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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZKSCAN3

Z-value: 0.32

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.252.3e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_32597232 0.98 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
CCL7
chemokine (C-C motif) ligand 7
chr19_+_39786962 0.78 ENST00000333625.2
IFNL1
interferon, lambda 1
chr7_+_155090271 0.67 ENST00000476756.1
INSIG1
insulin induced gene 1
chr7_+_155089486 0.64 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr1_+_3598871 0.54 ENST00000603362.1
ENST00000604479.1
TP73
tumor protein p73
chr1_+_66258846 0.52 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_+_150863596 0.33 ENST00000448726.1
ENST00000538575.1
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr1_-_935361 0.30 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr17_+_18625336 0.27 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
TRIM16L
tripartite motif containing 16-like
chr6_-_35656712 0.27 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr6_+_32936353 0.22 ENST00000374825.4
BRD2
bromodomain containing 2
chr12_+_109535373 0.21 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr2_+_191745535 0.20 ENST00000320717.3
GLS
glutaminase
chr16_-_28506840 0.19 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr19_-_39735646 0.19 ENST00000413851.2
IFNL3
interferon, lambda 3
chr12_+_109535923 0.18 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr1_+_93913665 0.16 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chr8_+_123793633 0.15 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr1_+_93913713 0.12 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr19_+_39759154 0.12 ENST00000331982.5
IFNL2
interferon, lambda 2
chr1_-_19811132 0.11 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr1_-_86622421 0.11 ENST00000370571.2
COL24A1
collagen, type XXIV, alpha 1
chrX_+_85403445 0.10 ENST00000373131.1
DACH2
dachshund homolog 2 (Drosophila)
chr12_+_100867486 0.10 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chrX_+_85403487 0.10 ENST00000373125.4
DACH2
dachshund homolog 2 (Drosophila)
chr12_-_113573495 0.09 ENST00000446861.3
RASAL1
RAS protein activator like 1 (GAP1 like)
chr19_-_42348692 0.09 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chr19_+_54372639 0.08 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr22_+_50312274 0.07 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2
chr11_+_66610883 0.07 ENST00000309657.3
ENST00000524506.1
RCE1
Ras converting CAAX endopeptidase 1
chr22_+_50312316 0.07 ENST00000328268.4
CRELD2
cysteine-rich with EGF-like domains 2
chr22_-_50312052 0.07 ENST00000330817.6
ALG12
ALG12, alpha-1,6-mannosyltransferase
chr3_-_122512619 0.06 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr15_+_41624892 0.05 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr5_-_95297534 0.05 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr22_+_50312379 0.05 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr5_-_114598548 0.04 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr1_-_99470368 0.04 ENST00000263177.4
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr2_-_61244308 0.04 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr12_+_113796347 0.03 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr1_-_115259337 0.03 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr14_-_106069247 0.02 ENST00000479229.1
RP11-731F5.1
RP11-731F5.1
chr2_-_167232484 0.02 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr1_-_99470558 0.02 ENST00000370188.3
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr17_-_60142609 0.02 ENST00000397786.2
MED13
mediator complex subunit 13
chr10_+_21823243 0.02 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr10_+_6779326 0.02 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr19_-_4182530 0.01 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr19_+_49258775 0.01 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr10_+_21823079 0.00 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 1.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.0 0.2 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0001079 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.0 0.5 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 0.8 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.0 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.0 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines