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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZIC2_GLI1

Z-value: 0.74

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Transcription factors associated with ZIC2_GLI1

Gene Symbol Gene ID Gene Info
ZIC2
ENSG00000043355.6 Zic family member 2
GLI1
ENSG00000111087.5 GLI family zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLI1hg19_v2_chr12_+_57853918_57853934-0.414.0e-02Click!
ZIC2hg19_v2_chr13_+_100634004_100634026-0.223.0e-01Click!

Activity profile of ZIC2_GLI1 motif

Sorted Z-values of ZIC2_GLI1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_205782304 4.80 ENST00000367137.3
SLC41A1
solute carrier family 41 (magnesium transporter), member 1
chr6_-_29595779 3.37 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr6_-_32821599 3.01 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_57522813 2.78 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_45308616 2.56 ENST00000447098.2
ENST00000372192.3
PTCH2
patched 2
chr11_-_111783595 2.52 ENST00000528628.1
CRYAB
crystallin, alpha B
chr6_-_55739542 1.99 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr4_-_5021164 1.91 ENST00000506508.1
ENST00000509419.1
ENST00000307746.4
CYTL1
cytokine-like 1
chr8_+_31497271 1.61 ENST00000520407.1
NRG1
neuregulin 1
chr17_+_40834580 1.58 ENST00000264638.4
CNTNAP1
contactin associated protein 1
chr19_+_676385 1.55 ENST00000166139.4
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr5_-_150460539 1.50 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNIP1
TNFAIP3 interacting protein 1
chr15_+_67430339 1.31 ENST00000439724.3
SMAD3
SMAD family member 3
chr7_-_108096765 1.26 ENST00000379024.4
ENST00000351718.4
NRCAM
neuronal cell adhesion molecule
chr5_-_150460914 1.21 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr7_-_108096822 1.20 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM
neuronal cell adhesion molecule
chr1_+_183155373 1.19 ENST00000493293.1
ENST00000264144.4
LAMC2
laminin, gamma 2
chr4_-_38666430 1.15 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr5_+_161495038 1.08 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr5_-_141704566 1.03 ENST00000344120.4
ENST00000434127.2
SPRY4
sprouty homolog 4 (Drosophila)
chr10_-_90712520 0.99 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr6_+_43739697 0.98 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr5_+_161494770 0.88 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr16_+_75256507 0.82 ENST00000495583.1
CTRB1
chymotrypsinogen B1
chr17_+_43238438 0.80 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr2_-_208030647 0.78 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_109625378 0.77 ENST00000277225.5
ENST00000457913.1
ENST00000472574.1
ZNF462
zinc finger protein 462
chr16_+_86612112 0.72 ENST00000320241.3
FOXL1
forkhead box L1
chr7_-_92463210 0.72 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr16_+_30675654 0.72 ENST00000287468.5
ENST00000395073.2
FBRS
fibrosin
chr7_+_119913688 0.68 ENST00000331113.4
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr12_+_72148614 0.68 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr5_+_52776228 0.68 ENST00000256759.3
FST
follistatin
chr11_+_111783450 0.67 ENST00000537382.1
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr1_-_150208320 0.66 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr11_-_111782484 0.65 ENST00000533971.1
CRYAB
crystallin, alpha B
chr12_-_6798410 0.64 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr12_-_6798523 0.63 ENST00000319770.3
ZNF384
zinc finger protein 384
chr5_+_52776449 0.63 ENST00000396947.3
FST
follistatin
chrX_-_136113833 0.63 ENST00000298110.1
GPR101
G protein-coupled receptor 101
chr11_-_111783919 0.62 ENST00000531198.1
ENST00000533879.1
CRYAB
crystallin, alpha B
chr17_+_43239191 0.61 ENST00000589230.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr12_-_6798616 0.60 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr17_-_3819751 0.58 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr1_-_156023580 0.58 ENST00000368309.3
UBQLN4
ubiquilin 4
chr1_+_101361782 0.58 ENST00000357650.4
SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr7_-_92465868 0.58 ENST00000424848.2
CDK6
cyclin-dependent kinase 6
chr11_+_111782934 0.57 ENST00000304298.3
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr3_-_8686479 0.55 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr17_+_7211280 0.55 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr5_-_138739739 0.53 ENST00000514983.1
ENST00000507779.2
ENST00000451821.2
ENST00000450845.2
ENST00000509959.1
ENST00000302091.5
SPATA24
spermatogenesis associated 24
chr4_+_77870856 0.51 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chr14_+_22984601 0.51 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr14_-_61124977 0.49 ENST00000554986.1
SIX1
SIX homeobox 1
chr2_+_68694678 0.49 ENST00000303795.4
APLF
aprataxin and PNKP like factor
chr6_+_163148973 0.48 ENST00000366888.2
PACRG
PARK2 co-regulated
chr12_-_122985067 0.48 ENST00000540586.1
ENST00000543897.1
ZCCHC8
zinc finger, CCHC domain containing 8
chr10_+_99344071 0.48 ENST00000370647.4
ENST00000370646.4
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr12_-_122985494 0.48 ENST00000336229.4
ZCCHC8
zinc finger, CCHC domain containing 8
chr1_+_36621529 0.48 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr5_+_157158205 0.46 ENST00000231198.7
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_-_30607819 0.45 ENST00000448418.2
MPPED2
metallophosphoesterase domain containing 2
chr11_-_119991589 0.45 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr3_+_67048721 0.43 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr6_-_29600832 0.43 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_+_138145145 0.42 ENST00000415680.2
TRIM24
tripartite motif containing 24
chr1_-_2564423 0.42 ENST00000378412.3
MMEL1
membrane metallo-endopeptidase-like 1
chr9_+_131174024 0.41 ENST00000420034.1
ENST00000372842.1
CERCAM
cerebral endothelial cell adhesion molecule
chr1_-_2564450 0.41 ENST00000288709.6
MMEL1
membrane metallo-endopeptidase-like 1
chr8_-_22014339 0.41 ENST00000306317.2
LGI3
leucine-rich repeat LGI family, member 3
chr17_+_39261584 0.41 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr17_-_40835076 0.41 ENST00000591765.1
CCR10
chemokine (C-C motif) receptor 10
chr2_-_213403565 0.41 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chrX_+_12809463 0.41 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr4_+_77870960 0.41 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
SEPT11
septin 11
chr11_-_30608413 0.40 ENST00000528686.1
MPPED2
metallophosphoesterase domain containing 2
chr5_-_148758839 0.40 ENST00000261796.3
IL17B
interleukin 17B
chr15_+_60296421 0.40 ENST00000396057.4
FOXB1
forkhead box B1
chr2_+_149402553 0.40 ENST00000258484.6
ENST00000409654.1
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr8_+_30244580 0.38 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr1_+_101361626 0.38 ENST00000370112.4
SLC30A7
solute carrier family 30 (zinc transporter), member 7
chrX_-_23761317 0.38 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
ACOT9
acyl-CoA thioesterase 9
chr11_-_46142948 0.38 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr2_-_208989225 0.38 ENST00000264376.4
CRYGD
crystallin, gamma D
chr1_-_111217603 0.37 ENST00000369769.2
KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr10_-_86001210 0.37 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr20_+_57430162 0.36 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS
GNAS complex locus
chr2_+_46769798 0.36 ENST00000238738.4
RHOQ
ras homolog family member Q
chr2_+_106361333 0.36 ENST00000233154.4
ENST00000451463.2
NCK2
NCK adaptor protein 2
chr21_-_36259445 0.35 ENST00000399240.1
RUNX1
runt-related transcription factor 1
chr1_-_151798546 0.35 ENST00000356728.6
RORC
RAR-related orphan receptor C
chr20_+_62327996 0.35 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_-_150208363 0.35 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_+_70443050 0.34 ENST00000361726.6
GJB1
gap junction protein, beta 1, 32kDa
chr5_+_67088974 0.34 ENST00000513234.1
ENST00000504068.1
ENST00000515227.1
RP11-434D9.1
RP11-434D9.1
chr10_+_24755416 0.33 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chrX_-_107979616 0.33 ENST00000372129.2
IRS4
insulin receptor substrate 4
chr20_-_30310693 0.32 ENST00000307677.4
ENST00000420653.1
BCL2L1
BCL2-like 1
chr5_-_168727713 0.32 ENST00000404867.3
SLIT3
slit homolog 3 (Drosophila)
chr20_-_30310656 0.32 ENST00000376055.4
BCL2L1
BCL2-like 1
chr11_+_118478313 0.32 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr19_-_13068012 0.31 ENST00000316939.1
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr1_-_171621815 0.31 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr18_-_31803169 0.31 ENST00000590712.1
NOL4
nucleolar protein 4
chr1_-_12677714 0.30 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_-_150208291 0.30 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr9_-_35958151 0.29 ENST00000341959.2
OR2S2
olfactory receptor, family 2, subfamily S, member 2
chr11_-_46142615 0.29 ENST00000529734.1
ENST00000323180.6
PHF21A
PHD finger protein 21A
chr5_-_44388899 0.29 ENST00000264664.4
FGF10
fibroblast growth factor 10
chr9_+_34989638 0.29 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_31803435 0.28 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr2_+_25015968 0.27 ENST00000380834.2
ENST00000473706.1
CENPO
centromere protein O
chr1_+_209941827 0.27 ENST00000367023.1
TRAF3IP3
TRAF3 interacting protein 3
chr10_-_69455873 0.27 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr3_+_187871060 0.27 ENST00000448637.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_-_50970506 0.26 ENST00000428989.2
ENST00000403326.1
ODF3B
outer dense fiber of sperm tails 3B
chr8_+_22225041 0.26 ENST00000289952.5
ENST00000524285.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr15_+_40861487 0.26 ENST00000315616.7
ENST00000559271.1
RPUSD2
RNA pseudouridylate synthase domain containing 2
chr11_+_64009072 0.26 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr17_-_40540586 0.26 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr1_+_162531294 0.26 ENST00000367926.4
ENST00000271469.3
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr7_-_112726393 0.25 ENST00000449591.1
ENST00000449735.1
ENST00000438062.1
ENST00000424100.1
GPR85
G protein-coupled receptor 85
chr1_-_150208412 0.25 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr18_-_12884259 0.25 ENST00000353319.4
ENST00000327283.3
PTPN2
protein tyrosine phosphatase, non-receptor type 2
chr17_-_15496722 0.25 ENST00000472534.1
CDRT1
CMT1A duplicated region transcript 1
chrX_-_153236620 0.24 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_+_97481974 0.24 ENST00000377060.3
ENST00000305510.3
CNNM3
cyclin M3
chr16_-_1031259 0.24 ENST00000563837.1
ENST00000563863.1
ENST00000565069.1
ENST00000570014.1
RP11-161M6.2
LMF1
RP11-161M6.2
lipase maturation factor 1
chr20_-_50722183 0.24 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr14_+_29236269 0.23 ENST00000313071.4
FOXG1
forkhead box G1
chr6_-_32784687 0.23 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr1_-_150208498 0.23 ENST00000314136.8
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr19_-_6424783 0.23 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr20_-_30310797 0.23 ENST00000422920.1
BCL2L1
BCL2-like 1
chr10_-_97050777 0.22 ENST00000329399.6
PDLIM1
PDZ and LIM domain 1
chr17_-_74533734 0.22 ENST00000589342.1
CYGB
cytoglobin
chr22_+_37447771 0.22 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr22_-_50970919 0.22 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr15_-_101142401 0.22 ENST00000314742.8
LINS
lines homolog (Drosophila)
chr16_+_88493879 0.21 ENST00000565624.1
ENST00000437464.1
ZNF469
zinc finger protein 469
chr15_-_41408409 0.21 ENST00000361937.3
INO80
INO80 complex subunit
chr6_+_33172407 0.21 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr15_+_81591757 0.21 ENST00000558332.1
IL16
interleukin 16
chr12_-_31477072 0.21 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr1_-_40105617 0.20 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr2_-_31360887 0.20 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr15_+_101142722 0.20 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr15_-_75743915 0.20 ENST00000394949.4
SIN3A
SIN3 transcription regulator family member A
chr9_+_34990219 0.20 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr15_-_78526942 0.19 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr3_+_47844399 0.19 ENST00000446256.2
ENST00000445061.1
DHX30
DEAH (Asp-Glu-Ala-His) box helicase 30
chr9_-_139372141 0.19 ENST00000313050.7
SEC16A
SEC16 homolog A (S. cerevisiae)
chr1_+_24120143 0.19 ENST00000374501.1
LYPLA2
lysophospholipase II
chr12_-_45270151 0.19 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr14_-_24584138 0.19 ENST00000558280.1
ENST00000561028.1
NRL
neural retina leucine zipper
chr1_-_38512450 0.18 ENST00000373012.2
POU3F1
POU class 3 homeobox 1
chr14_-_23834411 0.18 ENST00000429593.2
EFS
embryonal Fyn-associated substrate
chr15_-_81282133 0.18 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr11_-_19223523 0.18 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr20_+_35202909 0.18 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24
TGIF2
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr12_-_45270077 0.18 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chr20_+_32319463 0.18 ENST00000342427.2
ENST00000375200.1
ZNF341
zinc finger protein 341
chr6_-_19804973 0.18 ENST00000457670.1
ENST00000607810.1
ENST00000606628.1
RP4-625H18.2
RP4-625H18.2
chr2_-_128643496 0.18 ENST00000272647.5
AMMECR1L
AMMECR1-like
chr3_+_170136642 0.18 ENST00000064724.3
ENST00000486975.1
CLDN11
claudin 11
chr3_+_4535025 0.17 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_-_112046110 0.17 ENST00000369716.4
ADORA3
adenosine A3 receptor
chr4_-_176733897 0.17 ENST00000393658.2
GPM6A
glycoprotein M6A
chr10_-_35379524 0.17 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr9_-_139371533 0.17 ENST00000290037.6
ENST00000431893.2
ENST00000371706.3
SEC16A
SEC16 homolog A (S. cerevisiae)
chr11_-_11643540 0.16 ENST00000227756.4
GALNT18
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
chr5_-_135701164 0.16 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr7_-_93204033 0.16 ENST00000359558.2
ENST00000360249.4
ENST00000426151.1
CALCR
calcitonin receptor
chr6_-_31620149 0.16 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BAG6
BCL2-associated athanogene 6
chr21_-_28217721 0.16 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_+_72052964 0.16 ENST00000264485.5
ENST00000425175.1
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr16_-_68002456 0.15 ENST00000576616.1
ENST00000572037.1
ENST00000338335.3
ENST00000422611.2
ENST00000316341.3
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr16_+_30034655 0.15 ENST00000300575.2
C16orf92
chromosome 16 open reading frame 92
chr5_-_137878887 0.15 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr19_+_36208877 0.15 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr15_-_41408339 0.15 ENST00000401393.3
INO80
INO80 complex subunit
chr17_+_17876127 0.14 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
LRRC48
leucine rich repeat containing 48
chr1_-_112531777 0.14 ENST00000315987.2
ENST00000302127.4
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr12_-_117175819 0.14 ENST00000261318.3
ENST00000536380.1
C12orf49
chromosome 12 open reading frame 49
chr20_+_3451732 0.14 ENST00000446916.2
ATRN
attractin
chr17_-_15244894 0.14 ENST00000338696.2
ENST00000543896.1
ENST00000539245.1
ENST00000539316.1
ENST00000395930.1
TEKT3
tektin 3
chr2_+_26915584 0.13 ENST00000302909.3
KCNK3
potassium channel, subfamily K, member 3
chr16_+_86229728 0.13 ENST00000601250.1
LINC01082
long intergenic non-protein coding RNA 1082
chr19_+_12848299 0.13 ENST00000357332.3
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr5_+_161275320 0.13 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_31620455 0.13 ENST00000437771.1
ENST00000404765.2
ENST00000375964.6
ENST00000211379.5
BAG6
BCL2-associated athanogene 6
chr9_+_8858102 0.13 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr14_-_88789581 0.13 ENST00000319231.5
KCNK10
potassium channel, subfamily K, member 10
chr13_+_44947941 0.13 ENST00000379179.3
SERP2
stress-associated endoplasmic reticulum protein family member 2
chr3_+_88108381 0.13 ENST00000473136.1
RP11-159G9.5
Uncharacterized protein
chr15_-_101142362 0.13 ENST00000559577.1
ENST00000561308.1
ENST00000560133.1
ENST00000560941.1
ENST00000559736.1
ENST00000560272.1
LINS
lines homolog (Drosophila)
chr8_-_71581377 0.13 ENST00000276590.4
ENST00000522447.1
LACTB2
lactamase, beta 2
chr4_+_62067860 0.13 ENST00000514591.1
LPHN3
latrophilin 3
chr7_-_91875109 0.13 ENST00000412043.2
ENST00000430102.1
ENST00000425073.1
ENST00000394503.2
ENST00000454017.1
ENST00000440209.1
ENST00000413688.1
ENST00000452773.1
ENST00000433016.1
ENST00000394505.2
ENST00000422347.1
ENST00000458493.1
ENST00000425919.1
KRIT1
KRIT1, ankyrin repeat containing
chr2_-_68694390 0.13 ENST00000377957.3
FBXO48
F-box protein 48

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.8 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.8 3.0 GO:0046967 cytosol to ER transport(GO:0046967)
0.7 2.8 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.7 2.7 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.7 2.0 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.4 4.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.0 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.3 2.9 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.3 1.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 1.9 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 1.8 GO:0009957 epidermal cell fate specification(GO:0009957)
0.2 3.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 1.0 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.5 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.1 1.3 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.7 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.1 0.4 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.4 GO:0007412 axon target recognition(GO:0007412) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 5.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.5 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.6 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.1 0.6 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.9 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.4 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.3 GO:0060661 proximal/distal axis specification(GO:0009946) bronchiole development(GO:0060435) bud outgrowth involved in lung branching(GO:0060447) submandibular salivary gland formation(GO:0060661) positive regulation of white fat cell proliferation(GO:0070352) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.3 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.4 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.2 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.3 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 0.3 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) apoptotic process involved in luteolysis(GO:0061364)
0.1 0.5 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.1 0.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046)
0.1 0.6 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 0.7 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 1.3 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.3 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.2 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.2 GO:0002584 negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.7 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 1.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 1.9 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.0 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 1.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0 0.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.0 0.4 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.6 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0002086 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.0 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.3 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.4 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.3 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.4 GO:0036315 cellular response to sterol(GO:0036315)
0.0 0.3 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.0 0.1 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.0 0.4 GO:0001771 immunological synapse formation(GO:0001771)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116) neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 1.0 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.4 3.0 GO:0042825 TAP complex(GO:0042825)
0.4 1.2 GO:0005607 laminin-2 complex(GO:0005607)
0.2 3.9 GO:0097512 cardiac myofibril(GO:0097512)
0.2 1.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.6 GO:0033010 paranodal junction(GO:0033010)
0.1 2.5 GO:0043194 axon initial segment(GO:0043194)
0.1 0.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.7 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 1.8 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.4 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 1.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.4 3.0 GO:0046979 TAP2 binding(GO:0046979)
0.3 1.8 GO:0005119 smoothened binding(GO:0005119)
0.3 1.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 4.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 2.9 GO:0048185 activin binding(GO:0048185)
0.2 0.5 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 2.0 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.0 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 4.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0032427 GBD domain binding(GO:0032427)
0.1 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.3 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.9 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.3 GO:0097677 STAT family protein binding(GO:0097677)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 3.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 0.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.6 GO:0004935 adrenergic receptor activity(GO:0004935)
0.0 0.2 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.5 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 1.5 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID BMP PATHWAY BMP receptor signaling
0.0 0.4 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.4 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling