ISMARA results: ZNF143

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ZNF143

Z-value: 1.11

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Transcription factors associated with ZNF143

Gene Symbol	Gene ID	Gene Info
ZNF143 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000166478.5	zinc finger protein 143

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF143	hg19_v2_chr11_+_9482512_9482534	0.45	2.3e-02	Click!

Activity profile of ZNF143 motif

Sorted Z-values of ZNF143 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_72385437 Show fit	2.40	ENST00000418754.2 ENST00000542969.2 ENST00000334456.5	PDE2A Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 2A, cGMP-stimulated
chr2_+_74757050 Show fit	2.19	ENST00000352222.3 ENST00000437202.1	HTRA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	HtrA serine peptidase 2
chr19_+_42746927 Show fit	2.03	ENST00000378108.1	AC006486.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC006486.1
chr1_+_244816371 Show fit	2.01	ENST00000263831.7	DESI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	desumoylating isopeptidase 2
chr9_+_35732312 Show fit	1.66	ENST00000353704.2	CREB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cAMP responsive element binding protein 3
chr20_+_32399093 Show fit	1.59	ENST00000217402.2	CHMP4B Ensembl NCBI GeneCards UniProt NextProt Show fit	charged multivesicular body protein 4B
chr6_+_160148593 Show fit	1.46	ENST00000337387.4	WTAP Ensembl NCBI GeneCards UniProt NextProt Show fit	Wilms tumor 1 associated protein
chr11_-_72492903 Show fit	1.40	ENST00000537947.1	STARD10 Ensembl NCBI GeneCards UniProt NextProt Show fit	StAR-related lipid transfer (START) domain containing 10
chr10_+_124134201 Show fit	1.39	ENST00000368990.3 ENST00000368988.1 ENST00000368989.2 ENST00000463663.2	PLEKHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr4_+_140222609 Show fit	1.38	ENST00000296543.5 ENST00000398947.1	NAA15 Ensembl NCBI GeneCards UniProt NextProt Show fit	N(alpha)-acetyltransferase 15, NatA auxiliary subunit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF143

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	GO:0032782	bile acid secretion(GO:0032782)
0.6	2.4	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.3	2.4	GO:0035624	receptor transactivation(GO:0035624)
0.7	2.2	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1	2.2	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.4	2.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	2.0	GO:0030166	proteoglycan biosynthetic process(GO:0030166)
0.0	1.9	GO:0051439	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.6	1.8	GO:0006423	cysteinyl-tRNA aminoacylation(GO:0006423)
0.3	1.7	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567)

Showing 1 to 10 of 183 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	2.9	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	2.9	GO:0035580	specific granule lumen(GO:0035580)
0.2	2.7	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	2.7	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.2	2.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	2.2	GO:0042734	presynaptic membrane(GO:0042734)
0.1	2.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	1.6	GO:0000815	ESCRT III complex(GO:0000815)
0.4	1.5	GO:0045293	MIS complex(GO:0036396) mRNA editing complex(GO:0045293)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.4	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0	2.3	GO:0051082	unfolded protein binding(GO:0051082)
0.7	2.2	GO:0004382	guanosine-diphosphatase activity(GO:0004382)
0.0	2.2	GO:0051087	chaperone binding(GO:0051087)
0.3	2.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1	2.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	2.0	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.1	1.9	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.6	1.8	GO:0004817	cysteine-tRNA ligase activity(GO:0004817)
0.0	1.8	GO:0008139	nuclear localization sequence binding(GO:0008139)

Showing 1 to 10 of 125 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	PID PLK1 PATHWAY	PLK1 signaling events
0.0	3.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	2.9	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	2.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	1.7	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	1.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	1.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	1.0	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.9	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.8	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	3.9	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.1	3.5	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	2.6	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.1	2.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	2.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	2.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	2.0	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	1.8	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1	1.7	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition

Showing 1 to 10 of 39 entries

Results for ZNF143

Z-value: 1.11

Motif logo

Transcription factors associated with ZNF143

Activity-expression correlation:

Activity profile of ZNF143 motif

Sorted Z-values of ZNF143 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF143

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: