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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZFX
Z-value: 1.14
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg19_v2_chrX_+_24167828_24167907 | -0.10 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.2 | GO:0060214 | endocardium formation(GO:0060214) |
| 0.2 | 1.7 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.3 | 1.5 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 1.5 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 1.5 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 1.3 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 1.3 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
| 0.1 | 1.1 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.0 | 1.1 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.1 | 1.0 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.9 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 1.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.9 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.1 | 0.9 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.9 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.9 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.2 | 0.8 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 1.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 1.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 1.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.4 | 1.1 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.0 | 1.0 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.9 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.8 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 0.9 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.2 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.7 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.6 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |