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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for THRB
Z-value: 0.31
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Transcription factors associated with THRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| THRB | hg19_v2_chr3_-_24207039_24207086 | -0.08 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_77997785 Show fit | 1.36 |
ENST00000478255.1
|
adenylate kinase 5 |
|
| chr20_+_37434329 Show fit | 1.05 |
ENST00000299824.1
ENST00000373331.2 |
protein phosphatase 1, regulatory subunit 16B |
|
| chr10_+_35456444 Show fit | 0.47 |
ENST00000361599.4
|
cAMP responsive element modulator |
|
| chr6_-_99842041 Show fit | 0.42 |
ENST00000254759.3
ENST00000369242.1 |
coenzyme Q3 methyltransferase |
|
| chr11_+_5617976 Show fit | 0.30 |
ENST00000445329.1
|
tripartite motif containing 6 |
|
| chr7_-_38394118 Show fit | 0.29 |
ENST00000390345.2
|
T cell receptor gamma variable 4 |
|
| chr11_+_5617858 Show fit | 0.28 |
ENST00000380097.3
|
tripartite motif containing 6 |
|
| chr14_+_75761099 Show fit | 0.22 |
ENST00000561000.1
ENST00000558575.1 |
RP11-293M10.5 |
|
| chr22_+_19938419 Show fit | 0.20 |
ENST00000412786.1
|
catechol-O-methyltransferase |
|
| chr11_-_18747727 Show fit | 0.20 |
ENST00000513874.1
|
immunoglobulin superfamily, member 22 |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0009183 | ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) |
| 0.3 | 1.0 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.1 | 0.6 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.0 | 0.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.4 | GO:0010566 | regulation of ketone biosynthetic process(GO:0010566) |
| 0.1 | 0.3 | GO:0015728 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
| 0.0 | 0.3 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.2 | GO:0016036 | cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668) |
| 0.0 | 0.2 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.0 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.5 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.4 | GO:0008169 | C-methyltransferase activity(GO:0008169) |
| 0.1 | 0.3 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
| 0.0 | 0.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.6 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.2 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |