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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for YY1_YY2
Z-value: 1.07
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg19_v2_chr14_+_100705322_100705360 | 0.63 | 7.3e-04 | Click! |
| YY2 | hg19_v2_chrX_+_21874105_21874105 | 0.01 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.4 | 4.1 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.0 | 4.0 | GO:0034968 | histone lysine methylation(GO:0034968) |
| 0.0 | 4.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 3.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 3.6 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.2 | 3.5 | GO:1901725 | regulation of histone deacetylase activity(GO:1901725) |
| 0.0 | 3.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.6 | 3.3 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.0 | 3.3 | GO:0007286 | spermatid development(GO:0007286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 5.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 4.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 4.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 3.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 3.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 2.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.3 | 2.8 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.3 | 2.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.3 | 5.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 5.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.8 | 4.1 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.1 | 4.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 3.8 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 3.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 3.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 3.3 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.1 | 3.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 2.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.4 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 2.2 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 4.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 3.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 3.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.9 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.1 | 2.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 2.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |