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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZBTB49

Z-value: 0.37

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Transcription factors associated with ZBTB49

Gene Symbol Gene ID Gene Info
ZBTB49
ENSG00000168826.11 zinc finger and BTB domain containing 49

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB49hg19_v2_chr4_+_4291924_4292011-0.291.5e-01Click!

Activity profile of ZBTB49 motif

Sorted Z-values of ZBTB49 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_123676827 1.88 ENST00000546084.1
TRAF1
TNF receptor-associated factor 1
chr1_+_79115503 1.40 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr16_-_28621353 1.18 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr5_-_146833222 0.89 ENST00000534907.1
DPYSL3
dihydropyrimidinase-like 3
chr3_-_172428959 0.84 ENST00000475381.1
ENST00000538775.1
ENST00000273512.3
ENST00000543711.1
NCEH1
neutral cholesterol ester hydrolase 1
chr10_+_90750493 0.77 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr11_-_2950642 0.73 ENST00000314222.4
PHLDA2
pleckstrin homology-like domain, family A, member 2
chrX_+_30265256 0.69 ENST00000397548.2
MAGEB1
melanoma antigen family B, 1
chr10_-_90751038 0.67 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
ACTA2
actin, alpha 2, smooth muscle, aorta
chrX_+_9431324 0.49 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr19_+_50145328 0.44 ENST00000360565.3
SCAF1
SR-related CTD-associated factor 1
chr7_-_103629963 0.39 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
RELN
reelin
chr22_-_42017021 0.39 ENST00000263256.6
DESI1
desumoylating isopeptidase 1
chr8_+_99129513 0.39 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr3_-_196242233 0.39 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr18_-_11148587 0.38 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr11_+_43702322 0.35 ENST00000395700.4
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr15_+_75639773 0.35 ENST00000567657.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr6_-_109777128 0.32 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr15_+_93749295 0.31 ENST00000599897.1
AC112693.2
AC112693.2
chr19_-_59070239 0.29 ENST00000595957.1
ENST00000253023.3
UBE2M
ubiquitin-conjugating enzyme E2M
chr14_+_77924204 0.29 ENST00000555133.1
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr20_+_33134619 0.27 ENST00000374837.3
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr3_+_196594727 0.27 ENST00000445299.2
ENST00000323460.5
ENST00000419026.1
SENP5
SUMO1/sentrin specific peptidase 5
chr19_-_6481776 0.25 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr19_-_54567035 0.24 ENST00000366170.2
ENST00000425006.2
VSTM1
V-set and transmembrane domain containing 1
chr22_+_21996549 0.23 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chr15_+_90728145 0.23 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr8_-_82024290 0.23 ENST00000220597.4
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr8_+_24151553 0.22 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr14_-_74485960 0.22 ENST00000556242.1
ENST00000334696.6
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chrX_+_64887512 0.21 ENST00000360270.5
MSN
moesin
chrX_-_153210107 0.20 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chr3_+_52232102 0.19 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
ALAS1
aminolevulinate, delta-, synthase 1
chr7_+_99006232 0.19 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chr1_+_9294822 0.19 ENST00000377403.2
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr6_-_49604545 0.18 ENST00000371175.4
ENST00000229810.7
RHAG
Rh-associated glycoprotein
chr19_-_51611623 0.18 ENST00000421832.2
CTU1
cytosolic thiouridylase subunit 1
chr2_+_234160217 0.17 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr1_+_240255166 0.16 ENST00000319653.9
FMN2
formin 2
chr5_-_180229833 0.16 ENST00000307826.4
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr1_+_46806837 0.15 ENST00000537428.1
NSUN4
NOP2/Sun domain family, member 4
chr2_+_234160340 0.15 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr12_+_53835508 0.14 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr18_+_32558208 0.14 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_-_53525406 0.14 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr2_-_118943930 0.13 ENST00000449075.1
ENST00000414886.1
ENST00000449819.1
AC093901.1
AC093901.1
chr2_+_30670077 0.13 ENST00000466477.1
ENST00000465200.1
ENST00000379509.3
ENST00000319406.4
ENST00000488144.1
ENST00000465538.1
ENST00000309052.4
ENST00000359433.1
LCLAT1
lysocardiolipin acyltransferase 1
chr8_+_58907104 0.13 ENST00000361488.3
FAM110B
family with sequence similarity 110, member B
chr7_-_44613494 0.13 ENST00000431640.1
ENST00000258772.5
DDX56
DEAD (Asp-Glu-Ala-Asp) box helicase 56
chr10_+_94352956 0.12 ENST00000260731.3
KIF11
kinesin family member 11
chrX_-_151903184 0.11 ENST00000357916.4
ENST00000393869.3
MAGEA12
melanoma antigen family A, 12
chr12_+_53835383 0.11 ENST00000429243.2
PRR13
proline rich 13
chr12_+_53835539 0.11 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr16_-_18937726 0.11 ENST00000389467.3
ENST00000446231.2
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr15_-_55489097 0.10 ENST00000260443.4
RSL24D1
ribosomal L24 domain containing 1
chr20_+_1115821 0.10 ENST00000435720.1
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr14_+_79745746 0.10 ENST00000281127.7
NRXN3
neurexin 3
chr16_+_69166418 0.10 ENST00000314423.7
ENST00000562237.1
ENST00000567460.1
ENST00000566227.1
ENST00000352319.4
ENST00000563094.1
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chrX_-_151903101 0.09 ENST00000393900.3
MAGEA12
melanoma antigen family A, 12
chr6_-_153452356 0.09 ENST00000206262.1
RGS17
regulator of G-protein signaling 17
chr8_+_24151620 0.09 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr21_-_26979786 0.08 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
MRPL39
mitochondrial ribosomal protein L39
chr11_+_63993738 0.08 ENST00000441250.2
ENST00000279206.3
NUDT22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
chr16_-_28415162 0.08 ENST00000398944.3
ENST00000398943.3
ENST00000380876.4
EIF3CL
eukaryotic translation initiation factor 3, subunit C-like
chr15_-_25684110 0.08 ENST00000232165.3
UBE3A
ubiquitin protein ligase E3A
chr4_+_128886424 0.08 ENST00000398965.1
C4orf29
chromosome 4 open reading frame 29
chr9_-_116102530 0.07 ENST00000374195.3
ENST00000341761.4
WDR31
WD repeat domain 31
chr14_-_35591433 0.07 ENST00000261475.5
ENST00000555644.1
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr6_-_43655511 0.07 ENST00000372133.3
ENST00000372116.1
ENST00000427312.1
MRPS18A
mitochondrial ribosomal protein S18A
chr22_-_29196546 0.07 ENST00000403532.3
ENST00000216037.6
XBP1
X-box binding protein 1
chr20_-_32700075 0.07 ENST00000374980.2
EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr2_+_95691417 0.07 ENST00000309988.4
MAL
mal, T-cell differentiation protein
chr14_+_79746249 0.06 ENST00000428277.2
NRXN3
neurexin 3
chr2_+_95691445 0.06 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
MAL
mal, T-cell differentiation protein
chr14_+_79745682 0.06 ENST00000557594.1
NRXN3
neurexin 3
chr1_+_46806452 0.06 ENST00000536062.1
NSUN4
NOP2/Sun domain family, member 4
chr22_-_20256054 0.05 ENST00000043402.7
RTN4R
reticulon 4 receptor
chr16_+_28722809 0.05 ENST00000566866.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr19_-_42894420 0.05 ENST00000597255.1
ENST00000222032.5
CNFN
cornifelin
chr22_-_20255212 0.05 ENST00000416372.1
RTN4R
reticulon 4 receptor
chr8_+_95653302 0.04 ENST00000423620.2
ENST00000433389.2
ESRP1
epithelial splicing regulatory protein 1
chr3_-_196756646 0.04 ENST00000439320.1
ENST00000296351.4
ENST00000296350.5
MFI2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr10_+_64893039 0.04 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr19_-_4182530 0.04 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr2_-_48982708 0.04 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr22_-_29196030 0.03 ENST00000405219.3
XBP1
X-box binding protein 1
chr22_+_42017459 0.03 ENST00000405878.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr17_+_54671047 0.03 ENST00000332822.4
NOG
noggin
chr19_+_18669809 0.03 ENST00000602094.1
KXD1
KxDL motif containing 1
chr1_+_24117627 0.03 ENST00000400061.1
LYPLA2
lysophospholipase II
chr15_+_31508174 0.03 ENST00000559292.2
ENST00000557928.1
RP11-16E12.1
RP11-16E12.1
chr10_-_46641003 0.02 ENST00000395721.2
ENST00000374218.2
ENST00000395725.3
ENST00000374346.3
ENST00000417004.1
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_151319283 0.02 ENST00000392746.3
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr16_+_810728 0.01 ENST00000563941.1
ENST00000545450.2
ENST00000566549.1
MSLN
mesothelin
chr17_+_80009741 0.01 ENST00000578552.1
ENST00000320548.4
ENST00000581578.1
ENST00000583885.1
ENST00000583641.1
ENST00000581418.1
ENST00000355130.2
ENST00000306823.6
ENST00000392358.2
GPS1
G protein pathway suppressor 1
chr17_-_3195876 0.01 ENST00000323404.1
OR3A1
olfactory receptor, family 3, subfamily A, member 1
chr4_+_53525573 0.01 ENST00000503051.1
USP46-AS1
USP46 antisense RNA 1
chr8_-_59572093 0.01 ENST00000427130.2
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr16_+_811073 0.01 ENST00000382862.3
ENST00000563651.1
MSLN
mesothelin
chr17_-_80009650 0.01 ENST00000310496.4
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_-_97401782 0.01 ENST00000375326.4
FBP1
fructose-1,6-bisphosphatase 1
chr11_+_117857063 0.00 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA
interleukin 10 receptor, alpha
chr16_+_81069433 0.00 ENST00000299575.4
ATMIN
ATM interactor
chr17_-_80231557 0.00 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.1 0.8 GO:0036337 Fas signaling pathway(GO:0036337)
0.1 0.7 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.4 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.2 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.4 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.3 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.2 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 1.2 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0034227 tRNA thio-modification(GO:0034227)
0.0 0.1 GO:1903487 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.3 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 1.9 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.8 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.0 0.0 GO:0042700 luteinizing hormone signaling pathway(GO:0042700) cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 0.1 GO:0060013 righting reflex(GO:0060013)
0.0 0.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.2 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.4 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0044754 autolysosome(GO:0044754)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 0.8 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.1 1.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 1.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.2 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.2 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.4 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction