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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for UBP1

Z-value: 0.40

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Transcription factors associated with UBP1

Gene Symbol Gene ID Gene Info
UBP1
ENSG00000153560.7 upstream binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UBP1hg19_v2_chr3_-_33481835_334819050.106.5e-01Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_156587853 1.50 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_+_156588115 1.46 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_+_156587979 1.37 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr4_-_159080806 0.94 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr4_-_70626314 0.94 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr2_+_228678550 0.77 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr14_-_92413353 0.66 ENST00000556154.1
FBLN5
fibulin 5
chr14_-_92413727 0.40 ENST00000267620.10
FBLN5
fibulin 5
chr15_-_101835110 0.38 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr5_-_111093759 0.36 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
NREP
neuronal regeneration related protein
chr11_+_7506713 0.35 ENST00000329293.3
ENST00000534244.1
OLFML1
olfactomedin-like 1
chr1_-_182641367 0.33 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr2_+_162087577 0.23 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr2_-_163175133 0.20 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr5_-_93447333 0.20 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A
family with sequence similarity 172, member A
chr12_+_100041527 0.19 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr6_-_29395509 0.18 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr9_+_130853715 0.17 ENST00000373066.5
ENST00000432073.2
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chrX_+_78426469 0.16 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr5_-_132200477 0.16 ENST00000296875.2
GDF9
growth differentiation factor 9
chr2_+_170550944 0.16 ENST00000359744.3
ENST00000438838.1
ENST00000438710.1
ENST00000449906.1
ENST00000498202.2
ENST00000272797.4
PHOSPHO2
KLHL23
phosphatase, orphan 2
kelch-like family member 23
chr1_-_114302086 0.15 ENST00000369604.1
ENST00000357783.2
PHTF1
putative homeodomain transcription factor 1
chr4_-_76861392 0.14 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr15_-_77712477 0.13 ENST00000560626.2
PEAK1
pseudopodium-enriched atypical kinase 1
chr1_-_153599732 0.13 ENST00000392623.1
S100A13
S100 calcium binding protein A13
chr8_-_66474884 0.13 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr19_-_11039188 0.13 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr17_+_32683456 0.13 ENST00000225844.2
CCL13
chemokine (C-C motif) ligand 13
chr7_+_132937820 0.12 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr15_+_28624878 0.12 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr7_+_101460882 0.11 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr6_+_6588316 0.11 ENST00000379953.2
LY86
lymphocyte antigen 86
chr19_-_49864746 0.11 ENST00000598810.1
TEAD2
TEA domain family member 2
chrX_+_38420623 0.10 ENST00000378482.2
TSPAN7
tetraspanin 7
chr3_+_111260980 0.10 ENST00000438817.2
CD96
CD96 molecule
chr8_-_107782463 0.10 ENST00000311955.3
ABRA
actin-binding Rho activating protein
chr11_-_11374904 0.10 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr14_-_75330537 0.10 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr1_-_150208291 0.10 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr21_+_43823983 0.09 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
UBASH3A
ubiquitin associated and SH3 domain containing A
chrX_-_70474910 0.09 ENST00000373988.1
ENST00000373998.1
ZMYM3
zinc finger, MYM-type 3
chr3_-_100712352 0.09 ENST00000471714.1
ENST00000284322.5
ABI3BP
ABI family, member 3 (NESH) binding protein
chr8_+_28747884 0.09 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr19_+_41257084 0.09 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr12_+_9067123 0.09 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr22_+_22385332 0.08 ENST00000390282.2
IGLV4-69
immunoglobulin lambda variable 4-69
chr19_-_11039261 0.08 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr9_+_108463234 0.07 ENST00000374688.1
TMEM38B
transmembrane protein 38B
chr12_+_47473369 0.07 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr11_-_134123142 0.07 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr4_-_168155169 0.06 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr19_+_49661079 0.06 ENST00000355712.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr14_+_75988768 0.06 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chrX_+_115567767 0.06 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_-_10851762 0.05 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_8815299 0.05 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr22_+_22676808 0.04 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr5_+_150051149 0.04 ENST00000523553.1
MYOZ3
myozenin 3
chr5_-_131329918 0.04 ENST00000357096.1
ENST00000431707.1
ENST00000434099.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr19_+_49660997 0.04 ENST00000598691.1
ENST00000252826.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chrX_+_24167828 0.04 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chrX_-_65253506 0.04 ENST00000427538.1
VSIG4
V-set and immunoglobulin domain containing 4
chr12_-_8815215 0.03 ENST00000544889.1
ENST00000543369.1
MFAP5
microfibrillar associated protein 5
chrX_+_149887090 0.03 ENST00000538506.1
MTMR1
myotubularin related protein 1
chrX_+_24167746 0.03 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr1_-_150208363 0.03 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_202129105 0.03 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr16_-_20556492 0.03 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr4_-_168155730 0.02 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr15_+_34638066 0.02 ENST00000333756.4
NUTM1
NUT midline carcinoma, family member 1
chr22_+_22730353 0.02 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr1_-_202129704 0.02 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_-_48450534 0.02 ENST00000503633.1
ENST00000442592.3
ENST00000225969.4
MRPL27
mitochondrial ribosomal protein L27
chr4_-_47839966 0.02 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
CORIN
corin, serine peptidase
chr2_+_61244697 0.02 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr6_+_29429217 0.02 ENST00000396792.2
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr1_+_48688357 0.02 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chrX_+_74493896 0.02 ENST00000373383.4
ENST00000373379.1
UPRT
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr1_+_41174988 0.01 ENST00000372652.1
NFYC
nuclear transcription factor Y, gamma
chr1_+_47901689 0.01 ENST00000334793.5
FOXD2
forkhead box D2
chr1_-_168698433 0.01 ENST00000367817.3
DPT
dermatopontin
chr1_-_157014865 0.01 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr5_-_41510656 0.01 ENST00000377801.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr9_+_15422702 0.01 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr1_-_150208412 0.00 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr11_+_128761220 0.00 ENST00000529694.1
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr1_-_152332480 0.00 ENST00000388718.5
FLG2
filaggrin family member 2
chrX_+_13587712 0.00 ENST00000361306.1
ENST00000380602.3
EGFL6
EGF-like-domain, multiple 6

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.3 0.8 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.1 0.2 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0055099 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) response to high density lipoprotein particle(GO:0055099) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
0.0 0.1 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 4.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10