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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for VAX2_RHOXF2

Z-value: 0.40

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
ENSG00000116035.2 ventral anterior homeobox 2
ENSG00000131721.4 Rhox homeobox family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX2hg19_v2_chr2_+_71127699_711277440.301.5e-01Click!
RHOXF2hg19_v2_chrX_+_119292467_119292467-0.291.7e-01Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186696425 1.68 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr1_+_35258592 0.94 ENST00000342280.4
ENST00000450137.1
gap junction protein, alpha 4, 37kDa
chr6_+_130339710 0.51 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr12_-_10022735 0.41 ENST00000228438.2
C-type lectin domain family 2, member B
chr3_-_112127981 0.41 ENST00000486726.2
RP11-231E6.1
chr20_-_29978286 0.36 ENST00000376315.2
defensin, beta 119
chr3_-_141747950 0.34 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_-_3469181 0.34 ENST00000366116.2
Uncharacterized protein
chr17_-_41466555 0.33 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr19_-_36001113 0.31 ENST00000434389.1
dermokine
chr4_-_138453606 0.28 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
protocadherin 18
chr4_+_66536248 0.27 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr7_+_12727250 0.26 ENST00000404894.1
ADP-ribosylation factor-like 4A
chr2_+_103089756 0.24 ENST00000295269.4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr20_-_33735070 0.23 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
ER degradation enhancer, mannosidase alpha-like 2
chr1_+_62439037 0.22 ENST00000545929.1
InaD-like (Drosophila)
chr1_-_211307404 0.22 ENST00000367007.4
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr12_+_131438443 0.22 ENST00000261654.5
G protein-coupled receptor 133
chr1_-_190446759 0.20 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr2_-_198540719 0.19 ENST00000295049.4
raftlin family member 2
chr11_+_71900703 0.19 ENST00000393681.2
folate receptor 1 (adult)
chr11_+_71900572 0.19 ENST00000312293.4
folate receptor 1 (adult)
chr2_-_74618964 0.19 ENST00000417090.1
ENST00000409868.1
dynactin 1
chr16_-_30122717 0.19 ENST00000566613.1
glycerophosphodiester phosphodiesterase domain containing 3
chr2_-_74619152 0.19 ENST00000440727.1
ENST00000409240.1
dynactin 1
chr11_-_5323226 0.17 ENST00000380224.1
olfactory receptor, family 51, subfamily B, member 4
chr13_+_36050881 0.16 ENST00000537702.1
neurobeachin
chr10_+_6779326 0.16 ENST00000417112.1
RP11-554I8.2
chr17_+_43238438 0.15 ENST00000593138.1
ENST00000586681.1
hexamethylene bis-acetamide inducible 2
chr1_-_201140673 0.15 ENST00000367333.2
transmembrane protein 9
chrX_-_18690210 0.14 ENST00000379984.3
retinoschisin 1
chr9_-_95166841 0.14 ENST00000262551.4
osteoglycin
chr9_+_125133315 0.14 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125132803 0.14 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr10_-_50396407 0.13 ENST00000374153.2
ENST00000374151.3
chromosome 10 open reading frame 128
chr3_-_151034734 0.13 ENST00000260843.4
G protein-coupled receptor 87
chr15_+_74218787 0.13 ENST00000261921.7
lysyl oxidase-like 1
chr4_-_66536196 0.12 ENST00000511294.1
EPH receptor A5
chr1_-_67266939 0.12 ENST00000304526.2
insulin-like 5
chr20_-_50418947 0.12 ENST00000371539.3
spalt-like transcription factor 4
chr15_+_49462434 0.11 ENST00000558145.1
ENST00000543495.1
ENST00000544523.1
ENST00000560138.1
galactokinase 2
chr20_-_50418972 0.11 ENST00000395997.3
spalt-like transcription factor 4
chr5_+_176811431 0.11 ENST00000512593.1
ENST00000324417.5
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr15_+_49462397 0.11 ENST00000396509.2
galactokinase 2
chr7_+_99717230 0.10 ENST00000262932.3
canopy FGF signaling regulator 4
chr4_+_88754113 0.10 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr9_-_21202204 0.10 ENST00000239347.3
interferon, alpha 7
chr17_-_38545799 0.10 ENST00000577541.1
topoisomerase (DNA) II alpha 170kDa
chr14_+_32798547 0.10 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr4_-_138453559 0.10 ENST00000511115.1
protocadherin 18
chr12_-_118797475 0.09 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr15_+_80351910 0.09 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr15_+_80351977 0.09 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr10_-_17171817 0.09 ENST00000377833.4
cubilin (intrinsic factor-cobalamin receptor)
chr17_-_39203519 0.09 ENST00000542137.1
ENST00000391419.3
keratin associated protein 2-1
chr12_-_9760482 0.09 ENST00000229402.3
killer cell lectin-like receptor subfamily B, member 1
chr16_+_53133070 0.09 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chrX_+_72783026 0.09 ENST00000373504.6
ENST00000373502.5
cysteine-rich hydrophobic domain 1
chr15_+_58702742 0.09 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr21_+_17443434 0.09 ENST00000400178.2
long intergenic non-protein coding RNA 478
chr17_+_48823896 0.08 ENST00000511974.1
LUC7-like 3 (S. cerevisiae)
chr15_-_89755034 0.08 ENST00000563254.1
retinaldehyde binding protein 1
chr1_+_153747746 0.08 ENST00000368661.3
solute carrier family 27 (fatty acid transporter), member 3
chr4_+_159727272 0.08 ENST00000379346.3
folliculin interacting protein 2
chr7_+_115862858 0.08 ENST00000393481.2
testis derived transcript (3 LIM domains)
chr21_+_17443521 0.08 ENST00000456342.1
long intergenic non-protein coding RNA 478
chr4_+_76481258 0.08 ENST00000311623.4
ENST00000435974.2
chromosome 4 open reading frame 26
chr20_-_50419055 0.07 ENST00000217086.4
spalt-like transcription factor 4
chr14_-_39639523 0.07 ENST00000330149.5
ENST00000554018.1
ENST00000347691.5
trafficking protein particle complex 6B
chr14_+_74034310 0.07 ENST00000538782.1
acyl-CoA thioesterase 2
chr1_-_24151903 0.07 ENST00000436439.2
ENST00000374490.3
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr21_+_17442799 0.07 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
long intergenic non-protein coding RNA 478
chr19_+_11071546 0.07 ENST00000358026.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr6_+_3259148 0.07 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
proteasome (prosome, macropain) assembly chaperone 4
chrX_+_135730297 0.07 ENST00000370629.2
CD40 ligand
chr4_-_25865159 0.06 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_-_5304432 0.06 ENST00000416837.1
ENST00000308420.3
relaxin 2
chrX_+_43515467 0.06 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr5_+_129083772 0.06 ENST00000564719.1
KIAA1024-like
chr9_-_95166884 0.06 ENST00000375561.5
osteoglycin
chr12_-_10959892 0.06 ENST00000240615.2
taste receptor, type 2, member 8
chr5_-_89770582 0.06 ENST00000316610.6
metallo-beta-lactamase domain containing 2
chr1_+_54569968 0.06 ENST00000391366.1
Uncharacterized protein
chr5_+_174151536 0.06 ENST00000239243.6
ENST00000507785.1
msh homeobox 2
chr9_+_12693336 0.06 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chrX_+_135730373 0.06 ENST00000370628.2
CD40 ligand
chr17_-_38821373 0.06 ENST00000394052.3
keratin 222
chr7_-_44122063 0.06 ENST00000335195.6
ENST00000395831.3
ENST00000414235.1
ENST00000452049.1
ENST00000242248.5
polymerase (DNA directed), mu
chr5_+_89770664 0.05 ENST00000503973.1
ENST00000399107.1
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chrX_+_7137475 0.05 ENST00000217961.4
steroid sulfatase (microsomal), isozyme S
chr17_-_18430160 0.05 ENST00000392176.3
family with sequence similarity 106, member A
chr4_+_80584903 0.05 ENST00000506460.1
RP11-452C8.1
chr5_+_89770696 0.05 ENST00000504930.1
ENST00000514483.1
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr12_-_6233828 0.05 ENST00000572068.1
ENST00000261405.5
von Willebrand factor
chr18_-_44181442 0.05 ENST00000398722.4
lipoxygenase homology domains 1
chr19_+_50016610 0.05 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_191000172 0.05 ENST00000427544.2
urotensin 2B
chr1_-_212965104 0.05 ENST00000422588.2
ENST00000366975.6
ENST00000366977.3
ENST00000366976.1
NSL1, MIS12 kinetochore complex component
chr20_-_29978383 0.04 ENST00000339144.3
ENST00000376321.3
defensin, beta 119
chr14_+_32798462 0.04 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr1_+_212965170 0.04 ENST00000532324.1
ENST00000366974.4
ENST00000530441.1
ENST00000526641.1
ENST00000531963.1
ENST00000366973.4
ENST00000526997.1
ENST00000488246.2
TatD DNase domain containing 3
chr17_+_48823975 0.04 ENST00000513969.1
ENST00000503728.1
LUC7-like 3 (S. cerevisiae)
chr4_-_159956333 0.04 ENST00000434826.2
chromosome 4 open reading frame 45
chr11_-_111794446 0.04 ENST00000527950.1
crystallin, alpha B
chr17_+_40610862 0.04 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr7_-_99716952 0.04 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr9_-_21239978 0.03 ENST00000380222.2
interferon, alpha 14
chr6_-_82957433 0.03 ENST00000306270.7
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr4_-_74486347 0.03 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr17_-_10372875 0.03 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr20_+_15177480 0.03 ENST00000402914.1
MACRO domain containing 2
chr2_-_85555385 0.03 ENST00000377386.3
trans-golgi network protein 2
chr9_+_131062367 0.03 ENST00000601297.1
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr4_-_74486109 0.03 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr7_-_99717463 0.03 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_+_158519654 0.03 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr7_+_138145076 0.02 ENST00000343526.4
tripartite motif containing 24
chr1_-_152386732 0.02 ENST00000271835.3
cornulin
chr12_+_31812121 0.02 ENST00000395763.3
methyltransferase like 20
chr4_-_69111401 0.02 ENST00000332644.5
transmembrane protease, serine 11B
chr16_-_28608424 0.02 ENST00000335715.4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr2_+_228736321 0.02 ENST00000309931.2
dynein assembly factor with WDR repeat domains 1
chr7_+_148936732 0.02 ENST00000335870.2
zinc finger protein 212
chr14_+_56584414 0.02 ENST00000559044.1
pellino E3 ubiquitin protein ligase family member 2
chr3_+_157154578 0.02 ENST00000295927.3
pentraxin 3, long
chr10_-_99205607 0.02 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
exosome component 1
chr7_+_100860949 0.02 ENST00000305105.2
zinc finger, HIT-type containing 1
chr4_-_66536057 0.01 ENST00000273854.3
EPH receptor A5
chr11_+_101918153 0.01 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
chromosome 11 open reading frame 70
chr4_+_88896819 0.01 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr7_+_73245193 0.01 ENST00000340958.2
claudin 4
chr8_-_7243080 0.01 ENST00000400156.4
zinc finger protein 705G
chr7_-_121944491 0.01 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr15_+_58430567 0.01 ENST00000536493.1
aquaporin 9
chr12_+_16500037 0.01 ENST00000536371.1
ENST00000010404.2
microsomal glutathione S-transferase 1
chr7_-_100860851 0.01 ENST00000223127.3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr12_-_50643664 0.01 ENST00000550592.1
LIM domain and actin binding 1
chr15_+_58430368 0.01 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr14_+_20923350 0.01 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr2_-_40680578 0.01 ENST00000455476.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_-_149829244 0.01 ENST00000312037.5
ribosomal protein S14
chr16_+_72088376 0.01 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
haptoglobin
haptoglobin-related protein
chr5_-_20575959 0.00 ENST00000507958.1
cadherin 18, type 2
chr5_-_149829294 0.00 ENST00000401695.3
ribosomal protein S14
chr7_-_111032971 0.00 ENST00000450877.1
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr5_-_149829314 0.00 ENST00000407193.1
ribosomal protein S14
chr12_+_81110684 0.00 ENST00000228644.3
myogenic factor 5
chr3_+_152552685 0.00 ENST00000305097.3
purinergic receptor P2Y, G-protein coupled, 1

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 0.2 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 1.8 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:2000118 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.9 GO:0048265 response to pain(GO:0048265)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0006012 galactose metabolic process(GO:0006012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.2 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.0 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.4 GO:0070840 dynein complex binding(GO:0070840)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation