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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ZNF263
Z-value: 0.59
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Transcription factors associated with ZNF263
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF263 | hg19_v2_chr16_+_3313791_3313834 | 0.07 | 7.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29595779 Show fit | 2.41 |
ENST00000355973.3
ENST00000377012.4 |
gamma-aminobutyric acid (GABA) B receptor, 1 |
|
| chr17_+_77020224 Show fit | 2.14 |
ENST00000339142.2
|
C1q and tumor necrosis factor related protein 1 |
|
| chr16_+_86544113 Show fit | 1.96 |
ENST00000262426.4
|
forkhead box F1 |
|
| chr6_-_32821599 Show fit | 1.93 |
ENST00000354258.4
|
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
|
| chr4_+_74702214 Show fit | 1.83 |
ENST00000226317.5
ENST00000515050.1 |
chemokine (C-X-C motif) ligand 6 |
|
| chr17_+_77020325 Show fit | 1.83 |
ENST00000311661.4
|
C1q and tumor necrosis factor related protein 1 |
|
| chr6_+_32821924 Show fit | 1.75 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr3_-_127542021 Show fit | 1.65 |
ENST00000434178.2
|
monoglyceride lipase |
|
| chr19_-_55658687 Show fit | 1.64 |
ENST00000593046.1
|
troponin T type 1 (skeletal, slow) |
|
| chr3_-_127542051 Show fit | 1.62 |
ENST00000398104.1
|
monoglyceride lipase |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF263
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.0 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.6 | 4.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 3.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 2.6 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 2.6 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.0 | 2.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.7 | 2.0 | GO:0007439 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) right lung development(GO:0060458) |
| 0.5 | 1.9 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.2 | 1.6 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 1.4 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 4.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.8 | 2.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.3 | 1.9 | GO:0042825 | TAP complex(GO:0042825) |
| 0.2 | 1.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 1.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.5 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.3 | 1.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 3.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 2.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 2.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.6 | 2.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 2.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 2.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.3 | 1.9 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.1 | 1.8 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 1.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.2 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 2.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 2.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 2.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 2.2 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.0 | 1.2 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |