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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZIC1

Z-value: 0.60

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Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ZIC1
ENSG00000152977.5 Zic family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg19_v2_chr3_+_147127142_147127171-0.331.0e-01Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_46020497 3.04 ENST00000380102.2
KRTAP10-7
keratin associated protein 10-7
chr21_-_46012386 2.29 ENST00000400368.1
KRTAP10-6
keratin associated protein 10-6
chr1_+_61869748 1.84 ENST00000357977.5
NFIA
nuclear factor I/A
chr4_-_186733363 1.59 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr14_+_38677123 1.33 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr11_-_2160180 1.30 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_+_132891461 1.27 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr17_+_40913210 1.23 ENST00000253796.5
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr10_-_33623826 1.05 ENST00000374867.2
NRP1
neuropilin 1
chr4_-_7105056 0.98 ENST00000504402.1
ENST00000499242.2
ENST00000501888.2
RP11-367J11.3
RP11-367J11.3
chr10_-_33623564 0.87 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr12_-_59314246 0.81 ENST00000320743.3
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_+_65775204 0.79 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr11_-_134123142 0.78 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr7_+_150264365 0.76 ENST00000255945.2
ENST00000461940.1
GIMAP4
GTPase, IMAP family member 4
chr13_-_29069232 0.74 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
FLT1
fms-related tyrosine kinase 1
chr11_+_66824346 0.73 ENST00000532559.1
RHOD
ras homolog family member D
chr19_-_11450249 0.73 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr17_-_18945798 0.69 ENST00000395635.1
GRAP
GRB2-related adaptor protein
chrX_+_77166172 0.68 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr6_-_146285221 0.65 ENST00000367503.3
ENST00000438092.2
ENST00000275233.7
SHPRH
SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
chr22_+_29702572 0.65 ENST00000407647.2
ENST00000416823.1
ENST00000428622.1
GAS2L1
growth arrest-specific 2 like 1
chr17_+_60704762 0.63 ENST00000303375.5
MRC2
mannose receptor, C type 2
chr1_-_94586651 0.62 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr17_-_67057047 0.62 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr12_-_15038779 0.60 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr17_-_67057114 0.60 ENST00000370732.2
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr3_+_50192499 0.58 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr9_-_127263265 0.58 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr10_-_33624002 0.58 ENST00000432372.2
NRP1
neuropilin 1
chr10_-_101945771 0.58 ENST00000370408.2
ENST00000407654.3
ERLIN1
ER lipid raft associated 1
chr17_-_39183452 0.57 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr14_+_57735614 0.55 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr16_+_2521500 0.55 ENST00000293973.1
NTN3
netrin 3
chr19_+_34287751 0.51 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr3_+_148847371 0.51 ENST00000296051.2
ENST00000460120.1
HPS3
Hermansky-Pudlak syndrome 3
chr11_-_74022658 0.50 ENST00000427714.2
ENST00000331597.4
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr11_+_66824276 0.50 ENST00000308831.2
RHOD
ras homolog family member D
chr11_-_73309228 0.50 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr21_+_46117087 0.49 ENST00000400365.3
KRTAP10-12
keratin associated protein 10-12
chr18_-_52989217 0.49 ENST00000570287.2
TCF4
transcription factor 4
chr17_-_67057203 0.48 ENST00000340001.4
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr18_-_52989525 0.48 ENST00000457482.3
TCF4
transcription factor 4
chr8_-_120685608 0.47 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr21_-_39870339 0.45 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chrX_+_24711997 0.45 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr12_+_13197218 0.44 ENST00000197268.8
KIAA1467
KIAA1467
chr4_-_7941596 0.42 ENST00000420658.1
ENST00000358461.2
AFAP1
actin filament associated protein 1
chr16_+_28858004 0.40 ENST00000322610.8
SH2B1
SH2B adaptor protein 1
chr9_-_16870704 0.40 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr14_+_36295638 0.40 ENST00000543183.1
BRMS1L
breast cancer metastasis-suppressor 1-like
chr19_-_46142637 0.38 ENST00000590043.1
ENST00000589876.1
EML2
echinoderm microtubule associated protein like 2
chr16_-_2379688 0.38 ENST00000567910.1
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr10_+_49917751 0.36 ENST00000325239.5
ENST00000413659.2
WDFY4
WDFY family member 4
chr1_-_60392452 0.36 ENST00000371204.3
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr17_-_53809473 0.36 ENST00000575734.1
TMEM100
transmembrane protein 100
chr19_+_45409011 0.35 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr19_-_16582815 0.35 ENST00000455140.2
ENST00000248070.6
ENST00000594975.1
EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
chr1_+_95699704 0.34 ENST00000370202.4
RWDD3
RWD domain containing 3
chr17_-_39191107 0.33 ENST00000344363.5
KRTAP1-3
keratin associated protein 1-3
chr22_+_44319648 0.32 ENST00000423180.2
PNPLA3
patatin-like phospholipase domain containing 3
chr11_+_64002292 0.32 ENST00000426086.2
VEGFB
vascular endothelial growth factor B
chr8_-_82754427 0.31 ENST00000353788.4
ENST00000520618.1
ENST00000518183.1
ENST00000396330.2
ENST00000519119.1
ENST00000345957.4
SNX16
sorting nexin 16
chr17_+_18280976 0.31 ENST00000399134.4
EVPLL
envoplakin-like
chr1_+_95699740 0.31 ENST00000429514.2
ENST00000263893.6
RWDD3
RWD domain containing 3
chr22_+_44319619 0.30 ENST00000216180.3
PNPLA3
patatin-like phospholipase domain containing 3
chr1_+_1567474 0.30 ENST00000356026.5
MMP23B
matrix metallopeptidase 23B
chr1_+_100315613 0.30 ENST00000361915.3
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr16_+_30996502 0.29 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr1_+_100316041 0.29 ENST00000370165.3
ENST00000370163.3
ENST00000294724.4
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr2_-_99552620 0.29 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211L
KIAA1211-like
chr1_+_1567546 0.29 ENST00000378675.3
MMP23B
matrix metallopeptidase 23B
chr11_-_2193025 0.28 ENST00000333684.5
ENST00000381178.1
ENST00000381175.1
ENST00000352909.3
TH
tyrosine hydroxylase
chr14_+_36295504 0.27 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr1_+_161087873 0.27 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
NIT1
nitrilase 1
chr19_-_58609570 0.26 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18
zinc finger and SCAN domain containing 18
chr2_+_120189422 0.26 ENST00000306406.4
TMEM37
transmembrane protein 37
chr21_+_18811205 0.26 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr2_+_169926047 0.26 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_-_102789629 0.25 ENST00000417955.1
ENST00000341533.4
ENST00000425379.1
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D
chr1_+_93544821 0.25 ENST00000370303.4
MTF2
metal response element binding transcription factor 2
chrX_-_153979315 0.25 ENST00000369575.3
ENST00000369568.4
ENST00000424127.2
GAB3
GRB2-associated binding protein 3
chr12_-_25801478 0.25 ENST00000540106.1
ENST00000445693.1
ENST00000545543.1
ENST00000542224.1
IFLTD1
intermediate filament tail domain containing 1
chr1_+_93544791 0.25 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
MTF2
metal response element binding transcription factor 2
chr5_+_140514782 0.25 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr17_+_37894570 0.25 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr12_+_27091426 0.24 ENST00000546072.1
ENST00000327214.5
FGFR1OP2
FGFR1 oncogene partner 2
chr4_-_89444883 0.24 ENST00000273968.4
PYURF
PIGY upstream reading frame
chr11_+_64001962 0.24 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chr12_+_27091316 0.24 ENST00000229395.3
FGFR1OP2
FGFR1 oncogene partner 2
chr21_-_31864275 0.24 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr13_-_100624012 0.24 ENST00000267294.4
ZIC5
Zic family member 5
chr11_+_67071050 0.23 ENST00000376757.5
SSH3
slingshot protein phosphatase 3
chr12_-_27091183 0.23 ENST00000544548.1
ENST00000261191.7
ENST00000537336.1
ASUN
asunder spermatogenesis regulator
chrX_+_46771848 0.22 ENST00000218343.4
PHF16
jade family PHD finger 3
chrX_+_46771711 0.22 ENST00000424392.1
ENST00000397189.1
PHF16
jade family PHD finger 3
chrX_-_78622805 0.22 ENST00000373298.2
ITM2A
integral membrane protein 2A
chr15_-_71407806 0.22 ENST00000566432.1
ENST00000567117.1
CT62
cancer/testis antigen 62
chr19_-_6433765 0.22 ENST00000321510.6
SLC25A41
solute carrier family 25, member 41
chr19_+_35940486 0.21 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr2_-_46769694 0.20 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr16_+_838614 0.20 ENST00000262315.9
ENST00000455171.2
CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr15_-_71407833 0.20 ENST00000449977.2
CT62
cancer/testis antigen 62
chr9_+_35792151 0.20 ENST00000342694.2
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr12_-_11036844 0.20 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chrX_-_129299847 0.19 ENST00000319908.3
ENST00000287295.3
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr11_+_120207787 0.19 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_-_177134024 0.19 ENST00000367654.3
ASTN1
astrotactin 1
chr6_-_168720382 0.19 ENST00000610183.1
ENST00000607983.1
ENST00000366795.3
DACT2
dishevelled-binding antagonist of beta-catenin 2
chr19_+_13135731 0.19 ENST00000587260.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr14_-_50999190 0.19 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_16348497 0.19 ENST00000439316.2
CLCNKA
chloride channel, voltage-sensitive Ka
chr17_-_76274572 0.18 ENST00000374945.1
RP11-219G17.4
RP11-219G17.4
chr1_-_244615425 0.18 ENST00000366535.3
ADSS
adenylosuccinate synthase
chr1_+_22962948 0.18 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr8_+_85097110 0.17 ENST00000517638.1
ENST00000522647.1
RALYL
RALY RNA binding protein-like
chr6_+_31949801 0.17 ENST00000428956.2
ENST00000498271.1
C4A
complement component 4A (Rodgers blood group)
chr16_+_771663 0.16 ENST00000568916.1
FAM173A
family with sequence similarity 173, member A
chr19_-_46142680 0.16 ENST00000245925.3
EML2
echinoderm microtubule associated protein like 2
chr19_-_2740036 0.16 ENST00000586572.1
ENST00000269740.4
AC006538.4
SLC39A3
Uncharacterized protein
solute carrier family 39 (zinc transporter), member 3
chr5_+_64920543 0.15 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr17_-_3796334 0.15 ENST00000381771.2
ENST00000348335.2
ENST00000158166.5
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr4_-_66536196 0.15 ENST00000511294.1
EPHA5
EPH receptor A5
chrX_-_129299638 0.14 ENST00000535724.1
ENST00000346424.2
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr15_+_80351910 0.14 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr15_+_77712993 0.14 ENST00000336216.4
ENST00000381714.3
ENST00000558651.1
HMG20A
high mobility group 20A
chr4_-_66536057 0.14 ENST00000273854.3
EPHA5
EPH receptor A5
chr2_-_74780176 0.14 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr1_+_16370271 0.13 ENST00000375679.4
CLCNKB
chloride channel, voltage-sensitive Kb
chr5_-_64920115 0.13 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr6_-_34216766 0.13 ENST00000481533.1
ENST00000468145.1
ENST00000413013.2
ENST00000394990.4
ENST00000335352.3
C6orf1
chromosome 6 open reading frame 1
chr19_+_37095719 0.12 ENST00000423582.1
ZNF382
zinc finger protein 382
chr21_+_31768348 0.12 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr10_+_21823079 0.11 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_+_22963158 0.10 ENST00000438241.1
C1QA
complement component 1, q subcomponent, A chain
chr2_-_29297127 0.10 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chrX_+_72064690 0.10 ENST00000438696.1
DMRTC1B
DMRT-like family C1B
chr14_+_22739823 0.10 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr19_+_42364460 0.10 ENST00000593863.1
RPS19
ribosomal protein S19
chr6_+_28109703 0.10 ENST00000457389.2
ENST00000330236.6
ZKSCAN8
zinc finger with KRAB and SCAN domains 8
chr1_+_207039154 0.09 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr1_+_18958008 0.09 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr1_+_89990431 0.09 ENST00000330947.2
ENST00000358200.4
LRRC8B
leucine rich repeat containing 8 family, member B
chr11_+_15095108 0.08 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr1_-_71513471 0.08 ENST00000370931.3
ENST00000356595.4
ENST00000306666.5
ENST00000370932.2
ENST00000351052.5
ENST00000414819.1
ENST00000370924.4
PTGER3
prostaglandin E receptor 3 (subtype EP3)
chr19_+_54024251 0.08 ENST00000253144.9
ZNF331
zinc finger protein 331
chr3_+_141105705 0.08 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_+_62417957 0.07 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chrX_+_18725758 0.07 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr19_-_50168962 0.07 ENST00000599223.1
ENST00000593922.1
ENST00000600022.1
ENST00000596765.1
ENST00000599144.1
ENST00000596822.1
ENST00000598108.1
ENST00000601373.1
ENST00000595034.1
ENST00000601291.1
IRF3
interferon regulatory factor 3
chr6_-_168476511 0.06 ENST00000440994.2
FRMD1
FERM domain containing 1
chr4_-_66535653 0.06 ENST00000354839.4
ENST00000432638.2
EPHA5
EPH receptor A5
chr1_+_16348366 0.06 ENST00000375692.1
ENST00000420078.1
CLCNKA
chloride channel, voltage-sensitive Ka
chr19_-_14586125 0.06 ENST00000292513.3
PTGER1
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr5_-_126409159 0.06 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr16_-_31100284 0.06 ENST00000280606.6
PRSS53
protease, serine, 53
chr2_+_11679963 0.06 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr1_-_43833628 0.05 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr9_-_35103105 0.05 ENST00000452248.2
ENST00000356493.5
STOML2
stomatin (EPB72)-like 2
chr10_+_21823243 0.05 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr17_+_75450075 0.05 ENST00000592951.1
SEPT9
septin 9
chr20_+_61924532 0.05 ENST00000358894.6
ENST00000326996.6
ENST00000435874.1
COL20A1
collagen, type XX, alpha 1
chr7_+_107384579 0.05 ENST00000222597.2
ENST00000415884.2
CBLL1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr18_+_61420169 0.05 ENST00000425392.1
ENST00000336429.2
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_+_63606558 0.05 ENST00000350490.7
ENST00000502399.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr6_-_35656685 0.04 ENST00000539068.1
ENST00000540787.1
FKBP5
FK506 binding protein 5
chr17_-_9940058 0.04 ENST00000585266.1
GAS7
growth arrest-specific 7
chr1_-_211307315 0.04 ENST00000271751.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr15_+_73976715 0.04 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr6_+_31730773 0.04 ENST00000415669.2
ENST00000425424.1
SAPCD1
suppressor APC domain containing 1
chr11_+_63606477 0.03 ENST00000508192.1
ENST00000361128.5
MARK2
MAP/microtubule affinity-regulating kinase 2
chr19_-_50169064 0.03 ENST00000593337.1
ENST00000598808.1
ENST00000600453.1
ENST00000593818.1
ENST00000597198.1
ENST00000601809.1
ENST00000377139.3
IRF3
interferon regulatory factor 3
chr11_-_57417405 0.03 ENST00000524669.1
ENST00000300022.3
YPEL4
yippee-like 4 (Drosophila)
chr13_+_102104952 0.03 ENST00000376180.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr17_-_62208169 0.03 ENST00000606895.1
ERN1
endoplasmic reticulum to nucleus signaling 1
chr2_+_234668894 0.02 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr3_-_71803474 0.02 ENST00000448225.1
ENST00000496214.2
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr17_-_4464081 0.02 ENST00000574154.1
GGT6
gamma-glutamyltransferase 6
chr11_-_59612969 0.02 ENST00000541311.1
ENST00000257248.2
GIF
gastric intrinsic factor (vitamin B synthesis)
chr6_+_41755389 0.01 ENST00000398884.3
ENST00000398881.3
TOMM6
translocase of outer mitochondrial membrane 6 homolog (yeast)
chr11_-_110582773 0.01 ENST00000524756.1
ARHGAP20
Rho GTPase activating protein 20
chr22_-_23922448 0.01 ENST00000438703.1
ENST00000330377.2
IGLL1
immunoglobulin lambda-like polypeptide 1
chr4_+_66536248 0.00 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr2_+_79347577 0.00 ENST00000233735.1
REG1A
regenerating islet-derived 1 alpha
chr4_+_2627159 0.00 ENST00000382839.3
ENST00000324666.5
ENST00000545951.1
ENST00000502458.1
ENST00000505311.1
FAM193A
family with sequence similarity 193, member A
chr18_+_76829385 0.00 ENST00000426216.2
ENST00000307671.7
ENST00000586672.1
ENST00000586722.1
ATP9B
ATPase, class II, type 9B
chr2_+_232457569 0.00 ENST00000313965.2
C2orf57
chromosome 2 open reading frame 57
chr11_+_63606373 0.00 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0060301 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.3 1.3 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2 0.7 GO:0071284 cellular response to lead ion(GO:0071284)
0.2 0.7 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.2 0.6 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.2 0.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.7 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.6 GO:0007538 primary sex determination(GO:0007538)
0.1 1.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.9 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.4 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.3 GO:0052314 terpene metabolic process(GO:0042214) phytoalexin metabolic process(GO:0052314)
0.1 0.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 1.8 GO:0072189 ureter development(GO:0072189)
0.1 0.2 GO:0072061 inner medullary collecting duct development(GO:0072061) negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.6 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.1 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.6 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.3 GO:0035900 response to isolation stress(GO:0035900)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.3 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
0.0 0.1 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.5 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 1.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.3 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.7 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.3 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 5.6 GO:0031424 keratinization(GO:0031424)
0.0 0.1 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.0 1.2 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.5 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.4 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 0.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.4 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.0 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0097443 sorting endosome(GO:0097443)
0.2 1.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 0.5 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.4 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.4 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 6.2 GO:0045095 keratin filament(GO:0045095)
0.1 0.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.3 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.7 GO:0042588 zymogen granule(GO:0042588)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.7 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 2.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 0.7 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 1.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.2 1.2 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.3 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.0 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 2.0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.5 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)