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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for TWIST1_SNAI1
Z-value: 1.05
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Transcription factors associated with TWIST1_SNAI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SNAI1 | hg19_v2_chr20_+_48599506_48599536 | 0.12 | 5.7e-01 | Click! |
| TWIST1 | hg19_v2_chr7_-_19157248_19157295 | 0.06 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_160148356 Show fit | 6.85 |
ENST00000401980.3
ENST00000545162.1 |
superoxide dismutase 2, mitochondrial |
|
| chr18_-_71959159 Show fit | 4.67 |
ENST00000494131.2
ENST00000397914.4 ENST00000340533.4 |
cytochrome b5 type A (microsomal) |
|
| chr16_+_66638685 Show fit | 4.42 |
ENST00000565003.1
|
CKLF-like MARVEL transmembrane domain containing 3 |
|
| chr21_+_43639211 Show fit | 4.12 |
ENST00000450121.1
ENST00000398449.3 ENST00000361802.2 |
ATP-binding cassette, sub-family G (WHITE), member 1 |
|
| chr4_+_142557717 Show fit | 3.82 |
ENST00000320650.4
ENST00000296545.7 |
interleukin 15 |
|
| chr1_-_1149506 Show fit | 3.35 |
ENST00000379236.3
|
tumor necrosis factor receptor superfamily, member 4 |
|
| chr21_+_37507210 Show fit | 3.26 |
ENST00000290354.5
|
carbonyl reductase 3 |
|
| chr4_+_142557771 Show fit | 3.15 |
ENST00000514653.1
|
interleukin 15 |
|
| chr17_+_77030267 Show fit | 2.87 |
ENST00000581774.1
|
C1q and tumor necrosis factor related protein 1 |
|
| chr19_+_19322758 Show fit | 2.69 |
ENST00000252575.6
|
neurocan |
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.7 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 2.8 | 8.3 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.3 | 5.2 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.2 | 4.7 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 1.1 | 4.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 4.0 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.4 | 3.4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.2 | 3.4 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.7 | 3.3 | GO:1901662 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.1 | 3.0 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 6.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 4.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 4.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 3.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 3.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 2.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 1.8 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 8.7 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 8.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.2 | 6.1 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 5.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.4 | 4.1 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 1.1 | 3.3 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.0 | 3.3 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 3.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 2.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 2.9 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 8.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 4.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.9 | PID IFNG PATHWAY | IFN-gamma pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 3.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.2 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.2 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 1.7 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 1.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |