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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for VDR

Z-value: 0.62

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Transcription factors associated with VDR

Gene Symbol Gene ID Gene Info
VDR
ENSG00000111424.6 vitamin D receptor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VDRhg19_v2_chr12_-_48298785_482988280.038.8e-01Click!

Activity profile of VDR motif

Sorted Z-values of VDR motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_53313905 0.86 ENST00000377962.3
ENST00000448904.2
LECT1
leukocyte cell derived chemotaxin 1
chr3_+_54157480 0.66 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr17_-_34807272 0.52 ENST00000535592.1
ENST00000394453.1
TBC1D3G
TBC1 domain family, member 3G
chr17_-_34808047 0.52 ENST00000592614.1
ENST00000591542.1
ENST00000330458.7
ENST00000341264.6
ENST00000592987.1
ENST00000400684.4
TBC1D3G
TBC1D3H
TBC1 domain family, member 3G
TBC1 domain family, member 3H
chr17_-_36347835 0.50 ENST00000519532.1
TBC1D3
TBC1 domain family, member 3
chr17_-_34756219 0.49 ENST00000451448.2
ENST00000394359.3
TBC1D3C
TBC1D3H
TBC1 domain family, member 3C
TBC1 domain family, member 3H
chr17_-_36348610 0.49 ENST00000339023.4
ENST00000354664.4
TBC1D3
TBC1 domain family, member 3
chr8_-_93115445 0.48 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr19_+_13261216 0.47 ENST00000587885.1
ENST00000292433.3
IER2
immediate early response 2
chr17_+_36284791 0.46 ENST00000505415.1
TBC1D3F
TBC1 domain family, member 3F
chr16_-_67260691 0.46 ENST00000447579.1
ENST00000393992.1
ENST00000424285.1
LRRC29
leucine rich repeat containing 29
chr11_+_65266507 0.45 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr14_-_35873856 0.43 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr12_-_25348007 0.42 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr1_+_61869748 0.39 ENST00000357977.5
NFIA
nuclear factor I/A
chr16_-_75282088 0.35 ENST00000542031.2
BCAR1
breast cancer anti-estrogen resistance 1
chr21_+_25801041 0.34 ENST00000453784.2
ENST00000423581.1
AP000476.1
AP000476.1
chr16_-_30107491 0.32 ENST00000566134.1
ENST00000565110.1
ENST00000398841.1
ENST00000398838.4
YPEL3
yippee-like 3 (Drosophila)
chr17_-_34591208 0.31 ENST00000336331.5
TBC1D3C
TBC1 domain family, member 3C
chr6_-_32145101 0.31 ENST00000375104.2
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr22_+_18593507 0.30 ENST00000330423.3
TUBA8
tubulin, alpha 8
chr6_-_42016385 0.30 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3
cyclin D3
chr2_+_230787213 0.29 ENST00000409992.1
FBXO36
F-box protein 36
chr2_+_230787201 0.28 ENST00000283946.3
FBXO36
F-box protein 36
chr2_-_25194476 0.28 ENST00000534855.1
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr10_-_18940501 0.27 ENST00000377304.4
NSUN6
NOP2/Sun domain family, member 6
chr16_-_67281413 0.27 ENST00000258201.4
FHOD1
formin homology 2 domain containing 1
chr19_+_49122785 0.26 ENST00000598088.1
SPHK2
sphingosine kinase 2
chr1_+_35258592 0.26 ENST00000342280.4
ENST00000450137.1
GJA4
gap junction protein, alpha 4, 37kDa
chr6_+_125475335 0.26 ENST00000532429.1
ENST00000534199.1
TPD52L1
tumor protein D52-like 1
chr12_+_3069037 0.26 ENST00000397122.2
TEAD4
TEA domain family member 4
chr6_+_35227449 0.26 ENST00000373953.3
ENST00000440666.2
ENST00000339411.5
ZNF76
zinc finger protein 76
chr13_+_24844819 0.25 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr1_+_200993071 0.25 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
RP11-168O16.1
chr11_-_73882029 0.25 ENST00000539061.1
C2CD3
C2 calcium-dependent domain containing 3
chr1_-_205091115 0.25 ENST00000264515.6
ENST00000367164.1
RBBP5
retinoblastoma binding protein 5
chr12_-_56848426 0.25 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr1_+_44457261 0.24 ENST00000372318.3
CCDC24
coiled-coil domain containing 24
chr7_-_36764004 0.24 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr17_+_56270084 0.23 ENST00000225371.5
EPX
eosinophil peroxidase
chr9_+_131644781 0.23 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr16_-_68404908 0.23 ENST00000574662.1
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr19_+_49122548 0.23 ENST00000245222.4
ENST00000340932.3
ENST00000601712.1
ENST00000600537.1
SPHK2
sphingosine kinase 2
chr13_+_57721622 0.22 ENST00000377930.1
PRR20B
proline rich 20B
chrX_+_153770421 0.22 ENST00000369609.5
ENST00000369607.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr7_+_155089486 0.22 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr16_+_14802801 0.21 ENST00000526520.1
ENST00000531598.2
NPIPA3
nuclear pore complex interacting protein family, member A3
chr11_+_60869867 0.21 ENST00000347785.3
CD5
CD5 molecule
chr11_+_124609823 0.21 ENST00000412681.2
NRGN
neurogranin (protein kinase C substrate, RC3)
chr17_+_68100989 0.20 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_-_25874440 0.20 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr7_-_105029812 0.20 ENST00000482897.1
SRPK2
SRSF protein kinase 2
chr7_-_36764142 0.20 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr16_-_2770216 0.19 ENST00000302641.3
PRSS27
protease, serine 27
chr12_-_58135903 0.19 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_+_71789133 0.19 ENST00000348208.4
ENST00000265384.7
TJP2
tight junction protein 2
chr16_-_67217844 0.19 ENST00000563902.1
ENST00000561621.1
ENST00000290881.7
KIAA0895L
KIAA0895-like
chr15_+_40226304 0.19 ENST00000559624.1
ENST00000382727.2
ENST00000263791.5
ENST00000560648.1
EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr19_-_54693401 0.19 ENST00000338624.6
MBOAT7
membrane bound O-acyltransferase domain containing 7
chr5_+_133861790 0.18 ENST00000395003.1
PHF15
jade family PHD finger 2
chr7_-_16844611 0.18 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr15_-_31283798 0.18 ENST00000435680.1
ENST00000425768.1
MTMR10
myotubularin related protein 10
chr6_+_30525051 0.18 ENST00000376557.3
PRR3
proline rich 3
chr5_-_177210399 0.17 ENST00000510276.1
FAM153A
family with sequence similarity 153, member A
chr16_+_1128781 0.17 ENST00000293897.4
ENST00000562758.1
SSTR5
somatostatin receptor 5
chr10_-_33623826 0.17 ENST00000374867.2
NRP1
neuropilin 1
chr15_-_59225844 0.17 ENST00000380516.2
SLTM
SAFB-like, transcription modulator
chr6_+_131521120 0.17 ENST00000537868.1
AKAP7
A kinase (PRKA) anchor protein 7
chr2_+_177134134 0.17 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr17_-_43487741 0.17 ENST00000455881.1
ARHGAP27
Rho GTPase activating protein 27
chr11_-_61582579 0.17 ENST00000539419.1
ENST00000545245.1
ENST00000545405.1
ENST00000542506.1
FADS1
fatty acid desaturase 1
chr17_-_7082861 0.17 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr11_-_506316 0.16 ENST00000532055.1
ENST00000531540.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr3_+_48264816 0.16 ENST00000296435.2
ENST00000576243.1
CAMP
cathelicidin antimicrobial peptide
chr14_+_100531615 0.16 ENST00000392920.3
EVL
Enah/Vasp-like
chr19_+_18530146 0.16 ENST00000348495.6
ENST00000270061.7
SSBP4
single stranded DNA binding protein 4
chr5_+_175487692 0.16 ENST00000510151.1
FAM153B
family with sequence similarity 153, member B
chr11_-_4629388 0.16 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr6_-_117086873 0.16 ENST00000368557.4
FAM162B
family with sequence similarity 162, member B
chr15_+_41851211 0.16 ENST00000263798.3
TYRO3
TYRO3 protein tyrosine kinase
chr6_+_30524663 0.16 ENST00000376560.3
PRR3
proline rich 3
chr22_-_29663954 0.16 ENST00000216085.7
RHBDD3
rhomboid domain containing 3
chr19_-_47987419 0.16 ENST00000536339.1
ENST00000595554.1
ENST00000600271.1
ENST00000338134.3
KPTN
kaptin (actin binding protein)
chr14_+_95047744 0.16 ENST00000553511.1
ENST00000554633.1
ENST00000555681.1
ENST00000554276.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr8_+_24298597 0.15 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr5_+_177433973 0.15 ENST00000507848.1
FAM153C
family with sequence similarity 153, member C
chr17_-_6616678 0.15 ENST00000381074.4
ENST00000293800.6
ENST00000572352.1
ENST00000576323.1
ENST00000573648.1
SLC13A5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
chr10_+_54074033 0.15 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr8_+_24298531 0.15 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr1_-_19426149 0.15 ENST00000429347.2
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr10_-_106240032 0.15 ENST00000447860.1
RP11-127O4.3
RP11-127O4.3
chr14_+_89290965 0.15 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
TTC8
tetratricopeptide repeat domain 8
chr17_+_27895609 0.15 ENST00000581411.2
ENST00000301057.7
TP53I13
tumor protein p53 inducible protein 13
chr15_-_72563585 0.14 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr7_-_72722783 0.14 ENST00000428206.1
ENST00000252594.6
ENST00000310326.8
ENST00000438747.2
NSUN5
NOP2/Sun domain family, member 5
chr19_-_11494975 0.14 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr14_-_91884115 0.14 ENST00000389857.6
CCDC88C
coiled-coil domain containing 88C
chr22_-_24126145 0.14 ENST00000598975.1
AP000349.1
Uncharacterized protein
chr5_-_179051579 0.14 ENST00000505811.1
ENST00000515714.1
ENST00000513225.1
ENST00000503664.1
ENST00000356731.5
ENST00000523137.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_-_205326022 0.14 ENST00000367155.3
KLHDC8A
kelch domain containing 8A
chr16_+_31119615 0.14 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
BCKDK
branched chain ketoacid dehydrogenase kinase
chr12_+_52695617 0.14 ENST00000293525.5
KRT86
keratin 86
chr17_-_43487780 0.14 ENST00000532038.1
ENST00000528677.1
ARHGAP27
Rho GTPase activating protein 27
chr19_+_7599597 0.14 ENST00000414982.3
ENST00000450331.3
PNPLA6
patatin-like phospholipase domain containing 6
chr11_+_64808675 0.14 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr9_-_34376851 0.14 ENST00000297625.7
KIAA1161
KIAA1161
chr20_+_30028322 0.14 ENST00000376309.3
DEFB123
defensin, beta 123
chr3_-_178969403 0.14 ENST00000314235.5
ENST00000392685.2
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr4_-_36246060 0.13 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_532503 0.13 ENST00000412256.1
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr1_-_205326161 0.13 ENST00000367156.3
ENST00000606887.1
ENST00000607173.1
KLHDC8A
kelch domain containing 8A
chr20_+_58630972 0.13 ENST00000313426.1
C20orf197
chromosome 20 open reading frame 197
chr15_-_59225758 0.13 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
SLTM
SAFB-like, transcription modulator
chr2_-_203736452 0.13 ENST00000419460.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr10_-_104001231 0.13 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr11_-_111794446 0.12 ENST00000527950.1
CRYAB
crystallin, alpha B
chr7_+_155090271 0.12 ENST00000476756.1
INSIG1
insulin induced gene 1
chr2_+_210517895 0.12 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr19_-_5719860 0.12 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr11_+_73882311 0.12 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr20_+_48909240 0.12 ENST00000371639.3
RP11-290F20.1
RP11-290F20.1
chr3_+_13521665 0.12 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
HDAC11
histone deacetylase 11
chr10_-_5541525 0.12 ENST00000380332.3
CALML5
calmodulin-like 5
chr9_+_131038425 0.11 ENST00000320188.5
ENST00000608796.1
ENST00000419867.2
ENST00000418976.1
SWI5
SWI5 recombination repair homolog (yeast)
chr8_-_13134045 0.11 ENST00000512044.2
DLC1
deleted in liver cancer 1
chr8_-_135522425 0.11 ENST00000521673.1
ZFAT
zinc finger and AT hook domain containing
chr4_-_11430221 0.11 ENST00000514690.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr9_+_111624577 0.11 ENST00000333999.3
ACTL7A
actin-like 7A
chr12_-_114404111 0.11 ENST00000545145.2
ENST00000392561.3
ENST00000261741.5
RBM19
RNA binding motif protein 19
chr3_-_27763803 0.11 ENST00000449599.1
EOMES
eomesodermin
chr8_+_119294456 0.11 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr11_-_65667997 0.11 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr12_-_96390063 0.11 ENST00000541929.1
HAL
histidine ammonia-lyase
chr11_+_73882144 0.11 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr12_+_57857475 0.11 ENST00000528467.1
GLI1
GLI family zinc finger 1
chr22_+_39077947 0.11 ENST00000216034.4
TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr22_+_23213658 0.11 ENST00000390318.2
IGLV4-3
immunoglobulin lambda variable 4-3
chr7_-_151433393 0.11 ENST00000492843.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr2_+_38893208 0.11 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr7_-_151433342 0.11 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr12_+_110906169 0.11 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr19_+_39936267 0.11 ENST00000359191.6
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr3_-_27764190 0.11 ENST00000537516.1
EOMES
eomesodermin
chr5_-_177209832 0.11 ENST00000393518.3
ENST00000505531.1
ENST00000503567.1
FAM153A
family with sequence similarity 153, member A
chr2_+_233527443 0.10 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr11_-_65667884 0.10 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr11_-_6624801 0.10 ENST00000534343.1
ENST00000254605.6
RRP8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr11_-_82782861 0.10 ENST00000524635.1
ENST00000526205.1
ENST00000527633.1
ENST00000533486.1
ENST00000533276.2
RAB30
RAB30, member RAS oncogene family
chr19_+_39936186 0.10 ENST00000432763.2
ENST00000402194.2
ENST00000601515.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr20_-_23549334 0.10 ENST00000376979.3
CST9L
cystatin 9-like
chr5_+_175488258 0.10 ENST00000512862.1
FAM153B
family with sequence similarity 153, member B
chr9_-_139839064 0.10 ENST00000325285.3
ENST00000428398.1
FBXW5
F-box and WD repeat domain containing 5
chr2_-_25194963 0.10 ENST00000264711.2
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr2_-_85625857 0.10 ENST00000453973.1
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_41305085 0.10 ENST00000303961.4
EGLN2
egl-9 family hypoxia-inducible factor 2
chr16_-_87799505 0.10 ENST00000353170.5
ENST00000561825.1
ENST00000270583.5
ENST00000562261.1
ENST00000347925.5
KLHDC4
kelch domain containing 4
chr14_-_106781017 0.10 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr10_-_33623564 0.10 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr4_+_144434584 0.10 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr15_+_69307028 0.10 ENST00000388866.3
ENST00000530406.2
NOX5
NADPH oxidase, EF-hand calcium binding domain 5
chr9_+_130213774 0.09 ENST00000373324.4
ENST00000323301.4
LRSAM1
leucine rich repeat and sterile alpha motif containing 1
chr10_+_47894572 0.09 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr7_+_99699280 0.09 ENST00000421755.1
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr19_+_14017116 0.09 ENST00000589606.1
CC2D1A
coiled-coil and C2 domain containing 1A
chr19_+_50270219 0.09 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr8_+_23104130 0.09 ENST00000313219.7
ENST00000519984.1
CHMP7
charged multivesicular body protein 7
chr19_+_41281060 0.09 ENST00000594436.1
ENST00000597784.1
MIA
melanoma inhibitory activity
chr2_+_220363579 0.09 ENST00000313597.5
ENST00000373917.3
ENST00000358215.3
ENST00000373908.1
ENST00000455657.1
ENST00000435316.1
ENST00000341142.3
GMPPA
GDP-mannose pyrophosphorylase A
chr12_+_48876275 0.09 ENST00000314014.2
C12orf54
chromosome 12 open reading frame 54
chr1_+_26348259 0.09 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr1_+_153232160 0.09 ENST00000368742.3
LOR
loricrin
chr8_+_75736761 0.09 ENST00000260113.2
PI15
peptidase inhibitor 15
chr20_+_42193856 0.09 ENST00000412111.1
ENST00000423407.3
SGK2
serum/glucocorticoid regulated kinase 2
chr13_-_38172863 0.09 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr5_-_179227540 0.09 ENST00000520875.1
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr12_-_96390108 0.09 ENST00000538703.1
ENST00000261208.3
HAL
histidine ammonia-lyase
chr16_+_28834303 0.08 ENST00000340394.8
ENST00000325215.6
ENST00000395547.2
ENST00000336783.4
ENST00000382686.4
ENST00000564304.1
ATXN2L
ataxin 2-like
chr1_+_100111580 0.08 ENST00000605497.1
PALMD
palmdelphin
chr9_-_139343294 0.08 ENST00000313084.5
SEC16A
SEC16 homolog A (S. cerevisiae)
chr3_-_93781750 0.08 ENST00000314636.2
DHFRL1
dihydrofolate reductase-like 1
chr11_+_28129795 0.08 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr3_+_157154578 0.08 ENST00000295927.3
PTX3
pentraxin 3, long
chr16_-_28506840 0.08 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_+_92414952 0.08 ENST00000449584.1
ENST00000427104.1
ENST00000355011.3
ENST00000448194.1
ENST00000426141.1
ENST00000450792.1
ENST00000548992.1
ENST00000552654.1
ENST00000457265.1
BRDT
bromodomain, testis-specific
chr1_+_109234907 0.08 ENST00000370025.4
ENST00000370022.5
ENST00000370021.1
PRPF38B
pre-mRNA processing factor 38B
chr19_-_49122384 0.08 ENST00000550973.1
ENST00000550645.1
ENST00000549273.1
ENST00000552588.1
RPL18
ribosomal protein L18
chr19_+_41281282 0.08 ENST00000263369.3
MIA
melanoma inhibitory activity
chr2_-_232329186 0.08 ENST00000322723.4
NCL
nucleolin
chr1_+_36348790 0.08 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chr10_-_22292675 0.08 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr16_+_88636789 0.08 ENST00000301011.5
ENST00000452588.2
ZC3H18
zinc finger CCCH-type containing 18
chr14_+_105212297 0.08 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr12_+_53895364 0.08 ENST00000552817.1
ENST00000394357.2
TARBP2
TAR (HIV-1) RNA binding protein 2
chr10_-_76995769 0.08 ENST00000372538.3
COMTD1
catechol-O-methyltransferase domain containing 1
chr13_+_113656022 0.07 ENST00000423482.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_+_176957619 0.07 ENST00000392539.3
HOXD13
homeobox D13
chrX_+_149737046 0.07 ENST00000370396.2
ENST00000542741.1
ENST00000543350.1
ENST00000424519.1
ENST00000413012.2
MTM1
myotubularin 1
chr2_+_38893047 0.07 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr16_-_28937027 0.07 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr15_+_75940218 0.07 ENST00000308527.5
SNX33
sorting nexin 33

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1 0.3 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.6 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.2 GO:0002215 defense response to nematode(GO:0002215)
0.1 0.2 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 0.2 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.2 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.1 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0021997 neural plate axis specification(GO:0021997)
0.0 0.2 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.2 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.1 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.0 0.2 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 3.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.0 0.3 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0 0.1 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.0 0.1 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.0 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)
0.0 0.2 GO:0090154 sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.1 GO:1990523 response to vitamin K(GO:0032571) bone regeneration(GO:1990523)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692)
0.0 0.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.2 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0035701 immunoglobulin biosynthetic process(GO:0002378) hematopoietic stem cell migration(GO:0035701)
0.0 0.4 GO:0035729 cellular response to hepatocyte growth factor stimulus(GO:0035729)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.2 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.0 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0006853 carnitine shuttle(GO:0006853)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.2 GO:0036027 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.2 GO:0032044 DSIF complex(GO:0032044)
0.0 0.1 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.5 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0070362 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.2 GO:0015137 citrate transmembrane transporter activity(GO:0015137) succinate transmembrane transporter activity(GO:0015141) tricarboxylic acid transmembrane transporter activity(GO:0015142) sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins