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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZFHX3

Z-value: 0.35

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73093597_73093597,
hg19_v2_chr16_-_73082274_73082274		0.395.5e-02Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_149365827 0.87 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chrX_-_32173579 0.33 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr11_+_74459876 0.31 ENST00000299563.4
RNF169
ring finger protein 169
chrM_-_14670 0.31 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr7_+_100026406 0.29 ENST00000414441.1
MEPCE
methylphosphate capping enzyme
chr5_+_95066823 0.28 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr20_-_33735070 0.25 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr7_+_130126165 0.24 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr22_+_31488433 0.24 ENST00000455608.1
SMTN
smoothelin
chr7_+_130126012 0.23 ENST00000341441.5
MEST
mesoderm specific transcript
chr15_+_76352178 0.21 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr12_-_2944184 0.20 ENST00000337508.4
NRIP2
nuclear receptor interacting protein 2
chr1_+_76540386 0.18 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr10_-_75226166 0.18 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_59989791 0.18 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chrX_-_110655306 0.17 ENST00000371993.2
DCX
doublecortin
chr11_-_111649015 0.17 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr2_-_87248975 0.16 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr19_-_58864848 0.16 ENST00000263100.3
A1BG
alpha-1-B glycoprotein
chr11_+_5410607 0.15 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr3_+_46919235 0.14 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr2_+_88047606 0.14 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr1_-_168464875 0.14 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr12_+_80750134 0.14 ENST00000546620.1
OTOGL
otogelin-like
chr19_-_36304201 0.13 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr11_+_22696314 0.13 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr3_-_114477787 0.13 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_71868354 0.12 ENST00000412588.1
CALN1
calneuron 1
chr22_-_22337204 0.12 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr2_-_68052694 0.12 ENST00000457448.1
AC010987.6
AC010987.6
chrX_-_18690210 0.11 ENST00000379984.3
RS1
retinoschisin 1
chr20_+_42187608 0.11 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_42187682 0.11 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_14541060 0.10 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr1_+_159557607 0.10 ENST00000255040.2
APCS
amyloid P component, serum
chr2_+_234621551 0.10 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr2_+_234637754 0.10 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chrY_+_20708557 0.10 ENST00000307393.2
ENST00000309834.4
ENST00000382856.2
HSFY1
heat shock transcription factor, Y-linked 1
chr6_-_30899924 0.10 ENST00000359086.3
SFTA2
surfactant associated 2
chr15_+_58724184 0.09 ENST00000433326.2
LIPC
lipase, hepatic
chrY_-_20935572 0.09 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chr3_+_69915385 0.09 ENST00000314589.5
MITF
microphthalmia-associated transcription factor
chr3_+_101659682 0.09 ENST00000465215.1
RP11-221J22.1
RP11-221J22.1
chr8_-_145754428 0.09 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr12_-_11184006 0.08 ENST00000390675.2
TAS2R31
taste receptor, type 2, member 31
chr6_+_28317685 0.08 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr12_+_131438443 0.08 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr12_-_131200810 0.08 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr5_+_60933634 0.08 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr1_-_247921982 0.08 ENST00000408896.2
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr3_-_49066811 0.08 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr2_+_190541153 0.07 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chrM_+_9207 0.07 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr14_+_39703112 0.07 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr22_-_30970560 0.07 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr7_-_44580861 0.07 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr11_-_102576537 0.07 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr14_+_39703084 0.07 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr2_+_234627424 0.07 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chrX_-_15288154 0.07 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ASB9
ankyrin repeat and SOCS box containing 9
chr18_+_5748793 0.06 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chrM_+_8527 0.06 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr7_+_150725510 0.06 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr4_-_69111401 0.06 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr17_-_39156138 0.06 ENST00000391587.1
KRTAP3-2
keratin associated protein 3-2
chr6_+_161123270 0.06 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr6_-_29013017 0.05 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr6_+_47749718 0.05 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr12_-_68553512 0.05 ENST00000229135.3
IFNG
interferon, gamma
chrX_+_84258832 0.05 ENST00000373173.2
APOOL
apolipoprotein O-like
chr19_+_926000 0.05 ENST00000263620.3
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr9_-_95298314 0.05 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_59989918 0.05 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr1_-_197036364 0.04 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr3_+_69812701 0.04 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr4_-_100356551 0.04 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr13_-_30881134 0.04 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr4_-_100356291 0.04 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr2_+_105050794 0.04 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr2_+_133174147 0.04 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr7_-_100026280 0.03 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr6_+_34204642 0.03 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr7_-_7575477 0.03 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr5_-_125930929 0.03 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr7_+_48211048 0.03 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr19_-_46234119 0.03 ENST00000317683.3
FBXO46
F-box protein 46
chr1_-_160549235 0.02 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chrX_+_16668278 0.02 ENST00000380200.3
S100G
S100 calcium binding protein G
chr8_-_18541603 0.02 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr19_+_50016610 0.02 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr16_-_15474904 0.02 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr17_-_26697304 0.02 ENST00000536498.1
VTN
vitronectin
chr1_-_67266939 0.02 ENST00000304526.2
INSL5
insulin-like 5
chr10_+_118083919 0.01 ENST00000333254.3
CCDC172
coiled-coil domain containing 172
chr6_-_32374900 0.01 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
BTNL2
butyrophilin-like 2 (MHC class II associated)
chr3_-_164796269 0.01 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_+_192544857 0.01 ENST00000367459.3
ENST00000469578.2
RGS1
regulator of G-protein signaling 1
chr4_-_155511887 0.01 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr11_-_125366089 0.00 ENST00000366139.3
ENST00000278919.3
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr6_+_50061315 0.00 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr6_+_25754927 0.00 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.3 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.1 GO:0046136 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation