrome c oxidase subunit VIc
chr20_+_3024266 0.12 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
GNRH2
gonadotropin-releasing hormone 2
chr9_-_139268068 0.11 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr17_-_73840415 0.11 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr5_+_131746575 0.10 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr7_-_100253993 0.09 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr10_+_62538248 0.09 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr9_+_100069933 0.08 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chr15_-_101084446 0.07 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
CERS3
ceramide synthase 3
chr2_-_9563319 0.07 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr3_+_50606577 0.07 ENST00000434410.1
ENST00000232854.4
HEMK1
HemK methyltransferase family member 1
chr10_+_62538089 0.07 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr15_-_101084547 0.07 ENST00000394113.1
CERS3
ceramide synthase 3
chr4_+_114214125 0.06 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr17_+_1646130 0.06 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr11_+_73498898 0.06 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr3_+_50606901 0.05 ENST00000455834.1
HEMK1
HemK methyltransferase family member 1
chr8_-_124037890 0.04 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr10_+_60145155 0.04 ENST00000373895.3
TFAM
transcription factor A, mitochondrial
chr1_+_32712815 0.04 ENST00000373582.3
FAM167B
family with sequence similarity 167, member B
chr8_+_28174649 0.04 ENST00000301908.3
PNOC
prepronociceptin
chrY_-_1461617 0.03 ENSTR0000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr11_-_47399942 0.03 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr19_-_9003586 0.03 ENST00000380951.5
MUC16
mucin 16, cell surface associated
chr11_+_46366918 0.03 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr7_+_102937869 0.03 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
PMPCB
peptidase (mitochondrial processing) beta
chr1_+_3668962 0.02 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr19_-_52643157 0.02 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
ZNF616
zinc finger protein 616
chr8_+_105352050 0.01 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr17_+_7533439 0.01 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr19_+_55085248 0.01 ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
LILRA2
LILRB1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr11_-_47400078 0.01 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr17_-_73840774 0.00 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr15_+_35838396 0.00 ENST00000501169.2
DPH6-AS1
DPH6 antisense RNA 1 (head to head)

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.3 1.4 GO:0009183 ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183)
0.1 0.3 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.6 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.2 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.4 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.0 GO:0036502 Derlin-1-VIMP complex(GO:0036502)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade