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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZIC3_ZIC4

Z-value: 0.52

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ZIC3
ENSG00000156925.7 Zic family member 3
ZIC4
ENSG00000174963.13 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC4hg19_v2_chr3_-_147124547_147124647-0.423.9e-02Click!
ZIC3hg19_v2_chrX_+_136648297_136648319-0.096.8e-01Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_37507210 1.30 ENST00000290354.5
CBR3
carbonyl reductase 3
chr19_+_45251804 1.15 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr5_+_121647924 0.91 ENST00000414317.2
SNCAIP
synuclein, alpha interacting protein
chr5_+_121647764 0.89 ENST00000261368.8
ENST00000379533.2
ENST00000379536.2
ENST00000379538.3
SNCAIP
synuclein, alpha interacting protein
chr10_+_35416223 0.88 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr5_+_121647877 0.88 ENST00000514497.2
ENST00000261367.7
SNCAIP
synuclein, alpha interacting protein
chr8_+_90770008 0.73 ENST00000540020.1
RIPK2
receptor-interacting serine-threonine kinase 2
chr8_+_90769967 0.63 ENST00000220751.4
RIPK2
receptor-interacting serine-threonine kinase 2
chr11_+_33563821 0.55 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr19_-_12992244 0.54 ENST00000538460.1
DNASE2
deoxyribonuclease II, lysosomal
chr20_+_61340179 0.51 ENST00000370501.3
NTSR1
neurotensin receptor 1 (high affinity)
chr1_+_33207381 0.45 ENST00000401073.2
KIAA1522
KIAA1522
chr9_+_115913222 0.44 ENST00000259392.3
SLC31A2
solute carrier family 31 (copper transporter), member 2
chr11_-_2160180 0.43 ENST00000381406.4
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_20646824 0.43 ENST00000272233.4
RHOB
ras homolog family member B
chr20_+_35201857 0.43 ENST00000373874.2
TGIF2
TGFB-induced factor homeobox 2
chr12_-_51419924 0.43 ENST00000541174.2
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr12_-_51420108 0.42 ENST00000547198.1
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr1_-_52521831 0.42 ENST00000371626.4
TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr11_-_2906979 0.41 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr17_+_74734052 0.40 ENST00000590514.1
MFSD11
major facilitator superfamily domain containing 11
chr6_-_10419871 0.38 ENST00000319516.4
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_+_35201993 0.38 ENST00000373872.4
TGIF2
TGFB-induced factor homeobox 2
chr14_-_100841670 0.37 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr3_-_129035120 0.36 ENST00000333762.4
H1FX
H1 histone family, member X
chr6_+_132455118 0.36 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr16_+_4364762 0.35 ENST00000262366.3
GLIS2
GLIS family zinc finger 2
chr10_+_112257596 0.35 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr1_-_32801825 0.34 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr19_+_13135731 0.34 ENST00000587260.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr16_-_11681023 0.33 ENST00000570904.1
ENST00000574701.1
LITAF
lipopolysaccharide-induced TNF factor
chr16_+_29818857 0.33 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr17_-_39197699 0.33 ENST00000306271.4
KRTAP1-1
keratin associated protein 1-1
chr12_-_57400227 0.32 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr11_-_71159458 0.32 ENST00000355527.3
DHCR7
7-dehydrocholesterol reductase
chr17_-_41738931 0.32 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr3_-_112356944 0.31 ENST00000461431.1
CCDC80
coiled-coil domain containing 80
chr7_-_105925367 0.31 ENST00000354289.4
NAMPT
nicotinamide phosphoribosyltransferase
chr15_-_69113218 0.30 ENST00000560303.1
ENST00000465139.2
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr3_-_17783990 0.30 ENST00000429383.4
ENST00000446863.1
ENST00000414349.1
ENST00000428355.1
ENST00000425944.1
ENST00000445294.1
ENST00000444471.1
ENST00000415814.2
TBC1D5
TBC1 domain family, member 5
chrX_+_41192595 0.30 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr4_+_78079570 0.30 ENST00000509972.1
CCNG2
cyclin G2
chr22_-_39636914 0.29 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr16_+_30996502 0.29 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr6_+_132455526 0.29 ENST00000443303.1
LINC01013
long intergenic non-protein coding RNA 1013
chr17_+_78194205 0.28 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr5_+_140753444 0.28 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr17_+_39261584 0.28 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr19_-_12992274 0.28 ENST00000592506.1
ENST00000222219.3
DNASE2
deoxyribonuclease II, lysosomal
chr10_+_28966271 0.28 ENST00000375533.3
BAMBI
BMP and activin membrane-bound inhibitor
chr7_+_75511362 0.27 ENST00000428119.1
RHBDD2
rhomboid domain containing 2
chr11_-_71159380 0.27 ENST00000525346.1
ENST00000531364.1
ENST00000529990.1
ENST00000527316.1
ENST00000407721.2
DHCR7
7-dehydrocholesterol reductase
chr9_-_74383799 0.26 ENST00000377044.4
TMEM2
transmembrane protein 2
chr1_-_55680762 0.25 ENST00000407756.1
ENST00000294383.6
USP24
ubiquitin specific peptidase 24
chr15_-_70388599 0.25 ENST00000560996.1
ENST00000558201.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr1_-_150552006 0.25 ENST00000307940.3
ENST00000369026.2
MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr12_-_48152853 0.24 ENST00000171000.4
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr17_+_45331184 0.24 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr8_-_80993010 0.24 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr1_+_38273988 0.24 ENST00000446260.2
C1orf122
chromosome 1 open reading frame 122
chr9_-_139581875 0.24 ENST00000371696.2
AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2
chr6_+_143857949 0.24 ENST00000367584.4
PHACTR2
phosphatase and actin regulator 2
chr4_+_74718906 0.24 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr11_-_2158507 0.23 ENST00000381392.1
ENST00000381395.1
ENST00000418738.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_-_100841930 0.23 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chrX_+_51927919 0.23 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr2_+_11273179 0.23 ENST00000381585.3
ENST00000405022.3
C2orf50
chromosome 2 open reading frame 50
chr16_-_11680759 0.23 ENST00000571459.1
ENST00000570798.1
ENST00000572255.1
ENST00000574763.1
ENST00000574703.1
ENST00000571277.1
ENST00000381810.3
LITAF
lipopolysaccharide-induced TNF factor
chr11_-_2182388 0.23 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
INS
INS-IGF2
insulin
INS-IGF2 readthrough
chr2_-_64881018 0.23 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr9_-_139581848 0.23 ENST00000538402.1
ENST00000371694.3
AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2
chr16_+_29466426 0.22 ENST00000567248.1
SLX1B
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr17_+_38599693 0.22 ENST00000542955.1
ENST00000269593.4
IGFBP4
insulin-like growth factor binding protein 4
chr11_-_85779786 0.22 ENST00000356360.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr9_-_140082983 0.22 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr21_+_46117087 0.21 ENST00000400365.3
KRTAP10-12
keratin associated protein 10-12
chr1_+_38273818 0.21 ENST00000373042.4
C1orf122
chromosome 1 open reading frame 122
chr19_-_12833361 0.21 ENST00000592287.1
TNPO2
transportin 2
chr11_-_119211525 0.21 ENST00000528368.1
C1QTNF5
C1q and tumor necrosis factor related protein 5
chr17_+_74733744 0.21 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
MFSD11
major facilitator superfamily domain containing 11
chr17_+_39394250 0.21 ENST00000254072.6
KRTAP9-8
keratin associated protein 9-8
chr16_-_11680791 0.20 ENST00000571976.1
ENST00000413364.2
LITAF
lipopolysaccharide-induced TNF factor
chr11_-_78128811 0.20 ENST00000530915.1
ENST00000361507.4
GAB2
GRB2-associated binding protein 2
chr11_-_407103 0.20 ENST00000526395.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr7_-_44924939 0.19 ENST00000395699.2
PURB
purine-rich element binding protein B
chr2_+_79740118 0.19 ENST00000496558.1
ENST00000451966.1
CTNNA2
catenin (cadherin-associated protein), alpha 2
chrX_-_102319092 0.19 ENST00000372728.3
BEX1
brain expressed, X-linked 1
chr19_-_14316980 0.19 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr5_-_111091948 0.19 ENST00000447165.2
NREP
neuronal regeneration related protein
chr1_-_154928562 0.19 ENST00000368463.3
ENST00000539880.1
ENST00000542459.1
ENST00000368460.3
ENST00000368465.1
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr3_-_71802760 0.19 ENST00000295612.3
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr10_+_50818343 0.18 ENST00000374115.3
SLC18A3
solute carrier family 18 (vesicular acetylcholine transporter), member 3
chr12_-_59314246 0.18 ENST00000320743.3
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr5_-_176923846 0.17 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chrX_-_78622805 0.17 ENST00000373298.2
ITM2A
integral membrane protein 2A
chr15_+_31619013 0.17 ENST00000307145.3
KLF13
Kruppel-like factor 13
chr19_-_1174226 0.17 ENST00000587024.1
ENST00000361757.3
SBNO2
strawberry notch homolog 2 (Drosophila)
chr6_+_144904334 0.17 ENST00000367526.4
UTRN
utrophin
chr18_-_77276057 0.17 ENST00000597412.1
AC018445.1
Uncharacterized protein
chr10_+_81466084 0.17 ENST00000342531.2
NUTM2B
NUT family member 2B
chr5_-_176923803 0.17 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr8_+_90914073 0.16 ENST00000297438.2
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr17_+_15902694 0.16 ENST00000261647.5
ENST00000486880.2
TTC19
tetratricopeptide repeat domain 19
chr7_+_302918 0.16 ENST00000599994.1
AC187652.1
Protein LOC100996433
chr17_-_74582191 0.16 ENST00000225276.5
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr5_+_139027877 0.16 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr17_-_42276574 0.15 ENST00000589805.1
ATXN7L3
ataxin 7-like 3
chr1_+_218519577 0.15 ENST00000366930.4
ENST00000366929.4
TGFB2
transforming growth factor, beta 2
chrX_+_106871713 0.15 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr7_-_105925558 0.15 ENST00000222553.3
NAMPT
nicotinamide phosphoribosyltransferase
chr16_-_8962200 0.15 ENST00000562843.1
ENST00000561530.1
ENST00000396593.2
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr17_-_15902951 0.15 ENST00000472495.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr2_+_42795839 0.15 ENST00000405094.1
MTA3
metastasis associated 1 family, member 3
chr17_-_78194147 0.15 ENST00000534910.1
ENST00000326317.6
SGSH
N-sulfoglucosamine sulfohydrolase
chr1_-_151119087 0.15 ENST00000341697.3
ENST00000368914.3
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr22_+_19467261 0.15 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45
cell division cycle 45
chr6_-_105584560 0.15 ENST00000336775.5
BVES
blood vessel epicardial substance
chr1_+_155293702 0.14 ENST00000368347.4
RUSC1
RUN and SH3 domain containing 1
chr11_-_116968987 0.14 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
SIK3
SIK family kinase 3
chr17_-_15903002 0.14 ENST00000399277.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr5_-_180076613 0.14 ENST00000261937.6
ENST00000393347.3
FLT4
fms-related tyrosine kinase 4
chr22_+_19466980 0.14 ENST00000407835.1
ENST00000438587.1
CDC45
cell division cycle 45
chr17_+_7531281 0.14 ENST00000575729.1
ENST00000340624.5
SHBG
sex hormone-binding globulin
chr5_+_140718396 0.14 ENST00000394576.2
PCDHGA2
protocadherin gamma subfamily A, 2
chr12_+_51785057 0.14 ENST00000535225.2
SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr2_+_219187871 0.14 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr14_+_103243813 0.14 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chrX_-_153881842 0.14 ENST00000369585.3
ENST00000247306.4
CTAG2
cancer/testis antigen 2
chr1_+_28995258 0.14 ENST00000361872.4
ENST00000294409.2
GMEB1
glucocorticoid modulatory element binding protein 1
chr3_+_50192499 0.13 ENST00000413852.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr7_-_135412925 0.13 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr8_-_27462822 0.13 ENST00000522098.1
CLU
clusterin
chr10_-_126849588 0.13 ENST00000411419.2
CTBP2
C-terminal binding protein 2
chr2_+_10183651 0.13 ENST00000305883.1
KLF11
Kruppel-like factor 11
chr20_-_3154162 0.13 ENST00000360342.3
LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr7_-_752577 0.13 ENST00000544935.1
ENST00000430040.1
ENST00000456696.2
ENST00000406797.1
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr19_+_33865218 0.13 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr11_+_73675873 0.13 ENST00000537753.1
ENST00000542350.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr4_+_492985 0.13 ENST00000296306.7
ENST00000536264.1
ENST00000310340.5
ENST00000453061.2
ENST00000504346.1
ENST00000503111.1
ENST00000383028.4
ENST00000509768.1
PIGG
phosphatidylinositol glycan anchor biosynthesis, class G
chr7_+_155250824 0.13 ENST00000297375.4
EN2
engrailed homeobox 2
chr5_-_76383133 0.13 ENST00000255198.2
ZBED3
zinc finger, BED-type containing 3
chr16_+_89753070 0.13 ENST00000353379.7
ENST00000505473.1
ENST00000564192.1
CDK10
cyclin-dependent kinase 10
chr19_+_13051206 0.13 ENST00000586760.1
CALR
calreticulin
chr14_+_54976546 0.13 ENST00000216420.7
CGRRF1
cell growth regulator with ring finger domain 1
chr7_+_65540780 0.13 ENST00000304874.9
ASL
argininosuccinate lyase
chr13_-_52378231 0.13 ENST00000280056.2
ENST00000444610.2
DHRS12
dehydrogenase/reductase (SDR family) member 12
chr17_-_40428359 0.13 ENST00000293328.3
STAT5B
signal transducer and activator of transcription 5B
chr17_-_43045439 0.12 ENST00000253407.3
C1QL1
complement component 1, q subcomponent-like 1
chr12_-_132834281 0.12 ENST00000411988.2
ENST00000535228.1
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr16_-_67840442 0.12 ENST00000536251.1
ENST00000448631.2
ENST00000602677.1
ENST00000411657.2
ENST00000425512.2
ENST00000317506.3
RANBP10
RAN binding protein 10
chr11_-_73694346 0.12 ENST00000310473.3
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_-_85779971 0.12 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr22_-_19165917 0.12 ENST00000451283.1
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr17_-_15902903 0.12 ENST00000486655.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr9_-_123639600 0.12 ENST00000373896.3
PHF19
PHD finger protein 19
chr1_+_156024552 0.12 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chrX_+_105066524 0.12 ENST00000243300.9
ENST00000428173.2
NRK
Nik related kinase
chr19_+_10362882 0.12 ENST00000393733.2
ENST00000588502.1
MRPL4
mitochondrial ribosomal protein L4
chr7_+_106809406 0.12 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HBP1
HMG-box transcription factor 1
chr5_-_180018540 0.12 ENST00000292641.3
SCGB3A1
secretoglobin, family 3A, member 1
chr17_-_4871085 0.12 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr19_+_10531150 0.12 ENST00000352831.6
PDE4A
phosphodiesterase 4A, cAMP-specific
chr6_-_168397757 0.12 ENST00000456585.1
ENST00000414364.1
KIF25-AS1
KIF25 antisense RNA 1
chr10_-_13390021 0.12 ENST00000537130.1
SEPHS1
selenophosphate synthetase 1
chrX_+_24711997 0.12 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr5_-_179499086 0.11 ENST00000261947.4
RNF130
ring finger protein 130
chr3_+_11196206 0.11 ENST00000431010.2
HRH1
histamine receptor H1
chr17_+_37844331 0.11 ENST00000578199.1
ENST00000406381.2
ERBB2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
chr4_-_15656923 0.11 ENST00000382358.4
ENST00000412094.2
ENST00000341285.3
FBXL5
F-box and leucine-rich repeat protein 5
chr11_+_125774258 0.11 ENST00000263576.6
DDX25
DEAD (Asp-Glu-Ala-Asp) box helicase 25
chr16_+_29465822 0.11 ENST00000330181.5
ENST00000351581.4
SLX1B
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr7_+_115850547 0.11 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr16_+_30205225 0.11 ENST00000345535.4
ENST00000251303.6
SLX1A
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr20_-_4982132 0.11 ENST00000338244.1
ENST00000424750.2
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr14_-_105635090 0.11 ENST00000331782.3
ENST00000347004.2
JAG2
jagged 2
chr9_+_134269439 0.11 ENST00000405995.1
PRRC2B
proline-rich coiled-coil 2B
chr6_+_33168597 0.11 ENST00000374675.3
SLC39A7
solute carrier family 39 (zinc transporter), member 7
chr17_-_76124812 0.11 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr10_-_134145321 0.11 ENST00000368625.4
ENST00000368619.3
ENST00000456004.1
ENST00000368620.2
STK32C
serine/threonine kinase 32C
chr7_+_65540853 0.11 ENST00000380839.4
ENST00000395332.3
ENST00000362000.5
ENST00000395331.3
ASL
argininosuccinate lyase
chr9_-_123639304 0.11 ENST00000436309.1
PHF19
PHD finger protein 19
chrX_-_2847366 0.10 ENST00000381154.1
ARSD
arylsulfatase D
chr6_+_33168637 0.10 ENST00000374677.3
SLC39A7
solute carrier family 39 (zinc transporter), member 7
chr7_-_5569588 0.10 ENST00000417101.1
ACTB
actin, beta
chr3_-_99833333 0.10 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
FILIP1L
filamin A interacting protein 1-like
chr7_-_96654133 0.10 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr11_+_12695944 0.10 ENST00000361905.4
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr17_-_7531121 0.10 ENST00000573566.1
ENST00000269298.5
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chr12_+_108523133 0.10 ENST00000547525.1
WSCD2
WSC domain containing 2
chr22_+_19705928 0.10 ENST00000383045.3
ENST00000438754.2
SEPT5
septin 5
chr19_+_13906250 0.10 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr20_+_44563267 0.10 ENST00000372409.3
PCIF1
PDX1 C-terminal inhibiting factor 1
chr2_+_42795651 0.10 ENST00000407270.3
MTA3
metastasis associated 1 family, member 3
chr1_+_156024525 0.10 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr12_-_57522813 0.10 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr16_+_24550857 0.10 ENST00000568015.1
RBBP6
retinoblastoma binding protein 6
chr4_-_141677267 0.09 ENST00000442267.2
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr12_-_12503156 0.09 ENST00000543314.1
ENST00000396349.3
MANSC1
MANSC domain containing 1
chr11_-_74109422 0.09 ENST00000298198.4
PGM2L1
phosphoglucomutase 2-like 1
chr16_+_1128781 0.09 ENST00000293897.4
ENST00000562758.1
SSTR5
somatostatin receptor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.3 1.4 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.3 1.3 GO:0042376 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.2 0.9 GO:0015692 lead ion transport(GO:0015692)
0.1 0.6 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.1 0.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.6 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.3 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.4 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.4 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.3 GO:0061056 sclerotome development(GO:0061056)
0.1 0.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:1905174 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.4 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.1 2.7 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 0.2 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 0.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.2 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.2 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) negative regulation of alkaline phosphatase activity(GO:0010693) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.4 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.3 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.1 GO:0060931 sinoatrial node cell development(GO:0060931)
0.0 0.1 GO:0015882 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.0 0.1 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.2 GO:0046101 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0015870 acetylcholine transport(GO:0015870)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.3 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.2 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0033084 regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.8 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.3 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.0 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.0 0.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.0 GO:0021913 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
0.0 0.2 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 1.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.0 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.4 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.0 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.1 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.2 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.1 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0032962 regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.2 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0070914 UV-damage excision repair(GO:0070914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.2 0.9 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.4 GO:0097196 Shu complex(GO:0097196)
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.8 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.2 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 0.8 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 0.9 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.5 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.2 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0008523 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.2 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.2 GO:0015266 protein channel activity(GO:0015266) BH3 domain binding(GO:0051434)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 2.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters