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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZBTB3

Z-value: 0.42

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.7 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB3hg19_v2_chr11_-_62521614_625216600.039.0e-01Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_92414055 1.00 ENST00000342058.4
FBLN5
fibulin 5
chr14_-_92413353 0.90 ENST00000556154.1
FBLN5
fibulin 5
chr9_+_72002837 0.76 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr6_+_30850697 0.64 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr14_-_92413727 0.51 ENST00000267620.10
FBLN5
fibulin 5
chr16_-_19896220 0.42 ENST00000562469.1
ENST00000300571.2
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr5_-_94417339 0.40 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr5_-_94417314 0.39 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr1_-_154458520 0.38 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr6_+_29274403 0.38 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr17_-_7531121 0.36 ENST00000573566.1
ENST00000269298.5
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chr7_+_16793160 0.36 ENST00000262067.4
TSPAN13
tetraspanin 13
chr17_-_5487768 0.31 ENST00000269280.4
ENST00000345221.3
ENST00000262467.5
NLRP1
NLR family, pyrin domain containing 1
chr12_-_10022735 0.29 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_82782861 0.28 ENST00000524635.1
ENST00000526205.1
ENST00000527633.1
ENST00000533486.1
ENST00000533276.2
RAB30
RAB30, member RAS oncogene family
chr14_+_22538811 0.26 ENST00000390450.3
TRAV22
T cell receptor alpha variable 22
chrX_+_152240819 0.25 ENST00000421798.3
ENST00000535416.1
PNMA6C
PNMA6A
paraneoplastic Ma antigen family member 6C
paraneoplastic Ma antigen family member 6A
chr2_+_241631262 0.25 ENST00000337801.4
ENST00000429564.1
AQP12A
aquaporin 12A
chr2_+_42396574 0.25 ENST00000401738.3
EML4
echinoderm microtubule associated protein like 4
chr4_-_15939963 0.23 ENST00000259988.2
FGFBP1
fibroblast growth factor binding protein 1
chrX_+_69454505 0.22 ENST00000374521.3
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr19_-_19006920 0.22 ENST00000429504.2
ENST00000427170.2
CERS1
ceramide synthase 1
chr5_+_75379224 0.21 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr2_+_42396472 0.21 ENST00000318522.5
ENST00000402711.2
EML4
echinoderm microtubule associated protein like 4
chr7_-_38403077 0.21 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr1_+_211433275 0.20 ENST00000367005.4
RCOR3
REST corepressor 3
chr3_-_39322728 0.20 ENST00000541347.1
ENST00000412814.1
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr6_-_41122063 0.19 ENST00000426005.2
ENST00000437044.2
ENST00000373127.4
TREML1
triggering receptor expressed on myeloid cells-like 1
chr19_-_19006890 0.19 ENST00000247005.6
GDF1
growth differentiation factor 1
chr11_-_82782952 0.19 ENST00000534141.1
RAB30
RAB30, member RAS oncogene family
chr1_+_65210772 0.19 ENST00000371072.4
ENST00000294428.3
RAVER2
ribonucleoprotein, PTB-binding 2
chr5_+_75378997 0.19 ENST00000502798.2
SV2C
synaptic vesicle glycoprotein 2C
chr8_+_42196000 0.17 ENST00000518925.1
ENST00000538005.1
POLB
polymerase (DNA directed), beta
chr19_-_2042065 0.17 ENST00000591588.1
ENST00000591142.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr7_-_38394118 0.17 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr4_-_17783135 0.15 ENST00000265018.3
FAM184B
family with sequence similarity 184, member B
chr5_+_140514782 0.15 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr6_-_31939734 0.15 ENST00000375356.3
DXO
decapping exoribonuclease
chr21_-_48024986 0.14 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr6_-_31940065 0.14 ENST00000375349.3
ENST00000337523.5
DXO
decapping exoribonuclease
chr1_+_12040238 0.13 ENST00000444836.1
ENST00000235329.5
MFN2
mitofusin 2
chr3_-_53878644 0.13 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr17_+_75123947 0.12 ENST00000586429.1
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr6_+_31939608 0.12 ENST00000375331.2
ENST00000375333.2
STK19
serine/threonine kinase 19
chr5_+_74807886 0.12 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr7_+_62809239 0.12 ENST00000456890.1
AC006455.1
AC006455.1
chr19_+_52848659 0.12 ENST00000327920.8
ZNF610
zinc finger protein 610
chr16_+_89787393 0.11 ENST00000289816.5
ENST00000568064.1
ZNF276
zinc finger protein 276
chr20_+_62289640 0.11 ENST00000508582.2
ENST00000360203.5
ENST00000356810.4
RTEL1
regulator of telomere elongation helicase 1
chr1_-_32801825 0.11 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr10_-_73533255 0.11 ENST00000394957.3
C10orf54
chromosome 10 open reading frame 54
chrX_+_134166333 0.11 ENST00000257013.7
FAM127A
family with sequence similarity 127, member A
chr4_-_140216948 0.11 ENST00000265500.4
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr3_+_98250743 0.10 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chrX_+_152338301 0.10 ENST00000453825.2
PNMA6A
paraneoplastic Ma antigen family member 6A
chr11_-_67980744 0.10 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr20_+_54987305 0.10 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr19_-_6670128 0.09 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr12_-_43945724 0.09 ENST00000389420.3
ENST00000553158.1
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr6_+_12958137 0.09 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr2_+_88824161 0.09 ENST00000303254.3
TEX37
testis expressed 37
chr6_-_107436473 0.08 ENST00000369042.1
BEND3
BEN domain containing 3
chr14_-_90085458 0.08 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr17_+_33895090 0.08 ENST00000592381.1
RP11-1094M14.11
RP11-1094M14.11
chr13_+_27998681 0.08 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr1_-_111148241 0.08 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr8_-_42623924 0.07 ENST00000276410.2
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chrX_+_11776278 0.07 ENST00000312196.4
ENST00000337339.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr11_-_130786400 0.07 ENST00000265909.4
SNX19
sorting nexin 19
chr1_+_28285973 0.07 ENST00000373884.5
XKR8
XK, Kell blood group complex subunit-related family, member 8
chr8_-_42623747 0.07 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr12_+_48577366 0.07 ENST00000316554.3
C12orf68
chromosome 12 open reading frame 68
chr1_-_169555779 0.07 ENST00000367797.3
ENST00000367796.3
F5
coagulation factor V (proaccelerin, labile factor)
chr6_+_44126545 0.07 ENST00000532171.1
ENST00000398776.1
ENST00000542245.1
CAPN11
calpain 11
chr20_+_54987168 0.06 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr11_+_64692143 0.06 ENST00000164133.2
ENST00000532850.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr1_-_111148969 0.06 ENST00000316361.4
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr3_-_49131013 0.06 ENST00000424300.1
QRICH1
glutamine-rich 1
chr3_-_149688655 0.06 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr2_+_202899310 0.06 ENST00000286201.1
FZD7
frizzled family receptor 7
chr3_-_49131473 0.06 ENST00000430979.1
ENST00000357496.2
ENST00000437939.1
QRICH1
glutamine-rich 1
chr5_-_74807418 0.05 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr4_+_48492269 0.05 ENST00000327939.4
ZAR1
zygote arrest 1
chr4_-_5894777 0.05 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr7_+_23719749 0.05 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr19_+_47852538 0.05 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr10_-_105156198 0.05 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
USMG5
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr6_-_46138676 0.04 ENST00000371383.2
ENST00000230565.3
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chrX_+_118708493 0.04 ENST00000371558.2
UBE2A
ubiquitin-conjugating enzyme E2A
chr19_-_55549624 0.04 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr1_-_155270770 0.04 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr1_-_236046872 0.04 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr7_-_127225620 0.04 ENST00000321407.2
GCC1
GRIP and coiled-coil domain containing 1
chr2_-_74570520 0.04 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
SLC4A5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chrX_+_118708517 0.04 ENST00000346330.3
UBE2A
ubiquitin-conjugating enzyme E2A
chr3_-_149688896 0.04 ENST00000239940.7
PFN2
profilin 2
chr11_-_18548426 0.03 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr11_+_82783097 0.03 ENST00000501011.2
ENST00000527627.1
ENST00000526795.1
ENST00000533528.1
ENST00000533708.1
ENST00000534499.1
RAB30-AS1
RAB30 antisense RNA 1 (head to head)
chr1_+_160121356 0.03 ENST00000368081.4
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr17_-_39623681 0.02 ENST00000225899.3
KRT32
keratin 32
chr3_-_49131788 0.02 ENST00000395443.2
ENST00000411682.1
QRICH1
glutamine-rich 1
chr8_+_38261880 0.02 ENST00000527175.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr17_+_72983674 0.02 ENST00000337231.5
CDR2L
cerebellar degeneration-related protein 2-like
chr2_-_25565377 0.01 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chrX_+_70364667 0.01 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr5_-_169725231 0.01 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_+_160160346 0.01 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_+_100081542 0.01 ENST00000300179.2
ENST00000423930.1
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr15_+_64428529 0.00 ENST00000560861.1
SNX1
sorting nexin 1
chr3_+_178276488 0.00 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr4_+_159236462 0.00 ENST00000460056.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr16_+_28986085 0.00 ENST00000565975.1
ENST00000311008.11
ENST00000323081.8
ENST00000334536.8
SPNS1
spinster homolog 1 (Drosophila)
chr10_-_76868931 0.00 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr8_+_22424551 0.00 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr16_+_28986134 0.00 ENST00000352260.7
SPNS1
spinster homolog 1 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.4 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 0.2 GO:0036146 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.1 0.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.2 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.1 0.2 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.4 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.1 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0071027 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:2001015 response to methylmercury(GO:0051597) negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.0 0.3 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.0 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.0 0.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0071953 elastic fiber(GO:0071953)
0.1 0.3 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.1 0.2 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.0 0.1 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 2.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.0 GO:0004743 pyruvate kinase activity(GO:0004743)