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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for TP73

Z-value: 0.37

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.10 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3569129_3569150-0.203.4e-01Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_182641367 0.44 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr17_+_73750699 0.37 ENST00000584939.1
ITGB4
integrin, beta 4
chr19_+_44037546 0.34 ENST00000601282.1
ZNF575
zinc finger protein 575
chr2_-_26864228 0.31 ENST00000288861.4
CIB4
calcium and integrin binding family member 4
chr8_+_120885949 0.28 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr19_-_35981358 0.24 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr19_-_19626838 0.23 ENST00000360913.3
TSSK6
testis-specific serine kinase 6
chr1_-_203055129 0.21 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr6_+_155537771 0.20 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr19_+_45254529 0.17 ENST00000444487.1
BCL3
B-cell CLL/lymphoma 3
chr16_+_84178874 0.17 ENST00000378553.5
DNAAF1
dynein, axonemal, assembly factor 1
chr11_+_60197069 0.17 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr5_+_43120985 0.17 ENST00000515326.1
ZNF131
zinc finger protein 131
chr2_+_114163945 0.16 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr10_-_105238997 0.15 ENST00000369783.4
CALHM3
calcium homeostasis modulator 3
chr17_-_42200996 0.14 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr14_-_36983034 0.13 ENST00000518529.2
SFTA3
surfactant associated 3
chr3_-_48936272 0.13 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr8_-_145016692 0.12 ENST00000357649.2
PLEC
plectin
chr9_+_87285257 0.12 ENST00000323115.4
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr12_+_113495492 0.12 ENST00000257600.3
DTX1
deltex homolog 1 (Drosophila)
chr16_+_67197288 0.12 ENST00000264009.8
ENST00000421453.1
HSF4
heat shock transcription factor 4
chr21_+_43442100 0.12 ENST00000455701.1
ENST00000596595.1
ZNF295-AS1
ZNF295 antisense RNA 1
chr1_-_78444776 0.12 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr15_+_75498355 0.11 ENST00000567617.1
C15orf39
chromosome 15 open reading frame 39
chr7_-_128045984 0.11 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr14_+_103566665 0.11 ENST00000559116.1
EXOC3L4
exocyst complex component 3-like 4
chr16_-_8891481 0.11 ENST00000333050.6
TMEM186
transmembrane protein 186
chr5_-_141060389 0.11 ENST00000504448.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_+_100120441 0.11 ENST00000489752.1
LNP1
leukemia NUP98 fusion partner 1
chr14_+_75745477 0.10 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr1_-_78444738 0.10 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr15_+_74466744 0.10 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr14_+_75746340 0.10 ENST00000555686.1
ENST00000555672.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr7_-_100171270 0.10 ENST00000538735.1
SAP25
Sin3A-associated protein, 25kDa
chr12_-_117319236 0.10 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr17_+_37356528 0.09 ENST00000225430.4
RPL19
ribosomal protein L19
chr14_+_103566481 0.09 ENST00000380069.3
EXOC3L4
exocyst complex component 3-like 4
chr11_+_66234216 0.09 ENST00000349459.6
ENST00000320740.7
ENST00000524466.1
ENST00000526296.1
PELI3
pellino E3 ubiquitin protein ligase family member 3
chr17_+_37356586 0.09 ENST00000579260.1
ENST00000582193.1
RPL19
ribosomal protein L19
chr20_-_52790055 0.09 ENST00000395955.3
CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr1_-_111148241 0.09 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr16_+_222846 0.09 ENST00000251595.6
ENST00000397806.1
HBA2
hemoglobin, alpha 2
chr19_-_39226045 0.08 ENST00000597987.1
ENST00000595177.1
CAPN12
calpain 12
chr17_+_7792101 0.08 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr11_+_60197040 0.08 ENST00000300190.2
MS4A5
membrane-spanning 4-domains, subfamily A, member 5
chr5_+_38258511 0.08 ENST00000354891.3
ENST00000322350.5
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr17_+_37356555 0.08 ENST00000579374.1
RPL19
ribosomal protein L19
chr16_+_8891670 0.08 ENST00000268261.4
ENST00000539622.1
ENST00000569958.1
ENST00000537352.1
PMM2
phosphomannomutase 2
chr8_+_37654424 0.08 ENST00000315215.7
GPR124
G protein-coupled receptor 124
chr22_+_39966758 0.08 ENST00000407673.1
ENST00000401624.1
ENST00000404898.1
ENST00000402142.3
ENST00000336649.4
ENST00000400164.3
CACNA1I
calcium channel, voltage-dependent, T type, alpha 1I subunit
chr2_-_230135937 0.08 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
PID1
phosphotyrosine interaction domain containing 1
chr18_-_28681950 0.07 ENST00000251081.6
DSC2
desmocollin 2
chr22_-_37976082 0.07 ENST00000215886.4
LGALS2
lectin, galactoside-binding, soluble, 2
chr20_+_35504522 0.07 ENST00000602922.1
ENST00000217320.3
TLDC2
TBC/LysM-associated domain containing 2
chr3_+_136676707 0.07 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr3_+_136676851 0.07 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr12_-_57505121 0.07 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr17_-_2614927 0.06 ENST00000435359.1
CLUH
clustered mitochondria (cluA/CLU1) homolog
chr15_+_41136216 0.06 ENST00000562057.1
ENST00000344051.4
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr2_-_27357479 0.06 ENST00000406567.3
ENST00000260643.2
PREB
prolactin regulatory element binding
chr15_-_74043816 0.06 ENST00000379822.4
C15orf59
chromosome 15 open reading frame 59
chr19_+_41856816 0.06 ENST00000539627.1
TMEM91
transmembrane protein 91
chr14_+_72399833 0.06 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr3_-_185538849 0.06 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr11_-_65686496 0.06 ENST00000449692.3
C11orf68
chromosome 11 open reading frame 68
chr6_-_46703069 0.06 ENST00000538237.1
ENST00000274793.7
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr14_+_96858433 0.05 ENST00000267584.4
AK7
adenylate kinase 7
chr16_-_2581409 0.05 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
CEMP1
cementum protein 1
chr8_+_37654693 0.05 ENST00000412232.2
GPR124
G protein-coupled receptor 124
chr11_+_63449045 0.05 ENST00000354497.4
RTN3
reticulon 3
chr19_-_36233332 0.05 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGFLR1
IGF-like family receptor 1
chr12_-_91573249 0.05 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr6_+_31515337 0.05 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr13_-_48877795 0.05 ENST00000436963.1
ENST00000433480.2
LINC00441
long intergenic non-protein coding RNA 441
chr20_-_52790512 0.05 ENST00000216862.3
CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr8_+_63161491 0.05 ENST00000523211.1
ENST00000524201.1
NKAIN3
Na+/K+ transporting ATPase interacting 3
chr19_+_19627026 0.05 ENST00000608404.1
ENST00000555938.1
ENST00000503283.1
ENST00000512771.3
ENST00000428459.2
YJEFN3
CTC-260F20.3
NDUFA13
YjeF N-terminal domain containing 3
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr10_-_97200772 0.04 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr11_+_63448955 0.04 ENST00000377819.5
ENST00000339997.4
ENST00000540798.1
ENST00000545432.1
ENST00000543552.1
ENST00000537981.1
RTN3
reticulon 3
chr16_+_75032901 0.04 ENST00000335325.4
ENST00000320619.6
ZNRF1
zinc and ring finger 1, E3 ubiquitin protein ligase
chr11_+_63448918 0.04 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
RTN3
reticulon 3
chr5_+_125758813 0.04 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr1_+_26485511 0.04 ENST00000374268.3
FAM110D
family with sequence similarity 110, member D
chr16_+_21312170 0.04 ENST00000338573.5
ENST00000561968.1
CRYM-AS1
CRYM antisense RNA 1
chr3_+_42201653 0.04 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chr6_-_46703430 0.04 ENST00000537365.1
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_-_158485387 0.04 ENST00000243349.8
ACVR1C
activin A receptor, type IC
chr17_-_80059726 0.03 ENST00000583053.1
CCDC57
coiled-coil domain containing 57
chr9_-_138391692 0.03 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr10_-_91295304 0.03 ENST00000341233.4
ENST00000371790.4
SLC16A12
solute carrier family 16, member 12
chr5_+_125758865 0.03 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr17_-_39023462 0.03 ENST00000251643.4
KRT12
keratin 12
chr17_+_52978185 0.03 ENST00000572405.1
ENST00000572158.1
ENST00000540336.1
ENST00000572298.1
ENST00000536554.1
ENST00000575333.1
ENST00000570499.1
ENST00000572576.1
TOM1L1
target of myb1 (chicken)-like 1
chr14_-_105531759 0.02 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
GPR132
G protein-coupled receptor 132
chr1_-_52344471 0.02 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr20_+_48807351 0.02 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chrX_-_38186775 0.02 ENST00000339363.3
ENST00000309513.3
ENST00000338898.3
ENST00000342811.3
ENST00000378505.2
RPGR
retinitis pigmentosa GTPase regulator
chr9_+_6757634 0.02 ENST00000543771.1
ENST00000401787.3
ENST00000381306.3
ENST00000381309.3
KDM4C
lysine (K)-specific demethylase 4C
chrX_-_38186811 0.02 ENST00000318842.7
RPGR
retinitis pigmentosa GTPase regulator
chr12_+_44152740 0.02 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
IRAK4
interleukin-1 receptor-associated kinase 4
chr17_+_4835580 0.02 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr1_-_26197744 0.02 ENST00000374296.3
PAQR7
progestin and adipoQ receptor family member VII
chr17_-_47492236 0.02 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr10_+_70661014 0.02 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr5_-_135528822 0.02 ENST00000607574.1
AC009014.3
AC009014.3
chr17_+_54230819 0.02 ENST00000318698.2
ENST00000566473.2
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr10_-_79686284 0.02 ENST00000372391.2
ENST00000372388.2
DLG5
discs, large homolog 5 (Drosophila)
chr15_+_64680003 0.01 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr18_-_4455260 0.01 ENST00000581527.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_95940220 0.01 ENST00000542147.1
PROM2
prominin 2
chr17_-_42452063 0.01 ENST00000588098.1
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr2_+_220283091 0.01 ENST00000373960.3
DES
desmin
chr17_-_79818354 0.01 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr14_+_22554680 0.01 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr14_-_25519095 0.01 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chrX_+_153770421 0.01 ENST00000369609.5
ENST00000369607.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr14_-_25519317 0.01 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chr15_+_41136586 0.01 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr17_+_21191341 0.01 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr5_-_156593273 0.01 ENST00000302938.4
FAM71B
family with sequence similarity 71, member B
chr16_-_20367584 0.01 ENST00000570689.1
UMOD
uromodulin
chr11_+_75479850 0.01 ENST00000376262.3
ENST00000604733.1
DGAT2
diacylglycerol O-acyltransferase 2
chrX_+_72667090 0.01 ENST00000373514.2
CDX4
caudal type homeobox 4
chr19_+_17326521 0.01 ENST00000593597.1
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chrX_-_131228291 0.01 ENST00000370879.1
FRMD7
FERM domain containing 7
chr5_+_119799927 0.01 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16
chr19_+_45281118 0.00 ENST00000270279.3
ENST00000341505.4
CBLC
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr7_-_2883928 0.00 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr14_+_105190514 0.00 ENST00000330877.2
ADSSL1
adenylosuccinate synthase like 1
chr11_-_75062829 0.00 ENST00000393505.4
ARRB1
arrestin, beta 1
chr17_+_72427477 0.00 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_-_236228403 0.00 ENST00000366595.3
NID1
nidogen 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.1 GO:0042369 vitamin D catabolic process(GO:0042369)
0.0 0.1 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 0.2 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:2001170 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.2 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0042599 lamellar body(GO:0042599)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.0 GO:0052857 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions