ISMARA results: WRNIP1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for WRNIP1

Z-value: 1.88

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Transcription factors associated with WRNIP1

Gene Symbol	Gene ID	Gene Info
WRNIP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000124535.11	WRN helicase interacting protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WRNIP1	hg19_v2_chr6_+_2765595_2765797	-0.79	2.2e-06	Click!

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_29595779 Show fit	19.87	ENST00000355973.3 ENST00000377012.4	GABBR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) B receptor, 1
chr15_+_89182156 Show fit	13.01	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr6_-_31550192 Show fit	12.59	ENST00000429299.2 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphotoxin beta (TNF superfamily, member 3)
chr15_+_89182178 Show fit	10.61	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr11_-_60719213 Show fit	8.76	ENST00000227880.3	SLC15A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_89181974 Show fit	8.60	ENST00000306072.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr2_+_228678550 Show fit	8.49	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr4_-_120549163 Show fit	7.53	ENST00000394439.1 ENST00000420633.1	PDE5A Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 5A, cGMP-specific
chr5_-_150466692 Show fit	7.40	ENST00000315050.7 ENST00000523338.1 ENST00000522100.1	TNIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TNFAIP3 interacting protein 1
chr21_+_27011899 Show fit	6.69	ENST00000425221.2	JAM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	junctional adhesion molecule 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	35.9	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
6.5	32.3	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.6	26.7	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.6	18.2	GO:1902624	positive regulation of neutrophil migration(GO:1902624)
2.2	17.3	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.5	15.7	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1	14.6	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.3	13.8	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
3.1	12.4	GO:0002296	T-helper 1 cell lineage commitment(GO:0002296)
1.7	11.9	GO:0033590	response to cobalamin(GO:0033590)

Showing 1 to 10 of 1,281 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	68.1	GO:0005615	extracellular space(GO:0005615)
0.0	56.8	GO:0005887	integral component of plasma membrane(GO:0005887)
0.5	36.0	GO:0015030	Cajal body(GO:0015030)
0.0	31.7	GO:0000139	Golgi membrane(GO:0000139)
6.4	19.2	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1	18.5	GO:0005913	cell-cell adherens junction(GO:0005913)
2.6	18.4	GO:0042825	TAP complex(GO:0042825)
2.0	18.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	18.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	17.5	GO:0005581	collagen trimer(GO:0005581)

Showing 1 to 10 of 413 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	32.2	GO:0008859	exoribonuclease II activity(GO:0008859)
0.2	30.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.4	22.9	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.2	22.2	GO:0019903	protein phosphatase binding(GO:0019903)
0.1	22.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.0	21.0	GO:0046979	TAP2 binding(GO:0046979)
0.4	20.0	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
4.9	19.6	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.6	19.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3	15.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)

Showing 1 to 10 of 704 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	65.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	29.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	28.6	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	27.9	ST G ALPHA I PATHWAY	G alpha i Pathway
0.3	25.4	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	24.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	24.2	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.6	19.6	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.5	16.5	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.2	16.4	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 116 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	49.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	32.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.2	25.9	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3	23.8	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4	19.0	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.4	17.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.6	16.6	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.5	16.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.3	15.8	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.3	15.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling

Showing 1 to 10 of 194 entries

Results for WRNIP1

Z-value: 1.88

Motif logo

Transcription factors associated with WRNIP1

Activity-expression correlation:

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: