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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 2.81
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.13 | Y-box binding protein 1 | |
| ENSG00000170345.5 | Fos proto-oncogene, AP-1 transcription factor subunit | |
| ENSG00000066136.15 | nuclear transcription factor Y subunit gamma | |
| ENSG00000001167.10 | nuclear transcription factor Y subunit alpha | |
| ENSG00000120837.3 | nuclear transcription factor Y subunit beta | |
| ENSG00000115816.9 | CCAAT enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFYC | hg19_v2_chr1_+_41204506_41204541 | 0.58 | 2.3e-03 | Click! |
| NFYB | hg19_v2_chr12_-_104531945_104531996 | 0.31 | 1.3e-01 | Click! |
| NFYA | hg19_v2_chr6_+_41040678_41040722 | -0.30 | 1.4e-01 | Click! |
| FOS | hg19_v2_chr14_+_75746340_75746373 | 0.29 | 1.5e-01 | Click! |
| YBX1 | hg19_v2_chr1_+_43148059_43148111 | -0.09 | 6.6e-01 | Click! |
| CEBPZ | hg19_v2_chr2_-_37458749_37458856 | 0.05 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_160183492 Show fit | 8.55 |
ENST00000541436.1
|
acetyl-CoA acetyltransferase 2 |
|
| chr3_+_8543393 Show fit | 7.11 |
ENST00000157600.3
ENST00000415597.1 ENST00000535732.1 |
LIM and cysteine-rich domains 1 |
|
| chr19_+_45973120 Show fit | 6.50 |
ENST00000592811.1
ENST00000586615.1 |
FBJ murine osteosarcoma viral oncogene homolog B |
|
| chr3_+_8543561 Show fit | 5.93 |
ENST00000397386.3
|
LIM and cysteine-rich domains 1 |
|
| chr14_-_91526922 Show fit | 5.18 |
ENST00000418736.2
ENST00000261991.3 |
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
|
| chr5_+_74632993 Show fit | 5.05 |
ENST00000287936.4
|
3-hydroxy-3-methylglutaryl-CoA reductase |
|
| chr14_+_53019822 Show fit | 5.02 |
ENST00000321662.6
|
G protein-coupled receptor 137C |
|
| chr14_-_53019211 Show fit | 5.01 |
ENST00000557374.1
ENST00000281741.4 |
thioredoxin domain containing 16 |
|
| chr17_-_47841485 Show fit | 4.66 |
ENST00000506156.1
ENST00000240364.2 |
family with sequence similarity 117, member A |
|
| chr5_+_74633036 Show fit | 4.65 |
ENST00000343975.5
|
3-hydroxy-3-methylglutaryl-CoA reductase |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.1 | GO:1902653 | secondary alcohol biosynthetic process(GO:1902653) |
| 2.5 | 17.7 | GO:0016129 | phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129) |
| 0.6 | 16.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.6 | 11.1 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.7 | 10.0 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.2 | 8.7 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724) |
| 2.7 | 8.0 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 7.7 | GO:0031424 | keratinization(GO:0031424) |
| 2.4 | 7.1 | GO:0015817 | acyl carnitine transport(GO:0006844) histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024) acyl carnitine transmembrane transport(GO:1902616) |
| 0.1 | 6.9 | GO:0045454 | cell redox homeostasis(GO:0045454) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 17.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 12.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 11.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 10.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.6 | 8.0 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 7.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 6.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.2 | 6.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 6.2 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.4 | 10.5 | GO:0070402 | NADPH binding(GO:0070402) |
| 2.3 | 9.2 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.5 | 9.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.1 | 8.5 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.2 | 8.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.3 | 8.2 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 1.3 | 8.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 8.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 2.4 | 7.1 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.2 | 8.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 8.4 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 8.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 4.8 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.3 | 4.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 4.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 4.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 58.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.4 | 12.6 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.5 | 9.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 7.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 6.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 6.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 6.0 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 6.0 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 6.0 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.1 | 5.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |