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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TLX1_NFIC
Z-value: 1.31
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Transcription factors associated with TLX1_NFIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg19_v2_chr19_+_3366547_3366619 | 0.21 | 3.2e-01 | Click! |
| TLX1 | hg19_v2_chr10_+_102891048_102891078 | 0.18 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_74372662 Show fit | 6.40 |
ENST00000591651.1
ENST00000545180.1 |
sphingosine kinase 1 |
|
| chr15_+_89182178 Show fit | 6.38 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182156 Show fit | 6.27 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr1_+_110453109 Show fit | 5.63 |
ENST00000525659.1
|
colony stimulating factor 1 (macrophage) |
|
| chr15_+_89181974 Show fit | 5.56 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr8_-_80680078 Show fit | 5.44 |
ENST00000337919.5
ENST00000354724.3 |
hes-related family bHLH transcription factor with YRPW motif 1 |
|
| chr6_-_31550192 Show fit | 5.43 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr1_+_79086088 Show fit | 5.10 |
ENST00000370751.5
ENST00000342282.3 |
interferon-induced protein 44-like |
|
| chr11_-_128457446 Show fit | 4.68 |
ENST00000392668.4
|
v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
|
| chr1_+_101185290 Show fit | 4.46 |
ENST00000370119.4
ENST00000347652.2 ENST00000294728.2 ENST00000370115.1 |
vascular cell adhesion molecule 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 18.7 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 3.6 | 18.2 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.8 | 9.3 | GO:0098795 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 8.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 2.1 | 6.4 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 1.4 | 5.4 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820) |
| 0.7 | 5.4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.7 | 5.2 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.6 | 5.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.6 | 4.7 | GO:0030578 | PML body organization(GO:0030578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 18.7 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.2 | 17.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 9.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 8.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 6.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 1.5 | 4.5 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 4.0 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 3.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 2.8 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 18.7 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 6.1 | 18.2 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 12.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 9.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 9.2 | GO:0004386 | helicase activity(GO:0004386) |
| 1.1 | 6.4 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 6.4 | GO:0008201 | heparin binding(GO:0008201) |
| 1.4 | 5.4 | GO:0035939 | microsatellite binding(GO:0035939) |
| 1.3 | 5.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 4.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 16.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 10.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 7.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 6.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 6.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 4.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 4.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 3.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 3.2 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 8.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.2 | 6.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 6.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 5.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 5.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 3.7 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.1 | 2.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.8 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |