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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for UGCAUAG
Z-value: 0.51
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miRNA associated with seed UGCAUAG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-153-3p
|
MIMAT0000439 |
Network of associatons between targets according to the STRING database.
First level regulatory network of UGCAUAG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.1 | 1.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 1.5 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.2 | 1.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 1.3 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.2 | 1.2 | GO:0051945 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.1 | 1.2 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 1.1 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.3 | 0.9 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.3 | 0.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 1.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 0.9 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 0.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.9 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.2 | 1.5 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.2 | 1.2 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 1.2 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 1.1 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.3 | 1.0 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.1 | 0.9 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.6 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |