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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZEB1
Z-value: 1.03
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31610064_31610159 | -0.45 | 2.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_68788594 Show fit | 3.91 |
ENST00000396442.2
ENST00000380766.2 |
occludin |
|
| chr11_-_68518910 Show fit | 3.69 |
ENST00000544963.1
ENST00000443940.2 |
metallothionein-like 5, testis-specific (tesmin) |
|
| chr16_-_30107491 Show fit | 2.95 |
ENST00000566134.1
ENST00000565110.1 ENST00000398841.1 ENST00000398838.4 |
yippee-like 3 (Drosophila) |
|
| chr6_-_130031358 Show fit | 2.90 |
ENST00000368149.2
|
Rho GTPase activating protein 18 |
|
| chr8_+_144816303 Show fit | 2.84 |
ENST00000533004.1
|
FAM83H antisense RNA 1 (head to head) |
|
| chr4_-_186733363 Show fit | 2.66 |
ENST00000393523.2
ENST00000393528.3 ENST00000449407.2 |
sorbin and SH3 domain containing 2 |
|
| chr4_-_149363662 Show fit | 2.63 |
ENST00000355292.3
ENST00000358102.3 |
nuclear receptor subfamily 3, group C, member 2 |
|
| chr1_-_209979465 Show fit | 2.60 |
ENST00000542854.1
|
interferon regulatory factor 6 |
|
| chr11_+_59522900 Show fit | 2.54 |
ENST00000529177.1
|
syntaxin 3 |
|
| chr13_+_32605437 Show fit | 2.53 |
ENST00000380250.3
|
furry homolog (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.5 | GO:0098881 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 1.0 | 5.9 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.2 | 5.6 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.4 | 5.3 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.2 | 5.2 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.1 | 5.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 4.7 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.3 | 3.9 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.2 | 3.6 | GO:0070673 | response to interleukin-18(GO:0070673) |
| 0.1 | 3.1 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 1.6 | 6.5 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.2 | 6.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 5.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 5.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 4.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 3.6 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.2 | 3.2 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.3 | 2.7 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 2.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 6.2 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.2 | 6.1 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.2 | 5.9 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 3.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 3.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 3.3 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.5 | 2.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 2.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 2.4 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 3.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 3.3 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 2.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.4 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.0 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.0 | 4.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 3.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 3.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 3.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 2.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 2.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 2.1 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 2.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |