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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for WT1_MTF1_ZBTB7B
Z-value: 1.52
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Transcription factors associated with WT1_MTF1_ZBTB7B
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000184937.8 | WT1 transcription factor | |
| ENSG00000188786.9 | metal regulatory transcription factor 1 | |
| ENSG00000160685.9 | zinc finger and BTB domain containing 7B |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB7B | hg19_v2_chr1_+_154975258_154975330 | 0.51 | 8.8e-03 | Click! |
| MTF1 | hg19_v2_chr1_-_38325256_38325292 | -0.40 | 5.0e-02 | Click! |
| WT1 | hg19_v2_chr11_-_32452357_32452363, hg19_v2_chr11_-_32456891_32456906, hg19_v2_chr11_-_32457176_32457193 | -0.16 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_37903432 Show fit | 8.32 |
ENST00000443503.2
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr1_+_61548225 Show fit | 8.13 |
ENST00000371187.3
|
nuclear factor I/A |
|
| chr18_+_77155856 Show fit | 8.02 |
ENST00000253506.5
ENST00000591814.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr14_-_105635090 Show fit | 7.95 |
ENST00000331782.3
ENST00000347004.2 |
jagged 2 |
|
| chr7_+_74072288 Show fit | 7.19 |
ENST00000443166.1
|
general transcription factor IIi |
|
| chr9_+_139606983 Show fit | 7.15 |
ENST00000371692.4
|
family with sequence similarity 69, member B |
|
| chr11_-_2906979 Show fit | 7.13 |
ENST00000380725.1
ENST00000313407.6 ENST00000430149.2 ENST00000440480.2 ENST00000414822.3 |
cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
|
| chr1_+_61547894 Show fit | 6.72 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr1_+_25944341 Show fit | 6.56 |
ENST00000263979.3
|
mannosidase, alpha, class 1C, member 1 |
|
| chr22_+_51112800 Show fit | 6.32 |
ENST00000414786.2
|
SH3 and multiple ankyrin repeat domains 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of WT1_MTF1_ZBTB7B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 19.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 17.9 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 2.2 | 15.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 15.6 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 15.0 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 2.3 | 14.0 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 2.4 | 11.8 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 1.8 | 10.8 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 10.6 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.3 | 10.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 33.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 16.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.6 | 15.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 15.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.9 | 14.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 1.2 | 13.6 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.6 | 12.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.3 | 12.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 11.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 27.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 23.2 | GO:0008134 | transcription factor binding(GO:0008134) |
| 2.3 | 21.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 1.2 | 20.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 18.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.3 | 17.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.6 | 15.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 1.1 | 14.0 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.2 | 13.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 37.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 16.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.8 | 15.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 15.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 15.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.4 | 12.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.3 | 11.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 11.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 10.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.2 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 13.8 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.4 | 13.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.6 | 13.2 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.7 | 11.7 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.3 | 11.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 9.9 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 9.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.4 | 9.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 9.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |