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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZBTB33_CHD2
Z-value: 1.39
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93443419_93443580 | -0.24 | 2.6e-01 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 0.11 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 5.3 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.8 | 4.0 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 0.0 | 4.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 3.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 3.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.7 | 3.4 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.1 | 3.1 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 3.0 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.6 | 2.9 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 4.8 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.3 | 4.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.4 | 3.9 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 3.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 3.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 3.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 2.8 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 2.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.8 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 6.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 4.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.3 | 4.4 | GO:0008297 | single-stranded DNA exodeoxyribonuclease activity(GO:0008297) |
| 1.3 | 4.0 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.2 | 3.9 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 3.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 3.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 2.9 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.5 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.2 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.2 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 3.4 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 2.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 2.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.0 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 1.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 1.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |