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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TLX1_NFIC

Z-value: 1.31

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
TLX1
ENSG00000107807.8 T cell leukemia homeobox 1
NFIC
ENSG00000141905.13 nuclear factor I C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFIChg19_v2_chr19_+_3366547_33666190.213.2e-01Click!
TLX1hg19_v2_chr10_+_102891048_1028910780.183.9e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_74372662 6.40 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr15_+_89182178 6.38 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 6.27 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_110453109 5.63 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr15_+_89181974 5.56 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr8_-_80680078 5.44 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr6_-_31550192 5.43 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr1_+_79086088 5.10 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr11_-_128457446 4.68 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr1_+_101185290 4.46 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
VCAM1
vascular cell adhesion molecule 1
chr1_+_110453203 4.42 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr2_+_102721023 4.39 ENST00000409589.1
ENST00000409329.1
IL1R1
interleukin 1 receptor, type I
chr1_+_110453608 4.36 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr1_-_173020056 4.19 ENST00000239468.2
ENST00000404377.3
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr6_+_14117872 4.18 ENST00000379153.3
CD83
CD83 molecule
chr8_+_104384616 4.14 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr1_+_110453462 3.73 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr16_+_57662419 3.66 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr15_+_71228826 3.63 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr7_+_143079000 3.63 ENST00000392910.2
ZYX
zyxin
chr16_+_57662138 3.57 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
GPR56
G protein-coupled receptor 56
chr15_-_40213080 3.50 ENST00000561100.1
GPR176
G protein-coupled receptor 176
chr7_+_143078652 3.39 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr17_+_77030267 3.37 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr21_+_33784670 3.20 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chr6_+_150920999 3.11 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr21_+_33784957 3.09 ENST00000401402.3
ENST00000382699.3
EVA1C
eva-1 homolog C (C. elegans)
chr6_-_43595039 3.05 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr1_-_173174681 2.91 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_-_130487143 2.85 ENST00000419060.1
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr7_+_116165038 2.83 ENST00000393470.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr14_+_73704201 2.82 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr5_+_113697983 2.75 ENST00000264773.3
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr15_-_72523454 2.59 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
PKM
pyruvate kinase, muscle
chr11_-_57089671 2.54 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr15_-_72523924 2.51 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
PKM
pyruvate kinase, muscle
chr1_+_113217345 2.39 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_+_113217043 2.37 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_+_113217309 2.33 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr4_-_120549163 2.21 ENST00000394439.1
ENST00000420633.1
PDE5A
phosphodiesterase 5A, cGMP-specific
chr1_+_113217073 2.18 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_21168630 2.11 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr19_+_10397648 2.05 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397621 2.03 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr11_-_111637083 2.01 ENST00000427203.2
ENST00000341980.6
ENST00000311129.5
ENST00000393055.2
ENST00000426998.2
ENST00000527614.1
PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr15_+_45926919 1.86 ENST00000561735.1
ENST00000260324.7
SQRDL
sulfide quinone reductase-like (yeast)
chr17_-_48474828 1.86 ENST00000576448.1
ENST00000225972.7
LRRC59
leucine rich repeat containing 59
chr14_-_85996332 1.85 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr1_+_39456895 1.75 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr16_+_57653854 1.73 ENST00000568908.1
ENST00000568909.1
ENST00000566778.1
ENST00000561988.1
GPR56
G protein-coupled receptor 56
chr5_-_1112141 1.68 ENST00000264930.5
SLC12A7
solute carrier family 12 (potassium/chloride transporter), member 7
chr7_-_81399411 1.59 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_-_58613323 1.57 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr20_+_58251716 1.54 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr3_+_63953415 1.52 ENST00000484332.1
ATXN7
ataxin 7
chr2_-_37899323 1.46 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr21_-_37852359 1.45 ENST00000399137.1
ENST00000399135.1
CLDN14
claudin 14
chr2_+_234296792 1.44 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr6_-_53013620 1.42 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr22_-_46450024 1.34 ENST00000396008.2
ENST00000333761.1
C22orf26
chromosome 22 open reading frame 26
chr1_+_10271674 1.33 ENST00000377086.1
KIF1B
kinesin family member 1B
chr4_-_2758015 1.32 ENST00000510267.1
ENST00000503235.1
ENST00000315423.7
TNIP2
TNFAIP3 interacting protein 2
chr17_+_7461613 1.31 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr19_-_15087839 1.31 ENST00000600144.1
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr11_+_18417813 1.28 ENST00000540430.1
ENST00000379412.5
LDHA
lactate dehydrogenase A
chr16_-_46797149 1.24 ENST00000536476.1
MYLK3
myosin light chain kinase 3
chr1_-_200992827 1.24 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr5_-_114880533 1.23 ENST00000274457.3
FEM1C
fem-1 homolog c (C. elegans)
chr7_+_150065278 1.21 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr19_-_6737576 1.21 ENST00000601716.1
ENST00000264080.7
GPR108
G protein-coupled receptor 108
chr4_+_140222609 1.21 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr20_-_44519839 1.20 ENST00000372518.4
NEURL2
neuralized E3 ubiquitin protein ligase 2
chr1_+_27153173 1.18 ENST00000374142.4
ZDHHC18
zinc finger, DHHC-type containing 18
chr7_+_128355439 1.17 ENST00000315184.5
FAM71F1
family with sequence similarity 71, member F1
chr16_+_30662050 1.17 ENST00000568754.1
PRR14
proline rich 14
chr11_+_61717279 1.16 ENST00000378043.4
BEST1
bestrophin 1
chr11_+_61717336 1.13 ENST00000378042.3
BEST1
bestrophin 1
chr1_+_101003687 1.11 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chrX_-_83757399 1.10 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr1_+_156095951 1.10 ENST00000448611.2
ENST00000368297.1
LMNA
lamin A/C
chr8_-_42065075 1.10 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
PLAT
plasminogen activator, tissue
chr15_-_68724490 1.08 ENST00000315757.7
ENST00000423218.2
ITGA11
integrin, alpha 11
chr9_+_136399929 1.07 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr1_-_32264356 1.07 ENST00000452755.2
SPOCD1
SPOC domain containing 1
chr1_+_179262905 1.05 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr19_-_41388657 1.04 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr1_-_113247543 1.02 ENST00000414971.1
ENST00000534717.1
RHOC
ras homolog family member C
chr8_+_120428546 1.01 ENST00000259526.3
NOV
nephroblastoma overexpressed
chr14_-_76447494 1.00 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr20_+_61299155 1.00 ENST00000451793.1
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr17_+_7344057 0.98 ENST00000575398.1
ENST00000575082.1
FGF11
fibroblast growth factor 11
chr10_+_106034637 0.96 ENST00000401888.2
GSTO2
glutathione S-transferase omega 2
chr14_-_50999190 0.94 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr7_+_86274145 0.93 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3
glutamate receptor, metabotropic 3
chr17_-_73874654 0.93 ENST00000254816.2
TRIM47
tripartite motif containing 47
chr3_-_98620500 0.91 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr11_-_30607819 0.91 ENST00000448418.2
MPPED2
metallophosphoesterase domain containing 2
chr4_-_120548779 0.90 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr5_-_115872142 0.90 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_+_123100620 0.90 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr6_+_135502501 0.89 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr14_-_65569244 0.86 ENST00000557277.1
ENST00000556892.1
MAX
MYC associated factor X
chr2_+_27071045 0.84 ENST00000401478.1
DPYSL5
dihydropyrimidinase-like 5
chr8_-_42065187 0.84 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT
plasminogen activator, tissue
chr22_-_30960876 0.83 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr6_+_123100853 0.82 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr11_-_30608413 0.81 ENST00000528686.1
MPPED2
metallophosphoesterase domain containing 2
chr12_+_66217911 0.81 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr16_+_23765948 0.80 ENST00000300113.2
CHP2
calcineurin-like EF-hand protein 2
chr12_-_53207842 0.80 ENST00000458244.2
KRT4
keratin 4
chr1_+_156096336 0.79 ENST00000504687.1
ENST00000473598.2
LMNA
lamin A/C
chr12_-_109025849 0.78 ENST00000228463.6
SELPLG
selectin P ligand
chr8_-_145331153 0.78 ENST00000377412.4
KM-PA-2
KM-PA-2 protein; Uncharacterized protein
chr13_+_113622810 0.77 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr16_-_69385681 0.77 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr1_-_153538292 0.76 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr16_+_30751953 0.74 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr11_-_10715163 0.74 ENST00000541483.1
MRVI1
murine retrovirus integration site 1 homolog
chr14_+_24605361 0.73 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr5_+_140855495 0.73 ENST00000308177.3
PCDHGC3
protocadherin gamma subfamily C, 3
chr2_+_219187871 0.73 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr14_-_50999307 0.72 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_+_52083730 0.72 ENST00000282588.6
ENST00000274311.2
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chr22_-_37213045 0.72 ENST00000406910.2
ENST00000417718.2
PVALB
parvalbumin
chr11_-_10715502 0.71 ENST00000547195.1
MRVI1
murine retrovirus integration site 1 homolog
chr1_-_235491462 0.71 ENST00000418304.1
ENST00000264183.3
ENST00000349213.3
ARID4B
AT rich interactive domain 4B (RBP1-like)
chr4_+_66536248 0.69 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr22_+_25003606 0.69 ENST00000432867.1
GGT1
gamma-glutamyltransferase 1
chr11_+_5410607 0.69 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr6_+_29555683 0.68 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr1_+_200993071 0.68 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
RP11-168O16.1
chr8_-_145701718 0.68 ENST00000377317.4
FOXH1
forkhead box H1
chr6_+_36922209 0.67 ENST00000373674.3
PI16
peptidase inhibitor 16
chr2_+_228337079 0.66 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1
ArfGAP with FG repeats 1
chr5_+_67588391 0.66 ENST00000523872.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_+_7461580 0.65 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_+_48264816 0.65 ENST00000296435.2
ENST00000576243.1
CAMP
cathelicidin antimicrobial peptide
chr1_+_100818156 0.64 ENST00000336454.3
CDC14A
cell division cycle 14A
chr14_-_65569186 0.64 ENST00000555932.1
ENST00000358664.4
ENST00000284165.6
ENST00000358402.4
ENST00000246163.2
ENST00000556979.1
ENST00000555667.1
ENST00000557746.1
ENST00000556443.1
MAX
MYC associated factor X
chr20_-_50722183 0.64 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr11_+_71938925 0.63 ENST00000538751.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr11_-_10715287 0.62 ENST00000423302.2
MRVI1
murine retrovirus integration site 1 homolog
chr14_+_50999744 0.61 ENST00000441560.2
ATL1
atlastin GTPase 1
chr12_+_66218212 0.61 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
HMGA2
high mobility group AT-hook 2
chr1_-_27816556 0.60 ENST00000536657.1
WASF2
WAS protein family, member 2
chr9_+_35673853 0.59 ENST00000378357.4
CA9
carbonic anhydrase IX
chr3_-_191000172 0.59 ENST00000427544.2
UTS2B
urotensin 2B
chr19_+_46806856 0.59 ENST00000300862.3
HIF3A
hypoxia inducible factor 3, alpha subunit
chr8_+_22022653 0.58 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr11_+_74862032 0.58 ENST00000289575.5
ENST00000341411.4
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr9_-_23821842 0.57 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr2_-_25475120 0.57 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_+_57642886 0.57 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr17_+_7461849 0.57 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_+_7462031 0.57 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_85397167 0.56 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr17_-_37764128 0.56 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr19_+_11651942 0.56 ENST00000587087.1
CNN1
calponin 1, basic, smooth muscle
chr2_+_185463093 0.56 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr3_+_14058794 0.56 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
TPRXL
tetra-peptide repeat homeobox-like
chr3_-_155572164 0.56 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr3_-_12200851 0.55 ENST00000287814.4
TIMP4
TIMP metallopeptidase inhibitor 4
chr1_+_110453514 0.54 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr16_+_30662184 0.54 ENST00000300835.4
PRR14
proline rich 14
chr15_-_59665062 0.53 ENST00000288235.4
MYO1E
myosin IE
chr1_-_229569834 0.52 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr2_+_69001913 0.52 ENST00000409030.3
ENST00000409220.1
ARHGAP25
Rho GTPase activating protein 25
chr4_+_110834033 0.52 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr8_-_141728760 0.52 ENST00000430260.2
PTK2
protein tyrosine kinase 2
chr19_-_7764281 0.51 ENST00000360067.4
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr5_-_159546396 0.51 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr1_-_95392635 0.50 ENST00000538964.1
ENST00000394202.4
ENST00000370206.4
CNN3
calponin 3, acidic
chr1_+_172422026 0.50 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr1_-_120190396 0.50 ENST00000421812.2
ZNF697
zinc finger protein 697
chr16_-_51185172 0.50 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chr7_-_37024665 0.49 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr8_+_22022800 0.49 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr11_-_111783919 0.49 ENST00000531198.1
ENST00000533879.1
CRYAB
crystallin, alpha B
chr14_-_75330537 0.48 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chrX_-_70838306 0.48 ENST00000373691.4
ENST00000373693.3
CXCR3
chemokine (C-X-C motif) receptor 3
chr22_-_39640756 0.48 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr3_-_10547333 0.47 ENST00000383800.4
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr22_-_37213554 0.47 ENST00000443735.1
PVALB
parvalbumin
chr17_+_7461781 0.47 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_64764435 0.46 ENST00000534177.1
ENST00000301887.4
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr19_-_36247910 0.46 ENST00000587965.1
ENST00000004982.3
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr5_-_176923846 0.46 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr20_+_56136136 0.46 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chrX_+_144899314 0.45 ENST00000335565.4
SLITRK2
SLIT and NTRK-like family, member 2
chr3_-_52486841 0.45 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr1_+_100818009 0.44 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chrX_+_153770421 0.44 ENST00000369609.5
ENST00000369607.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr6_+_34204642 0.44 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr3_-_10547192 0.43 ENST00000360273.2
ENST00000343816.4
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr17_-_42277203 0.43 ENST00000587097.1
ATXN7L3
ataxin 7-like 3
chr2_+_228336849 0.43 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr3_+_53880588 0.43 ENST00000288167.3
ENST00000494338.1
IL17RB
interleukin 17 receptor B
chr3_+_181670131 0.42 ENST00000482787.3
ENST00000600750.1
ENST00000596820.1
ENST00000490001.1
ENST00000467313.1
ENST00000474045.1
RP11-416O18.1
RP11-416O18.1
chr5_+_72251857 0.42 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2
FCH domain only 2
chr4_+_54966198 0.42 ENST00000326902.2
ENST00000503800.1
GSX2
GS homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 18.7 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
3.6 18.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.1 6.4 GO:0046521 sphingoid catabolic process(GO:0046521)
1.5 4.4 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.4 5.4 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
1.0 4.2 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
1.0 2.9 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.9 2.8 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.8 9.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.7 5.2 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.7 5.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.6 5.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.6 4.5 GO:0022614 membrane to membrane docking(GO:0022614)
0.6 4.7 GO:0030578 PML body organization(GO:0030578)
0.5 4.2 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.4 3.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.4 3.4 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.4 1.2 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.4 1.9 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.4 1.8 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.4 3.9 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.4 1.4 GO:0060018 astrocyte fate commitment(GO:0060018)
0.3 1.3 GO:1904647 response to rotenone(GO:1904647)
0.3 0.9 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 1.1 GO:0061743 motor learning(GO:0061743)
0.3 2.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.3 1.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.3 0.8 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.3 1.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.7 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 2.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 0.7 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.2 0.2 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.2 0.8 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.2 1.9 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.2 0.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 2.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 1.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 1.0 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.2 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 1.3 GO:0023035 CD40 signaling pathway(GO:0023035)
0.1 0.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.4 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.5 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.7 GO:0090131 mesenchyme migration(GO:0090131)
0.1 1.0 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.7 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.4 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1 1.6 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 1.4 GO:0001675 acrosome assembly(GO:0001675)
0.1 0.4 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 1.5 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.5 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 2.0 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.1 0.6 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.1 0.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 1.3 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.5 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 0.8 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.1 0.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.5 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.5 GO:0048241 epinephrine transport(GO:0048241)
0.1 0.5 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 0.8 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 2.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 0.3 GO:1904640 response to methionine(GO:1904640)
0.1 1.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 0.6 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.7 GO:0060134 prepulse inhibition(GO:0060134)
0.1 1.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 3.5 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.1 1.1 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.1 1.9 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.4 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.3 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.1 1.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 2.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.4 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 8.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0070105 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 1.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.6 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 1.1 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.0 0.1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0 0.5 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.0 1.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.2 GO:1904970 brush border assembly(GO:1904970)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.5 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.3 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.3 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.5 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.0 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 2.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 0.7 GO:0007618 mating(GO:0007618)
0.0 0.3 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
0.0 0.5 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.0 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.4 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.9 GO:0048678 response to axon injury(GO:0048678)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 18.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.5 4.5 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.7 0.7 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.4 1.1 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
0.2 17.7 GO:0015030 Cajal body(GO:0015030)
0.2 1.9 GO:0005638 lamin filament(GO:0005638)
0.2 2.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 0.7 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.2 1.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.2 GO:0031415 NatA complex(GO:0031415)
0.1 0.7 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.7 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 2.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.1 GO:0060091 kinocilium(GO:0060091)
0.1 1.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 8.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 9.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.1 6.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0000322 storage vacuole(GO:0000322)
0.0 2.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 3.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 2.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 4.0 GO:0043197 dendritic spine(GO:0043197)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 3.4 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0005921 gap junction(GO:0005921)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0008859 exoribonuclease II activity(GO:0008859)
2.3 18.7 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.4 5.4 GO:0035939 microsatellite binding(GO:0035939)
1.3 5.1 GO:0004743 pyruvate kinase activity(GO:0004743)
1.1 4.4 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
1.1 6.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.9 2.8 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.6 4.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 2.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.5 2.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.4 1.4 GO:0035501 MH1 domain binding(GO:0035501)
0.3 1.6 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.3 1.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3 2.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 0.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 12.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.1 GO:0050436 microfibril binding(GO:0050436)
0.2 1.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.2 1.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.5 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.8 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.5 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.5 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 2.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 3.9 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 1.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 4.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.6 GO:0030226 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 4.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 3.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.6 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.8 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.7 GO:0043559 insulin binding(GO:0043559)
0.1 1.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.5 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.5 GO:0019863 IgE binding(GO:0019863)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.4 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0031013 troponin I binding(GO:0031013)
0.0 1.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 9.2 GO:0004386 helicase activity(GO:0004386)
0.0 1.0 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 1.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 3.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 6.4 GO:0008201 heparin binding(GO:0008201)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 9.3 GO:0005525 GTP binding(GO:0005525)
0.0 1.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.5 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 1.8 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0043531 ADP binding(GO:0043531)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 18.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 7.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 10.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 3.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 4.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 6.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 0.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.8 PID IL1 PATHWAY IL1-mediated signaling events
0.1 0.6 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 16.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.5 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.1 ST GAQ PATHWAY G alpha q Pathway
0.0 1.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 18.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 6.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 5.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 5.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 6.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 8.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.8 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.5 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.3 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 3.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis